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    Port Jefferson, NY Office Properties & Spaces for Lease

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    New York, NY Brooklyn, NY Queens, NY
    10 results
    Turnkey Office Space in Village
    $1,250 /Mo

    Turnkey Office Space in Village

    646 Main Street, Port Jefferson, NY 11777

    Furnished office space ideal for wellness clinician in Port Jefferson.

    • Turnkey, fully furnished office space (approx. 250 sf) with waiting room (approx. 320 sf).
    • Prime location in the heart of Port Jefferson Village.
    • Includes essential utilities: WiFi, heat, and central air conditioning.
    • Ample and free parking available.
    • Handicapped accessible.
    Updated: Nov 15, 2025
    View details
    Historic Port Jefferson Office Suite
    $895 /Mo

    Historic Port Jefferson Office Suite

    903 Main Street, Port Jefferson, NY 11777

    Bright corner office suite in historic Port Jefferson Village.

    • Prime location in historic Port Jefferson Village.
    • Dedicated parking included.
    • Excellent natural light and original hardwood floors.
    • Private office suite with ample closet storage.
    • Dedicated wall‑mounted Central Air unit.
    Updated: Dec 1, 2025
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    Port Jefferson Station Office Space
    $7,000 /Mo
    900 SF

    Port Jefferson Station Office Space

    Office space for rent with ample parking and close to LIRR.

    200 Wilson St, Port Jefferson Station, NY
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    Port Jefferson Station Office Space
    $25 SF/Yr
    6,800 SF

    Port Jefferson Station Office Space

    6,800 SF office space available for lease.

    170 N Country Rd, Port Jefferson Station, NY
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    Port Jefferson Office Space Available
    $21 SF/Yr
    1,700 SF

    Port Jefferson Office Space Available

    Office space available for rent in Port Jefferson, NY.

    306-308 Main St, Port Jefferson, NY
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    Medical Office with X-Ray Room
    $25 SF/Yr
    5,000 SF

    Medical Office with X-Ray Room

    Medical office space featuring exam rooms and an X-Ray room.

    102 Main St, Port Jefferson Station, NY
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    Port Jefferson Office Space Available
    Contact for pricing
    1,680 SF

    Port Jefferson Office Space Available

    Office space available for rent in Port Jefferson, NY.

    414 Main St, Port Jefferson, NY
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    Port Jefferson Office Space Available
    Contact for pricing
    650 SF

    Port Jefferson Office Space Available

    650 square feet office space for rent in Port Jefferson.

    625 Belle Terre Rd, Port Jefferson, NY
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    Route 112 Office Building
    $35 SF/Yr
    48,428 SF

    Route 112 Office Building

    48,428 SF building with frontage on Route 112.

    1201 Route 112, Port Jefferson Station, NY
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    Prime Office Space Available
    $24 SF/Yr
    8,500 SF

    Prime Office Space Available

    Office space for rent with ample parking and frontage.

    Prt Jefferson Station, NY
    View details
    Based on your search, we've compiled 25 Potential Opportunities for your consideration. Besides 10 Active listings in Port Jefferson, NY, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 7 Properties for Sales.

    Explore Office properties & Spaces for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Retail and Medical Office Space
    Contact for pricing
    42,800 SF

    Retail and Medical Office Space

    Planned development with retail, medical office, and luxury rentals.

    2 Myrtle St, Mt Sinai, NY
    View details
    Divisible Pad Site For Rent
    Contact for pricing
    5,000 SF

    Divisible Pad Site For Rent

    Divisible pad site with drive-through available for rent.

    9 Myrtle St, Mt Sinai, NY
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    East Setauket Office Space
    Contact for pricing
    5,600 SF

    East Setauket Office Space

    5,600 square foot office space available for rent.

    226 N Belle Mead Ave, East Setauket, NY
    View details
    East Setauket Office Space Available
    $25 SF/Yr
    3,000 SF

    East Setauket Office Space Available

    3,000 square foot office space for rent.

    232 N Belle Mead Ave, East Setauket, NY
    View details

    Explore Similar Spaces for Sale in Port Jefferson, NY

    Consider Similar Space for Sale. We found 7 Spaces matching your search parameters.

    Port Jefferson Station Dental Office
    $750,000
    0.33 Acres

    Port Jefferson Station Dental Office

    Move-in-ready dental office with expansion potential in prime location.

    488 Terryville Road, Port Jefferson Station, NY 11776
    View details
    Professional Office Building For Sale
    $799,000
    5,000 SF

    Professional Office Building For Sale

    Well-maintained 5,000 SF office building in Port Jefferson, NY.

    111 N Country Road, Port Jefferson, NY 11777
    View details
    Port Jefferson Station Industrial Building
    $2,495,000
    7,176 SF

    Port Jefferson Station Industrial Building

    6,980 SF industrial building with conversion potential.

    507 North Bicycle Path, Port Jefferson Station, NY 11776
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    Net-Leased Medical Office Asset
    $2,281,840
    5,000 SF

    Net-Leased Medical Office Asset

    Single-tenant medical office with predictable cash flow and rent growth.

    492 Old Town Rd, Port Jefferson Station, NY 11776
    View details
    Industrial Building Conversion Potential
    $2,500,000
    6,980 SF

    Industrial Building Conversion Potential

    6,980 SF industrial building with conversion potential in Port Jefferson.

    591 Bicycle Path, Port Jefferson Station, NY
    View details
    Updated Mixed-Use Property For Sale
    $799,000
    13,504 SF

    Updated Mixed-Use Property For Sale

    Versatile, updated mixed-use property with flexible layout and strong visibility.

    4515 Nesconset Highway, Port Jefferson Station, NY 11776
    View details
    Office
    $799,000
    5,000 SF

    Office

    Office buildings · 5,000 SF

    111 N Country Rd, Port Jefferson, NY 11777
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Corner Lot on Busy Road
    $1,500 /Mo

    Corner Lot on Busy Road

    High-visibility commercial land for lease on a busy road.

    574 Montauk Highway, Shirley, NY 11967
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    Commercial Land in High-Traffic Area
    $1,000 /Mo

    Commercial Land in High-Traffic Area

    0.18 acre vacant lot with high visibility and traffic.

    586 Montauk Highway, Shirley, NY 11967
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    Commercial Land on Montauk Highway
    $2,500 /Mo

    Commercial Land on Montauk Highway

    0.55-acre commercial lot on busy Montauk Highway.

    1467 Montauk Highway, Mastic, NY 11967
    View details
    Customizable Commercial Space for Lease
    $3,000 /Mo

    Customizable Commercial Space for Lease

    Flexible commercial space suitable for various business types.

    1228 Springfield Ave, Irvington, NJ 7111
    View details

    Port Jefferson, NY Office properties & Spaces Leasing Opportunities Market Analysis

    Explore Office properties & Spaces leasing options in Port Jefferson, NY with 10 listings featured on our commercial real estate exchange. The current inventory includes 1,252,332,559 square feet of properties with an estimated lease value of $0.52 SF/Yr.

    Estimated lease rates for Office properties & Spaces in Port Jefferson, NY begin at $0.52 SF/Yr, with an average of $0.52 SF/Yr and extend to $0.52 SF/Yr.
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    Most Searched ZIP Codes in Port Jefferson, NY

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