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    Columbia, SC Aiken, SC Greenville, SC

    Pickens County, SC Commercial Real Estate for Sale

    252 results
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    Unique Office Building Near Courthouse
    $350,000
    0.16 Acres

    Unique Office Building Near Courthouse

    113 Court St, Pickens, SC 29671

    Commercial office building with two units and distinctive architectural features.

    • Prime commercial location next to the Pickens County Court House.
    • Two rental units provide additional income potential.
    • Unique architectural features: soaring wood ceilings, solid wood beams, brick accents, and a double brick fireplace.
    • Flexible floor plan with spacious meeting and conference rooms, kitchenette, and open work areas.
    • Private brick courtyard provides natural light and an appealing outdoor space.
    Updated: Nov 25, 2025
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    Commercial Land in Easley, SC
    $449,900
    0.50 Acres

    Commercial Land in Easley, SC

    329 Prince Perry Rd, Easley, SC 29640

    Commercial land with investment potential in the heart of Easley.

    • Excellent investment opportunity or potential commercial site.
    • Located in the heart of Easley, beside The Ridge and Wal‑Mart.
    • 120 feet of road frontage.
    • Potential for annexation into the city.
    • Surrounding lots are already in the city.
    Updated: Feb 26
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    Prime Acreage in Pickens, SC
    $570,000
    1.55 Acres

    Prime Acreage in Pickens, SC

    Acreage in a rapidly growing area of Pickens County.

    106 Roberts Dr, Pickens, SC 29671
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    Prime Corner Lot in Liberty
    $375,000
    5.00 Acres

    Prime Corner Lot in Liberty

    5-acre corner lot near Hwy 123, ideal for development.

    Ruhamah Rd, Liberty, SC 29657
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    Secluded Liberty Acreage with River
    $330,000
    12.33 Acres

    Secluded Liberty Acreage with River

    Secluded 12.33-acre property in Liberty, SC with river frontage.

    637 Odell Rd, Liberty, SC 29657
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    Liberty SC Vacant Land Homesites
    $799,999
    31.50 Acres

    Liberty SC Vacant Land Homesites

    Homesites with building locations, views, timber, and trail system.

    10 Mill Pine Rd, Liberty, SC 29657
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    22 Acres in Liberty, SC
    $350,000
    22.00 Acres

    22 Acres in Liberty, SC

    Unrestricted 22-acre land parcel perfect for homestead or investment.

    177 Farmers Hill Rd, Liberty, SC 29657
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    Land Borders Southern Oaks Golf
    $999,900
    4.27 Acres

    Land Borders Southern Oaks Golf

    4.27 acres bordering golf course, ideal for homes or business.

    8426 81 Hwy N, Easley, SC 29642
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    Prime Land in Pickens, SC
    $1,200,000
    3.24 Acres

    Prime Land in Pickens, SC

    3.24 acres in a rapidly growing area with development potential.

    2663 Gentry Memorial Hwy, Pickens, SC 29671
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    Downtown Easley Retail Opportunity
    Contact for pricing

    Downtown Easley Retail Opportunity

    2,000 SF retail space in downtown Easley, SC.

    106 N Pendleton St, Easley, SC 29640
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    Land Borders Southern Oaks Golf
    $999,900
    4.27 Acres

    Land Borders Southern Oaks Golf

    4.27 acres bordering golf course, ideal for development.

    8426 81 Hwy N, Easley, SC 29642
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    Clemson Tailgating Lot For Sale
    $50,000
    0.01 Acres

    Clemson Tailgating Lot For Sale

    Tailgating lot near Clemson Football, behind the Esso Club.

    101 Oak St, Clemson, SC 29630
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    Commercial Building on Highway 123
    $1,349,990
    0.48 Acres

    Commercial Building on Highway 123

    Commercial building in Clemson with ample parking and high traffic.

    990 Tiger Blvd, Clemson, SC 29631
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    Clemson Tailgating Lot Opportunity
    $50,000
    0.01 Acres

    Clemson Tailgating Lot Opportunity

    Tailgating lot near Clemson Football, prime location behind Esso Club.

    101 Oak St, Clemson, SC 29630
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    Easley Commercial Land For Sale
    $605,000
    5.70 Acres

    Easley Commercial Land For Sale

    5.7 acre commercial land available in Easley, South Carolina.

    533 Crest Dr, Easley, SC 29640
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    Clemson Multi-Family Investment Opportunity
    $1,500,000
    1.00 Acre

    Clemson Multi-Family Investment Opportunity

    Six apartments in three duplexes near Clemson's Calhoun area.

    101 Cochran Rd, Clemson, SC 29631
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    Land Parcel Near Highway 123
    $118,500
    3.00 Acres

    Land Parcel Near Highway 123

    4-acre commercial land parcel near Highway 123 in Liberty, SC.

    Farmers Hill Rd, Liberty, SC 29657
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    Prime Development Site in Easley
    $1,615,000
    17.00 Acres

    Prime Development Site in Easley

    17+/- acres for development near Highway 123 in Easley, SC.

    00 Prince Perry Rd, Easley, SC 29640
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    Easley Commercial Land Opportunity
    $275,000
    2.00 Acres

    Easley Commercial Land Opportunity

    2-acre commercial land with existing building, development potential.

    2625 Farrs Bridge Rd, Easley, SC 29640
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    Easley Commercial Site For Sale
    $1,900,000
    17.22 Acres

    Easley Commercial Site For Sale

    17+ acre commercial site near Easley, SC.

    00 Cardinal Dr, Easley, SC 29642
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    Easley SC Acreage For Sale
    $1,900,000
    17.22 Acres

    Easley SC Acreage For Sale

    17+ acres near Easley, SC, ideal for development.

    00 Cardinal Dr, Easley, SC 29642
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    Liberty Acreage with Utilities Ready
    $450,000
    18.37 Acres

    Liberty Acreage with Utilities Ready

    18.37 acres in Liberty, SC with utilities in place.

    472 Flat Rock Rd, Liberty, SC 29657
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    Easley Commercial Land For Sale
    $55,000
    0.39 Acres

    Easley Commercial Land For Sale

    0.39 acre commercial lot with road frontage in Easley, SC.

    315 Gentry Memorial Hwy, Easley, SC 29640
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    Land Parcels in Dacusville Community
    $255,000
    8.60 Acres

    Land Parcels in Dacusville Community

    Mini-farms with mountain views near Greenville, Easley, and Pickens.

    01 Hood Rd, Easley, SC 29640
    View details

    Pickens County, SC Commercial Real Estate Investment Opportunities Market Analysis

    Explore 97 commercial real estate for sale in Pickens County, SC, showcased through 252 active listings on our real estate platform. These investment opportunities span a total of 14,333,636 square feet of properties for sale, with an estimated market value of $44,555,409.

    Sale prices for business properties in Pickens County, SC start at $50,000, averaging $873,635, and reaching up to $4,052,500 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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