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    Monroe County, FL Mixed-use Properties for Lease

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    Retail Space with Suite Flexibility
    Updated: Mar 3
    Retail Space with Suite Flexibility

    3201 Flagler Avenue, Key West, FL 33040

    $6,000/Mo
    1,491 sqft
    Approximately 1,491 square feet of retail space
    Two combined units can operate together or be divided into two suites
    White‑box shell delivery supports a tenant‑designed interior
    Under construction with completion scheduled for late 2026
    Mixed‑use project includes 14 residential and 14 commercial units
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    Mixed-Use Building with Open Layout
    Updated: Nov 12, 2025
    Mixed-Use Building with Open Layout

    607 Fleming Street, Key West, FL 33040

    $4,650/Mo
    1,496 sqft
    1,496 SF mixed‑use building constructed in 1933
    Open interior layout with street‑level entry
    Corner location at Fleming Street and Simonton Street
    One block from Duval Street
    Across from Marquesa Restaurant
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    Turn a Listing Into an Investment Snapshot Cap Rate, Potential NOI, Demand score for every listing. Go To Analytics Center
    Based on your search, we've compiled 33 Potential Opportunities for your consideration. Besides 2 Active listings in Monroe County, FL, we suggest exploring alternatives. Similar 31 Properties for Sales.

    Similar Spaces for Sale in Monroe County, FL

    Consider Similar Space for Sale. We found 31 Spaces matching your search parameters.

    Mixed-Use Building with Highway Frontage
    Mixed-Use Building with Highway Frontage

    92295 Old State Road, Key Largo, FL 33070

    $2,895,000
    6,241 sqft 0.86 AC lot

    Six connected units on a fenced lot zoned SC - Sub Urban Commercial, with central air and concrete construction.

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    Mixed-Use Property with Six Storefronts
    Mixed-Use Property with Six Storefronts

    218 Whitehead Street, Key West, FL 33040

    $4,200,000
    7,755 sqft 0.16 AC lot

    Corner property combines six retail spaces with a three-bedroom, two-bath apartment and separate utility meters.

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    High-Frontage Mixed-Use Building with Suites
    High-Frontage Mixed-Use Building with Suites

    92295 Old State Road, #4A, Key Largo, FL 33070

    $2,895,000
    6,214 sqft 0.86 AC lot

    Concrete mixed-use building with six exterior-access suites and extensive US-1 frontage for flexible retail, office, and medical use.

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    Three-Unit Mixed-Use Condo Property
    Three-Unit Mixed-Use Condo Property

    1200-1206 White Street, Key West, FL 33040

    $1,489,000
    3,380 sqft

    Three commercial condominium units combine established occupancy with one space available for immediate use or leasing.

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    Oceanfront Mixed-Use Property
    Oceanfront Mixed-Use Property

    Islamorada, FL 33036

    $1,680,000
    1,980 sqft 0.16 AC lot

    Neighborhood Commercial zoning supports a flexible residential and commercial configuration with Atlantic Ocean frontage.

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    Mixed-Use Commercial Land
    Mixed-Use Commercial Land

    5331 5th Avenue, Stock Island, FL 33040

    $2,050,000
    5,705 sqft 0.69 AC lot

    The site carries MU zoning and includes seven electric meters and seven water meters.

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    White Box Commercial Suite
    White Box Commercial Suite

    3201 Flagler Avenue, #STE 507, Key West, FL 33040

    $749,000
    1,491 sqft

    Under-construction suite with white-box delivery, ADA access, ample parking, and flexibility to split into two units.

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    Mixed-Use Building with Drive-Through
    Mixed-Use Building with Drive-Through

    11401 Overseas Highway, Marathon, FL 33050

    $1,533,333
    3,429 sqft 0.34 AC lot

    MU - Mixed Use Commercial zoning supports office and retail use potential.

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    Freestanding Mixed-Use Concrete Building
    Freestanding Mixed-Use Concrete Building

    100636 Overseas Highway, Key Largo, FL 33037

    $1,790,000
    4,910 sqft 0.18 AC lot

    Free-standing concrete mixed-use building on Overseas Highway with ground-floor commercial space, upstairs 3BD/3BA residence, and 10 parking spaces.

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    Mixed-Use White-Box Space
    Mixed-Use White-Box Space

    3201 Flagler Avenue, Key West, FL 33040

    $749,000
    1,491 sqft 0.71 AC lot

    White-box commercial space allows buyers to configure the interior for professional, medical office, or retail operations.

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    Overseas Highway Mixed-Use Investment
    Overseas Highway Mixed-Use Investment

    7070 Overseas Highway, Marathon, FL 33050

    $1,450,000
    4,168 sqft

    Mixed-use property with commercial space and residential rental units.

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    Two-Story Office Building
    Two-Story Office Building

    88101 Old Highway, Plantation Key, FL 33036

    $999,999
    2,244 sqft 0.14 AC lot

    Mixed-use highway commercial property with private offices, conference rooms, and rear parking access.

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    Waterfront Mixed-Use Property
    Waterfront Mixed-Use Property

    14 125th Street Gulf, Marathon, FL 33050

    $3,549,000
    1.72 AC lot

    Mixed-use zoning, an existing raised block building, and approved dockage support commercial-residential redevelopment planning.

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    Waterfront Mixed-Use Property
    Waterfront Mixed-Use Property

    Islamorada, FL 33036

    $3,300,000
    6,071 sqft 0.35 AC lot

    Oceanfront commercial property with marine access, wraparound windows, and space for residential and business uses.

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    Commercial Land with Mixed-Use Zoning
    Commercial Land with Mixed-Use Zoning

    5331 5th Avenue, Stock Island, FL 33040

    $2,050,000
    0.69 AC lot

    Four parcels offer utility connections and a mixed-use development framework on Stock Island.

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    Mixed-Use Building with Apartment
    Mixed-Use Building with Apartment

    22814 Overseas Highway, Cudjoe Key, FL 33042

    $875,000
    1,120 sqft 0.19 AC lot

    SC - Sub Urban Commercial zoning with office space, residential occupancy, and additional outdoor and storage areas.

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    Mixed-Use Property with Ocean Access
    Mixed-Use Property with Ocean Access

    101900 Overseas Hwy, Key Largo, FL 33037

    $10,800,000
    2.08 AC lot

    Two-acre Florida Keys property includes a gift shop, offices, classrooms, and public water and sewer service.

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    Waterfront Land with Dockage Approval
    Waterfront Land with Dockage Approval

    14 125th Street Gulf, Marathon, FL 33050

    $3,549,000
    1.72 AC lot

    Mixed-use zoning accompanies an existing raised CBS building with public water and sewer service.

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    Waterfront Mixed-Use Property
    Waterfront Mixed-Use Property

    14 125Th Street Gulf, Marathon, FL 33050

    $3,549,000
    6,128 sqft 1.72 AC lot

    Two-story CBS building with mixed-use zoning and an approved conditional use permit.

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    Mixed-Use Property with Paved Yard
    Mixed-Use Property with Paved Yard

    5580 1st Avenue, Stock Island, FL 33040

    $2,200,000
    2,040 sqft 0.57 AC lot

    MU-zoned site combines a concrete office and utility building with fenced paved yard space.

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    Waterfront Mixed-Use Property
    Waterfront Mixed-Use Property

    14 125Th Street Gulf, Marathon, FL 33050

    $3,549,000
    6,128 sqft 1.57 AC lot

    MU - Mixed Use Commercial zoning accompanies a raised concrete building and waterfront redevelopment site.

    View details
    Two-Story Mixed-Use Building
    Two-Story Mixed-Use Building

    2901 Overseas Highway, Marathon, FL 33050

    Contact for pricing
    4,560 sqft 0.35 AC lot

    Flexible commercial suites occupy the lower level, with two residential apartments above and a rear parcel with canal access.

    View details

    Monroe County, FL Mixed-use properties Market Trends and Statistics

    Explore Mixed-use properties leasing options in Monroe County, FL with 2 listings featured on our commercial real estate exchange. The current inventory includes 2,987 square feet of properties with an estimated lease value of $85.59.

    Estimated lease rates for Mixed-use properties in Monroe County, FL begin at $37.30 SF/Yr, with an average of $42.80 SF/Yr and extend to $48.29 SF/Yr.
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    Featured Monroe County Real Estate Agencies

    Realmo connects you with licensed Monroe County CRE brokers providing property specifications, local market pricing, and commercial transaction underwriting support.

    Berkshire Hathaway Keys Real Estate | Knight & Gardner Realty
    336 Duval St Key West, FL 33040
    Phone: 13052945155
    www.keysrealestate.com
    Berkshire Hathaway HomeServices Freewheeler Realty
    85992 Overseas Hwy, P.O. Box 1634 Islamorada, FL 33036
    Phone: 13056644444
    www.bhhsfreewheeler.com
    American Caribbean Real Estate
    99900 Overseas Highway, PO Box 600 Key Largo, FL 33037
    Phone: 13054514078
    www.americancaribbean.com/

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