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    Portsmouth, NH Commercial Real Estate for Lease

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    Greenland, NH Newington, NH North Hampton, NH
    95 listings
    Portsmouth
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    Second-Floor Office Suite
    $3,700/Mo
    1,300 SF
    Second-Floor Office Suite

    96 Penhallow Street, Portsmouth, NH 3801

    Historic downtown office suite with private restroom and shared patio access, available immediately.
    • 1,300± SF second‑floor office space available immediately
    • Includes one private restroom
    • Access to shared outdoor space/patio
    • Right to exterior signage (inquire for details)
    • Located at 96 Penhallow Street in downtown Portsmouth
    Updated: Jun 2
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    Second-Floor Office Suite
    $3,700/Mo
    1,300 SF
    Second-Floor Office Suite

    96-98 Penhallow St, Portsmouth, NH 3801

    Historic downtown office with a private restroom, shared patio access, and exterior signage rights.
    • Lease 1,300± SF of second‑floor office space at 96 Penhallow Street in downtown Portsmouth
    • Includes one private restroom
    • Access to shared outdoor space/patio
    • Rights to exterior signage; inquire for details
    • Downtown setting steps from Market Square and Prescott Park, with close proximity to major commuter routes
    Updated: Jun 1
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    Downtown Portsmouth Office Suites Available
    $15 SF/Yr
    8,644 SF
    Downtown Portsmouth Office Suites Available

    Office suites for lease in downtown Portsmouth, NH.

    501 Islington St Suite 3, Portsmouth, NH 3801

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    Retail Spaces in Hannaford-Anchored Plaza
    $22 SF/Yr
    10,660 SF
    Retail Spaces in Hannaford-Anchored Plaza

    Retail and office spaces available in Portsmouth's West End.

    800 Islington St Units 10A & 10B, Portsmouth, NH 3801

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    Retail Space on Route 1
    $14,500/Mo
    7,000 SF
    Retail Space on Route 1

    7,000 SF retail space in high-visibility Portsmouth location.

    2299 Lafayette Rd, Portsmouth, NH 3801

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    Two-Story Retail and Office Suite
    $17 SF/Yr
    3,331 SF
    Two-Story Retail and Office Suite

    Two-story space with on-site parking and flexible layout for retail or office operations.

    72 Mirona Rd Suite 2, Portsmouth, NH 3801

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    Downtown Office Suites
    $20 SF/Yr
    5,793 SF
    Downtown Office Suites

    Two move-in ready office suites with efficient floor plans and excellent natural light in Downtown Portsmouth.

    25 Chestnut Street, Portsmouth, NH 3801

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    Retail and Office Building
    $17 SF/Yr
    5,381 SF
    Retail and Office Building

    Two-floor retail and office layout with ample parking and convenient highway access for a wide range of users.

    72 Mirona Rd, Portsmouth, NH 3801

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    Portsmouth Office Space For Lease
    $10 SF/Yr
    3,921 SF
    Portsmouth Office Space For Lease

    Versatile office space in Portsmouth, accessible from city or bypass.

    500 Maplewood Ave Unit A, Portsmouth, NH 3801

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    Turnkey Florist Retail Space
    $2,500/Mo
    856 SF
    Turnkey Florist Retail Space

    Fully built-out florist retail space with greenhouses in Portsmouth.

    1000 Woodbury Ave, Portsmouth, NH 3801

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    West End Office Space Available
    $19 SF/Yr
    2,300 SF
    West End Office Space Available

    Second-floor office space in Portsmouth's West End.

    801 Islington St Unit 33, Portsmouth, NH 3801

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    Highly Visible Retail/Office Suite
    $6,750/Mo
    2,242 SF
    Highly Visible Retail/Office Suite

    First-floor retail or office space with an added basement area, located just off Market Square for strong visibility.

    21 Daniel Street, Portsmouth, NH 3801

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    Downtown Portsmouth Modern Open Office
    $3,350/Mo
    2,000 SF
    Downtown Portsmouth Modern Open Office

    Modern 2000 sqft office space in downtown Portsmouth.

    299 Hanover St First Floor, Portsmouth, NH 3801

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    Industrial/Flex Space For Lease
    $15 SF/Yr
    4,994 SF
    Industrial/Flex Space For Lease

    4,994± SF industrial/flex space near Route 1.

    270 West Rd 3, Portsmouth, NH 3801

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    Retail and Office Space Available
    $17 SF/Yr
    3,331 SF
    Retail and Office Space Available

    Retail and office spaces with ample parking and flexible layout.

    72 Mirona Rd Suite 3, Portsmouth, NH 3801

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    Versatile Flex/Industrial Unit Available
    $14 SF/Yr
    5,100 SF
    Versatile Flex/Industrial Unit Available

    5,100 SF flex/industrial unit in Portsmouth's commercial corridor.

    280 Heritage Avenue, Portsmouth, NH 3801

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    Shared Office Space Available
    $1,000/Mo
    387 SF
    Shared Office Space Available

    Shared office space in central location near downtown Portsmouth.

    101-1 Greenleaf Woods Dr, Portsmouth, NH 3801

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    Retail Space on Daniel Street
    $6,750/Mo
    2,242 SF
    Retail Space on Daniel Street

    Retail spaces available in Portsmouth, NH with street access.

    21 Daniel St, Portsmouth, NH 3801

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    Restaurant Space in Former Bank Building
    Contact for pricing
    Restaurant Space in Former Bank Building

    Restaurant space in an iconic former bank building with 165 seats and outdoor dining in Portsmouth’s Market Square.

    22 Market Square, Portsmouth, NH 03801

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    Highly Visible Retail/Office Space
    Contact for pricing
    Highly Visible Retail/Office Space

    First-floor retail or office space with additional basement area, positioned for strong walk-in visibility off Market Square.

    21 Daniel Street, Portsmouth, NH 03801

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    Shared Office Suite with Waiting Area
    Contact for pricing
    Shared Office Suite with Waiting Area

    Three-room shared office suite with kitchenette and a dedicated waiting area, well suited for client-facing teams.

    1 Greenleaf Woods Drive, Portsmouth, NH 03801

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    Office and Retail Storefront Space
    $3,500/Mo
    Office and Retail Storefront Space

    Flexible office and retail space located on a walkway beside Buckley’s Market.

    21a Daniel Street, Portsmouth, NH 3801

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    Retail/Office Space in Portsmouth
    $3,100/Mo
    Retail/Office Space in Portsmouth

    Updated retail/office space with patio and parking in Portsmouth.

    33 Deer St 3A, Portsmouth, NH 3801

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    Portsmouth, NH Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Portsmouth, NH with 95 listings featured on our commercial real estate exchange. The current inventory includes 566,824 square feet of properties with an estimated lease value of $1,223 /Mo.

    Estimated lease rates for Commercial real estate in Portsmouth, NH begin at $0.98 SF/Yr, with an average of $22 SF/Yr and extend to $140 SF/Yr.
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