Mixed-Use

Durham, NC Mixed-use Properties for Lease

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Chapel Hill, NC Cary, NC Morrisville, NC Wake Forest, NC Hillsborough, NC Carrboro, NC Creedmoor, NC Apex, NC
Erwin Road Mixed-Use Retail Space
Updated: Sep 25, 2025
Erwin Road Mixed-Use Retail Space

2812 & 2816 Erwin Rd, Durham, NC 27705

$25 SF/Yr
1,696 sqft
Walking distance to Duke University Hospital, Duke University, Durham VA Hospital, and Lenox Baker Children’s Hospital
Class A mixed‑use development with luxury apartments, offices, and retail
Ample surface and structured parking
Convenient to US 15‑501 and NC 147/Durham Freeway
Property adjoins a 141‑key AC Hotel by Marriott
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One City Center Mixed-Use High-Rise
Updated: Aug 23
One City Center Mixed-Use High-Rise

110 Corcoran St., Durham, NC 27701

Contact for pricing
27‑story mixed‑use high‑rise
One City Center property name
Located at 110 Corcoran St., Durham, NC 27701
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Mixed-Use Development Opportunity in Durham
Mixed-Use Development Opportunity in Durham

3214 Hillsborough Road, Durham, NC 27705

Watts Hospital-Hillandale
Contact for pricing

Mixed-use development with retail, restaurants, and residential dwellings.

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Downtown Durham Mixed-Use Asset
Downtown Durham Mixed-Use Asset

601 West Main Street, Durham, NC 27701

Warehouse District
Contact for pricing

Mixed-use property in the heart of Downtown Durham.

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Mixed-Use Redevelopment Opportunity
Mixed-Use Redevelopment Opportunity

University Dr & Shannon Rd, Durham, NC 27707, USA, Durham, NC 27707

Colchester
Contact for pricing

Mixed-use redevelopment with main street setting.

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5 active listings match your search: Mixed-Use for lease in Durham, NC. Based on your search, we've also compiled 9 Potential Opportunities for your consideration: 4 spaces in nearby cities and 5 properties for sale.

Mixed-use properties for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Mixed-Use and Industrial Buildings
Mixed-Use and Industrial Buildings

3101 Industrial Dr, Raleigh, NC 27609

Pinecrest
Contact for pricing
21,918 sqft

15 mixed-use and light industrial buildings in Midtown Raleigh.

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Class A Office Suites
Class A Office Suites

155 West Chatham Street, Cary, NC 27511

Contact for pricing

Flexible leasing options within a new mixed-use development near downtown dining, retail, entertainment, a public park, and rail service.

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Fenton Mixed-Use Destination Pad
Fenton Mixed-Use Destination Pad

1085 Fenton Gateway Drive, Cary, NC 27511

Contact for pricing

Pad ready for sublease in Cary's Fenton Gateway.

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Mixed-Use Development with Food Spaces
Mixed-Use Development with Food Spaces

Wake Forest Road & Whitaker Road, Raleigh, NC 27608

Country Club Houses
Contact for pricing

Mixed-use development with food and beverage spaces for rent.

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Similar Spaces for Sale in Durham, NC

Consider Similar Space for Sale. We found 5 Spaces matching your search parameters.

NNN Property with Retail Space
NNN Property with Retail Space

1105 W Main Street Ste 100, Durham, NC 27701

Duke East Campus
Contact for pricing
5,985 sqft  Built 2019  brick  Single tenant

A 2019 condominium component with expansive glazing, city views, and solar-equipped parking canopies serving common areas.

Solar panels on parking canopies
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Downtown Durham Mixed-Use Property
Downtown Durham Mixed-Use Property

114 E Main St, Durham, NC 27701

Downtown
Contact for pricing
2,386 sqft  Built 1920 / renov 1998

Historic building with modern upgrades, suitable for multiple uses.

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Mixed-Use Building with Rooftop Deck
Mixed-Use Building with Rooftop Deck

211 Rigsbee Ave, Durham, NC 27701

Central Park
$3,595,000
Mid-Century Modern  Multi-tenant

Ground-floor space is available below an occupied upper level, with zoning flexibility for office, retail, mixed-use, or residential use.

Rooftop deck  Sweeping views
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Commercial Flex Space
Commercial Flex Space

3421 Angier Ave, Durham, NC 27703

Pleasant Drive
Contact for pricing
2,296 sqft  0.8 acres  1 building
Highway access  General Commercial

General Commercial zoning accompanies a versatile building configuration on an established commercial corridor.

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Retail and Office Development Site
Retail and Office Development Site

5802 & 5904 S Miami Blvd |, Durham, NC 27560

Contact for pricing
33 sqft

Approved site for 33,000 SF retail and office development.

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Durham, NC Mixed-use properties Lease Rates & Market Statistics

Explore 5 Mixed-use properties for lease in Durham, NC on Realmo, a commercial real estate exchange covering the Durham area. The current inventory totals 1,696 square feet of properties.

Asking lease rates for Mixed-use properties in Durham start at $25 SF/Yr, average $25 SF/Yr, and reach $25 SF/Yr at the top of the market. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. The local average of $25 SF/Yr is 42% above the North Carolina state average of $17.58 SF/Yr.

Durham accounts for 100% of the 5 mixed-use properties currently available across Durham County.

How to lease space in a mixed-use property in Durham, NC

  1. Leverage the built-in customer base. Multi-use developments (retail-over-residential, live-work buildings, mixed-use complexes) put your customers upstairs. Use Location Intelligence to compare Durham, NC developments by resident density and spending profile.
  2. Confirm your use fits the building's mix. Zoning applies per component, so verify your specific business is permitted in the commercial portion and complements (not clashes with) the existing tenant lineup.
  3. Read the coexistence rules first. Operating below residents means quiet hours, delivery windows, trash schedules, and signage limits written into the lease. These are the deal-breakers for late-night, noisy, or odor-producing concepts.
  4. Decode the shared-cost allocation. Lobbies, elevators, and parking are split among residential and commercial tenants. Demand a clear breakdown of how CAM is allocated across use types and model it with the Lease Calculator.
  5. Vet the landlord and management. Mixed-use buildings live or die by management quality. Check reviews, BBB complaints, and court records, and talk to current tenants before committing.
  6. Negotiate a tailored lease, not a template. Standard commercial forms miss mixed-use realities. Nail down your parking allocation, after-hours access, dispute-resolution process, and flexibility clauses with an attorney's review.
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