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    Sikeston, MO Retail Properties & Spaces for Sale

    12 results
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    Historic Downtown Sikeston Retail Opportunity
    $275,000
    14,642 SF

    Historic Downtown Sikeston Retail Opportunity

    124 E Front St, Sikeston, MO 63801

    Two-story retail space in high-traffic downtown Sikeston.

    • Prime downtown location with high visibility and foot traffic.
    • Value‑add opportunity with a blank canvas upstairs for customization.
    • Existing leases on the ground floor provide immediate income.
    • Historic building (built in 1915) with unique character.
    • Close proximity to retail, professional services, and restaurants.
    Updated: Feb 25
    View details
    Sikeston Commercial Property For Sale
    $650,000
    1.28 Acres

    Sikeston Commercial Property For Sale

    1105 S Main St, Sikeston, MO 63801

    Prime commercial location with high visibility and established business history.

    • Prime commercial location with high‑visibility at a 4‑way stoplight intersection.
    • Zoned C3 Highway Commercial, ideal for QSR or redevelopment.
    • Outstanding traffic count and accessibility.
    • Proven location with a 20+ year history.
    • Substantial 471’ highway frontage and 1.2‑acre lot size.
    Updated: Mar 3
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    Sikeston Car Wash with Expansion Potential
    $1,000,000
    40,511 SF

    Sikeston Car Wash with Expansion Potential

    Turnkey car wash with expansion potential in high-demand market.

    531 N Main St, Sikeston, MO 63780
    View details
    Historical Building in Downtown Sikeston
    $269,000
    6,321 SF

    Historical Building in Downtown Sikeston

    Two-story historic building in downtown Sikeston, ideal for investors.

    112 Front St, Sikeston, MO 63801
    View details
    Sikeston Commercial Property For Sale
    $600,000
    1.30 Acres

    Sikeston Commercial Property For Sale

    Income-producing property with commercial spaces and storage units.

    2008 N Main St, Sikeston, MO 63801
    View details
    Sikeston Carwash with High Visibility
    $1,250,000
    40,946 SF

    Sikeston Carwash with High Visibility

    Turnkey carwash with high traffic, visibility, and recurring revenue.

    900 S Main St, Sikeston, MO 63801
    View details
    Sikeston Retail Property For Sale
    $550,000
    1,150 SF

    Sikeston Retail Property For Sale

    Established family-owned business with high visibility for over 30 years.

    1018 Linn St, Sikeston, MO 63801
    View details
    Sikeston Commercial Property with Income
    $290,000
    4,244 SF

    Sikeston Commercial Property with Income

    Commercial building, duplex, and storage on 1.22 acres.

    101-103 Donald Fulton Dr, Sikeston, MO 63801
    View details
    Historic Downtown Mixed-Use Opportunity
    $299,000
    14,642 SF

    Historic Downtown Mixed-Use Opportunity

    Two-story historic building in downtown Sikeston with modern potential.

    124 E Front St, Sikeston, MO 63801
    View details
    Sikeston Commercial Building Investment Opportunity
    $979,500

    Sikeston Commercial Building Investment Opportunity

    High-visibility commercial building with income and upside potential.

    808 E Wakefield Ave, Sikeston, MO 63801
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    Neighborhood Center with Established Businesses
    Contact for pricing

    Neighborhood Center with Established Businesses

    Neighborhood center with high traffic, visibility, and established businesses.

    1100 S Main St, Sikeston, MO 63801
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    Turnkey Carwash in Sikeston, MO
    Contact for pricing
    40,946 SF

    Turnkey Carwash in Sikeston, MO

    Established carwash with high traffic, visibility, and membership program.

    900 S Main St, Sikeston, MO 63801
    View details
    Based on your search, we've compiled 20 Potential Opportunities for your consideration. Besides 12 Active listings in Sikeston, MO, we suggest exploring several alternatives: 4 properties in Nearby Cities, plus 4 Land Listings that present a potential for development.

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Retail Building on Highway 105
    $84,000
    1,452 SF

    Retail Building on Highway 105

    Retail building with great visibility and expansion potential.

    2380 S Main St, Charleston, MO 63834
    View details
    Remodeled Commercial Property in Charleston
    $350,000
    4,173 SF

    Remodeled Commercial Property in Charleston

    Turnkey commercial property with residential zoning in prime location.

    506 S Main St, Charleston, MO 63834
    View details
    Prime Dexter Retail Opportunity
    $999,500

    Prime Dexter Retail Opportunity

    High-visibility retail space with drive-thru and highway access.

    1007 W Business Us Highway 60, Dexter, MO 63841
    View details
    Remodeled Commercial Building in Downtown
    $259,900
    4,000 SF

    Remodeled Commercial Building in Downtown

    Turn-key restaurant or flexible commercial space in downtown Dexter.

    117 S Locust St, Dexter, MO 63841
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Commercial Land on Highway 61
    $144,000
    1.01 Acres

    Commercial Land on Highway 61

    Commercial land on high-traffic route near Sikeston Industrial Park.

    103 Grove St, Sikeston, MO 63801
    View details
    Commercial Land in Sikeston, MO
    $195,000
    0.72 Acres

    Commercial Land in Sikeston, MO

    Vacant, level commercial lot available in Sikeston, Missouri.

    116 Hospitality Dr, Sikeston, MO 63801
    View details
    Commercial Land in Retail Area
    $500,000
    1.05 Acres

    Commercial Land in Retail Area

    1.05 acres of commercial land for development in Sikeston.

    1209 Lawrence St, Sikeston, MO 63801
    View details
    Prime Land for Commercial Development
    $3,960,000
    88.00 Acres

    Prime Land for Commercial Development

    88 acres at I-55 and I-57, Sikeston, MO.

    Ables Rd, Sikeston, MO 63801
    View details

    Explore Off-Market Properties in Sikeston, MO

    Consider similar Off-Market properties in Sikeston, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    1405 Malone Ave

    1405 Malone Ave

    RESTAURANT • 680 SF
    Value Estimation by Request
    1405 Malone Ave, Sikeston, MO 63801-3411
    View details
    1207 Malone Ave

    1207 Malone Ave

    RETAIL STORES (PERSONAL SERVICES) • 2,196 SF
    Value Estimation by Request
    1207 Malone Ave, Sikeston, MO 63801-4350
    View details
    835 Malone Ave

    835 Malone Ave

    BAR, TAVERN • 2,800 SF
    Value Estimation by Request
    835 Malone Ave, Sikeston, MO 63801-2558
    View details
    2405 Malone Ave

    2405 Malone Ave

    RETAIL STORES (PERSONAL SERVICES) • 11,032 SF
    Value Estimation by Request
    2405 Malone Ave, Sikeston, MO 63801-3803
    View details
    Malone E Ave

    Malone E Ave

    AUTO REPAIR, GARAGE • 8,165 SF
    Value Estimation by Request
    Malone E Ave, Sikeston, MO 63801
    View details
    921 Malone Ave

    921 Malone Ave

    RESTAURANT • 2,684 SF
    Value Estimation by Request
    921 Malone Ave, Sikeston, MO 63801-3207
    View details
    119 Malone Ave

    119 Malone Ave

    RETAIL STORES (PERSONAL SERVICES) • 5,280 SF
    Value Estimation by Request
    119 Malone Ave, Sikeston, MO 63801-2823
    View details
    Malone E Ave

    Malone E Ave

    AUTO REPAIR, GARAGE • 2,438 SF
    Value Estimation by Request
    Malone E Ave, Sikeston, MO 63801
    View details
    2001 Malone Ave

    2001 Malone Ave

    FINANCIAL BUILDING • 5,800 SF
    Value Estimation by Request
    2001 Malone Ave, Sikeston, MO 63801-3633
    View details
    1617 Malone Ave

    1617 Malone Ave

    RESTAURANT • 10,396 SF
    Value Estimation by Request
    1617 Malone Ave, Sikeston, MO 63801-3415
    View details
    2407 Malone Ave

    2407 Malone Ave

    RETAIL STORES (PERSONAL SERVICES) • 1,075 SF
    Value Estimation by Request
    2407 Malone Ave, Sikeston, MO 63801-3802
    View details
    616 Virginia St

    616 Virginia St

    RETAIL STORES (PERSONAL SERVICES) • 2,000 SF
    Value Estimation by Request
    616 Virginia St, Sikeston, MO 63801-3308
    View details

    Sikeston, MO Retail Properties & Spaces Investment Opportunities Market Analysis

    Explore 279 retail properties & spaces for sale in Sikeston, MO, showcased through 12 active listings on our real estate platform. These investment opportunities span a total of 1,538,642 square feet of properties for sale, with an estimated market value of $12,704,000.

    Sale prices for stores in Sikeston, MO start at $269,000, averaging $552,347, and reaching up to $1,250,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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