Chillicothe, OH Commercial real estate for sale

High-Traffic Commercial Property in Chillicothe

Pending

$169,900

1,496 SF

High-Traffic Commercial Property in Chillicothe

945 E Main St, Chillicothe, OH 45601

Versatile commercial building on East Main Street with high visibility.

High‑traffic location on East Main Street in Chillicothe.
Versatile building suitable for office, retail, or studio.
Large glass storefront providing excellent natural light and signage exposure.
Numerous off‑street parking spaces.
Large, open‑concept layout offering a blank canvas for customization.

Updated: Jan 9

View details

$150,000

Historic Downtown Chillicothe Commercial Building

20 E Main St, Chillicothe, OH 45601

Three-story commercial building in historic downtown Chillicothe, Ohio.

Prime location on Main Street in historic downtown Chillicothe with high visibility and foot traffic.
Two second‑floor one‑bedroom apartments offer immediate rental income potential or live/work flexibility.
Spacious third floor with original coffered ceilings, tall windows, and city views, ready for development.
Large storefront on the main floor with display windows and street‑level access.
Full basement provides abundant storage space.

Updated: Nov 26, 2025

View details

Downtown Chillicothe Mixed-Use Investment

$214,900

2,200 SF

Downtown Chillicothe Mixed-Use Investment

Versatile building in historic Union Block with retail and residential potential.

11 W 2Nd St, Chillicothe, OH 45601

View details

$399,999

Cozy Inn Bar & Grill

Iconic Chillicothe bar and grill with loyal customer base.

339 Western Ave, Chillicothe, OH 45601

View details

$214,900

2,200 SF

Downtown Chillicothe Mixed-Use Building

Versatile building in historic downtown Chillicothe with retail and residential/office potential.

13 W 2Nd St, Chillicothe, OH 45602

View details

$550,000

5,244 SF

Main Street Investment Opportunity

High-visibility commercial building with established tenants in a prime location.

946-954 E Main St, Chillicothe, OH 45601

View details

$36,000

Historic Gazette Building Commercial Space

Commercial space in the Historic Gazette Building, downtown Chillicothe.

62 W Main St, Chillicothe, OH 45601

View details

$169,900

2,064 SF

Westend Duplex Investment Opportunity

Duplex with separate utilities and long-term tenants, ideal investment.

346 Yoctangee Pkwy, Chillicothe, OH 45601

View details

Chillicothe Retail Space - Investment Opportunity

$325,000

0.70 Acres

Chillicothe Retail Space - Investment Opportunity

High-traffic retail space, ample parking, US-23 proximity.

375 Marietta Rd, Chillicothe, OH 45601

View details

$1,500,000

7,107 SF

Chillicothe Tire Business & Real Estate

Turnkey Tire Shop, Established Business, Ohio

320 Paint St, Chillicothe, OH 45601

View details

$300,000

1,848 SF

Chillicothe Commercial Property - $300K

Fully renovated, high-visibility commercial space.

2111 Western Ave, Chillicothe, OH 45601

View details

Versatile Commercial Property on US Route 50

$1,295,000

10,668 SF

Versatile Commercial Property on US Route 50

Commercial property with redevelopment potential on 2.54 acres.

1075 Western Ave, Chillicothe, OH 45601

View details

$2,552,631

2,325 SF

New Chipotle with Drive-Thru

New Chipotle with drive-thru in growing Ross County.

6 St Andrews Blvd, Chillicothe, OH

View details

$650,000

4,832 SF

Renovated Mixed-Use Building For Sale

Renovated mixed-use building with high visibility and ample parking.

7 Saint Andrews Blvd, Chillicothe, OH 45601

View details

$5,801,000

72,010 SF

Two-Tenant Retail Building For Sale

Two-tenant retail building with long-term leases in Chillicothe, Ohio.

1470 N Bridge St, Chillicothe, OH 45601

View details

$1,295,000

10,668 SF

Commercial Space on US Route 50

Commercial property with multiple buildings, ample parking, and redevelopment potential.

1075 Western Ave, Chillicothe, OH 45601

View details

$650,000

4,832 SF

Renovated Mixed-Use Building For Sale

4,832 SF renovated mixed-use building with commercial zoning.

7 Saint Andrews Blvd, Chillicothe, OH 45601

View details

$895,000

7,524 SF

Commercial Space on US Route 50

Commercial space suitable for retail, nursery, or creative event purposes.

1075 Western Ave, Chillicothe, OH 45601

View details

Explore Off-Market Properties in Chillicothe, OH

Consider similar Off-Market properties in Chillicothe, OH. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

11437 Co Rd

Specialty properties • 2,560 SF

Value Estimation by Request

11437 Co Rd, Chillicothe, OH 45601

View details

00 Eastern Ave

Specialty properties

Value Estimation by Request

00 Eastern Ave, Chillicothe, OH 45601

View details

2111 Western Ave Ave

Commercial real estate • 1,848 SF

Value Estimation by Request

2111 Western Ave Ave, Chillicothe, OH 45601

View details

37-39 Paint St St

Mixed-use properties

Value Estimation by Request

37-39 Paint St St, Chillicothe, OH 45601

View details

159 At Seney Rd

Neighborhood centers • 105,000 SF

Value Estimation by Request

159 At Seney Rd, Chillicothe, OH 45601

View details

65 Paint St

Specialty properties • 14,000 SF

Value Estimation by Request

65 Paint St, Chillicothe, OH 45601

View details

Chillicothe, OH Commercial Real Estate Investment Opportunities Market Analysis

Explore 1452 commercial real estate investment opportunities in Chillicothe, OH with 18 listings featured on our commercial real estate marketplace. The current inventory includes 123,373,206 square feet of properties with an estimated value of $286,466,800.

Estimated prices for commercial real estate in Chillicothe, OH begin at $60,000, with an average of $366,794 and extend to $10,895,000.

In Chillicothe, OH, current investment values show:

Retail properties positioned at $399,691
Office Properties & Spaces measuring $324,827
Individual retail properties assessed at $401,156
Office buildings calculated at $355,458

Chillicothe, OH Commercial Real Estate for Sale

High-Traffic Commercial Property in Chillicothe

Versatile commercial building on East Main Street with high visibility.

Historic Downtown Chillicothe Commercial Building

Three-story commercial building in historic downtown Chillicothe, Ohio.