Office Building

San Diego, CA Office Buildings for Lease

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Professional Office Suite
Updated: Jun 21
Professional Office Suite

6155 Cornerstone Ct E, Suite 210, San Diego, CA 92121

$1,500/Mo
5,966 sqft
31,489 SF professional office building
For rent: professional office space within a larger office building in San Diego
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Renovated Corner Office Building
Updated: Jun 10
Renovated Corner Office Building

4394 30th, San Diego, CA 92104

$6,072/Mo
1,735 sqft
1,735 SF freestanding office building on a prominent North Park corner lot
Recently renovated with modern finishes and presented as move‑in ready
Interior layout includes five private offices, conference room, reception/waiting area, kitchen, and two restrooms
Gated on‑site parking with six dedicated spaces
Lease rate listed as $3.50/SF/mo NNN; NNN estimated at $0.55/SF/mo
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Laboratory Office Suite
Laboratory Office Suite

6650 Nancy Ridge Dr, San Diego, CA 92121

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6,357 sqft

Includes lab areas, microscopy rooms, open office, and multiple cold storage and freezer rooms with loading access.

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Flex Office with Production Areas
Flex Office with Production Areas

15025 Innovation Dr, San Diego, CA 92128

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11,437 sqft

Flexible workspace includes offices, multiple conference and huddle rooms, break areas, and production space.

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Office Space for Lease
Office Space for Lease

9265 Activity Rd., San Diego, CA 92126

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4,872 sqft

Lease an office space at 9265 Activity Rd. in San Diego, sized for flexible commercial use.

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Recently Renovated Office Suite
Recently Renovated Office Suite

2355 Northside Dr, San Diego, CA 92108

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4,257 sqft

Recently renovated office suite available in a sublease expiring 5/31/2030, with EV charging and FF&E available.

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Office Building for Lease
Office Building for Lease

1045 14th Street, San Diego, CA 92101

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8,714 sqft

For lease office space at 1045 14th Street, suited for professional and creative teams needing a dedicated workspace.

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Creative Office Build-Out with Huddle Rooms
Creative Office Build-Out with Huddle Rooms

15255 Innovation Dr, San Diego, CA 92128

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17,591 sqft

Office space with Class A finishes, polished concrete floors, and multiple meeting rooms including huddle rooms and conference rooms.

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Downtown Office Building Amenities
Downtown Office Building Amenities

550 W C St, San Diego, CA 92101

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1,442 sqft

Office building offers an enhanced lobby, gym, fully equipped conference room, and 24/7 security.

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Office Building For Lease
Office Building For Lease

8902-8940 Activity Rd., San Diego, CA 92126

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3,965 sqft

For-lease office building totaling approximately 3,965 square feet.

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Laboratory Office Space
Laboratory Office Space

6370 Nancy Ridge Dr, San Diego, CA 92121

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4,955 sqft

Laboratory office space totaling 7,074 SF is now available for lease.

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Centrally Located Office Building
Centrally Located Office Building

8885 Rio San Diego Dr, San Diego, CA 92108

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1,120 sqft

Mission Valley office building adjacent to the San Diego River with south-facing views.

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Laboratory-Ready Office Building
Laboratory-Ready Office Building

12250 El Camino Real, San Diego, CA 92130

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3,200 sqft

Upgraded office building offering lab suites sized for flexible occupancy and equipped with robust MEP systems.

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5-Story Office Building
5-Story Office Building

6154 Nancy Ridge Dr, San Diego, CA 92121

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50,000 sqft

Five-story office building with exterior signage opportunity and tenant parking to support daily operations.

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Move-In Ready Furnished Office
Move-In Ready Furnished Office

12780 El Camino Real, San Diego, CA 92130

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20,636 sqft

Fully furnished office suite with large first-floor all-hands meeting area and on-site fitness center.

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Office Building with Lab Space
Office Building with Lab Space

10581 Roselle St., San Diego, CA 92121

Contact for pricing
5,523 sqft

Flexible office and lab space within the SOVA Science District, supported by conferencing, dining, and outdoor amenities.

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Prominent Corner Office Building
Prominent Corner Office Building

15015 Avenue of Science, San Diego, CA 92128

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9,483 sqft

Office building with high visibility and natural light.

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Office Suites in Corporate Campus
Office Suites in Corporate Campus

12750 High Bluff Dr, San Diego, CA 92130

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2,996 sqft

Upgraded office suites within Highlands Corporate Center, featuring collaborative lounges and a fully equipped fitness center.

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Office Building with I-5 and I-805 Access
Office Building with I-5 and I-805 Access

3560 Dunhill Street, San Diego, CA 92121

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5,400 sqft

Office building with restrooms and showers, plus immediate access to I-5 and I-805.

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Modernized Office Space in Liberty
Modernized Office Space in Liberty

2305 Historic Decatur Road, San Diego, CA 92106

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12,627 sqft

Class A office space in revitalized Liberty Station community.

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Office Shell Space
Office Shell Space

401 W A St, San Diego, CA 92101

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1,877 sqft

Available for rent in shell condition, this office space is ready for tenant improvements.

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Office Space
Office Space

3323 Carmel Mountain Rd, San Diego, CA 92121

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2,600 sqft

Office space includes open office, private offices, a utility room, and restroom.

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Office Building in San Diego
Office Building in San Diego

2100 Kettner Blvd, San Diego, CA 92101

$5.50 SF/Yr
234,000 sqft

Office building with 234,000 square feet available for rent.

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Office Suite with Amenities
Office Suite with Amenities

4225 Executive Square, La Jolla, CA 92037

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4,343 sqft

Office space offering negotiable FF&E, plus an on-site gym and conference center.

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San Diego, CA Office buildings Lease Rates & Market Statistics

Explore 196 Office buildings for lease in San Diego, CA on Realmo, a commercial real estate exchange covering the San Diego area. The current inventory totals 3,924,215 square feet of properties — an average of ~20,000 SF per listing.

Office buildings lease rates in San Diego range from $3.02 SF/Yr at the entry level to $42 SF/Yr at the top of the market, averaging $16.84 SF/Yr. That's a 14x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. The local average of $16.84 SF/Yr is 30% below the California state average of $24.18 SF/Yr.

San Diego accounts for 80% of the 244 office buildings currently available across San Diego County, where nearby markets include Carlsbad and La Jolla. Office buildings make up 25% of the 793 Office Spaces currently for lease in San Diego, with asking rates averaging $16.84 SF/Yr — 19% below the citywide Office Spaces average of $20.81 SF/Yr. Also worth a look for tenants weighing alternatives: Office Units (521 listings) and Medical Office Space (50 listings) elsewhere in the San Diego market.

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