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    Saint Charles, MO Office Properties & Spaces for Lease

    22 results
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    Office Space in Historic Building
    $1,200 /Mo
    7,318 SF

    Office Space in Historic Building

    Saint Charles, MO 63301

    Move-in ready office suites with amenities in St. Charles.

    • Prime downtown St. Charles location with quick access to 5th Street, Main Street, Lindenwood University, and Highways 70 and 370.
    • Move‑in ready office suite (30' x 20') suitable for three desks and one private office.
    • Convenient accessible entry and parking right outside the door.
    • Included amenities: 24/7 digital keypad access, reception area, small conference room, Internet & Wi‑Fi, dedicated mailbox, cleaning service, water filtration system, and security cameras.
    • Historic building with renovated office spaces.
    Updated: Mar 10
    View details
    Move-in Ready Office Space
    $500 /Mo

    Move-in Ready Office Space

    Saint Charles, MO 63304

    Full service office space with modern amenities included in rent.

    • All‑inclusive rent: Includes heat, electricity, trash, Wi‑Fi, kitchenette, and conference room use.
    • Move‑in ready office with recent renovations: new carpet, paint, lighting, interior and exterior updates.
    • Convenient location: Ample parking and easy access to Hwy 364 and 94.
    • Corner unit on the 1st floor with large windows providing natural light.
    • Access to atrium space with tables and outdoor seating.
    Updated: Dec 16, 2025
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    Turnkey Dental Office in St Charles
    $20 SF/Yr

    Turnkey Dental Office in St Charles

    2880 SF turnkey dental office or medical space for lease.

    Saint Charles, MO 63303
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    St Charles Lower-Level Office Space
    $700 /Mo

    St Charles Lower-Level Office Space

    660 SF office space with utilities and Wi-Fi included.

    Saint Charles, MO 63304
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    Office/Flex Building in Saint Charles
    $16 SF/Yr
    53,932 SF

    Office/Flex Building in Saint Charles

    Class A office/flex building with high visibility and heavy power.

    500 Fountain Lakes Blvd, Saint Charles, MO 63301
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    Professional Office in Business Park
    $15 SF/Yr
    7,200 SF

    Professional Office in Business Park

    Office space for lease in a well-located business park.

    Saint Charles, MO 63303
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    Westgate 200 Available For Lease
    $5 SF/Yr
    86,800 SF

    Westgate 200 Available For Lease

    86,800 SF divisible space with office and showroom.

    3817-3841 Millstone Parkway, Saint Charles, MO 63301
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    St. Charles Retail/Office Space
    $22 SF/Yr
    31,716 SF

    St. Charles Retail/Office Space

    Retail and office spaces available in high-traffic St. Charles location.

    3910-3930 South Old Highway 94, Saint Charles, MO 63304
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    Professional Office Building For Lease
    $18 SF/Yr
    1,600 SF

    Professional Office Building For Lease

    Freestanding office building with private offices, reception, and breakroom.

    2260 Bluestone Dr, Saint Charles, MO
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    Historic Building Office Suites Available
    $14 SF/Yr
    1,961 SF

    Historic Building Office Suites Available

    Well-maintained office suites in historic building near courthouse.

    300 N Main St, Saint Charles, MO
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    Stand Alone Office For Rent
    $15 SF/Yr
    1,377 SF

    Stand Alone Office For Rent

    1,377 SF stand-alone office space remodeled in 2023.

    1518 Caulks Hill Rd, Saint Charles, MO
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    Professional Office Space Available
    Contact for pricing
    598 SF

    Professional Office Space Available

    Office space with excellent highway exposure and convenient location.

    2480 Executive Dr, Saint Charles, MO
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    Office Space in Regions Bank
    $162 SF/Yr

    Office Space in Regions Bank

    Lower level office space with nearby amenities for rent.

    Saint Charles, MO 63303
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    Office Space in Saint Charles
    Contact for pricing
    3,500 SF

    Office Space in Saint Charles

    Single tenant office space available for rent, 3,500 SqFt.

    2010 Bluestone Dr, Saint Charles, MO 63303
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    Mixed-Use Property in Riverfront District
    Contact for pricing

    Mixed-Use Property in Riverfront District

    Retail, office, and warehouse space in entertainment district.

    1735 S River Rd, Saint Charles, MO 63303
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    Office Spaces Available For Rent
    Contact for pricing
    814 SF

    Office Spaces Available For Rent

    Office spaces ranging from 180 to 814 SqFt available.

    1811 Sherman Dr, Saint Charles, MO 63303
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    Office Space For Lease
    $24 SF/Yr

    Office Space For Lease

    Office space available for lease in St. Charles, MO.

    Saint Charles, MO 63301
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    New Town Coworking Space
    Contact for pricing

    New Town Coworking Space

    Private offices and shared workspaces in St. Charles business district.

    Saint Charles, MO 63301
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    Historical District Retail/Office Space
    Contact for pricing
    550 SF

    Historical District Retail/Office Space

    550 SF suite in St. Charles Historical District.

    Saint Charles, MO 63301
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    Office and Retail Space Available
    Contact for pricing

    Office and Retail Space Available

    Prime location with upgrades and custom finishes available.

    Saint Charles, MO 63301
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    Fountainview Plaza Retail Opportunity
    Contact for pricing

    Fountainview Plaza Retail Opportunity

    Retail spaces in a densely populated St. Charles neighborhood.

    2633 Muegge Rd, Saint Charles, MO 63303
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    Office Space with Ample Parking
    Contact for pricing
    1,685 SF

    Office Space with Ample Parking

    Office space for rent with easy highway access and parking.

    205 N 5 St, Saint Charles, MO
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    Based on your search, we've compiled 32 Potential Opportunities for your consideration. Besides 22 Active listings in Saint Charles, MO, we suggest exploring alternatives. Similar 10 Properties for Sales.

    Explore Similar Spaces for Sale in Saint Charles, MO

    Consider Similar Space for Sale. We found 10 Spaces matching your search parameters.

    High-Visibility Parcel Near Lindenwood University
    $350,000
    1,146 SF

    High-Visibility Parcel Near Lindenwood University

    Rare opportunity: 1,146 SF building near a signalized corner.

    Saint Charles, MO 63301
    View details
    Saint Charles Adaptable Commercial Building
    $3,160,000
    8,128 SF

    Saint Charles Adaptable Commercial Building

    8,128 SF building suited for various uses in Saint Charles.

    1821 S River Rd, Saint Charles, MO
    View details

    Saint Charles, MO Office properties & Spaces Leasing Opportunities Market Analysis

    Explore Office properties & Spaces leasing options in Saint Charles, MO with 22 listings featured on our commercial real estate exchange. The current inventory includes 3,893,061,676 square feet of properties with an estimated lease value of $128 SF/Yr.

    Estimated lease rates for Office properties & Spaces in Saint Charles, MO begin at $1.97 SF/Yr, with an average of $16 SF/Yr and extend to $21 SF/Yr.
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    Most Searched ZIP Codes in Saint Charles, MO

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    • 63303
    • 63304

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