Rancho Santa Margarita, CA Office buildings for Rent & Lease

Updated: Nov 26, 2025

Office Building with Mountain Views

22362 Gilberto, Rancho Santa Margarita, CA 92688

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18,538 sqft

Prime South Orange County location
Spectacular panoramic Saddleback Mountain views
Easy access to the 241 Foothill Transportation Corridor
Elevator served office building
Corporate headquarters building with formal entry lobby

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Updated: Mar 21, 2025

Rancho Santa Margarita Office Building

28672 Deerpath, Rancho Santa Margarita, CA

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8,309 sqft

Early education/school permitted use.
Lease rate with no annual increases in base rent.
Office building available.
Tenant in place.
Property is available for lease.

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Turn Any Listing Into an Investment Snapshot Owner equity, real caprate, demand score for every listing. Go To Analytics Center

Based on your search, we've compiled 11 Potential Opportunities for your consideration. Besides 2 Active listings in Rancho Santa Margarita, CA, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 1 Properties for Sales.

Office buildings for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Multi-Tenant Stand-Alone Office Building

26391 Crown Valley Pkwy., Mission Viejo, CA 92691

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2,091 sqft

Stand-alone, multi-tenant office building offers convenient freeway access for business operations.

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Professional Office Building For Rent

25212 Marguerite Pkwy., Mission Viejo, CA 92692

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17,667 sqft

Two-story office building in prime South Orange County location.

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Class A Office Space Available

27422 Portola Parkway, Lake Forest, CA 92610

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58,560 sqft

High-image office campus with excellent amenities and access.

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Versatile Office and Flex Space

1-13 Orchard Road, Lake Forest, CA 92630

$19.80 SF/Yr

Class A office and flex buildings in Orchard Technology Park.

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Similar Spaces for Sale in Rancho Santa Margarita, CA

Consider Similar Space for Sale. We found 1 Spaces matching your search parameters.

Owner-User Medical Office Building

22331 El Paseo, Rancho Santa Margarita, CA 92688

$10,978,000

22,000 sqft 1.67 AC lot

22,000-SF owner-user building on a corner lot with permitted medical, retail, and office uses.

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Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Service Commercial Land For Rent

1798 Hanford Armona Road, Hanford, CA 93230

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3-acre service commercial land in high-traffic Hanford location.

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Build-to-Suit Corner Commercial Land

996 E 1st Avenue, Chico, CA 95926

$5,000/Mo

Corner commercial land with power onsite and city services on the street for a customizable build-to-suit project.

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Los Ranchos Commercial Land For Rent

6401 4th Street NW, Los Ranchos, NM 87107

$1,000/Mo

High-traffic commercial land with excellent visibility in Los Ranchos, NM.

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El Paso Land For Rent

9400 Stonewall Road, El Paso, TX 79924

$160,000/Mo

Commercial land available for rent in El Paso, Texas.

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Rancho Santa Margarita, CA Office Buildings for Lease

22362 Gilberto, Rancho Santa Margarita, CA 92688

28672 Deerpath, Rancho Santa Margarita, CA