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    Portsmouth, NH

    Portsmouth, NH Commercial Real Estate for Lease

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    Retail Space in Portsmouth, NH
    Retail Space in Portsmouth, NH

    1111 Off Market St, Portsmouth, NH

    Contact for pricing
    4,000 sqft 19.87 AC lot

    Retail space available in a strong Southern New Hampshire market.

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    Class A Office Space Sublease
    Class A Office Space Sublease

    90 Aboretum Dr, Portsmouth, NH 03801

    $22 SF/Yr

    Class A office space for sublease in Portsmouth, NH.

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    Shopping Center Retail Space
    Shopping Center Retail Space

    100 Durgin Ln, Portsmouth, NH 03801

    Contact for pricing
    38,215 sqft

    For lease retail space within a shopping center anchored by major national retailers nearby.

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    Shopping Center Retail Space
    Shopping Center Retail Space

    100 Durgin Ln, Portsmouth, NH 03801

    Contact for pricing
    40,215 sqft

    Retail space available within a shopping center featuring national and regional retailers.

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    Office Units with On-Site Parking
    Office Units with On-Site Parking

    4 Greenleaf Woods Drive, Portsmouth, NH 03801

    $595/Mo
    6,414 sqft

    Updated professional offices support healthcare and therapy practices in a campus-style setting near downtown.

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    Medical Office Suite with Private Bath
    Medical Office Suite with Private Bath

    301-4 Greenleaf Woods Dr, Portsmouth, NH 03801

    $595/Mo

    Office suite includes a private bath with shower, kitchenette, and natural light from windows on three sides.

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    Class A Office Spaces Available
    Class A Office Spaces Available

    300 Constitution Ave, Portsmouth, NH 03801

    Contact for pricing
    10,275 sqft

    Class A office spaces for lease with modern designer furniture.

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    Warehouse/Flex/Manufacturing Space Available
    Warehouse/Flex/Manufacturing Space Available

    230 Corporate Dr, Portsmouth, NH

    Contact for pricing
    20,167 sqft 590.11 AC lot

    20,167 SF warehouse/flex/manufacturing space with HVAC and office area.

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    Based on your search, we've compiled 145 Potential Opportunities for your consideration. Besides 104 Active listings in Portsmouth, NH, we suggest exploring alternatives. Consider Similar 37 Spaces for Sales.

    Commercial real estate for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Renovated Medical Office Suite
    Renovated Medical Office Suite

    101-1 Bayside Rd, Greenland, NH 03840

    $2,150/Mo
    1,519 sqft

    Renovated in 2025 with treatment rooms, private bathrooms, and laundry hookups.

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    Office Units with Common Entry
    Office Units with Common Entry

    19 Bridge Street, Kittery, ME 03904

    $600-$900/Mo
    0.09 AC lot

    Five leasable office suites share kitchen and bathroom facilities in a compact commercial property.

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    New Office Suites
    New Office Suites

    19 Bridge St Unit 9, Kittery, ME 03904

    $600/Mo

    New office suites feature a common entry with included kitchens and bathrooms, available as individual or multiple suites.

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    Retail Space in Greenland, NH
    Retail Space in Greenland, NH

    1 Bayside Road, Greenland, NH 03840

    $350/Mo

    Retail space available for lease in Greenland, New Hampshire.

    View details

    Similar Spaces for Sale in Portsmouth, NH

    Consider Similar Space for Sale. We found 37 Spaces matching your search parameters.

    Downtown Mixed-Use Property
    Downtown Mixed-Use Property

    84-88 Pleasant St, Portsmouth, NH 03801

    $1,750,000
    7,165 sqft

    Existing shell offers a redevelopment opportunity for commercial space with residential use above.

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    Waterfront Restaurant Site with Full Bar
    Waterfront Restaurant Site with Full Bar

    990 Lafayette Rd, Portsmouth, NH 03801

    $3,600,000
    17,900 sqft 2.80 AC lot

    Owner-occupied restaurant with a full bar and seating for 214, positioned on a high-visibility US Rt 1 waterfront site.

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    Ground-Floor Retail Condominium
    Ground-Floor Retail Condominium

    53 Green St, Portsmouth, NH 03801

    $1,195,000
    2,828 sqft

    Cold, dark shell offers flexibility for a custom commercial build-out.

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    Retail Condominium Unit
    Retail Condominium Unit

    135 Market Street, Unit G, Portsmouth, NH 03801

    $715,000
    994 sqft

    Leased retail condo in a well-maintained building with prominent signage along Market Street.

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    Retail Space with Loading Bays
    Retail Space with Loading Bays

    720 Lafayette Rd, Portsmouth, NH 03801

    $8,500,000
    17,700 sqft

    Occupied commercial space offers covered drive-up access and infrastructure for loading, unloading, and customer pickup.

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    Single-Unit Office Building
    Single-Unit Office Building

    330 Borthwick Ave Unit 210, Portsmouth, NH 03801

    $550,000
    2,132 sqft

    Single-unit office property offering 2,132 SF for sale.

    View details
    Recently Built Office Units
    Recently Built Office Units

    1-54 Maplewood Ave, Portsmouth, NH 03801

    $3,440,000
    4,862 sqft

    Downtown commercial space includes on-site parking and access to nearby public parking options.

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    Downtown Office Condominium Suite
    Downtown Office Condominium Suite

    118 Maplewood Avenue, Unit C-1, Portsmouth, NH 03801

    $450,000
    951 sqft

    Own a functional office condominium with private offices, a conference room, and dedicated on-site parking.

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    Renovated Mixed-Use Building
    Renovated Mixed-Use Building

    8 Bow Street, Portsmouth, NH 03801

    $4,200,000
    4,101 sqft 0.03 AC lot

    Four furnished residences and a ground-floor commercial suite occupy a historic masonry property with separate residential access.

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    Office Condominium with Private Offices
    Office Condominium with Private Offices

    C1-118 Maplewood Ave, Portsmouth, NH 03801

    $450,000
    951 sqft

    Professional suite includes three enclosed offices, a flexible conference room, kitchenette, storage, and a private restroom.

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    Two-Building Flex Industrial Site
    Two-Building Flex Industrial Site

    3601 Lafayette Road, Portsmouth, NH 03801

    $1,300,000
    2,615 sqft 4.50 AC lot

    Two commercial buildings on 4.5 acres include offices and a rear workshop/warehouse with four drive-in doors.

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    Historic Portsmouth Office Building For Sale
    Historic Portsmouth Office Building For Sale

    144 Washington Street, Portsmouth, NH 03801

    $3,300,000
    3,034 sqft

    Landmark Federal-style building in Portsmouth's historic Puddle Dock area.

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    Compact Medical Office Condo
    Compact Medical Office Condo

    230 Lafayette Rd Unit 11D, Portsmouth, NH 03801

    $94,160
    428 sqft

    A private, in-suite restroom medical office suite with ample on-site parking and easy access to major routes.

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    Portsmouth Mixed-Use Historical Gem
    Portsmouth Mixed-Use Historical Gem

    8 Bow Street, Portsmouth, NH 03801

    $4,200,000
    4,101 sqft

    Renovated mixed-use building with residential and commercial units.

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    Historic Office Building
    Historic Office Building

    144 Washington Street, Portsmouth, NH 03801

    $3,300,000
    0.25 AC lot

    Federal-style professional office property with period details, public water, and off-street parking in Portsmouth’s South End.

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    Medical Office Condominium Suite
    Medical Office Condominium Suite

    200 Griffin Rd, Portsmouth, NH 03801

    Contact for pricing
    2,870 sqft

    Office suite includes a waiting room, reception area, nine exam rooms, private offices, and ample on-site parking.

    View details
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