Chillicothe, OH Office Properties & Spaces for sale

High-Traffic Commercial Property in Chillicothe

$169,900

1,496 SF

High-Traffic Commercial Property in Chillicothe

945 E Main St, Chillicothe, OH 45601

Versatile commercial building on East Main Street with high visibility.

High‑traffic location on East Main Street in Chillicothe.
Versatile building suitable for office, retail, or studio.
Large glass storefront providing excellent natural light and signage exposure.
Numerous off‑street parking spaces.
Large, open‑concept layout offering a blank canvas for customization.

Updated: Nov 27, 2025

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Explore Opportunities in Nearby Cities

Here are 4 Similar properties we found in Nearby Locations for your consideration.

$225,000

Columbus Ave Commercial Land Opportunity

Prime 3+ acre commercial lot, high visibility.

0 Columbus Ave, Washington Court House, OH 43160

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$178,900

6,760 SF

Downtown Office Building For Sale

6,760 SF office building in downtown Jackson, Ohio.

231 E Main St, Jackson, OH 45640

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Professional Office Building in Jackson, OH

$949,000

5,280 SF

Professional Office Building in Jackson, OH

Prime commercial building with excellent access and high visibility.

317 Broadway St, Jackson, OH 45640

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$1,500,000

3,500 SF

Freestanding Urgent Care Facility

Turnkey urgent care facility with equipment and patient base.

1311 Leesburg Ave, Washington Court House, OH 43160

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Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

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Commercial Land in Chillicothe, OH

Corner lot with development potential near Central Center Shopping Center.

563 Mill St, Chillicothe, OH 45601

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Explore Off-Market Properties in Chillicothe, OH

Consider similar Off-Market properties in Chillicothe, OH. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

6 Medical Dr

MEDICAL BUILDING • 3,120 SF

Value Estimation

$220,000

6 Medical Dr, Chillicothe, OH 45601-8603

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265 Woodbridge Ave

CONDOMINIUM OFFICES • 1,624 SF

Value Estimation

$220,000

265 Woodbridge Ave, Chillicothe, OH 45601-2306

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1273 Riv Rd

PROFESSIONAL BUILDING (MULTI-STORY) • 3,600 SF

Value Estimation

$400,000

1273 Riv Rd, Chillicothe, OH 45601-7709

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84 2nd St

MEDICAL BUILDING • 1,371 SF

Value Estimation

$185,000

84 2nd St, Chillicothe, OH 45601-3110

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77 Main St

MEDICAL BUILDING • 828 SF

Value Estimation

$305,000

77 Main St, Chillicothe, OH 45601-3104

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54 Ewing St

PROFESSIONAL BUILDING (MULTI-STORY) • 867 SF

Value Estimation by Request

54 Ewing St, Chillicothe, OH 45601-3402

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18828 Us Hwy 50

PROFESSIONAL BUILDING (MULTI-STORY) • 9,600 SF

Value Estimation

$315,000

18828 Us Hwy 50, Chillicothe, OH 45601-9268

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95 Brg St

PROFESSIONAL BUILDING (MULTI-STORY) • 1,920 SF

Value Estimation

$300,000

95 Brg St, Chillicothe, OH 45601-2616

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610 Blackwater Rd

MEDICAL BUILDING • 5,476 SF

Value Estimation

$195,000

610 Blackwater Rd, Chillicothe, OH 45601-9003

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68 Star Dr

PROFESSIONAL BUILDING (MULTI-STORY) • 1,408 SF

Value Estimation

$205,000

68 Star Dr, Chillicothe, OH 45601-9583

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56 Star Dr

PROFESSIONAL BUILDING (MULTI-STORY) • 1,408 SF

Value Estimation

$200,000

56 Star Dr, Chillicothe, OH 45601-9583

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45 2nd St

PROFESSIONAL BUILDING (MULTI-STORY) • 2,400 SF

Value Estimation by Request

45 2nd St, Chillicothe, OH 45601-3105

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273 Delano Ave

OFFICE BUILDING • 1,100 SF

Value Estimation by Request

273 Delano Ave, Chillicothe, OH 45601-2251

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229 Main St

OFFICE BUILDING • 720 SF

Value Estimation

$70,000

229 Main St, Chillicothe, OH 45601-3413

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278-280 Main St

OFFICE BUILDING • 1,156 SF

Value Estimation

$305,000

278-280 Main St, Chillicothe, OH 45601

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4 Medical Dr

MEDICAL BUILDING • 1,480 SF

Value Estimation

$225,000

4 Medical Dr, Chillicothe, OH 45601-8603

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28 Mulberry St

OFFICE BUILDING • 1,365 SF

Value Estimation by Request

28 Mulberry St, Chillicothe, OH 45601-2511

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142 2nd St, Unit 152

PROFESSIONAL BUILDING (MULTI-STORY) • 1,288 SF

Value Estimation

$320,000

142 2nd St, Chillicothe, OH 45601-2525

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83-85 Main St

OFFICE BUILDING • 1,270 SF

Value Estimation by Request

83-85 Main St, Chillicothe, OH 45601

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1256 Western Ave

PROFESSIONAL BUILDING (MULTI-STORY) • 3,960 SF

Value Estimation

$310,000

1256 Western Ave, Chillicothe, OH 45601-1105

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53 2nd St

OFFICE BUILDING • 1,738 SF

Value Estimation

$320,000

53 2nd St, Chillicothe, OH 45601-2543

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192 Paint St

MEDICAL BUILDING • 1,584 SF

Value Estimation

$325,000

192 Paint St, Chillicothe, OH 45601-3827

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78 Mulberry St

OFFICE BUILDING • 720 SF

Value Estimation

$200,000

78 Mulberry St, Chillicothe, OH 45601-3321

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Chillicothe, OH Office Properties & Spaces Investment Opportunities Market Analysis

Explore 229 office properties & spaces for sale in Chillicothe, OH on our real estate platform. These investment opportunities span a total of 20,537,973 square feet of properties for sale, with an estimated market value of $56,520,000.

Prices for office spaces in Chillicothe, OH start at $60,000, averaging $324,827, and reaching up to $3,470,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you have the most current data.

Chillicothe, OH Office Properties & Spaces for Sale

High-Traffic Commercial Property in Chillicothe

Versatile commercial building on East Main Street with high visibility.