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    Key West, FL Mixed-use Properties for Sale

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    Lehigh Acres, FL Cape Coral, FL Port Charlotte, FL
    8 results
    Historic Key West Multi-Family Property
    $5,250,000
    8,472 SF

    Historic Key West Multi-Family Property

    314 Simonton Street, Key West, FL 33040

    Unique historic property near Duval Street with multi-unit and commercial potential.

    • Prime location: One block from Duval Street and across from the Federal Courthouse.
    • Legally recognized as 8 units with an atrium, garage, and pool.
    • Historic significance: Originally a hotel and Ford dealership, with Ernest Hemingway as a past guest.
    • Three‑level building offering flexible use: potential for a grand single‑family estate, multi‑unit living, or commercial space.
    • Unique trophy property, available for the first time in generations.
    Updated: Apr 8
    View details
    Turnkey Restaurant in Old Town
    $2,950,000

    Turnkey Restaurant in Old Town

    532 Margaret Street, Key West, FL 33040

    Remodeled 150-seat restaurant with apartment in historic Key West.

    • Completely remodeled, turnkey restaurant in Old Town Key West.
    • Licensed for 150 seats with expansive indoor‑outdoor dining.
    • State‑of‑the‑art, fully equipped commercial‑grade kitchen.
    • Includes a beautifully updated 1‑bedroom, 1‑bathroom apartment.
    • All new electrical, plumbing, HVAC, flooring, lighting, and fixtures.
    Updated: Oct 3, 2025
    View details
    Historic Key West Mixed-Use Property
    $5,250,000

    Historic Key West Mixed-Use Property

    Unique historic property near Duval Street with multi-use potential.

    314 Simonton Street, Key West, FL 33040
    View details
    Stock Island Mixed-Use Redevelopment Opportunity
    $2,295,000

    Stock Island Mixed-Use Redevelopment Opportunity

    25,000 SF mixed-use property with redevelopment potential near Key West.

    Key West, FL 33040
    View details
    Key West Mixed-Use Investment Property
    $2,999,999

    Key West Mixed-Use Investment Property

    Fully rented mixed-use property in the heart of Old Town.

    405 Petronia Street, Key West, FL 33040
    View details
    New Mixed-Use Development in Key West
    $749,000

    New Mixed-Use Development in Key West

    New commercial space in mixed-use development, completion end of 2026.

    3201 Flagler Avenue, Key West, FL 33040
    View details
    Stock Island Commercial Property For Sale
    $1,950,000
    5,258 SF

    Stock Island Commercial Property For Sale

    Commercial property on Stock Island with mixed-use zoning.

    5670 Laurel Ave, Key West, FL 33040
    View details
    Key West Mixed-Use Income Property
    $2,999,999
    1,596 SF

    Key West Mixed-Use Income Property

    Fully rented mixed-use property in the heart of Old Town.

    405 Petronia Street, Key West, FL 33040
    View details
    Based on your search, we've compiled 281 Potential Opportunities for your consideration. Besides 8 Active listings in Key West, FL, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 265 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Gulf Front Estate in Marathon
    $9,950,000

    Gulf Front Estate in Marathon

    3.86-acre mixed-use commercial property with waterfront and highway frontage.

    6500-6600 Overseas Highway, Marathon, FL 33050
    View details
    Established Business in Florida Keys
    $99,000

    Established Business in Florida Keys

    Work and live in paradise with this established business.

    Montage FL Keys Souvenirs, Marathon, FL 33050
    View details
    Islamorada Redevelopment Opportunity
    $5,500,000
    3,312 SF

    Islamorada Redevelopment Opportunity

    Prime Islamorada property with redevelopment potential in a desirable location.

    82929 Overseas Hwy, Islamorada, FL 33036
    View details
    Islamorada Mixed-Use Commercial Property
    $1,899,000
    3,000 SF

    Islamorada Mixed-Use Commercial Property

    Luxury mixed-use property with highway frontage and flexible commercial/residential space.

    87847 Overseas Hwy, Islamorada, FL 33036
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Waterfront Land in Key West
    $9,499,000

    Waterfront Land in Key West

    Two parcels of land with waterfront views and commercial potential.

    7000 5th Street, Key West, FL 33040
    View details
    Cudjoe Key Commercial Development Land
    $2,000,000

    Cudjoe Key Commercial Development Land

    1.56 acres of commercial land with US1 frontage.

    Summerland Key, FL 33042
    View details
    Oceanfront Lot on Overseas Highway
    $265,000
    0.34 Acres

    Oceanfront Lot on Overseas Highway

    Buildable oceanfront lot in Marathon, Florida with multiple uses.

    Overseas Highway Over Hwy, Marathon, FL 33050
    View details
    Waterfront Redevelopment Opportunity in Marathon, FL
    $3,549,000

    Waterfront Redevelopment Opportunity in Marathon, FL

    Rare waterfront property with deep water dockage and redevelopment potential.

    14 125Th Street Gulf, Marathon, FL 33050
    View details

    Explore Off-Market Properties in Key West, FL

    Consider similar Off-Market properties in Key West, FL. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    1805 Staples Ave

    1805 Staples Ave

    MIXED USE (COMMERCIAL/INDUSTRIAL) • 13,958 SF
    Value Estimation
    $2,160,000
    1805 Staples Ave, Key West, FL 33040-3633
    View details
    928 Truman Ave Ste, Unit 101

    928 Truman Ave Ste, Unit 101

    MIXED USE (COMMERCIAL/INDUSTRIAL) • 1,830 SF
    Value Estimation by Request
    928 Truman Ave Ste, Key West, FL 33040-7793
    View details
    1028 Truman Ave, Unit 1

    1028 Truman Ave, Unit 1

    MIXED USE (COMMERCIAL/INDUSTRIAL) • 2,030 SF
    Value Estimation by Request
    1028 Truman Ave, Key West, FL 33040-3373
    View details
    625 Overseas Hwy

    625 Overseas Hwy

    MIXED USE (COMMERCIAL/INDUSTRIAL) • 10,212 SF
    Value Estimation
    $2,530,000
    625 Overseas Hwy, Key West, FL 33040-5605
    View details
    830 Fleming St

    830 Fleming St

    MIXED USE (COMMERCIAL/INDUSTRIAL) • 1,299 SF
    Value Estimation by Request
    830 Fleming St, Key West, FL 33040-6964
    View details
    1109 Truman Ave

    1109 Truman Ave

    MIXED USE (COMMERCIAL/INDUSTRIAL) • 4,410 SF
    Value Estimation by Request
    1109 Truman Ave, Key West, FL 33040
    View details
    1900 Staples Ave

    1900 Staples Ave

    MIXED USE (COMMERCIAL/INDUSTRIAL) • 1,749 SF
    Value Estimation by Request
    1900 Staples Ave, Key West, FL 33040-3644
    View details
    516 White St

    516 White St

    MIXED USE (COMMERCIAL/INDUSTRIAL) • 4,494 SF
    Value Estimation by Request
    516 White St, Key West, FL 33040-7170
    View details
    517 Duval St Ste, Unit 200

    517 Duval St Ste, Unit 200

    MIXED USE (COMMERCIAL/INDUSTRIAL) • 8,687 SF
    Value Estimation by Request
    517 Duval St Ste, Key West, FL 33040-6587
    View details
    1013 Truman Ave

    1013 Truman Ave

    MIXED USE (COMMERCIAL/INDUSTRIAL) • 1,440 SF
    Value Estimation
    $855,000
    1013 Truman Ave, Key West, FL 33040-3349
    View details
    1100 Packer St

    1100 Packer St

    MIXED USE (COMMERCIAL/INDUSTRIAL) • 2,399 SF
    Value Estimation
    $515,000
    1100 Packer St, Key West, FL 33040-3263
    View details
    518 Fleming St

    518 Fleming St

    MIXED USE (COMMERCIAL/INDUSTRIAL) • 1,888 SF
    Value Estimation by Request
    518 Fleming St, Key West, FL 33040-6882
    View details
    524 Frnt St

    524 Frnt St

    MIXED USE (COMMERCIAL/INDUSTRIAL) • 9,730 SF
    Value Estimation
    $3,500,000
    524 Frnt St, Key West, FL 33040-6658
    View details
    811 Fleming St

    811 Fleming St

    MIXED USE (COMMERCIAL/INDUSTRIAL) • 1,170 SF
    Value Estimation by Request
    811 Fleming St, Key West, FL 33040-6903
    View details
    1130 Duval St

    1130 Duval St

    MIXED USE (COMMERCIAL/INDUSTRIAL) • 7,239 SF
    Value Estimation by Request
    1130 Duval St, Key West, FL 33040-3157
    View details
    509 Whitehead St

    509 Whitehead St

    MIXED USE (COMMERCIAL/INDUSTRIAL) • 3,152 SF
    Value Estimation
    $915,000
    509 Whitehead St, Key West, FL 33040-6503
    View details

    Key West, FL Mixed-Use Properties Investment Opportunities Market Analysis

    Explore 273 mixed-use properties for sale in Key West, FL, showcased through 8 active listings on our real estate platform. These investment opportunities span a total of 553,557 square feet of properties for sale, with an estimated market value of $106,604,999.

    Sale prices for multi use buildings in Key West, FL start at $115,000, averaging $1,110,468, and reaching up to $5,735,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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