San Antonio, TX Medical Office Space for Sale

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49 properties

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Updated: Feb 19, 2025

Standalone Medical Office Building

13039 Nacogdoches Road, San Antonio, TX 78217

$438,000

2,243 sqft 0.31 AC lot

2,243‑square‑foot standalone building on 0.314 acres
Three examination rooms plus operating and x‑ray rooms
Kennel room with over 15 kennels and a dedicated pet bathing area
16‑space parking lot
Kitchen includes washer, dryer, stove, sink, and microwave

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Updated: Jul 17

Turnkey Corner Restaurant and Apartment

San Antonio, TX 78228

$699,000

6,025 sqft 0.43 AC lot

6,025 SF corner property on 0.43 acres with C‑2 zoning and three access points (Bandera Rd + dual W. Ashby).
Restaurant space totals 4,781 SF and conveys with existing restaurant FF&E for immediate food service operation.
Includes a 1,245 SF upstairs apartment for live/work use or supplemental rental income.
Located on Bandera Road with reported 25,000 VPD traffic visibility.
No tenant leases in place—immediate possession available at closing (real estate sale only).

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Net-Leased Dental Office Property

9590 Marbach Rd, San Antonio, TX 78245

$2,100,000

4,364 sqft 0.91 AC lot

4,317-square-foot dental facility with NNN lease structure, recently replaced HVAC in 2025, and in-place long-term tenant occupancy.

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Single-Story Medical Office Space

2620 McCullough Avenue, San Antonio, TX 78212

$800,000

2,844 sqft 0.27 AC lot

Existing dermatopathology configuration with gated parking and direct access from McCullough Avenue.

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Professional Office Building with Waiting Area

San Antonio, TX 78249

$1,150,000

2,650 sqft

Turnkey 2,650-square-foot office building configured for a medical practice with private offices, waiting area, and soundproofing.

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Fully Leased Medical Office Condo

10423 State Highway 151, San Antonio, TX 78251

$2,500,000

5,436 sqft

An established medical tenant currently occupies the condominium.

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Single-Story Medical Office Building

9518 Tioga Dr, San Antonio, TX 78230

$1,329,000

3,720 sqft 0.53 AC lot

Configured with private rooms, executive suites, reception, waiting, and staff kitchen areas.

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New Garden Office Units

12606 Hausman Rd S, San Antonio, TX 78249

$1,304,415

20,463 sqft

Newly built office units with flexible layouts and surface parking at each suite.

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Medical Office Suite with Reception

8265 Fredericksburg, San Antonio, TX 78229

$325,000

1,001 sqft

Professional office setting with a welcoming entry area, natural light, and updated finishes for patient-facing operations.

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Medical Office Building

5902 COMPUTER DR, San Antonio, TX 78229

$3,800,000

31,320 sqft 1.20 AC lot

Two-story configuration accommodates medical offices with suites spanning a range of sizes.

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Class A Office Building

4306 De Zavala, San Antonio, TX 78249

$6,900,000

45,528 sqft

Newly completed Class A office building in 2023, zoned O-2 and suited for medical or professional office use.

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Medical Office Building with Flexible Suites

2 Spurs Lane, San Antonio, TX 78240

Contact for pricing

8,696 sqft

Two-story medical office property with existing clinical buildout and configurable suite options.

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Shopping Center with Medical Office

6623 S Zarzamora St, San Antonio, TX 78211

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39,759 sqft 2.01 AC lot

Multi-tenant retail property includes a fully built-out medical office suite and established retail surroundings.

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Medical Office Space in Oak Hollow

6348 Prue Rd., San Antonio, TX 78240

Contact for pricing

2,515 sqft 7.80 AC lot

Medical office opportunity within a completed healthcare center with access to Prue Road, Babcock Road, and regional routes.

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Shell Office Suite for Medical Use

13035 Nacogdoches, San Antonio, TX 78217

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4,290 sqft

1,400 SF suite in shell condition with flexible space planning for medical, wellness, or professional office users.

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Top-Floor Medical Office Condominium

1314 East Sonterra Boulevard, San Antonio, TX 78258

Contact for pricing

5,253 sqft

Class A medical-office condo on the building’s top floor within an established medical office park.

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Medical Office Space with Private Rooms

San Antonio, TX 78237

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5,552 sqft

The suite includes private rooms with sinks, plus reception, storage, and a break area.

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Medical Office Campus with Suites

4025 E Southcross Blvd, San Antonio, TX 78222

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21,624 sqft 2.40 AC lot

Five one-story red brick office buildings totaling 12 suites, with most suites built out for medical office use.

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Medical Office Suite with Private Rooms

1302 S GENERAL MCMULLEN DR #102, San Antonio, TX 78237

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1,050 sqft

Configured for medical office use, the suite includes a reception area, storage, and a separate break area.

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Medical Office Space with Anchor Tenant

1036 E Borgfeld Dr #2, San Antonio, TX 78260

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1,500 sqft 0.65 AC lot

Two-tenant commercial building includes San Martin Orthodontics as the named anchor occupant.

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Medical Office Space at Legacy Oaks

5372 Fredericksburg Rd, San Antonio, TX 78229

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16,241 sqft

Renovated finishes and upgraded mechanical systems support medical office use.

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Medical Office with Exam Rooms

2011 E Houston St Unit E, San Antonio, TX 78202

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1,900 sqft

Configured medical suite with dedicated entry, patient waiting area, treatment space, and clinical support areas.

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Freestanding Day Care Center

1909 W Bitters Rd, San Antonio, TX 78248

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17,996 sqft 3.64 AC lot

Licensed preschool facility with separate classroom and office areas on a sizable paved-parking site.

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Medical Office Building

818 Lexington Ave, San Antonio, TX 78212

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7,421 sqft 0.94 AC lot

Fully leased healthcare property with two occupants under NNN lease structures near downtown San Antonio.

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San Antonio, TX Medical Office Space Market Trends and Statistics

Explore 72 medical office space for sale in San Antonio, TX, showcased through 49 active listings on our real estate platform. These investment opportunities span a total of 405,460 square feet of properties for sale, with an estimated market value of $24,309,785.

Sale prices for medical spaces in San Antonio, TX start at $325,000, averaging $1,869,983, and reaching up to $6,900,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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Top Commercial Asset Segments

Commercial property segments ranked by active listings on the market

Demographics Overview

Population 1.87M

Population Growth (5Y) +6.6%

Median Household Income $73,633

College Educated 29.7%

High-Yield Neighborhoods for Investment

Identify San Antonio submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

Neighborhood	Average Price
78237	$70K
78240	$175K
78217	$219K
78229	$325K
78212	$800K

Taxes & Financing

Tax Rate (average for all types) 2.26%

Property Tax per SF $27.36 per SF

Tax Rate vs County Average 0.01 pp below county avg

Average Loan-to-Value 65.0%

Listings Trend

New vs delisted commercial listings in Bexar County

New Delisted

Total CRE Inventory on Market (SF)

Property Size Breakdown

The majority of commercial real estate listings in San Antonio fall within the 100,000+ square foot range.

How Realmo verifies these figures

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