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Marathon, FL Office Spaces for Lease

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Plantation Key, FL Islamorada, FL Big Pine Key, FL
10 properties
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Office Unit with Foyer
Updated: Sep 23
Office Unit with Foyer

5270 Overseas Highway, Marathon, FL 33050

$3,000/Mo
500 sqft
500‑square‑foot office unit
Foyer with access to 2 restrooms
Meeting area available for larger gatherings by appointment
Possible access to exterior growing areas
Central heating
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Medical Office Space with Highway Frontage
Updated: Feb 6, 2025
Medical Office Space with Highway Frontage

2357 Overseas Highway, Marathon, FL 33050

$7,000/Mo
4,188 sqft 0.11 AC lot
Medical office property at 2357 Overseas Highway, Marathon, FL 33050
0.11‑acre site with frontage on U.S. 1
MU - Mixed Use Commercial zoning
Two entrances provide separate access for patients and staff
CBS construction with tile and terrazzo flooring
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Combined Professional Office Units
Combined Professional Office Units

10055-10095 Overseas Hwy, Marathon, FL 33050

$2,228/Mo
2,139 sqft

Two adjacent units currently function together, with future division into separate office spaces under consideration.

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Key Vaca Center: Marathon Office Space
Key Vaca Center: Marathon Office Space

10045 Overseas Hwy, Marathon, FL 33050

$7.20 SF/Yr
10,288 sqft

14,000 SF Office Building, Multiple Suites Available

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Professional Office Units
Professional Office Units

5701 Overseas Hwy, Marathon, FL 33050

Contact for pricing
4,139 sqft

Professional center includes medical, legal, service, retail, and social-service occupants.

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Top-Floor Office Unit
Top-Floor Office Unit

207208-11400 Overseas Hwy, Marathon, FL 33050

$2,300/Mo

Flexible workspace with reception, private office, break area, elevator access, parking, and US-1 signage availability.

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Top-Floor Office Suite with Private Bath
Top-Floor Office Suite with Private Bath

216217-11400 Overseas Hwy, Marathon, FL 33050

$2,300/Mo

Top-floor office suite in a managed commercial plaza with private bath, elevator access, and ample client parking.

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Shared Office Space with Natural Lighting
Shared Office Space with Natural Lighting

9141 Overseas Hwy, Marathon, FL 33050

Contact for pricing
83 sqft

Shared office space in the Marathon Berkshire Business Center with electric and water included.

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KEY VACA CENTER
KEY VACA CENTER

10095 Overseas Hwy, Marathon, FL 33050

Contact for pricing
10,288 sqft

Office / Retail / Medical Offices - 3 spaces available | 1,000 SqFt - 4,020 SqFt

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Key Vaca Center: Marathon Office Space
Key Vaca Center: Marathon Office Space

10045 Overseas Hwy, Marathon, FL 33050

$7.20 SF/Yr
10,288 sqft

14,000 SF Office Building, Multiple Suites Available

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Based on your search, we've compiled 22 Potential Opportunities for your consideration. Besides 10 Active listings in Marathon, FL, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 8 Properties for Sales.

Office Spaces for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Office Unit with Private Bathroom
Office Unit with Private Bathroom

2-85992 Overseas Highway, Plantation Key, FL 33036

$2,900/Mo
394 sqft

Ground-level workspace includes air conditioning, power, water, and on-site parking.

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Four-Office Professional Suite
Four-Office Professional Suite

29872 Overseas Highway, Big Pine Key, FL 33043

$3,500/Mo
1,440 sqft 0.43 AC lot

Renovated workspace combines private offices with a shared area on US-1.

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Renovated Office Unit
Renovated Office Unit

1-29872 Overseas Hwy, Big Pine Key, FL 33042

$3,500/Mo
1,440 sqft

Elevated professional suite with four private offices, a shared common area, and two restrooms.

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Office Unit with Fenced Storage
Office Unit with Fenced Storage

C2-88900 Overseas Highway, Plantation Key, FL 33070

$2,500/Mo

Includes use of one fenced storage area positioned behind the business.

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Similar Spaces for Sale in Marathon, FL

Consider Similar Space for Sale. We found 8 Spaces matching your search parameters.

Contiguous Medical Office Suites
Contiguous Medical Office Suites

5701 Overseas Hwy 10, Marathon, FL 33050

$725,000
2,556 sqft

Three contiguous office units offer flexible medical or professional office configurations within a prominent highway retail corridor.

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Frontage Professional Office Unit
Frontage Professional Office Unit

1-5701 Overseas Hwy, Marathon, FL 33050

$395,000
1,128 sqft

Reception, three private offices, kitchen area, and half bath support a flexible professional layout.

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Mixed-Use Building with Drive-Through
Mixed-Use Building with Drive-Through

11401 Overseas Highway, Marathon, FL 33050

$1,533,333
3,429 sqft 0.34 AC lot

MU - Mixed Use Commercial zoning supports office and retail use potential.

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Two-Story Mixed-Use Building
Two-Story Mixed-Use Building

2901 Overseas Highway, Marathon, FL 33050

Contact for pricing
4,560 sqft 0.35 AC lot

Flexible commercial suites occupy the lower level, with two residential apartments above and a rear parcel with canal access.

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Shared Office Coworking Space
Shared Office Coworking Space

9141 Overseas Highway, Marathon, FL 33050

Contact for pricing
84 sqft 0.47 AC lot

Professional workspace within a mixed-use commercial property with shared break-room and restroom facilities.

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Updated Medical Office Suite
Updated Medical Office Suite

5-5701 Overseas Hwy, Marathon, FL 33050

$265,000

Updated office suite with a front desk, waiting room, three separate rooms, and one full bathroom.

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Corner Mixed-Use Land with Office
Corner Mixed-Use Land with Office

4000 Overseas Highway, Marathon, FL 33050

Contact for pricing
850 sqft 0.87 AC lot

Elevated corner property with 200 feet of Overseas Highway frontage, enclosed with CBS retaining walls, plus an 850 sq. ft. office.

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Established Business in Florida Keys
Established Business in Florida Keys

Montage FL Keys Souvenirs, Marathon, FL 33050

$99,000

Work and live in paradise with this established business.

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Marathon, FL Office Spaces Lease Rates & Market Statistics

Explore 10 Office Spaces for lease in Marathon, FL on Realmo, a commercial real estate exchange covering the Marathon area. The current inventory totals 41,913 square feet of properties — an average of ~4,200 SF per listing.

Asking lease rates for Office Spaces in Marathon start at $7.20 SF/Yr, average $23.79 SF/Yr, and reach $72 SF/Yr at the top of the market. That's a 10x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. At $23.79 SF/Yr, the local average runs 32% below Florida's state average of $34.81 SF/Yr.

Marathon accounts for 22% of the 46 office spaces currently available across Monroe County, where nearby markets include Key West and Key Largo. By space type, the market includes 6 office units and 3 other office properties — other office properties typically offer the lowest entry point, while office units command the highest rates.

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