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    Key West, FL Commercial Real Estate for Lease

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    Stock Island, FL Cudjoe Key, FL
    37 results
    Key West Office/Medical Space
    $26,276 SF/Yr
    7,007 SF

    Key West Office/Medical Space

    1111 12th Street, Key West, FL 33040

    7,007 SF office/medical space in desirable New Town location.

    • Rare large space (7,007 SF, approximately half a floor) in a desirable professional hub.
    • Ideal for office or medical use, currently configured with over 25 private offices and a conference room.
    • Central location in Key West with high visibility.
    • Ample off‑street parking and elevator access.
    • Professionally managed building with a welcoming common lobby and shared restrooms.
    Updated: Mar 30
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    Prime Duval Street Commercial Building
    $35,000 SF/Yr
    6,230 SF

    Prime Duval Street Commercial Building

    132 Duval Street, Key West, FL 33040

    Two-story building on Duval Street, ideal for retail or restaurant.

    • Prime Duval Street location in the heart of Old Town Key West with high tourist foot traffic.
    • Totally renovated building with new plumbing, electric, foundation, central AC, impact doors and windows.
    • Large open floor plan with 3,200 sq ft of retail space on the ground floor and 3,000 sq ft of storage/office space on the second floor.
    • 35' of Duval St. visibility & frontage with large impact display windows.
    • Two valuable off‑street parking spaces included.
    Updated: Feb 9
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    Key West Office/Medical Space
    $4,635/Mo
    1,235 SF

    Key West Office/Medical Space

    Move-in ready office or medical suite in central Key West.

    1111 12th Street, Key West, FL 33040
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    High-Visibility Retail Space on Highway
    $8,000/Mo
    1,913 SF

    High-Visibility Retail Space on Highway

    Prime commercial property on Overseas Highway with high visibility.

    5300 Overseas Highway, Key West, FL 33040
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    Key West Office Space Available
    $1,100/Mo

    Key West Office Space Available

    190 sq ft office space for rent in Key West.

    3706 N Roosevelt Boulevard, Key West, FL 33040
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    New Retail Space in Key West
    $6,000/Mo
    1,491 SF

    New Retail Space in Key West

    New retail space for lease in a mixed-use development.

    3201 Flagler Avenue, Key West, FL 33040
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    Updated Office Space in Key West
    $1,400/Mo

    Updated Office Space in Key West

    Small, updated office space in Old Town Key West.

    524 Eaton Street, Key West, FL 33040
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    Key West Retail Space For Rent
    $5,828/Mo
    657 SF

    Key West Retail Space For Rent

    Retail space in high-traffic Key West location.

    431 Front Street, Key West, FL 33040
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    Updated Office Space in Key West
    $1,250/Mo

    Updated Office Space in Key West

    Small, updated office space in Old Town Key West.

    524 Eaton Street, Key West, FL 33040
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    Duval Street Retail Opportunity
    $44,677 SF/Yr
    5,901 SF

    Duval Street Retail Opportunity

    Prime retail or restaurant space on Key West's Duval Street.

    210-216 Duval Street, Key West, FL 33040
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    Key West Corner Retail/Office
    $3,850/Mo
    773 SF

    Key West Corner Retail/Office

    Renovated corner space in Old Town Key West.

    1110 Truman Avenue, Key West, FL 33040
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    Key West Retail/Office Opportunity
    $4,750/Mo
    1,496 SF

    Key West Retail/Office Opportunity

    Mixed-use building in Old Town Key West, near Duval Street.

    607 Fleming Street, Key West, FL 33040
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    Duval Street Retail Opportunity
    $18,052/Mo
    1,733 SF

    Duval Street Retail Opportunity

    Prime retail space on Duval Street in Key West.

    400 Duval Street, Key West, FL 33040
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    Prime Retail Space on Duval
    $41,000 SF/Yr
    5,500 SF

    Prime Retail Space on Duval

    High-visibility retail space in Key West's premier location.

    100 Duval Street, Key West, FL 33040
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    Conch Harbor Retail Center Space
    $3,600/Mo
    1,200 SF

    Conch Harbor Retail Center Space

    Office or retail space available in Key West, Florida.

    951 Caroline Street, Key West, FL 33040
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    Key West Commercial Space
    $3,250/Mo
    2,265 SF

    Key West Commercial Space

    2265 sq ft storage/garage space available for lease.

    111 Overseas Highway, Key West, FL 33040
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    Duval Street Retail Opportunity
    $10,416/Mo
    1,000 SF

    Duval Street Retail Opportunity

    Prime retail or restaurant space on Duval Street, Key West.

    210-216 Duval Street, Key West, FL 33040
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    Duval Street Retail Opportunity
    $15,500/Mo
    2,155 SF

    Duval Street Retail Opportunity

    Premier retail space on Key West's heavily trafficked Duval Street.

    518 Duval Street, Key West, FL 33040
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    Prime Office Space on Eaton
    $2,450/Mo
    385 SF

    Prime Office Space on Eaton

    385 sq ft office space in Old Town Key West.

    425 Eaton Street, Key West, FL 33040
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    Key West Shopping Center Space
    $3,040/Mo
    1,459 SF

    Key West Shopping Center Space

    Centrally located shopping center space available for rent.

    3100 Flagler Avenue, Key West, FL 33040
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    Self-Storage Facility on US Highway 1
    $11,000/Mo
    6,912 SF

    Self-Storage Facility on US Highway 1

    Key West self-storage facility for lease with excellent exposure.

    323 Overseas Highway, Key West, FL 33040
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    Prime Retail Space on Duval
    $17,600/Mo
    2,500 SF

    Prime Retail Space on Duval

    Retail space in a thriving Key West business environment.

    B-423 Duval St, Key West, FL 33040
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    Commercial Space in Key West
    $4,400/Mo
    942 SF

    Commercial Space in Key West

    942 SF commercial space on Fleming St, Key West.

    421 Fleming Street, Key West, FL 33040
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    Flagler Avenue Professional Office Space
    $11,300/Mo
    3,877 SF

    Flagler Avenue Professional Office Space

    Commercial space for rent in Key West, Florida.

    3216 Flagler Avenue, Key West, FL 33040
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    Key West, FL Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Key West, FL with 37 listings featured on our commercial real estate exchange. The current inventory includes 74,957 square feet of properties with an estimated lease value of $202,004.

    Estimated lease rates for Commercial real estate in Key West, FL begin at $17 SF/Yr, with an average of $6,516 /Mo and extend to $44,677.
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