Fort Myers, FL Mixed-use Properties for Lease

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Estero, FL Cape Coral, FL Fort Myers Beach, FL

$30 SF/Yr

40,000 SF

Mixed-Use Development in Fort Myers

1380-1400 Colonial Blvd, Fort Myers, FL 33907

Mixed-use development with retail, office, and medical spaces for lease.

Premier mixed‑use development with retail, medical, office, multifamily, and hotel components.
Located at the high‑traffic intersection of Colonial Blvd. and Summerlin Rd. in Fort Myers.
Flexible floor plans and build‑to‑suit options available for retail, medical, and office spaces.
High‑demand market with over $2 billion in consumer spending within a 5‑mile radius.
New, Class A medical office buildings with convenient access to major healthcare systems.

Updated: Feb 10, 2025

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Prime Commercial Space on College

8140 College Parkway, Fort Myers, FL 33919

Commercial space for lease in Fort Myers with excellent accessibility.

Prime location on College Parkway with high traffic count (39,000 vehicles per day).
Excellent accessibility to major roads and highways including U.S. Highway 41 and I‑75.
Versatile floor plans and customizable layouts suitable for office, retail, or mixed‑use.
Ample parking for tenants and clients.
Modern and attractive architectural design.

Updated: Nov 27, 2025

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$14 SF/Yr

Alico Commercial Park7916 Drew Cir

26,611 SF of 4-Star Industrial Space Available in Fort Myers, FL 33967

7916 Drew Cir, Fort Myers, FL 33967, Fort Myers, FL 33967

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Mixed-Use Property Available

Mixed-use property available for sale or lease.

12155 Metro Pkwy, Fort Myers, FL 33966

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$12 SF/Yr

1,200 SF

Office, Retail, and Warehouse Units

Office, retail, and warehouse units available for lease.

1939 Park Meadows Dr, Fort Myers, FL 33907

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Based on your search, we've compiled 29 Potential Opportunities for your consideration. Besides 5 Active listings in Fort Myers, FL, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 16 Properties for Sales.

Mixed-use properties for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Mixed-Use Destination in Venice, Florida

$3,500/Mo

1,500 SF

Mixed-Use Destination in Venice, Florida

Unique mixed-use property with high visibility and ample parking.

530 US-41-BYP, Venice, FL 34285

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$3,000/Mo

1,400 SF

Venice, FL Mixed-Use Space

Versatile mixed-use space in a high-traffic destination setting.

530 US-41-BYP, Venice, FL 34285

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Mixed-Use Commercial Opportunity in Sarasota

$20 SF/Yr

5,000 SF

Mixed-Use Commercial Opportunity in Sarasota

High-visibility commercial property with flexible use potential in Sarasota, FL.

2048 Bee Ridge Road, Sarasota, FL

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$33 SF/Yr

22,700 SF

Downtown Sarasota Mixed-Use Building

Mixed-use building in downtown Sarasota with flexible leasing options.

1990 Main St, Sarasota, FL 34236

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Similar Spaces for Sale in Fort Myers, FL

Consider Similar Space for Sale. We found 16 Spaces matching your search parameters.

$1,200,000

4,688 SF

Mixed-Use Property with Fenced Parking

Three distinct income spaces upstairs residential and ground-floor studio, supported by dedicated fenced parking for tenants and visitors.

2251 GRAND AVENUE, Fort Myers, FL 33901

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Waterfront Fort Myers Warehouse Opportunity

$3,495,000

7,500 SF

Waterfront Fort Myers Warehouse Opportunity

Waterfront industrial warehouse with loading docks near Downtown Fort Myers.

3131 E Riverside Drive, Fort Myers, FL 33916

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$696,000

0.69 Acres

Fort Myers Investment Opportunity

Four parcels with duplex and vacant lots near Lee Hospital.

2243/2245 Altamont Avenue, Fort Myers, FL 33901

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Renovated Commercial Property on Fowler Street

$1,249,900

6,200 SF

Renovated Commercial Property on Fowler Street

Fully renovated commercial building with flexible space in Fort Myers.

2730 Fowler Street, Fort Myers, FL 33901

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High-Visibility Retail and Industrial Facility

$2,400,000

1.00 Acre

High-Visibility Retail and Industrial Facility

Freestanding retail and industrial facility in Fort Myers for sale.

2941 Fowler St, Fort Myers, FL 33901

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$1,500,000

8,240 SF

Turn-Key Showroom and Office Building

Showroom and office building with storage near downtown Fort Myers.

3327 Railroad St, Fort Myers, FL 33916

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Mixed-Use Property with Retail Potential

$499,000

1,746 SF

Mixed-Use Property with Retail Potential

Mixed-use property with retail space, updated features, and historic charm.

1793 Fowler Street, Fort Myers, FL 33901

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$575,000

Downtown Fort Myers Commercial Opportunity

Freestanding building in downtown Fort Myers with flexible commercial zoning.

1793 Fowler St, Fort Myers, FL 33901

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$1,290,000

Mixed-Use Downtown Property

Three distinct spaces combine renovated condos with ground-floor creative/office use and a fenced parking lot.

2251 Grand Ave, Fort Myers, FL 33901

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$1,200,000

4,688 SF

Downtown Mixed-Use Income Property

Mixed-use building with two renovated condo units above a music studio, plus a fenced parking lot for tenants and guests.

2251 Grand Avenue, Fort Myers, FL 33901

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$696,000

3,048 SF

Fort Myers Investment Opportunity

Four-parcel package with income potential and development upside.

2243/2245 ALTAMONT AVE, Fort Myers, FL 33901

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$1,195,000

5,000 SF

Two-Unit Gateway Building For Sale

Two-unit building with long-term tenants, warehouse, and office space.

12221 Towne Lake Dr, Fort Myers, FL 33913

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18,428 SF

Downtown Fort Myers Commercial Property

Highly visible property in a Southwest Florida commercial corridor.

1782 Fowler Street, Fort Myers, FL 33901

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$3,300,000

10,485 SF

Prime Retail Investment Opportunity

Retail property in a thriving commercial district with high visibility.

11940 Fairway Lakes Dr, Fort Myers, FL 33913

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Waterfront Office with Development Potential

$3,495,000

24,700 SF

Waterfront Office with Development Potential

9,200 SF Class A office with river views.

3131 E Riverside Dr, Fort Myers, FL 33916

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Upscale Mixed-Use Development Opportunity

Contact for pricing

23.00 Acres

Upscale Mixed-Use Development Opportunity

23-acre site approved for condominium, hotel, and retail development.

20350 Summerlin Rd, Fort Myers, FL 33908

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Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

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Miami Development Opportunity on NW 27th

33,600 SF vacant land near transit with development potential.

6611 NW 27 Avenue, Miami, FL 33147

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$1,850/Mo

Atlanta Land for Lease

3-acre commercial land available for lease in Atlanta, GA.

1057 Constitution Road SW, Atlanta, GA 30315

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$6,000/Mo

Prime Commercial Acres For Lease

4.12 acres of commercial land for lease in Rainsville, AL.

4.12 Acres Al Highway 35, Rainsville, AL 35986

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Baton Rouge Commercial Parcel For Rent

1.33-acre commercial parcel in a prime Baton Rouge location.

7597 Jefferson Hwy, Baton Rouge, LA 70806

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Fort Myers, FL Mixed-use properties Market Trends and Statistics

Explore Mixed-use properties leasing options in Fort Myers, FL with 5 listings featured on our commercial real estate exchange. The current inventory includes 41,200 square feet of properties with an estimated lease value of $42 SF/Yr.

Estimated lease rates for Mixed-use properties in Fort Myers, FL begin at $12 SF/Yr, with an average of $21 SF/Yr and extend to $30 SF/Yr.

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