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    Key West, FL Office Units for Lease

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    13 results
    Key West Office/Medical Space
    $26,276 SF/Yr
    7,007 SF

    Key West Office/Medical Space

    1111 12th Street, Key West, FL 33040

    7,007 SF office/medical space in desirable New Town location.

    • Rare large space (7,007 SF, approximately half a floor) in a desirable professional hub.
    • Ideal for office or medical use, currently configured with over 25 private offices and a conference room.
    • Central location in Key West with high visibility.
    • Ample off‑street parking and elevator access.
    • Professionally managed building with a welcoming common lobby and shared restrooms.
    Updated: Mar 30
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    Prime Duval Street Commercial Building
    $35,000 SF/Yr
    6,230 SF

    Prime Duval Street Commercial Building

    132 Duval Street, Key West, FL 33040

    Two-story building on Duval Street, ideal for retail or restaurant.

    • Prime Duval Street location in the heart of Old Town Key West with high tourist foot traffic.
    • Totally renovated building with new plumbing, electric, foundation, central AC, impact doors and windows.
    • Large open floor plan with 3,200 sq ft of retail space on the ground floor and 3,000 sq ft of storage/office space on the second floor.
    • 35' of Duval St. visibility & frontage with large impact display windows.
    • Two valuable off‑street parking spaces included.
    Updated: Feb 9
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    Key West Office/Medical Space
    $4,635/Mo
    1,235 SF

    Key West Office/Medical Space

    Move-in ready office or medical suite in central Key West.

    1111 12th Street, Key West, FL 33040
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    Key West Office Space Available
    $1,100/Mo

    Key West Office Space Available

    190 sq ft office space for rent in Key West.

    3706 N Roosevelt Boulevard, Key West, FL 33040
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    Updated Office Space in Key West
    $1,400/Mo

    Updated Office Space in Key West

    Small, updated office space in Old Town Key West.

    524 Eaton Street, Key West, FL 33040
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    Updated Office Space in Key West
    $1,250/Mo

    Updated Office Space in Key West

    Small, updated office space in Old Town Key West.

    524 Eaton Street, Key West, FL 33040
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    Key West Retail/Office Opportunity
    $4,750/Mo
    1,496 SF

    Key West Retail/Office Opportunity

    Mixed-use building in Old Town Key West, near Duval Street.

    607 Fleming Street, Key West, FL 33040
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    Conch Harbor Retail Center Space
    $3,600/Mo
    1,200 SF

    Conch Harbor Retail Center Space

    Office or retail space available in Key West, Florida.

    951 Caroline Street, Key West, FL 33040
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    Prime Office Space on Eaton
    $2,450/Mo
    385 SF

    Prime Office Space on Eaton

    385 sq ft office space in Old Town Key West.

    425 Eaton Street, Key West, FL 33040
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    Flagler Avenue Professional Office Space
    $11,300/Mo
    3,877 SF

    Flagler Avenue Professional Office Space

    Commercial space for rent in Key West, Florida.

    3216 Flagler Avenue, Key West, FL 33040
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    Key West Office Condo Rental
    $4,300/Mo
    1,475 SF

    Key West Office Condo Rental

    Centrally located office condo in Key West, Florida.

    1010 Kennedy Drive, Key West, FL 33040
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    Key West Office Condo Rental
    $6,000/Mo
    2,058 SF

    Key West Office Condo Rental

    Centrally located office condo for lease in Key West, Florida.

    1010 Kennedy Drive, Key West, FL 33040
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    Retail Space Available For Rent
    Contact for pricing
    1,491 SF

    Retail Space Available For Rent

    Single tenant retail space available, approximately 1,491 square feet.

    3201 Flagler Ave, Key West, FL 33040
    View details
    Based on your search, we've compiled 31 Potential Opportunities for your consideration. Besides 13 Active listings in Key West, FL, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 14 Properties for Sales.

    Office Units for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Key Largo Commercial Building For Rent
    $3,600/Mo
    1,883 SF

    Key Largo Commercial Building For Rent

    Freestanding commercial building in central Key Largo with flexible zoning.

    110 Ocean Drive, Key Largo, FL 33037
    View details
    Key Largo Commercial Office Space
    $5,457/Mo
    5,457 SF

    Key Largo Commercial Office Space

    5,457 sqft Key Largo office space for lease.

    99451 Overseas Highway, Key Largo, FL 33037
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    Marco Island Office Space Available
    $26 SF/Yr
    2,500 SF

    Marco Island Office Space Available

    Office space suitable for medical, therapy, spa, or professional use.

    40 S Heathwood Dr, Marco Island, FL
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    Marco Island Retail Center
    $22 SF/Yr
    6,126 SF

    Marco Island Retail Center

    Redeveloped retail center with high visibility and accessibility.

    648-698 Bald Eagle Dr, Marco Island, FL
    View details

    Similar Spaces for Sale in Key West, FL

    Consider Similar Space for Sale. We found 14 Spaces matching your search parameters.

    Key West Commercial Condos
    $1,950,000
    Key West Commercial Condos

    Prime investment opportunity in Key West's Old Town.

    1200-1206 White Street, Key West, FL 33040

    View details
    Key West Office Condo Investment
    $599,000
    1,133 SF
    Key West Office Condo Investment

    Fully leased office condo with strong tenant and ocean view.

    3718 N Roosevelt Boulevard, Key West, FL 33040

    View details
    Old Town Key West Office
    Contact for pricing
    0.29 Acres
    Old Town Key West Office

    Small, updated office space in a friendly business environment.

    524 Eaton Street, Key West, FL 33040

    View details
    Updated Commercial Condos in Key West
    $1,275,000
    2,061 SF
    Updated Commercial Condos in Key West

    Two updated commercial condos in Key West with parking.

    1200+1202 White Street, Key West, FL 33040

    View details
    Old Town Key West Office
    Contact for pricing
    1,020 SF
    Old Town Key West Office

    Professional office space in a prime Key West location.

    1213 Truman Avenue, Key West, FL 33040

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    Downtown Key West Office Space
    Contact for pricing
    320 SF
    Downtown Key West Office Space

    Small, private corner office in downtown Key West.

    524 Eaton Street, Key West, FL 33040

    View details
    Key West Commercial Condo Opportunity
    $699,000
    1,389 SF
    Key West Commercial Condo Opportunity

    Commercial condo in Old Town Key West, available 2026.

    1206 White Street, Key West, FL 33040

    View details
    Accounting & Tax Practice For Sale
    $75,000
    Accounting & Tax Practice For Sale

    Established accounting and tax practice in Key West, Florida.

    Key West, FL 33040

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    Updated Commercial Condo in Key West
    $699,000
    1,169 SF
    Updated Commercial Condo in Key West

    Corner unit with updates, parking, and diverse zoning uses.

    1200 White Street, Key West, FL 33040

    View details
    Key West Office Condo
    $415,000
    665 SF
    Key West Office Condo

    Turnkey 665 SF office condo in Old Town.

    812 Fleming Street, Key West, FL 33040

    View details
    Old Town Commercial Office Space
    $975,000
    1,190 SF
    Old Town Commercial Office Space

    Commercial office space in Old Town with parking for sale.

    615 United Street, Key West, FL 33040

    View details

    Key West, FL Office Units Leasing Opportunities Market Analysis

    Explore Office Units leasing options in Key West, FL with 13 listings featured on our commercial real estate exchange. The current inventory includes 25,545 square feet of properties with an estimated lease value of $61,815.

    Estimated lease rates for Office Units in Key West, FL begin at $34 SF/Yr, with an average of $5,151 /Mo and extend to $35,000.
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