For Sale
  • For Sale
  • For Lease
  • Recently Sold
  • Property Lookup
  • Brokers
Office
1
  • Retail
  • Office
  • Residential Income
  • Restaurants
  • Industrial
  • Mixed-Use
  • Hospitality
  • Health Care
  • Sports & Entertainment
  • Land
  • Agricultural
  • Specialty
Price
Price range
$
$
Size
Property size / sq.ft.

Chillicothe, OH Office Properties & Spaces for Sale

Notify Me
List
Map
High-Traffic Commercial Property in Chillicothe
$169,900
1,496 SF

High-Traffic Commercial Property in Chillicothe

945 E Main St, Chillicothe, OH 45601

Versatile commercial building on East Main Street with high visibility.

  • High‑traffic location on East Main Street in Chillicothe.
  • Versatile building suitable for office, retail, or studio.
  • Large glass storefront providing excellent natural light and signage exposure.
  • Numerous off‑street parking spaces.
  • Large, open‑concept layout offering a blank canvas for customization.
Updated: Nov 27, 2025
View details
Based on your search, we've compiled 234 Potential Opportunities for your consideration. Besides 1 Active listings in Chillicothe, OH, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 228 Off-Market properties to explore as potential leads, plus 1 Land Listings that present a potential for development.

Explore Opportunities in Nearby Cities

Here are 4 Similar properties we found in Nearby Locations for your consideration.

Columbus Ave Commercial Land Opportunity
$225,000

Columbus Ave Commercial Land Opportunity

Prime 3+ acre commercial lot, high visibility.

0 Columbus Ave, Washington Court House, OH 43160
View details
Downtown Office Building For Sale
$178,900
6,760 SF

Downtown Office Building For Sale

6,760 SF office building in downtown Jackson, Ohio.

231 E Main St, Jackson, OH 45640
View details
Professional Office Building in Jackson, OH
$949,000
5,280 SF

Professional Office Building in Jackson, OH

Prime commercial building with excellent access and high visibility.

317 Broadway St, Jackson, OH 45640
View details
Freestanding Urgent Care Facility
$1,500,000
3,500 SF

Freestanding Urgent Care Facility

Turnkey urgent care facility with equipment and patient base.

1311 Leesburg Ave, Washington Court House, OH 43160
View details

Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Commercial Land in Chillicothe, OH
Contact for pricing

Commercial Land in Chillicothe, OH

Corner lot with development potential near Central Center Shopping Center.

563 Mill St, Chillicothe, OH 45601
View details

Explore Off-Market Properties in Chillicothe, OH

Consider similar Off-Market properties in Chillicothe, OH. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

6 Medical Dr

6 Medical Dr

MEDICAL BUILDING • 3,120 SF
Value Estimation
$220,000
6 Medical Dr, Chillicothe, OH 45601-8603
View details
265 Woodbridge Ave

265 Woodbridge Ave

CONDOMINIUM OFFICES • 1,624 SF
Value Estimation
$220,000
265 Woodbridge Ave, Chillicothe, OH 45601-2306
View details
1273 Riv Rd

1273 Riv Rd

PROFESSIONAL BUILDING (MULTI-STORY) • 3,600 SF
Value Estimation
$400,000
1273 Riv Rd, Chillicothe, OH 45601-7709
View details
84 2nd St

84 2nd St

MEDICAL BUILDING • 1,371 SF
Value Estimation
$185,000
84 2nd St, Chillicothe, OH 45601-3110
View details
77 Main St

77 Main St

MEDICAL BUILDING • 828 SF
Value Estimation
$305,000
77 Main St, Chillicothe, OH 45601-3104
View details
54 Ewing St

54 Ewing St

PROFESSIONAL BUILDING (MULTI-STORY) • 867 SF
Value Estimation by Request
54 Ewing St, Chillicothe, OH 45601-3402
View details
18828 Us Hwy 50

18828 Us Hwy 50

PROFESSIONAL BUILDING (MULTI-STORY) • 9,600 SF
Value Estimation
$315,000
18828 Us Hwy 50, Chillicothe, OH 45601-9268
View details
95 Brg St

95 Brg St

PROFESSIONAL BUILDING (MULTI-STORY) • 1,920 SF
Value Estimation
$300,000
95 Brg St, Chillicothe, OH 45601-2616
View details
610 Blackwater Rd

610 Blackwater Rd

MEDICAL BUILDING • 5,476 SF
Value Estimation
$195,000
610 Blackwater Rd, Chillicothe, OH 45601-9003
View details
68 Star Dr

68 Star Dr

PROFESSIONAL BUILDING (MULTI-STORY) • 1,408 SF
Value Estimation
$205,000
68 Star Dr, Chillicothe, OH 45601-9583
View details
56 Star Dr

56 Star Dr

PROFESSIONAL BUILDING (MULTI-STORY) • 1,408 SF
Value Estimation
$200,000
56 Star Dr, Chillicothe, OH 45601-9583
View details
45 2nd St

45 2nd St

PROFESSIONAL BUILDING (MULTI-STORY) • 2,400 SF
Value Estimation by Request
45 2nd St, Chillicothe, OH 45601-3105
View details
273 Delano Ave

273 Delano Ave

OFFICE BUILDING • 1,100 SF
Value Estimation by Request
273 Delano Ave, Chillicothe, OH 45601-2251
View details
229 Main St

229 Main St

OFFICE BUILDING • 720 SF
Value Estimation
$70,000
229 Main St, Chillicothe, OH 45601-3413
View details
278-280 Main St

278-280 Main St

OFFICE BUILDING • 1,156 SF
Value Estimation
$305,000
278-280 Main St, Chillicothe, OH 45601
View details
4 Medical Dr

4 Medical Dr

MEDICAL BUILDING • 1,480 SF
Value Estimation
$225,000
4 Medical Dr, Chillicothe, OH 45601-8603
View details
28 Mulberry St

28 Mulberry St

OFFICE BUILDING • 1,365 SF
Value Estimation by Request
28 Mulberry St, Chillicothe, OH 45601-2511
View details
142 2nd St, Unit 152

142 2nd St, Unit 152

PROFESSIONAL BUILDING (MULTI-STORY) • 1,288 SF
Value Estimation
$320,000
142 2nd St, Chillicothe, OH 45601-2525
View details
83-85 Main St

83-85 Main St

OFFICE BUILDING • 1,270 SF
Value Estimation by Request
83-85 Main St, Chillicothe, OH 45601
View details
1256 Western Ave

1256 Western Ave

PROFESSIONAL BUILDING (MULTI-STORY) • 3,960 SF
Value Estimation
$310,000
1256 Western Ave, Chillicothe, OH 45601-1105
View details
53 2nd St

53 2nd St

OFFICE BUILDING • 1,738 SF
Value Estimation
$320,000
53 2nd St, Chillicothe, OH 45601-2543
View details
192 Paint St

192 Paint St

MEDICAL BUILDING • 1,584 SF
Value Estimation
$325,000
192 Paint St, Chillicothe, OH 45601-3827
View details
78 Mulberry St

78 Mulberry St

OFFICE BUILDING • 720 SF
Value Estimation
$200,000
78 Mulberry St, Chillicothe, OH 45601-3321
View details

Chillicothe, OH Office Properties & Spaces Investment Opportunities Market Analysis

Explore 229 office properties & spaces for sale in Chillicothe, OH on our real estate platform. These investment opportunities span a total of 20,537,973 square feet of properties for sale, with an estimated market value of $56,520,000.

Prices for office spaces in Chillicothe, OH start at $60,000, averaging $324,827, and reaching up to $3,470,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you have the most current data.

List
Map