San Luis Obispo, CA Medical Office Space for Rent & Lease

Updated: Jun 12

Medical Office Suite with Exam Rooms

628-643 California Blvd, San Luis Obispo, CA 93401

$3 SF/Yr

1,107 sqft · $288/Mo

Office suite with ±1,107 SF
Zoned O (Office)
Includes private restroom
Features 3 exam rooms
Includes 1 physician’s office and a nurse’s station

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Updated: Mar 12

Aerovista Business Park Office Space

805 Aerovista Pl 205, San Luis Obispo, CA 93401

$6,678/Mo

Excellent parking available for staff and clients.
Zoned for both medical and office use, offering flexibility.
Seven private offices provide ample workspace.
Executive style conference room for important meetings.
Full‑size break room / kitchen.

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Downtown San Luis Obispo Office Space

990 Pacific Street |, San Luis Obispo, CA 93401

$1.05 SF/Yr

25 sqft · $2/Mo

First floor office suite suitable for medical or professional use.

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Class A Office Space Available

895 Aerovista Pl, San Luis Obispo, CA

$1.85 SF/Yr

7,197 sqft · $1,109/Mo

Ground floor office suite with upgraded finishes and private patios.

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Downtown San Luis Obispo Office

990 Pacific St, San Luis Obispo, CA 93401

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1,198 sqft

Medical office space for lease in downtown San Luis Obispo.

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Turn Key Medical Suite

628 California Blvd D-1, San Luis Obispo, CA 93401

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Medical suite with exam rooms, physician's office, and nurse's station.

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Medical Office Near Sierra Vista

100 Casa St, San Luis Obispo, CA

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1,300 sqft

Ground floor medical office space available near Sierra Vista Hospital.

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Freestanding Building with Parking Spaces

3565 S Higuera, San Luis Obispo, CA 93401

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Freestanding building with efficient layout, parking, and prominent signage.

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Remodeled Office Suite For Rent

1250 Peach St, San Luis Obispo, CA

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930 sqft

Remodeled office suite with mountain views in Fremont Medical Center.

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Renovated Medical/Dental Office Space

1223 Higuera St, San Luis Obispo, CA

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1,010 sqft

Recently renovated medical/dental office space available for immediate occupancy.

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Medical Suite Near Highway 101

620 California G, San Luis Obispo, CA 93401

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Medical suite available for rent near Highway 101.

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1288 Morro St, Suite 100

1288 Morro Street, Suite 100 | San Luis Obispo, CA 93401, San Luis Obispo, CA 93401

$1.85 SF/Yr

Medical Office | San Luis Obispo, CA

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Prime Commercial Parcels for Lease

250 Tank Farm Rd, San Luis Obispo, CA 93401

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Six improved parcels available for lease in San Luis Obispo.

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Based on your search, we've compiled 24 Potential Opportunities for your consideration. Besides 13 Active listings in San Luis Obispo, CA, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 3 Properties for Sales.

Medical Office Space for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Mixed-Use Building in Village Creek

200 Station Way C, Arroyo Grande, CA 93420

Contact for pricing

1,748 sqft

Mixed-use building with medical/office space in Village Creek Promenade.

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Ground Floor Medical Office Space

880 N Oak Park Blvd 103, Arroyo Grande, CA 93420

Contact for pricing

2,164 sqft

2164 SF office space available 8/1/2026.

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Medical Office Space Available

325 Posada Ln, Templeton, CA

Contact for pricing

1,877 sqft

Medical office condo for rent in established medical hub.

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Medical Office Condo with Exam Rooms

1105 Las Tablas Road, Templeton, CA 93465

Contact for pricing

Medical office condo with reception, two exam rooms, and backup power for uninterrupted patient care.

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Similar Spaces for Sale in San Luis Obispo, CA

Consider Similar Space for Sale. We found 3 Spaces matching your search parameters.

Corner Office Building with Private Deck

102 104 Santa Rosa, San Luis Obispo, CA 93405

$995,000

1,444 sqft

Well-positioned corner office building configured for two suites, with private deck space and tenant parking.

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Medical Condo with Onsite Parking

1250 Peach St H, San Luis Obispo, CA 93401

$525,000

0.03 AC lot

Well-appointed medical condo near Highway 101 with onsite parking.

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Two-Unit Medical Office Building

1338 Santa Rosa Street, San Luis Obispo, CA 93401

$1,950,000

3,861 sqft

Two independent medical office suites offer flexible medical or general office use in a 1962-built professional building.

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Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Commercial Land for Long-Term Lease

5538 E Paisano Drive, El Paso, TX 79905

$5,950/Mo

Lease a C4-zoned lot with easy interstate access, suited for a range of business and professional uses.

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Office Development Land For Lease

1323 Strawfloor Drive, Jonesboro, AR 72401

Contact for pricing

4,000 sqft

2.43 acres for office development with build-to-suit opportunity.

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Corner Lot on Highway 72

30472 Highway 72, Madison, AL 35756

$5,000/Mo

1,875 sqft · $32 SF/Yr

1.7 acre corner lot zoned for commercial, medical, residential.

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Beaumont Centre Outparcel Opportunity

3199 Beaumont Centre Circle, Lexington, KY 40513

Contact for pricing

Outparcel opportunity in established shopping center for ground lease.

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