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    Cape Girardeau, MO Retail Properties & Spaces for Lease

    16 results
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    Renovated Commercial Space For Lease
    $2,500 /Mo
    2,937 SF

    Renovated Commercial Space For Lease

    230 N Sprigg Street, Cape Girardeau, MO 63701

    Renovated commercial space with high visibility in a prime location.

    • Prime location with high traffic and road frontage on N Sprigg St, offering excellent visibility in the Business District.
    • Almost 3000 sq ft of renovated space suitable for multiple offices or service providers.
    • Completely renovated with brand new A/C, roof, gutters, flooring, fixtures, bathrooms, kitchenette, and siding.
    • Significant rental income potential.
    • Located downtown, in the midst of exciting activities.
    Updated: Jun 30, 2025
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    Mixed-Use Commercial Space Available
    $1,900 /Mo
    2,400 SF

    Mixed-Use Commercial Space Available

    2117 Broadway St. Suite B, Cape Girardeau, MO 63701

    Versatile storefront and warehouse space in downtown Cape Girardeau.

    • Prime location on Broadway Street, a high‑traffic commercial corridor in Cape Girardeau.
    • Versatile mixed‑use space: 1,000 SF storefront and 1,400 SF warehouse.
    • Flexible layout suitable for retail, wholesale, service, or light industrial operations.
    • Storefront is fully heated and cooled with a dedicated restroom.
    • Warehouse includes an overhead door for convenient loading and unloading.
    Updated: Mar 5
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    Historic Art Deco Landmark Space
    $2,900 /Mo

    Historic Art Deco Landmark Space

    Restored historic building in downtown Cape Girardeau's commercial district.

    824 Broadway St, Cape Girardeau, MO 63701
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    New Development Retail Space Available
    Contact for pricing
    10,000 SF

    New Development Retail Space Available

    Prime lease space with high visibility and build-out allowance.

    2510 Veterans Memorial Drive, Cape Girardeau, MO 63701
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    Prime Retail/Office Space Available
    Contact for pricing
    2,300 SF

    Prime Retail/Office Space Available

    New 2,300 SF space ideal for retail or office.

    3465 William, Cape Girardeau, MO 63703
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    Retail Storefront with Office Space
    Contact for pricing
    1,275 SF

    Retail Storefront with Office Space

    Downtown retail storefront with office space for rent.

    221 Merriwether Street, Cape Girardeau, MO 63703
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    Retail Space Near Interstate 55
    Contact for pricing
    10,800 SF

    Retail Space Near Interstate 55

    Retail space in regional shopping hub with interstate access.

    258 Siemers Dr, Cape Girardeau, MO
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    Retail Space Near St. Francis
    Contact for pricing
    3,154 SF

    Retail Space Near St. Francis

    Retail space available across from St. Francis Medical Center.

    3049 Williams St, Cape Girardeau, MO
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    Commercial Space For Lease
    Contact for pricing

    Commercial Space For Lease

    Commercial space available for lease at 3049 William St.

    3049 William St, Cape Girardeau, MO 63703
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    Regional Shopping Center Near I-55
    Contact for pricing
    9,400 SF

    Regional Shopping Center Near I-55

    Regional shopping center with easy access to Interstate 55.

    155-157 Siemers Dr, Cape Girardeau, MO
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    Retail Space Near West Park
    Contact for pricing
    7,908 SF

    Retail Space Near West Park

    Retail space in regional shopping hub with easy Interstate access.

    3047 William St, Cape Girardeau, MO
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    Retail Space Near West Park
    Contact for pricing
    4,970 SF

    Retail Space Near West Park

    Retail space in regional shopping hub with high visibility.

    3036-3048 William St, Cape Girardeau, MO
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    Retail Space Near West Park
    Contact for pricing
    1,595 SF

    Retail Space Near West Park

    Retail space available in regional shopping hub near West Park.

    240-250 S Silver Springs Rd, Cape Girardeau, MO
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    Retail Space Available For Rent
    Contact for pricing
    14,850 SF

    Retail Space Available For Rent

    Retail spaces available, ranging from 4,050 to 14,850 SqFt.

    258 Siemers Drive, Cape Girardeau, MO 63701
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    Retail Space Available For Rent
    Contact for pricing
    4,970 SF

    Retail Space Available For Rent

    Retail space available, offering 4,970 square feet.

    3036 William Street, Cape Girardeau, MO 63701
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    Commercial Space For Lease
    Contact for pricing

    Commercial Space For Lease

    Commercial space available for lease in Cape Girardeau, Missouri.

    155 Siemers Dr, Cape Girardeau, MO 63701
    View details
    Based on your search, we've compiled 40 Potential Opportunities for your consideration. Besides 16 Active listings in Cape Girardeau, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 16 Properties for Sales.

    Explore Retail properties & Spaces for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Professional Space Near Main Intersection
    $1,000 /Mo

    Professional Space Near Main Intersection

    Prime location, high visibility, and flexible floor plan.

    1226 Linn St, Suite D, Sikeston, MO 63801
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    New Office/Retail Center on Main
    $1,950 /Mo
    2,600 SF

    New Office/Retail Center on Main

    Prime location with excellent traffic and visibility.

    600 N. Main Street, Sikeston, MO 63801
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    Retail Space in Walmart Center
    Contact for pricing
    1,554 SF

    Retail Space in Walmart Center

    High-profile retail endcap in shadow-anchored shopping center for lease.

    2015 Jefferson St, Perryville, MO
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    Retail Space For Lease
    Contact for pricing

    Retail Space For Lease

    Retail space available for lease in Perryville, Missouri.

    2015-2021 Jefferson Street, Perryville, MO 63775
    View details

    Explore Similar Spaces for Sale in Cape Girardeau, MO

    Consider Similar Space for Sale. We found 16 Spaces matching your search parameters.

    Versatile Riverfront Commercial Property
    $400,000
    4,400 SF

    Versatile Riverfront Commercial Property

    Prime riverfront property suitable for office, restaurant, warehouse, or mixed-use.

    450 N Main Street, Cape Girardeau, MO 63701
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    Versatile Riverfront Commercial Property
    $475,000
    7,044 SF

    Versatile Riverfront Commercial Property

    Flexible commercial space with riverfront location and development potential.

    308 N Main Street, Cape Girardeau, MO 63701
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    Versatile Commercial Building in Cape
    $225,000
    0.57 Acres

    Versatile Commercial Building in Cape

    Adaptable 1800 sq ft commercial building in thriving Cape Girardeau.

    2357 Rust Avenue, Cape Girardeau, MO 63703
    View details
    Renovated Commercial Space in Cape Girardeau
    $239,900
    2,937 SF

    Renovated Commercial Space in Cape Girardeau

    Renovated commercial space with high potential in a prime location.

    230 N Sprigg Street, Cape Girardeau, MO 63701
    View details
    Versatile Commercial Property For Sale
    $295,000
    2,920 SF

    Versatile Commercial Property For Sale

    High-visibility commercial property with flexible layout and spacious attached warehouse.

    225 Clark Avenue, Cape Girardeau, MO 63701
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    Cape Girardeau Flex Space Building
    $299,900
    5,000 SF

    Cape Girardeau Flex Space Building

    5,000 sq ft building with concrete floors and possibilities.

    3188 Old Route V, Cape Girardeau, MO 63701
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    Broadway Commercial Space with Apartment
    $280,000
    5,100 SF

    Broadway Commercial Space with Apartment

    Versatile investment opportunity with remodeled apartment and commercial space.

    520 Broadway Street, Cape Girardeau, MO 63701
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    Renovated Commercial Building on Sprigg
    $239,900
    2,937 SF

    Renovated Commercial Building on Sprigg

    Renovated commercial space with high visibility and income potential.

    230 N Sprigg Street, Cape Girardeau, MO 63701
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Prime Commercial Land For Lease
    Contact for pricing

    Prime Commercial Land For Lease

    0.47 acre commercial land for lease in Cape Girardeau.

    2148 William St, Cape Girardeau, MO
    View details
    Retail Power Center Land Opportunity
    Contact for pricing

    Retail Power Center Land Opportunity

    Land available in new retail power center near destination retail.

    2900 Joseph Cannon Wy, Marion, IL
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    Mississippi Riverfront Barge Port Opportunity
    Contact for pricing

    Mississippi Riverfront Barge Port Opportunity

    9.3 acre barge port with river frontage for lease.

    550 Water St, Chester, IL
    View details
    Prime Commercial Land in Paducah
    $2.00 SF/Yr

    Prime Commercial Land in Paducah

    8 acres of commercial real estate on Paducah's retail corridor.

    5251 Hinkleville Road, Paducah, KY 42001
    View details

    Cape Girardeau, MO Retail properties & Spaces Leasing Opportunities Market Analysis

    Explore Retail properties & Spaces leasing options in Cape Girardeau, MO with 16 listings featured on our commercial real estate exchange. The current inventory includes 127,935,720 square feet of properties with an estimated lease value of $10 SF/Yr.

    Estimated lease rates for Retail properties & Spaces in Cape Girardeau, MO begin at $10 SF/Yr, with an average of $10 SF/Yr and extend to $10 SF/Yr.
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    Popular Searches in Cape Girardeau, MO

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    Most Searched ZIP Codes in Cape Girardeau, MO

    • 63701
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