San Luis Obispo, CA Commercial Real Estate for Sale

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Updated: Apr 21, 2025

Two-Unit Medical Office Building

1338 Santa Rosa Street, San Luis Obispo, CA 93401

$1,950,000

3,861 sqft

Two independent medical office suites in the Santa Rosa Professional Building at 1338‑1340 Santa Rosa Street
Built in 1962 and currently operated as a 2‑unit dental office since construction
Each suite offers approximately 1,930 SF with mirror‑image floorplans
Property features a corner lot and level, rectangular topography

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1338 Santa Rosa Street, San Luis Obispo, CA 93401

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Est. Cap Rate

5.5%
NOI ÷ price
Est. NOI

$106K
Annual
Price @ 7% Cap

$1.52M
Suggested
Last Sold

May 2012
$525K
Property Type

Medical Building
Built 1962

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Updated: Jun 19, 2025

Neighborhood Commercial Land Site

2040 Prado Road, San Luis Obispo, CA 93401

$3,900,000

3.59 AC lot

3.59‑acre (156,380 SF) Neighborhood Commercial site in San Luis Ranch
Highly visible from the freeway; centrally located in the San Luis Obispo area
Maximum building size of 75,000 SF with allowable uses including retail, office, and medical
Completed offsites and Blue Top pad; NNN lease type with negotiable TI allowance
Access via the Prado Road freeway overpass connecting Dalidio Road at San Luis Ranch to Prado Road (east of Highway 101)

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Turnkey Medical Office Building

699 California Blvd, San Luis Obispo, CA 93401

$2,150,000

3,000 sqft

Single-level medical office building with two separate suites, each featuring ADA-compliant restrooms, waiting, reception, and exam rooms.

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Downtown Office Building with Parking

1150 Palm ST, San Luis Obispo, CA 93401

$4,400,000

9,767 sqft

Fully occupied office building with private offices, conference rooms, and open work areas, plus on-site parking.

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Two-Story Mixed-Use Building

793 Higuera St, San Luis Obispo, CA 93401

$3,465,000

7,492 sqft

Two-story building with office and retail space located at the intersection of Higuera and Chorro Streets in downtown San Luis Obispo.

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Downtown SLO Historical Office Property

1334 Chorro St, San Luis Obispo, CA 93401

$1,599,000

1,600 sqft

Historical downtown San Luis Obispo office property with potential residential expansion.

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Bright Office Suite with Views

1035 Peach St 302, San Luis Obispo, CA 93401

$450,000

1,155 sqft 0.02 AC lot

Third-floor office suite with natural light and city views.

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Clear-Span Retail Building

2191 Parker St, San Luis Obispo, CA 93401

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8,230 sqft

Versatile clear-span retail building with strong South Street exposure and convenient freeway access for occupants.

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Flex Office-Warehouse with Fenced Yard

3474 Empresa Unit 150, San Luis Obispo, CA 93401

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8,277 sqft

Modern flex space combines office/warehouse improvements with a fenced yard, storefront, and rear roll-up doors.

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Office Suite for Sale

1250 PEACH Street, San Luis Obispo, CA 93401

$585,000

1,360 sqft

Office suite offered for sale at 1250 Peach Street in San Luis Obispo.

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Elevator-Served Office Suite

1411 Marsh Unit 203, San Luis Obispo, CA 93401

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936 sqft

Suite 203 offers three offices, a large reception area, an ensuite bathroom, and a kitchenette sink.

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Grocery-Drug Anchored Shopping Center

3900 Broad Street, San Luis Obispo, CA 93401

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174,428 sqft

Grocery/drug anchored center with Vons and complementary retail tenants, currently 91% occupied.

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Historic Office Suites

890 osos Street, San Luis Obispo, CA 93401

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572 sqft

Historic Teass House offers multiple office suites with on-site parking, patio access, and utilities included.

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Second-Floor Office Suite

641 Higuera Street Unit 202, San Luis Obispo, CA 93401

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728 sqft

Second-floor office suite with two private offices and a reception area within a naturally lit downtown setting.

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Medical Condo with Onsite Parking

1250 Peach St H, San Luis Obispo, CA 93401

$525,000

0.03 AC lot

Well-appointed medical condo near Highway 101 with onsite parking.

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Retail Storefront Property

1121 Broad Street, San Luis Obispo, CA 93401

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3,800 sqft

For-sale retail storefront property offering a practical space for neighborhood commercial use.

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Construction-Ready Hotel Site

2223 Monterey Street, San Luis Obispo, CA 93401

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2,410 sqft 4.21 AC lot

Fully entitled for an 83-key hotel on a freeway-adjacent site along US Highway 101 with immediate access.

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Office Flex Suite with Roll-Up Door

3195 Mcmillan Unit B1, San Luis Obispo, CA 93401

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1,275 sqft

Turnkey 1,275 SF office/flex suite includes reception, private offices, conference room, and a roll-up door for storage or light service.

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Modern Office Condo Suite

433 Marsh St, San Luis Obispo, CA 93401

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512 sqft

Bright open office condo with an ADA-compliant restroom, reception area, and one dedicated on-site parking space.

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Mixed-Use Development Site

1390 Walker, San Luis Obispo, CA 93401

$4,600,000

1,420 sqft 1.10 AC lot

City-approved for a 49-unit residential project and includes an existing 1,420 sq ft commercial building with added approval.

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Corner Retail Storefront

767 Higuera, San Luis Obispo, CA 93401

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3,900 sqft

Corner retail storefront with large display windows and former retail bookstore use history.

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Second-Level Office Suite with Offices

735 Tank Farm Road Unit 200, San Luis Obispo, CA 93401

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52,467 sqft

Second-level suite includes nine offices, a kitchenette, and server room with access to shared conference room and amenities.

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Medical Office with Conference Rooms

805 Aerovista Pl, San Luis Obispo, CA 93401

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4,012 sqft

Modern office suite includes seven private offices, an executive conference room, and a full break room.

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Four-Suite Professional Medical Office

894 Meinecke, San Luis Obispo, CA 93405

$1,650,000

Well maintained four-suite office building with long-term tenancies, located one block from Sierra Vista Hospital.

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San Luis Obispo, CA Commercial Real Estate Market Trends and Statistics

Explore 72 commercial real estate for sale in San Luis Obispo, CA, showcased through 71 active listings on our real estate platform. These investment opportunities span a total of 810,977 square feet of properties for sale, with an estimated market value of $63,192,900.

Sale prices for business properties in San Luis Obispo, CA start at $165,000, averaging $2,430,496, and reaching up to $7,700,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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Demographics Overview

Population 79K

Population Growth (5Y) -12.3%

Median Household Income $82,388

College Educated 27.6%

High-Yield Neighborhoods for Investment

Identify San Luis Obispo submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

Neighborhood	Average Price
93405	$1.8M
93401	$2.2M

Taxes & Financing

Tax Rate (average for all types) 1.14%

Property Tax per SF $13.51 per SF

Tax Rate vs County Average 0.01 pp below county avg

Average Loan-to-Value 65.0%

Listings Trend

New vs delisted commercial listings in San Luis Obispo County

New Delisted

Total CRE Inventory on Market (SF)

Property Size Breakdown

The majority of commercial real estate listings in San Luis Obispo fall within the 10,000 to 25,000 square foot range.

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