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    Chillicothe, OH Office Properties & Spaces for Sale

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    High-Traffic Commercial Property in Chillicothe
    Pending
    $169,900
    1,496 SF

    High-Traffic Commercial Property in Chillicothe

    945 E Main St, Chillicothe, OH 45601

    Versatile commercial building on East Main Street with high visibility.

    • High‑traffic location on East Main Street in Chillicothe.
    • Versatile building suitable for office, retail, or studio.
    • Large glass storefront providing excellent natural light and signage exposure.
    • Numerous off‑street parking spaces.
    • Large, open‑concept layout offering a blank canvas for customization.
    Updated: Jan 9
    View details
    Downtown Chillicothe Mixed-Use Building
    Pending
    $125,000

    Downtown Chillicothe Mixed-Use Building

    20 E Main St, Chillicothe, OH 45601

    Three-story commercial building with storefront and apartments in historic downtown.

    • Prime location on Main Street in historic downtown Chillicothe with high visibility and foot traffic.
    • Two second‑floor one‑bedroom apartments offer immediate rental income potential or live/work flexibility.
    • Spacious third floor with original coffered ceilings, tall windows, and city views, ready for development.
    • Large storefront on the main floor with display windows and street‑level access.
    • Full basement provides abundant storage space.
    Updated: Feb 14
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    Shovel Ready Development Site
    Contact for pricing

    Shovel Ready Development Site

    Development site with tax abatement, high visibility, and utility access.

    Hospital Rd, Chillicothe, OH 45601
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    Historic Gazette Building Commercial Space
    $36,000

    Historic Gazette Building Commercial Space

    Commercial space in the Historic Gazette Building, downtown Chillicothe.

    62 W Main St, Chillicothe, OH 45601
    View details
    Based on your search, we've compiled 236 Potential Opportunities for your consideration. Besides 4 Active listings in Chillicothe, OH, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 228 Off-Market properties to explore as potential leads

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Columbus Ave Commercial Land Opportunity
    $225,000

    Columbus Ave Commercial Land Opportunity

    Prime 3+ acre commercial lot, high visibility.

    0 Columbus Ave, Washington Court House, OH 43160
    View details
    Freestanding Urgent Care Facility
    Contact for pricing
    3,500 SF

    Freestanding Urgent Care Facility

    Turnkey urgent care facility with equipment and patient base.

    1311 Leesburg Ave, Washington Court House, OH 43160
    View details
    Charming Three-Story Commercial/Residential Property
    $219,900
    1,410 SF

    Charming Three-Story Commercial/Residential Property

    Versatile property with original features, suitable for office or residential.

    324 E Main St, Lancaster, OH 43130
    View details
    Lancaster Mixed-Use Opportunity
    $324,900
    0.24 Acres

    Lancaster Mixed-Use Opportunity

    Versatile mixed-use building in Lancaster's thriving downtown corridor.

    846 E Main St, Lancaster, OH 43130
    View details

    Explore Off-Market Properties in Chillicothe, OH

    Consider similar Off-Market properties in Chillicothe, OH. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    173 Renick Ave

    173 Renick Ave

    MEDICAL BUILDING • 3.78 Acres
    Value Estimation by Request
    173 Renick Ave, Chillicothe, OH 45601-2852
    View details
    238 Main St

    238 Main St

    OFFICE BUILDING • 0.09 Acres
    Value Estimation by Request
    238 Main St, Chillicothe, OH 45601-3414
    View details
    Medical Dr

    Medical Dr

    MEDICAL BUILDING • 0.01 Acres
    Value Estimation by Request
    Medical Dr, Chillicothe, OH 45601
    View details
    364 Main St

    364 Main St

    OFFICE BUILDING • 1,428 SF
    Value Estimation by Request
    364 Main St, Chillicothe, OH 45601-3416
    View details
    213 Paint St

    213 Paint St

    OFFICE BUILDING • 1,541 SF
    Value Estimation by Request
    213 Paint St, Chillicothe, OH 45601-3828
    View details
    68 Water St

    68 Water St

    OFFICE BUILDING • 1,188 SF
    Value Estimation by Request
    68 Water St, Chillicothe, OH 45601-2421
    View details
    43 Plz Blvd

    43 Plz Blvd

    PROFESSIONAL BUILDING (MULTI-STORY) • 1,240 SF
    Value Estimation by Request
    43 Plz Blvd, Chillicothe, OH 45601-1760
    View details
    235 Brg St

    235 Brg St

    OFFICE BUILDING • 1,442 SF
    Value Estimation by Request
    235 Brg St, Chillicothe, OH 45601-2621
    View details
    111 Water St

    111 Water St

    PROFESSIONAL BUILDING (MULTI-STORY) • 4,348 SF
    Value Estimation
    $635,000
    111 Water St, Chillicothe, OH 45601-2452
    View details
    141 Main St

    141 Main St

    OFFICE BUILDING • 7,150 SF
    Value Estimation
    $670,000
    141 Main St, Chillicothe, OH 45601-3107
    View details
    90 Main St

    90 Main St

    OFFICE BUILDING • 416 SF
    Value Estimation by Request
    90 Main St, Chillicothe, OH 45601-3103
    View details
    174 Main St

    174 Main St

    MEDICAL BUILDING • 1,438 SF
    Value Estimation by Request
    174 Main St, Chillicothe, OH 45601-3106
    View details
    229 Main St

    229 Main St

    OFFICE BUILDING • 720 SF
    Value Estimation by Request
    229 Main St, Chillicothe, OH 45601-3413
    View details
    165 Main St

    165 Main St

    OFFICE BUILDING • 980 SF
    Value Estimation by Request
    165 Main St, Chillicothe, OH 45601-2507
    View details
    363 Marietta Rd

    363 Marietta Rd

    PROFESSIONAL BUILDING (MULTI-STORY) • 6,000 SF
    Value Estimation
    $795,000
    363 Marietta Rd, Chillicothe, OH 45601-9433
    View details
    36 Paint St

    36 Paint St

    OFFICE BUILDING (MULTI-STORY) • 1,540 SF
    Value Estimation by Request
    36 Paint St, Chillicothe, OH 45601-3238
    View details
    Us Rt 23rd S

    Us Rt 23rd S

    PROFESSIONAL BUILDING (MULTI-STORY) • 2,240 SF
    Value Estimation by Request
    Us Rt 23rd S, Chillicothe, OH 45601
    View details
    20-22 2nd St

    20-22 2nd St

    OFFICE BUILDING • 1,100 SF
    Value Estimation by Request
    20-22 2nd St, Chillicothe, OH 45601
    View details
    56-58 2nd St

    56-58 2nd St

    OFFICE BUILDING • 1,397 SF
    Value Estimation by Request
    56-58 2nd St, Chillicothe, OH 45601
    View details
    37 2nd St

    37 2nd St

    OFFICE BUILDING • 3,266 SF
    Value Estimation by Request
    37 2nd St, Chillicothe, OH 45601-3111
    View details

    Chillicothe, OH Office Properties & Spaces Investment Opportunities Market Analysis

    Explore 232 office properties & spaces for sale in Chillicothe, OH, showcased through 4 active listings on our real estate platform. These investment opportunities span a total of 20,537,973 square feet of properties for sale, with an estimated market value of $56,520,000.

    Sale prices for office spaces in Chillicothe, OH start at $60,000, averaging $324,827, and reaching up to $3,470,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Popular Searches in Chillicothe, OH

    Most Searched ZIP Codes in Chillicothe, OH

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