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    Charlotte, NC Greensboro, NC Wilmington, NC

    Durham County, NC Office Buildings for Lease

    11 results
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    Class A Office Space
    $23 SF/Yr
    79,440 SF

    Class A Office Space

    4321 Medical Park Dr, Durham, NC 27704

    Class A office space for lease in North Durham.

    • Class A office space in Independence Park, a thriving medical hub across from Duke Regional Hospital.
    • Ability to combine suites for up to 29,098 RSF.
    • Plentiful parking onsite (4.8 per 1,000 SF).
    • High ceilings and upgraded finishes.
    • Freight elevator and backup generator onsite.
    Updated: Nov 26, 2025
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    Renovated Office Building Near University
    Contact for pricing
    58,249 SF

    Renovated Office Building Near University

    3710 University Drive, Durham, NC 27707

    Three-story office building near mixed-use development with ongoing renovations.

    • Steps away from the new University Hill mixed‑use development.
    • Significant renovations underway, including exterior refresh and new Tenant Hub.
    • Two move‑in‑ready pre‑built suites available.
    • Walkability to O2 Fitness and numerous retail/restaurant options.
    • More common area amenities coming soon.
    Updated: Jan 27
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    Premier Office Asset in Durham
    Contact for pricing
    105,130 SF

    Premier Office Asset in Durham

    Value-add opportunity in a highly coveted Raleigh-Durham market.

    4505 Emperor Blvd, Durham, NC
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    Durham Office Building Near University
    Contact for pricing
    59,650 SF

    Durham Office Building Near University

    59,650 SF office building near mixed-use development.

    3708 Mayfair Street, Durham, NC 27707
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    Downtown Durham Retail/Office Space
    Contact for pricing
    465,000 SF

    Downtown Durham Retail/Office Space

    Retail and office space available for lease in downtown Durham.

    110 Corcoran Street, Durham, NC 27701
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    Class-A Office with Prime Amenities
    Contact for pricing

    Class-A Office with Prime Amenities

    Landmark 11-story office building with unparalleled signage and amenities.

    4820 Emperor Blvd, Durham, NC 27703
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    Three-Story Office Building For Rent
    Contact for pricing
    58,249 SF

    Three-Story Office Building For Rent

    58,249 SF office building near University Hill development.

    3710 University Dr, Durham, NC 27707
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    Office Building Near University Hill
    Contact for pricing
    59,650 SF

    Office Building Near University Hill

    Three-story office building near mixed-use development available for rent.

    3708 Mayfair Street, Durham, NC 27707
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    Downtown Durham Office Space
    Contact for pricing

    Downtown Durham Office Space

    Office space for lease in downtown Durham, NC.

    433 W Main St, Durham, NC 27701
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    Office Building in Imperial Center
    Contact for pricing

    Office Building in Imperial Center

    Three-story office building in Imperial Center Business Park available for rent.

    4307 Emperor Boulevard, Durham, NC 27703
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    Class A Office Building
    Contact for pricing

    Class A Office Building

    Four-story office building in Imperial Center Business Park.

    4819 Emperor Blvd, Durham, NC 27703
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    Based on your search, we've compiled 25 Potential Opportunities for your consideration. Besides 11 Active listings in Durham County, NC, we suggest exploring alternatives. Similar 10 Properties for Sales.

    Explore Similar Spaces for Sale in Durham County, NC

    Consider Similar Space for Sale. We found 10 Spaces matching your search parameters.

    Colonial Square Office/Medical Building
    $3,499,000
    21,532 SF

    Colonial Square Office/Medical Building

    Multi-functional commercial building in Durham's Independence Park.

    4400 Ben Franklin Boulevard, Durham, NC 27704
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    Imperial Center Office Building For Sale
    Contact for pricing
    105,410 SF

    Imperial Center Office Building For Sale

    Four-story office building in Imperial Center Business Park with modern amenities.

    4819 Emperor Blvd., Durham, NC 27703
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    Class A Office Building, Durham
    Contact for pricing
    111,689 SF

    Class A Office Building, Durham

    Four-story Class A office building in Imperial Center Business Park.

    4309 Emperor Blvd., Durham, NC 27703
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    Imperial Center Office Building For Sale
    Contact for pricing
    81,145 SF

    Imperial Center Office Building For Sale

    Three-story office building in Imperial Center Business Park with walkable amenities.

    4307 Emperor Boulevard, Durham, NC 27703
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    Imperial Center Office Building For Sale
    Contact for pricing
    75,563 SF

    Imperial Center Office Building For Sale

    Three-story office building in Imperial Center Business Park.

    1101 Slater Road, Durham, NC 27703
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    Landmark Class-A Office Tower
    Contact for pricing
    264,598 SF

    Landmark Class-A Office Tower

    Iconic 11-story office building with prime location and amenities.

    4820 Emperor Boulevard, Durham, NC 27703
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    Class A Office Campus Redevelopment
    Contact for pricing
    151,376 SF

    Class A Office Campus Redevelopment

    Two-building Class A office campus with modern indoor/outdoor workspaces.

    2222 & 2224 NC 54, Durham, NC 27713
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    Versatile Income-Producing Asset in Durham
    $5,500,000
    34,433 SF

    Versatile Income-Producing Asset in Durham

    Multi-tenant building in a growing submarket with redevelopment potential.

    1020 South Miami Blvd, Durham, NC 27703
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    Turnkey Commercial Buildings in Durham
    Contact for pricing

    Turnkey Commercial Buildings in Durham

    Freestanding commercial buildings perfect for owner-user office or redevelopment.

    2117 Guess Rd, Durham, NC 27705
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    Southpoint Professional Center Office Space
    $2,995,000
    8,986 SF

    Southpoint Professional Center Office Space

    Office space in Durham, close to Chapel Hill and RTP.

    249 E Nc Hwy 54- Suite 100, Durham, NC 27713
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    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Prime Corner Parcel for Lease
    Contact for pricing

    Prime Corner Parcel for Lease

    2.38-acre corner parcel available for ground lease in Durham, NC.

    1011 Riddle Road, Durham, NC 27713
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    Corner Parcel for Ground Lease
    Contact for pricing

    Corner Parcel for Ground Lease

    2.38-acre parcel for ground lease in Durham, NC.

    1011 Riddle Rd, Durham, NC 27713
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    Durham Corner Parcel For Lease
    Contact for pricing

    Durham Corner Parcel For Lease

    5.08-acre corner parcel available for ground lease in Durham, NC.

    3700 Fayetteville Street & 108 Cook Road, Durham, NC 27707
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    South Durham Redevelopment Opportunity
    Contact for pricing

    South Durham Redevelopment Opportunity

    1.36-acre commercial land available for rent in South Durham.

    3700 Fayetteville St, Durham, NC 27707
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    Durham County, NC Office buildings Leasing Opportunities Market Analysis

    Explore Office buildings leasing options in Durham County, NC with 11 listings featured on our commercial real estate exchange. The current inventory includes 613,019,880 square feet of properties with an estimated lease value of $23 SF/Yr.

    Estimated lease rates for Office buildings in Durham County, NC begin at $23 SF/Yr, with an average of $23 SF/Yr and extend to $23 SF/Yr.
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