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    Monroe County, FL Mixed-use Properties for Lease

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    Retail Space with Suite Flexibility
    Updated: Mar 3
    Retail Space with Suite Flexibility

    3201 Flagler Avenue, Key West, FL 33040

    $6,000/Mo
    1,491 sqft
    Approximately 1,491 square feet of retail space
    Two combined units can operate together or be divided into two suites
    White‑box shell delivery supports a tenant‑designed interior
    Under construction with completion scheduled for late 2026
    Mixed‑use project includes 14 residential and 14 commercial units
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    Mixed-Use Building with Open Layout
    Updated: Nov 12, 2025
    Mixed-Use Building with Open Layout

    607 Fleming Street, Key West, FL 33040

    $4,650/Mo
    1,496 sqft
    1,496 SF mixed‑use building constructed in 1933
    Open interior layout with street‑level entry
    Corner location at Fleming Street and Simonton Street
    One block from Duval Street
    Across from Marquesa Restaurant
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    Mixed-Use Property with Restaurant
    Mixed-Use Property with Restaurant

    90184 Overseas Highway, Islamorada, FL 33070

    Contact for pricing

    Restaurant space combines indoor dining and bar areas with outdoor seating and seven apartments.

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    Based on your search, we've compiled 39 Potential Opportunities for your consideration. Besides 3 Active listings in Monroe County, FL, we suggest exploring alternatives. Similar 36 Properties for Sales.

    Similar Spaces for Sale in Monroe County, FL

    Consider Similar Space for Sale. We found 36 Spaces matching your search parameters.

    Mixed-Use Property with Work Areas
    Mixed-Use Property with Work Areas

    5670 Laurel Avenue, Stock Island, FL 33040

    $1,749,000
    5,258 sqft 0.29 AC lot

    Ground-level commercial building with covered and open work areas, mixed-use zoning, and access to Overseas Hwy.

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    High-Frontage Mixed-Use Building with Suites
    High-Frontage Mixed-Use Building with Suites

    92295 Old State Road, #4A, Key Largo, FL 33070

    $2,850,000
    6,214 sqft 0.86 AC lot

    Concrete mixed-use building with six exterior-access suites and extensive US-1 frontage for flexible retail, office, and medical use.

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    Six-Suite Mixed-Use Building
    Six-Suite Mixed-Use Building

    92295 Old State Road, Key Largo, FL 33070

    $2,850,000
    6,241 sqft 0.86 AC lot

    Fenced commercial property with flexible suites, exterior access, central air, and SC - Sub Urban Commercial zoning.

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    Mixed-Use Property with Six Storefronts
    Mixed-Use Property with Six Storefronts

    218 Whitehead Street, Key West, FL 33040

    $4,200,000
    7,755 sqft 0.16 AC lot

    Corner property combines six retail spaces with a three-bedroom, two-bath apartment and separate utility meters.

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    Three-Unit Mixed-Use Property
    Three-Unit Mixed-Use Property

    1200-1206 White Street, Key West, FL 33040

    $1,475,000
    3,380 sqft

    Commercial condominium offering with established occupants, one vacant unit, and flexible office, retail, service, and restaurant use potential.

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    Auto Shop with Covered Work Areas
    Auto Shop with Covered Work Areas

    5670 Laurel Avenue, Stock Island, FL 33040

    $1,749,000
    5,258 sqft 0.29 AC lot

    Mixed-use zoning supports commercial and residential uses, with licenses covering repair, towing, detailing, rentals, and retail sales.

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    Mixed-Use Commercial Land
    Mixed-Use Commercial Land

    5331 5th Avenue, Stock Island, FL 33040

    $2,050,000
    5,705 sqft 0.69 AC lot

    The site carries MU zoning and includes seven electric meters and seven water meters.

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    Fenced Mixed-Use Commercial Building
    Fenced Mixed-Use Commercial Building

    4a-92295 Old State Rd, Key Largo, FL 33037

    $2,850,000
    6,214 sqft 0.86 AC lot

    Concrete commercial property with multiple suites, highway frontage, and access serving both directions of US-1.

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    White Box Commercial Suite
    White Box Commercial Suite

    3201 Flagler Avenue, #STE 507, Key West, FL 33040

    $749,000
    1,491 sqft

    Under-construction suite with white-box delivery, ADA access, ample parking, and flexibility to split into two units.

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    Concrete Mixed-Use Building
    Concrete Mixed-Use Building

    100636 Overseas Highway, Key Largo, FL 33037

    $1,790,000
    4,910 sqft 0.18 AC lot

    Ground-floor commercial space is paired with a renovated three-bedroom, three-bath apartment and rooftop, patio, and yard areas.

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    Mixed-Use White-Box Space
    Mixed-Use White-Box Space

    3201 Flagler Avenue, Key West, FL 33040

    $749,000
    1,491 sqft 0.71 AC lot

    White-box commercial space allows buyers to configure the interior for professional, medical office, or retail operations.

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    Mixed-Use Property with Storefront
    Mixed-Use Property with Storefront

    1011 Whitehead Street, Key West, FL 33040

    $3,795,000
    2,024 sqft 0.03 AC lot

    Three furnished one-bedroom residences feature individual kitchens and transient rental licenses.

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    Mixed-Use Compound with Rental Units
    Mixed-Use Compound with Rental Units

    82891 Overseas Highway, Islamorada, FL 33036

    $2,100,000
    476 sqft 0.17 AC lot

    Commercial improvements combine a fortified shop-office with multi-unit accommodations and dedicated vehicle staging.

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    Overseas Highway Mixed-Use Investment
    Overseas Highway Mixed-Use Investment

    7070 Overseas Highway, Marathon, FL 33050

    $1,400,000
    4,168 sqft

    Mixed-use property with commercial space and residential rental units.

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    Mixed-Use Corner Property
    Mixed-Use Corner Property

    218 Whitehead Street, Key West, FL 33040

    $4,200,000
    7,755 sqft

    Six retail suites and a three-bedroom apartment combine commercial and residential occupancy in one property.

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    Fenced Mixed-Use Property
    Fenced Mixed-Use Property

    104980 Overseas Highway, Key Largo, FL 33037

    $1,200,000
    1,024 sqft 0.37 AC lot

    MU-zoned property with a concrete building, central air, dual access, and secure perimeter fencing.

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    Waterfront Mixed-Use Property
    Waterfront Mixed-Use Property

    Islamorada, FL 33036

    $3,150,000
    6,071 sqft 0.35 AC lot

    Oceanfront commercial property with marine access, wraparound windows, and space for residential and business uses.

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    Mixed-Use Building with Drive-Through
    Mixed-Use Building with Drive-Through

    11401 Overseas Highway, Marathon, FL 33050

    $1,533,333
    3,429 sqft 0.34 AC lot

    MU - Mixed Use Commercial zoning supports office and retail use potential.

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    Commercial Land with Mixed-Use Zoning
    Commercial Land with Mixed-Use Zoning

    5331 5th Avenue, Stock Island, FL 33040

    $2,050,000
    0.69 AC lot

    Four parcels offer utility connections and a mixed-use development framework on Stock Island.

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    Islamorada Mixed-Use Investment Opportunity
    Islamorada Mixed-Use Investment Opportunity

    88101 Old Highway, Plantation Key, FL 33036

    $999,999
    2,244 sqft

    Two-story mixed-use building with income potential in Islamorada.

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    Mixed-Use Property with Classrooms
    Mixed-Use Property with Classrooms

    101900 Overseas Hwy, Key Largo, FL 33037

    $10,800,000
    2.08 AC lot

    Gift shop and administrative space support on-site guest services and educational programming.

    View details

    Monroe County, FL Mixed-use properties Market Trends and Statistics

    Explore Mixed-use properties leasing options in Monroe County, FL with 3 listings featured on our commercial real estate exchange. The current inventory includes 2,987 square feet of properties with an estimated lease value of $85.59.

    Estimated lease rates for Mixed-use properties in Monroe County, FL begin at $37.30 SF/Yr, with an average of $42.80 SF/Yr and extend to $48.29 SF/Yr.
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    Featured Monroe County Real Estate Agencies

    Realmo connects you with licensed Monroe County CRE brokers providing property specifications, local market pricing, and commercial transaction underwriting support.

    Berkshire Hathaway Keys Real Estate | Knight & Gardner Realty
    336 Duval St Key West, FL 33040
    Phone: 13052945155
    www.keysrealestate.com
    Berkshire Hathaway HomeServices Freewheeler Realty
    85992 Overseas Hwy, P.O. Box 1634 Islamorada, FL 33036
    Phone: 13056644444
    www.bhhsfreewheeler.com
    American Caribbean Real Estate
    99900 Overseas Highway, PO Box 600 Key Largo, FL 33037
    Phone: 13054514078
    www.americancaribbean.com/
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