Advertise
    Durham, NC
    For Lease
    • For Sale
    • For Lease
    • Recently Sold
    • Property Lookup
    • Brokers
    Space Uses
    • Retail
    • Restaurant
    • Office
    • Coworking
    • Medical Space
    • Automotive
    • Industrial
    • Warehouse
    • Flex
    • Hospitality
    • Sports & Entertainment
    • Specialty
    Rent
    Rent
    $
    $
    Size
    Property Size / SF

    Durham, NC Mixed-use Properties for Lease

    Notify Me
    List
    Map
    Chapel Hill, NC Raleigh, NC Cary, NC
    Luxury Mixed-Use Development Near Duke
    $25 SF/Yr
    118,000 SF
    Luxury Mixed-Use Development Near Duke

    2812 & 2816 Erwin Rd |, Durham, NC 27705

    Class A mixed-use development near Duke University and hospitals.
    • Walking distance to Duke University Hospital, Duke University, Durham VA Hospital, and Lenox Baker Children’s Hospital
    • Class A mixed‑use development with luxury apartments, offices, and retail
    • Convenient to US 15‑501 and NC 147/Durham Freeway
    • Ample surface and structured parking available
    • Property adjoins a 141‑key AC Hotel by Marriott
    Updated: Sep 25, 2025
    View details
    Erwin Road Mixed-Use Retail Space
    Contact for pricing
    118,000 SF
    Erwin Road Mixed-Use Retail Space

    2812 & 2816 Erwin Rd |, Durham, NC 27705

    Class A retail space in mixed-use development near Duke University.
    • Walking distance to Duke University Hospital, Duke University, Durham VA Hospital, and Lenox Baker Children’s Hospital
    • Class A mixed‑use development with luxury apartments, offices, and retail
    • Ample surface and structured parking
    • Convenient to US 15‑501 and NC 147/Durham Freeway
    • Property adjoins a 141‑key AC Hotel by Marriott
    Updated: Sep 25, 2025
    View details
    Mixed-Use Development Opportunity in Durham
    Contact for pricing
    71,652 SF
    Mixed-Use Development Opportunity in Durham

    Mixed-use development site with retail, restaurant, and residential potential.

    3214 Hillsborough Road, Durham, NC 27705

    View details
    Downtown Durham Mixed-Use Asset
    Contact for pricing
    Downtown Durham Mixed-Use Asset

    Mixed-use property in the heart of Downtown Durham.

    601 West Main Street, Durham, NC 27701

    View details
    Mixed-Use Redevelopment Opportunity
    Contact for pricing
    Mixed-Use Redevelopment Opportunity

    Mixed-use redevelopment with main street setting.

    University Dr & Shannon Rd, Durham, NC 27707, USA, Durham, NC 27707

    View details
    Based on your search, we've compiled 22 Potential Opportunities for your consideration. Besides 5 Active listings in Durham, NC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 9 Properties for Sales.

    Mixed-use properties for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Mixed-Use and Industrial Buildings
    Contact for pricing
    568,560 SF
    Mixed-Use and Industrial Buildings

    15 mixed-use and light industrial buildings in Midtown Raleigh.

    3101 Industrial Drive, Raleigh, NC 27609

    View details
    Fenton Mixed-Use Destination Pad
    Contact for pricing
    Fenton Mixed-Use Destination Pad

    Pad ready for sublease in Cary's Fenton Gateway.

    1085 Fenton Gateway Drive, Cary, NC 27511

    View details
    Mixed-Use Development with Food Spaces
    Contact for pricing
    Mixed-Use Development with Food Spaces

    Mixed-use development with food and beverage spaces for rent.

    Wake Forest Road & Whitaker Road, Raleigh, NC 27608

    View details
    Mixed-Use Destination in Cary
    Contact for pricing
    Mixed-Use Destination in Cary

    Vertically integrated mixed-use destination for rent in Cary.

    1085 Fenton Gtwy Dr, Cary, NC 27511

    View details

    Similar Spaces for Sale in Durham, NC

    Consider Similar Space for Sale. We found 9 Spaces matching your search parameters.

    Downtown Durham Redevelopment Opportunity
    $1,000,000
    Downtown Durham Redevelopment Opportunity

    Mixed-use redevelopment opportunity in vibrant Downtown Durham on Main Street.

    113 West Main Street, Durham, NC 27701

    View details
    Downtown Mixed-Use Building
    $9,975,000
    28,900 SF
    Downtown Mixed-Use Building

    Neoclassical mixed-use building with retail space on lower floors and an ultra-luxury residence above, plus dedicated parking.

    300 E. Main St., Durham, NC 27701

    View details
    Downtown Durham Mixed-Use Property
    $830,000
    2,386 SF
    Downtown Durham Mixed-Use Property

    Historic building with modern upgrades, suitable for multiple uses.

    114 E Main St, Durham, NC 27701

    View details
    Downtown Durham Multifamily Development Opportunity
    Contact for pricing
    8,721 SF
    Downtown Durham Multifamily Development Opportunity

    Entitled mixed-use site with 201 residential units and commercial space.

    6 Grace Ln, Durham, NC 27701

    View details
    Downtown Durham Mixed-Use Property
    $1,400,000
    4,500 SF
    Downtown Durham Mixed-Use Property

    Mixed-use property in Downtown Durham with office and residential spaces.

    116 East Main Street, Durham, NC 27701

    View details
    Downtown Durham Mixed-Use Property
    $1,400,000
    4,500 SF
    Downtown Durham Mixed-Use Property

    Mixed-use property in Downtown Durham with office and residential spaces.

    116 E Main, Durham, NC 27701

    View details
    Multi-Purpose Building on 2.24 Acres
    $799,900
    1.27 Acres
    Multi-Purpose Building on 2.24 Acres

    Well-maintained multi-purpose building on 2.24 acres with lease in place.

    315 Southerland St, Durham, NC 27703

    View details
    Retail and Office Development Site
    Contact for pricing
    Retail and Office Development Site

    Approved site for 33,000 SF retail and office development.

    5802 & 5904 S Miami Blvd |, Durham, NC 27560

    View details
    Durham Mixed-Use Asset Near Duke
    Contact for pricing
    105,055 SF
    Durham Mixed-Use Asset Near Duke

    Mixed-use asset near Duke University with multifamily, retail, office.

    2816 Erwin Rd, Durham, NC 27705

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Prime Land in Jarrettsville Corridor
    Contact for pricing
    Prime Land in Jarrettsville Corridor

    1.55 acre parcel in Jarrettsville's business corridor.

    1753, Jarrettsville, MD 21084

    View details
    Harrisburg Redevelopment Site For Rent
    Contact for pricing
    11,000 SF
    Harrisburg Redevelopment Site For Rent

    5.85-acre redevelopment site approved for 92 residential units.

    2150 Herr Street, Harrisburg, PA 17103

    View details
    Atlanta Land for Lease
    $1,850/Mo
    Atlanta Land for Lease

    3-acre commercial land available for lease in Atlanta, GA.

    1057 Constitution Road SW, Atlanta, GA 30315

    View details
    Prime Commercial Acres For Lease
    $6,000/Mo
    Prime Commercial Acres For Lease

    4.12 acres of commercial land for lease in Rainsville, AL.

    4.12 Acres Al Highway 35, Rainsville, AL 35986

    View details

    Durham, NC Mixed-use properties Market Trends and Statistics

    Explore Mixed-use properties leasing options in Durham, NC with 5 listings featured on our commercial real estate exchange. The current inventory includes 118,000 square feet of properties with an estimated lease value of $25 SF/Yr.

    Estimated lease rates for Mixed-use properties in Durham, NC begin at $25 SF/Yr, with an average of $25 SF/Yr and extend to $25 SF/Yr.
    List
    Map

    Popular Searches in Durham, NC

    Popular Categories

    Most Searched ZIP Codes in Durham, NC

    • 27705
    • 27701
    • 27707

    Select Neighborhood

    Google sign-in failed. Please try again or use another login method.
    Sign Up Successful!
    You now have access to more from Realmo!