Durham, NC Office Spaces for Sale

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43 properties

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Updated: Aug 7, 2025

Two-Story Office and Medical Building

4400 Ben Franklin Boulevard, Durham, NC 27704

$3,499,000

21,532 sqft 2.10 AC lot

Significant income generation from leased area: $227,739 in 2024.
Large, multi‑functional commercial building with 21,532 total square feet.
Located in a sought‑after office/medical park in northern Durham County.
Flexible space suitable for various professional uses (medical, office, education, law).
Features include an elevator, ample storage, and a loading dock.

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This listing looks promising.

Here's a quick look at some key insights for

4400 Ben Franklin Boulevard, Durham, NC 27704

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Est. Cap Rate

9.2%
Above avg (5.9%)
Est. NOI

$321K
Annual
Mortgage

$150K
Jul 2016
Property Type

Office Building
Built 1916

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Updated: Apr 9

Durham Commercial Land Opportunity

3421 N Duke Street, Durham, NC 27704

$1,300,000

2,386 sqft 0.61 AC lot

Two adjacent properties (3413 & 3421 N Duke St) sold together, offering a larger footprint.
Prime location on the growing N Duke Street corridor with strong visibility.
Excellent potential for investors, small business owners, or future development.
Spacious lots provide flexibility for various uses (office, service‑based business, redevelopment).
Conveniently located minutes from downtown Durham, Duke University, and major highways.

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Live-Work Craftsman Bungalow with Porch

1814 Chapel Hill Road, Durham, NC 27707

$493,000

1,922 sqft 0.30 AC lot

1938 Craftsman live-work bungalow with central air, natural gas forced-air heat, and an unfinished walk-out basement.

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Suite 120 First-Floor Office Condominium

5003 Southpark Drive, Durham, NC 27713

$389,000

1,386 sqft

Zoned OI(D), suite 120 is leased to the US Government with a lease ending July 2029.

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Industrial Flex Property with Fenced Yard

1015 Ellis Road, Durham, NC 27703

$1,385,000

4,940 sqft 0.74 AC lot

Three-building industrial flex site includes multiple garage bays, a converted office, and a fully fenced yard for outdoor operations.

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Office Building for Sale

4007 N Roxboro Street, Durham, NC 27704

$2,500,000

2,605 sqft

Office building for sale at 4007 N Roxboro Street, positioned across from Lowes Home Improvements.

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Versatile Retail and Office Space

2620 Angier, Durham, NC 27703

$125,000

887 sqft

Versatile storefront and office space with on-site parking and convenient access to major routes near Downtown Durham.

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Live-Work Craftsman Bungalow

1814 Chapel Hill, Durham, NC 27707

$498,000

1,922 sqft

Craftsman-style home with office-ready interiors, a fireplace front parlor, and flexible outdoor parking behind a detached garage.

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Professional Center Office Suite

4210 N. Roxboro Street, Suite 140, Durham, NC 27704

$565,000

2,408 sqft

Office suite in the Roxboro Road Professional Center, offering space suitable for professional services or medical offices.

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Two-Story Office and Medical Building

4400 Ben Franklin Boulevard, Durham, NC 27704

$3,499,000

21,532 sqft

Flexible office and medical facility with elevator, ample storage, and a loading dock, including existing leased area.

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Class-A Office Building

110 Corcoran Street, Durham, NC 27701

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130,195 sqft

2018-built office building with panoramic rooftop terraces, flexible meeting spaces, and electronic keycard access.

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Industrial Flex with Laydown Yard

1101 E Cornwallis, Durham, NC 27713

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6,831 sqft 1.40 AC lot

Leased industrial flex with heated warehouse, office, and concrete laydown yard on about 1.4 acres.

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Renovated Office Buildings For Sale

2117 Guess Road, Durham, NC 27705

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5,220 sqft 0.72 AC lot

Two renovated office buildings ideal for owner-user or investment.

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Two-Story Office Building

3621 Lyckan Parkway, Durham, NC 27707

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12,000 sqft

Two-story, partial-shell office building with infrastructure in place for customized office or medical build-outs.

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Standalone Flex Building

1023 S Miami Blvd, Durham, NC 27703

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11,809 sqft

Standalone flex building combining office and warehouse space with access to major area highways.

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Standalone Commercial Building

112 N Mineral Springs Rd, Durham, NC 27703

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820 sqft 0.25 AC lot

Standalone commercial building on a 0.25-acre parcel, zoned CG for retail, service, and neighborhood-oriented uses.

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Historic Downtown Durham Corner Building

125 E Parrish, Durham, NC 27701

$1,360,000

3,775 sqft

Fully leased retail and office space in Durham's City Center.

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Imperial Center Office Building For Sale

4307 Emperor Boulevard, Durham, NC 27703

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81,145 sqft

Three-story office building in Imperial Center Business Park with walkable amenities.

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Imperial Center Office Building For Sale

4819 Emperor Blvd., Durham, NC 27703

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105,410 sqft

Four-story office building in Imperial Center Business Park with modern amenities.

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Durham Warehouse and Office Space

1000 Parliament Court, Suite 200, Durham, NC 27703

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32,320 sqft

Warehouse and office space available near Raleigh-Durham International Airport.

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Class A Office Building, Durham

4309 Emperor Blvd., Durham, NC 27703

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111,689 sqft

Four-story Class A office building in Imperial Center Business Park.

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Landmark Class-A Office Tower

4820 Emperor Boulevard, Durham, NC 27703

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264,598 sqft

Iconic 11-story office building with prime location and amenities.

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Standalone Office Building

4137 South Alston Avenue, Durham, NC 27713

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1,024 sqft

Versatile standalone office building offered for sale on a 1-acre site.

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Imperial Center Office Building For Sale

1101 Slater Road, Durham, NC 27703

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75,563 sqft

Three-story office building in Imperial Center Business Park.

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Durham, NC Office Spaces Market Trends and Statistics

Explore 72 office spaces for sale in Durham, NC, showcased through 43 active listings on our real estate platform. These investment opportunities span a total of 1,255,268 square feet of properties for sale, with an estimated market value of $17,663,000.

Sale prices for office spaces in Durham, NC start at $125,000, averaging $1,261,642, and reaching up to $3,499,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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Top Commercial Asset Segments

Commercial property segments ranked by active listings on the market

Demographics Overview

Population 314K

Population Growth (5Y) +7.7%

Median Household Income $79,426

College Educated 39.8%

High-Yield Neighborhoods for Investment

Identify Durham submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

Neighborhood	Average Price
27713	$234.8K
27703	$251.7K
27705	$750K
27707	$897K
27701	$1.4M

Taxes & Financing

Tax Rate (average for all types) 1.31%

Property Tax per SF $16.56 per SF

Tax Rate vs County Average 0.03 pp below county avg

Average Loan-to-Value 65.0%

Listings Trend

New vs delisted commercial listings in Durham County

New Delisted

Total CRE Inventory on Market (SF)

Property Size Breakdown

The majority of commercial real estate listings in Durham fall within the 50,000 to 100,000 square foot range.

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