Rancho Santa Margarita, CA Office Spaces for Rent & Lease

$129-$3,806/Mo

(972) 764-8885

Koll Center

Discover many ways to work your way in Koll Center

30211 Avenida De Las Banderas, Unit 200, Rancho Santa Margarita, CA 92688

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$2 SF/Yr

18,538 SF

Office Building with Mountain Views

22362 Gilberto, Rancho Santa Margarita, CA 92688

Two-story office building in South Orange County available for rent.

Prime South Orange County location
Spectacular panoramic Saddleback Mountain views
Easy access to the 241 Foothill Transportation Corridor
Elevator served office building
Corporate headquarters building with formal entry lobby

Updated: Nov 26, 2025

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$2 SF/Yr

2,360 SF

Medical Office Condo For Rent

30212 Tomas, Rancho Santa Margarita, CA

Medical office condo featuring private offices, conference room, and balcony.

Six private offices ideal for medical practice
Conference room for meetings and collaboration
Reception area for patient greeting and administration
Break room for staff convenience
Private balcony offering a relaxing space

Updated: Sep 23, 2025

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8,500 SF

Rancho Santa Margarita Retail Center

Multi-tenant center near 241 Toll Road in Rancho Santa Margarita.

29821-29941 Aventura, Rancho Santa Margarita, CA 92688

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18,400 SF

Medical Office Space For Rent

Medical office space in Rancho Santa Margarita available for lease.

29472 Avenida de las Banderas, Rancho Santa Margarita, CA 92688

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2,835 SF

Medical Office Sublease Opportunity

Medical office space available for sublease in Rancho Santa Margarita.

22032 El Paseo, Rancho Santa Margarita, CA 92688

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$22 SF/Yr

Rancho Santa Margarita Office Space

Furnished office spaces with mountain views and convenient access.

30211 Avenida de las Banderas Suite 200, Rancho Santa Margarita, CA 92688

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Office Space Available For Lease

Office property available for lease in Rancho Santa Margarita, CA.

30212 Tomas, Rancho Santa Margarita, CA 92688

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8,309 SF

Rancho Santa Margarita Office Building

Office building available, early education/school permitted.

28672 Deerpath, Rancho Santa Margarita, CA

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Based on your search, we've compiled 19 Potential Opportunities for your consideration. Besides 9 Active listings in Rancho Santa Margarita, CA, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 2 Properties for Sales.

Office Spaces for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

$2 SF/Yr

3,013 SF

Class A Office Space Available

High-image office space with excellent amenities and convenient parking.

27442 Portola Parkway, Lake Forest, CA 92610

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$2 SF/Yr

58,560 SF

Class A Office Space Available

High-image office campus with excellent amenities and access.

27422 Portola Parkway, Lake Forest, CA 92610

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Prime Office Space in Mission Viejo

Exceptional leasing opportunity in a vibrant Mission Viejo location.

Mission Viejo, CA 92692

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$31 SF/Yr

3,406 SF

Mission Viejo Retail Spaces Available

Retail and office spaces available in Mission Viejo, California.

27001 La Paz Rd, Mission Viejo, CA 92691

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Similar Spaces for Sale in Rancho Santa Margarita, CA

Consider Similar Space for Sale. We found 2 Spaces matching your search parameters.

$1,585,500

3,020 SF

Upgraded Office Condo For Sale

Office condo with private offices, conference room, and break room.

30372 Esperanza, Rancho Santa Margarita, CA 92688

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1,600 SF

Rancho Santa Margarita Retail Unit

1,600 SF retail unit with rear roll-up door.

29851 Aventura, Rancho Santa Margarita, CA 92688

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Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

$0.01 SF/Yr

1,565 SF

Prime Fontana Commercial Land Lease

4.33-acre commercial land for ground lease in Fontana, CA.

16203 Foothill Boulevard, Fontana, CA 92335

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75,000 SF

Prime Commercial Land for Lease

Highly visible 3.59-acre commercial land in San Luis Obispo.

2040 Prado Road, San Luis Obispo, CA 93401

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Service Commercial Land For Rent

3-acre service commercial land in high-traffic Hanford location.

1798 Hanford Armona Road, Hanford, CA 93230

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High Visibility Land For Lease

1.41 acres at signalized intersection available for ground lease.

1400 Willow Pass Rd, Concord, CA 94520

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Rancho Santa Margarita, CA Office Spaces Leasing Opportunities Market Analysis

Explore Office Spaces leasing options in Rancho Santa Margarita, CA with 9 listings featured on our commercial real estate exchange. The current inventory includes 22,201 square feet of properties with an estimated lease value of $145 SF/Yr.

Estimated lease rates for Office Spaces in Rancho Santa Margarita, CA begin at $2 SF/Yr, with an average of $48 SF/Yr and extend to $140 SF/Yr.