Sign Up Successful!
You now have access to more from Realmo!
    For Sale
    • For Sale
    • For Lease
    • Recently Sold
    • Property Lookup
    • Brokers
    Property Types
    • Retail
    • Office
    • Residential Income
    • Restaurants
    • Industrial
    • Mixed-Use
    • Hospitality
    • Health Care
    • Sports & Entertainment
    • Land
    • Agricultural
    • Specialty
    Price
    Price range
    $
    $
    Size
    Property size / sq.ft.
    AI Search
    List
    Map

    Chillicothe, OH Commercial Real Estate for Sale

    16 results
    Notify Me
    High-Traffic Commercial Property in Chillicothe
    $169,900
    1,496 SF

    High-Traffic Commercial Property in Chillicothe

    945 E Main St, Chillicothe, OH 45601

    Versatile commercial building on East Main Street with high visibility.

    • High‑traffic location on East Main Street in Chillicothe.
    • Versatile building suitable for office, retail, or studio.
    • Large glass storefront providing excellent natural light and signage exposure.
    • Numerous off‑street parking spaces.
    • Large, open‑concept layout offering a blank canvas for customization.
    Last Update: Nov 27
    View details
    Historic Downtown Chillicothe Commercial Building
    $150,000

    Historic Downtown Chillicothe Commercial Building

    20 E Main St, Chillicothe, OH 45601

    Three-story commercial building in historic downtown Chillicothe, Ohio.

    • Prime location on Main Street in historic downtown Chillicothe with high visibility and foot traffic.
    • Two second‑floor one‑bedroom apartments offer immediate rental income potential or live/work flexibility.
    • Spacious third floor with original coffered ceilings, tall windows, and city views, ready for development.
    • Large storefront on the main floor with display windows and street‑level access.
    • Full basement provides abundant storage space.
    Last Update: Nov 26
    View details
    Main Street Investment Opportunity
    $550,000
    5,244 SF

    Main Street Investment Opportunity

    High-visibility commercial building with established tenants in a prime location.
    946-954 E Main St, Chillicothe, OH 45601
    View details
    Downtown Chillicothe Mixed-Use Investment
    $214,900
    2,200 SF

    Downtown Chillicothe Mixed-Use Investment

    Versatile building in historic Union Block with retail and residential potential.
    11 W 2Nd St, Chillicothe, OH 45601
    View details
    Downtown Chillicothe Mixed-Use Building
    $214,900
    2,200 SF

    Downtown Chillicothe Mixed-Use Building

    Versatile building in historic downtown Chillicothe with retail and residential/office potential.
    13 W 2Nd St, Chillicothe, OH 45602
    View details
    Westend Duplex Investment Opportunity
    $169,900
    2,064 SF

    Westend Duplex Investment Opportunity

    Duplex with separate utilities and long-term tenants, ideal investment.
    346 Yoctangee Pkwy, Chillicothe, OH 45601
    View details
    Cozy Inn Bar & Grill
    $399,999

    Cozy Inn Bar & Grill

    Turn-key bar and grill with loyal customer base.
    339 Western Ave, Chillicothe, OH 45601
    View details
    Established Cleaning Business Opportunity
    $100,000

    Established Cleaning Business Opportunity

    Profitable commercial cleaning business with loyal customer base for sale.
    Egypt Pike, Chillicothe, OH 45601
    View details
    Chillicothe Retail Space - Investment Opportunity
    $325,000
    0.70 Acres

    Chillicothe Retail Space - Investment Opportunity

    High-traffic retail space, ample parking, US-23 proximity.
    375 Marietta Rd, Chillicothe, OH 45601
    View details
    Chillicothe Tire Business & Real Estate
    $1,500,000
    7,107 SF

    Chillicothe Tire Business & Real Estate

    Turnkey Tire Shop, Established Business, Ohio
    320 Paint St, Chillicothe, OH 45601
    View details
    Chillicothe Commercial Property - $300K
    $300,000
    1,848 SF

    Chillicothe Commercial Property - $300K

    Fully renovated, high-visibility commercial space.
    2111 Western Ave, Chillicothe, OH 45601
    View details
    Versatile Commercial Property on US Route 50
    $1,295,000
    10,668 SF

    Versatile Commercial Property on US Route 50

    Commercial property with redevelopment potential on 2.54 acres.
    1075 Western Ave, Chillicothe, OH 45601
    View details
    Renovated Commercial Property on Western
    $300,000
    1,848 SF

    Renovated Commercial Property on Western

    Renovated 1,848 SF commercial property on busy Western Ave.
    2111 Western Ave, Chillicothe, OH 45601
    View details
    New Chipotle with Drive-Thru
    $2,552,631
    2,325 SF

    New Chipotle with Drive-Thru

    New Chipotle with drive-thru in growing Ross County.
    6 St Andrews Blvd, Chillicothe, OH
    View details
    Two-Tenant Retail Building For Sale
    $5,801,000
    72,010 SF

    Two-Tenant Retail Building For Sale

    Two-tenant retail building with long-term leases in Chillicothe, Ohio.
    1470 N Bridge St, Chillicothe, OH 45601
    View details
    Renovated Mixed-Use Building For Sale
    $650,000
    4,832 SF

    Renovated Mixed-Use Building For Sale

    4,832 SF renovated mixed-use building with commercial zoning.
    7 Saint Andrews Blvd, Chillicothe, OH 45601
    View details
    Based on your search, we've compiled 2029 Potential Opportunities for your consideration. Besides 16 Active listings in Chillicothe, OH, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 2005 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Hocking Hills Wooded Lot
    $55,000
    2.00 Acres

    Hocking Hills Wooded Lot

    Scenic wooded lot near Hocking Hills hiking destinations.
    Sams Creek Rd, Laurelville, OH 43135
    View details
    Scenic 10-Acre Pike County Land
    $94,900
    10.00 Acres

    Scenic 10-Acre Pike County Land

    10 acres near Waverly with creek, hardwoods, buildable sites.
    Buchanan Rd, Waverly, OH 45690
    View details
    Scenic 10-Acre Pike County Retreat
    $94,900
    10.01 Acres

    Scenic 10-Acre Pike County Retreat

    10 acres near Waverly, OH with creek and hardwoods.
    Buchanan Rd, Waverly, OH 45690
    View details
    Hocking Hills Land Opportunity
    $599,999
    76.97 Acres

    Hocking Hills Land Opportunity

    76+ acres in Hocking Hills with off-grid cabin.
    Bellia Rd, Laurelville, OH 43135
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    New
    Commercial Land in Chillicothe, OH
    Contact for pricing

    Commercial Land in Chillicothe, OH

    Corner lot with development potential near Central Center Shopping Center.
    563 Mill St, Chillicothe, OH 45601
    View details
    Land Ready for Development
    $1,351,500

    Land Ready for Development

    Shovel-ready land with high visibility and multiple potential uses.
    Chillicothe, OH
    View details
    Prime Retail Land Opportunity
    $118,000
    1.36 Acres

    Prime Retail Land Opportunity

    1.35 acre commercial land in high-traffic retail corridor.
    Bridge St, Chillicothe, OH 45601
    View details
    Prime Land with River Views
    $550,000
    17.34 Acres

    Prime Land with River Views

    17+ acre lot in Chillicothe with development potential.
    N Bridge St, Chillicothe, OH 45601
    View details

    Explore Off-Market Properties in Chillicothe, OH

    Consider similar Off-Market properties in Chillicothe, OH. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    11437 Co Rd

    11437 Co Rd

    Specialty properties • 2,560 SF
    Value Estimation by Request
    11437 Co Rd, Chillicothe, OH 45601
    View details
    00 Eastern Ave

    00 Eastern Ave

    Specialty properties
    Value Estimation by Request
    00 Eastern Ave, Chillicothe, OH 45601
    View details
    2111 Western Ave Ave

    2111 Western Ave Ave

    Commercial real estate • 1,848 SF
    Value Estimation by Request
    2111 Western Ave Ave, Chillicothe, OH 45601
    View details
    37-39 Paint St St

    37-39 Paint St St

    Mixed-use properties
    Value Estimation by Request
    37-39 Paint St St, Chillicothe, OH 45601
    View details
    159 At Seney Rd

    159 At Seney Rd

    Neighborhood centers • 105,000 SF
    Value Estimation by Request
    159 At Seney Rd, Chillicothe, OH 45601
    View details
    65 Paint St

    65 Paint St

    Specialty properties • 14,000 SF
    Value Estimation by Request
    65 Paint St, Chillicothe, OH 45601
    View details
    1318&1328 Western Ave Ave Ave

    1318&1328 Western Ave Ave Ave

    Commercial real estate
    Value Estimation by Request
    1318&1328 Western Ave Ave Ave, Chillicothe, OH 45601
    View details
    1075 Western Ave Ave

    1075 Western Ave Ave

    Mixed-use properties • 2,487 SF
    Value Estimation by Request
    1075 Western Ave Ave, Chillicothe, OH 45601
    View details

    Chillicothe, OH Commercial Real Estate Investment Opportunities Market Analysis

    Explore 1450 commercial real estate investment opportunities in Chillicothe, OH with 16 listings featured on our commercial real estate marketplace. The current inventory includes 130,063,848 square feet of properties with an estimated value of $288,317,800.

    Estimated prices for commercial real estate in Chillicothe, OH begin at $60,000, with an average of $368,692 and extend to $10,895,000.

    In Chillicothe, OH, current investment values show:

    • Retail properties positioned at $399,691
    • Office Properties & Spaces measuring $324,965
    • Individual retail properties assessed at $401,156
    • Office buildings calculated at $355,404
    List
    Map

    Browse Commercial real estate for Sale Near Chillicothe, OH

    Popular Searches in Chillicothe, OH

    Most Searched ZIP Codes in Chillicothe, OH

    • 45601
    • 45602

    Select Neighborhood

    Google sign-in failed. Please try again or use another login method.
    Create New Password
    • At least 8 characters
    • Contains both letters and numbers
    • Contains uppercase and lowercase letters
    • At most 32 characters
    • Password required
    • Password reset link has expired. Please request a new one.