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    Monroe County, FL Mixed-use Properties for Lease

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    Key West Retail/Office Opportunity
    Updated: Nov 12, 2025
    Key West Retail/Office Opportunity

    607 Fleming Street, Key West, FL 33040

    $4,750/Mo
    1,496 sqft $38 SF/Yr
    Prime Old Town Key West location, one block from Duval Street.
    High foot traffic area surrounded by top restaurants and shops.
    1496 Sq.ft. of customizable space.
    Mixed‑use building suitable for retail or office.
    Street‑level entrance.
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    Stock Island Commercial Space For Rent
    Updated: Oct 1, 2024
    Stock Island Commercial Space For Rent

    6150 2Nd Street, Stock Island, FL 33040

    $5,000/Mo
    3,618 sqft $16 SF/Yr
    Prime corner location just over the bridge from Key West on US Highway 1
    Large approximately 3,000 SF outdoor tiki hut
    618 SF commercial space offering versatile indoor/outdoor business use
    High‑visibility location across from Wrecker's Cay housing complex and Beach Weekend Marina
    Excellent traffic exposure
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    Turn Any Listing Into an Investment Snapshot Owner equity, real caprate, demand score for every listing. Go To Analytics Center
    Based on your search, we've compiled 24 Potential Opportunities for your consideration. Besides 2 Active listings in Monroe County, FL, we suggest exploring alternatives. Similar 18 Properties for Sales.

    Similar Spaces for Sale in Monroe County, FL

    Consider Similar Space for Sale. We found 18 Spaces matching your search parameters.

    Prime US-1 Mixed-Use Opportunity
    Prime US-1 Mixed-Use Opportunity

    92295 Old State Road, Key Largo, FL 33070

    $2,895,000
    6,241 sqft 0.86 AC lot

    Mixed-use commercial building with highway frontage in Tavernier.

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    New Mixed-Use Development in Key West
    New Mixed-Use Development in Key West

    3201 Flagler Avenue, Key West, FL 33040

    $749,000
    1,491 sqft 0.71 AC lot

    Commercial space in new mixed-use development, completion end of 2026.

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    Key Largo Mixed-Use Property
    Key Largo Mixed-Use Property

    100636 Overseas Highway, Key Largo, FL 33037

    $1,790,000
    4,910 sqft 0.18 AC lot

    High-visibility mixed-use property with commercial storefront and residential apartment.

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    Ocean-View Mixed-Use Property
    Ocean-View Mixed-Use Property

    Islamorada, FL 33036

    $1,680,000
    1,980 sqft 0.16 AC lot

    High-visibility mixed-use setup with ocean views and substantial parking along the Overseas Highway.

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    Stock Island Mixed-Use Opportunity
    Stock Island Mixed-Use Opportunity

    5580 1st Avenue, Stock Island, FL 33040

    $2,200,000
    2,040 sqft 0.57 AC lot

    25,000 SF mixed-use property with redevelopment potential near Key West.

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    High-Frontage Mixed-Use Building with Suites
    High-Frontage Mixed-Use Building with Suites

    92295 Old State Road, #4A, Key Largo, FL 33070

    $2,895,000
    6,214 sqft 0.86 AC lot

    Concrete mixed-use building with six exterior-access suites and extensive US-1 frontage for flexible retail, office, and medical use.

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    Stock Island Commercial Property Available
    Stock Island Commercial Property Available

    5670 Laurel Avenue, Stock Island, FL 33040

    $1,950,000
    5,258 sqft 0.29 AC lot

    Prime commercial property with mixed-use zoning and income potential.

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    Stock Island Commercial Property For Sale
    Stock Island Commercial Property For Sale

    5670 Laurel Ave, Key West, FL 33040

    $1,950,000
    5,258 sqft 0.29 AC lot

    Commercial property on Stock Island with mixed-use zoning.

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    Islamorada Mixed-Use Commercial Property
    Islamorada Mixed-Use Commercial Property

    105 Palm Avenue, Upper Matecumbe Key, Islamorada, FL 33036

    $4,600,000
    0.21 AC lot

    Versatile commercial property in Islamorada's established business corridor.

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    White Box Commercial Suite
    White Box Commercial Suite

    3201 Flagler Avenue, #STE 507, Key West, FL 33040

    $749,000
    1,491 sqft

    Under-construction suite with white-box delivery, ADA access, ample parking, and flexibility to split into two units.

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    Key West Mixed-Use Investment
    Key West Mixed-Use Investment

    405 Petronia Street, Key West, FL 33040

    $2,999,999
    1,596 sqft 0.05 AC lot

    Fully rented mixed-use property in Old Town Key West.

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    Key Largo Commercial Opportunity
    Key Largo Commercial Opportunity

    106600 Overseas Highway, Key Largo, FL 33037

    Contact for pricing
    2,400 sqft 0.82 AC lot

    Highway frontage building with upstairs space for lease.

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    Islamorada Mixed-Use Investment Opportunity
    Islamorada Mixed-Use Investment Opportunity

    88101 Old Hwy, Plantation Key, FL 33036

    $999,999
    2,244 sqft

    Two-story mixed-use building with income potential in Islamorada.

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    Treasure Harbor Marina Business Opportunity
    Treasure Harbor Marina Business Opportunity

    200 Treasure Harbor Dr., Plantation Key, FL 33036

    $8,500,000
    1,069 sqft

    Marina business for sale in Plantation Key, Florida.

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    Waterfront Redevelopment Opportunity with Dockage
    Waterfront Redevelopment Opportunity with Dockage

    14 125th Street Gulf, Marathon, FL 33050

    $3,549,000
    6,128 sqft 1.72 AC lot

    Rare waterfront redevelopment site with deep water dockage and highway frontage.

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    Overseas Highway Mixed-Use Investment
    Overseas Highway Mixed-Use Investment

    7070 Overseas Highway, Marathon, FL 33050

    $1,450,000
    4,168 sqft

    Mixed-use property with commercial space and residential rental units.

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    Established Business in Florida Keys
    Established Business in Florida Keys

    Montage FL Keys Souvenirs, Marathon, FL 33050

    $99,000

    Work and live in paradise with this established business.

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    Waterfront Property with Private Boat Ramp
    Waterfront Property with Private Boat Ramp

    81 Coco Plum Dr, Marathon, FL 33050

    $4,250,000

    Waterfront property featuring a private boat ramp and multiple slips.

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    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Miami Development Opportunity on NW 27th
    Miami Development Opportunity on NW 27th

    6611 NW 27 Avenue, Miami, FL 33147

    Contact for pricing

    33,600 SF vacant land near transit with development potential.

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    Vacant Commercial Parcel For Sale
    Vacant Commercial Parcel For Sale

    1508 Nw 1st Ave, Miami, FL 33136

    $2,000/Mo

    Vacant commercial land parcel available for sale.

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    Atlanta Land for Lease
    Atlanta Land for Lease

    1057 Constitution Road SW, Atlanta, GA 30315

    $1,850/Mo

    3-acre commercial land available for lease in Atlanta, GA.

    View details
    Baton Rouge Commercial Parcel For Rent
    Baton Rouge Commercial Parcel For Rent

    7597 Jefferson Hwy, Baton Rouge, LA 70806

    Contact for pricing

    1.33-acre commercial parcel in a prime Baton Rouge location.

    View details

    Monroe County, FL Mixed-use properties Market Trends and Statistics

    Explore Mixed-use properties leasing options in Monroe County, FL with 2 listings featured on our commercial real estate exchange. The current inventory includes 5,114 square feet of properties with an estimated lease value of $54 SF/Yr.

    Estimated lease rates for Mixed-use properties in Monroe County, FL begin at $16 SF/Yr, with an average of $27 SF/Yr and extend to $38 SF/Yr.
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