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    Clayton, MO Office Properties & Spaces for Lease

    40 results
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    Sevens Building
    Contact for pricing

    Sevens Building

    Discover many ways to work your way in Sevens Building

    7777 Bonhomme Ave, Unit 1800, Clayton, MO 63105
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    Pierre Laclede
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    Pierre Laclede

    Discover many ways to work your way in Pierre Laclede

    7733 Forsyth Blvd, Unit 11TH, Clayton, MO 63105
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    Downtown Clayton Office Building
    $21 SF/Yr
    102,600 SF

    Downtown Clayton Office Building

    225-235 S Meramec Ave, Clayton, MO 63105

    Two interconnected office buildings in downtown Clayton with on-site amenities.

    • Prime Downtown Clayton location with high visibility and close proximity to the Courthouse.
    • Enjoy on‑site amenities including management, post office, cafe, and common space.
    • Abundant parking with a 1,200‑space garage and street parking.
    • Newly built‑out spaces with high‑end finishes.
    • Brand new lobby and updated common areas.
    Updated: Nov 25, 2025
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    Renovated Office Space in Clayton
    $18 SF/Yr
    30,210 SF

    Renovated Office Space in Clayton

    200 South Hanley Road, Clayton, MO 63105

    Newly renovated office building with convenient access and excellent views.

    • Convenient Clayton location with outstanding visibility
    • Newly renovated building lobby, entrance, elevator cabs, and common areas (2022)
    • Easy access to Forest Park Parkway
    • Walking distance to numerous restaurants, retail, and hotels
    • Garage and surface parking available
    Updated: Nov 22, 2025
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    Class A Office Tower Clayton
    $35 SF/Yr
    2,610 SF

    Class A Office Tower Clayton

    Class A office tower in downtown Clayton for lease.

    8235 Forsyth Blvd, Clayton, MO
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    Class A Office Tower Clayton
    $35 SF/Yr
    4,086 SF

    Class A Office Tower Clayton

    Class A office tower in downtown Clayton for lease.

    8182 Maryland Ave, Clayton, MO
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    Clayton Office Space Available Now
    $30 SF/Yr
    4,288 SF

    Clayton Office Space Available Now

    Former law firm space with elevator exposure and tenant amenities.

    231 S Bemiston Ave, Clayton, MO
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    Clayton Office Space For Rent
    $26 SF/Yr
    3,346 SF

    Clayton Office Space For Rent

    Eleven-story office building in Clayton with recent renovations.

    222 S Central Ave, Clayton, MO
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    Downtown Clayton Office Space Available
    $29 SF/Yr
    1,737 SF

    Downtown Clayton Office Space Available

    Office space for lease in downtown Clayton with amenities.

    150 N Meramec Ave, Clayton, MO
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    Clayton Office Space For Rent
    $14 SF/Yr
    350 SF

    Clayton Office Space For Rent

    Office spaces in the heart of Clayton near I-170 & I-64/40.

    30-44 N Brentwood Blvd, Clayton, MO
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    Class A Office Space Available
    $45 SF/Yr
    27,666 SF

    Class A Office Space Available

    High-end office space with many amenities and ample parking.

    7700 Forsyth Blvd, Clayton, MO
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    Downtown Clayton Office Space Available
    $29 SF/Yr
    2,372 SF

    Downtown Clayton Office Space Available

    Office space for rent in downtown Clayton, Missouri.

    165 N Meramec Ave, Clayton, MO
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    Downtown Clayton Office Space Available
    $28 SF/Yr
    10,007 SF

    Downtown Clayton Office Space Available

    Office space in downtown Clayton with convenient access and amenities.

    168 N Meramec Ave, Clayton, MO
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    Global Network of Flexible Workspaces
    $84 SF/Yr

    Global Network of Flexible Workspaces

    Tailored office spaces with coworking and virtual office options.

    7777 Bonhomme Ave Suite 1800, Clayton, MO 63105
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    Clayton CBD Office Space
    $31 SF/Yr
    1,464 SF

    Clayton CBD Office Space

    Move-in ready office suites in central Clayton location.

    7777 Bonhomme Ave, Clayton, MO
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    Clayton Office Space Available
    $24 SF/Yr
    3,270 SF

    Clayton Office Space Available

    Office space available for lease in Clayton, Missouri.

    8251 Maryland Ave, Clayton, MO
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    Clayton Office Space For Rent
    $24 SF/Yr
    3,305 SF

    Clayton Office Space For Rent

    3,305 SF office space available in Clayton, Missouri.

    8301 Maryland Ave, Clayton, MO
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    Clayton Office Space For Rent
    $31 SF/Yr
    7,441 SF

    Clayton Office Space For Rent

    7,441 square foot office space available for lease.

    135 N Meramec Ave, Clayton, MO
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    Energy Efficient Clayton Office Space
    Contact for pricing

    Energy Efficient Clayton Office Space

    Sophisticated office space in a central Clayton location.

    7733 Forsyth Boulevard Suite 1100, Clayton, MO 63105
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    Renovated Office Space in Clayton
    $26 SF/Yr
    1,993 SF

    Renovated Office Space in Clayton

    Multiple suites available in a recently renovated building.

    7711 Bonhomme Ave, Clayton, MO
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    Clayton Office Space For Rent
    $31 SF/Yr
    45,777 SF

    Clayton Office Space For Rent

    Office space available in Clayton, Missouri with multiple amenities.

    7701 Forsyth Blvd, Clayton, MO
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    Clayton Office Space For Rent
    $31 SF/Yr
    39,547 SF

    Clayton Office Space For Rent

    Office space available with conferencing center and fitness center.

    7733 Forsyth Blvd, Clayton, MO
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    Clayton Office Space For Rent
    $32 SF/Yr
    4,494 SF

    Clayton Office Space For Rent

    Office space for rent in Clayton, Missouri.

    120 S Central Ave, Clayton, MO
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    Prime St. Louis Office Space
    Contact for pricing

    Prime St. Louis Office Space

    Modern office space in a vibrant St. Louis location.

    212 S Central Ave, Clayton, MO 63105
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    Clayton, MO Office properties & Spaces Leasing Opportunities Market Analysis

    Explore Office properties & Spaces leasing options in Clayton, MO with 40 listings featured on our commercial real estate exchange. The current inventory includes 4,655,954,160 square feet of properties with an estimated lease value of $341 /Mo.

    Estimated lease rates for Office properties & Spaces in Clayton, MO begin at $14 SF/Yr, with an average of $28 SF/Yr and extend to $45 SF/Yr.
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    Browse Office properties & Spaces for Lease Near Clayton, MO

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    Most Searched ZIP Codes in Clayton, MO

    • 63105
    • 63117

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