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Portsmouth, NH Mixed-use Properties for Sale

6 results
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Portsmouth Commercial Property on Route 1
$950,000
1,782 SF

Portsmouth Commercial Property on Route 1

930 Rte 1 Byp, Portsmouth, NH 03801

1,782 SF commercial building on 0.33 acres in Portsmouth, NH.

  • High visibility location on Route 1 Bypass with strong traffic counts.
  • Versatile 1,782 SF building suitable for retail, service, or mechanic use.
  • Multiple overhead doors provide operational flexibility.
  • Excellent potential for mixed‑use redevelopment in a growing corridor.
  • Located on 0.33 acres.
Updated: Feb 2
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Waterfront Lot Near Downtown Portsmouth
$1,000,000
0.41 Acres

Waterfront Lot Near Downtown Portsmouth

98 Cornwall St, Portsmouth, NH 03801

Waterfront mixed-use property near downtown Portsmouth, offering versatile development opportunities.

  • Prime waterfront location on North Mill Pond with direct water access.
  • Walking distance to downtown Portsmouth.
  • Opportunity to redevelop for luxury living.
  • Large lot size suitable for various development plans.
  • Currently features industrial and office buildings.
Updated: Dec 10, 2025
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Mixed-Use Investment in Downtown Portsmouth
$4,800,000

Mixed-Use Investment in Downtown Portsmouth

Mixed-use property with income and repositioning potential in vibrant downtown.

172 Hanover St, Portsmouth, NH 03801
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Mixed-Use Development in Portsmouth, NH
$5,400,000
0.20 Acres

Mixed-Use Development in Portsmouth, NH

Mixed-use development with retail and luxury residences in Portsmouth.

266 State St, Portsmouth, NH 03801
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Historic Portsmouth Mixed-Use Gem
$3,600,000
0.11 Acres

Historic Portsmouth Mixed-Use Gem

Mixed-use property with commercial space and residential apartments in Portsmouth.

56 Market St, Portsmouth, NH 03801
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Portsmouth Mixed-Use Opportunity
$1,200,000

Portsmouth Mixed-Use Opportunity

Mixed-use property in Portsmouth Green, flexible zoning, rapid use-change potential.

2425 Lafayette Rd, Portsmouth, NH 03801
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Based on your search, we've compiled 129 Potential Opportunities for your consideration. Besides 6 Active listings in Portsmouth, NH, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 119 Off-Market properties to explore as potential leads

Explore Opportunities in Nearby Cities

Here are 4 Similar properties we found in Nearby Locations for your consideration.

Kittery Assemblage: Mixed-Use Potential
Contact for pricing

Kittery Assemblage: Mixed-Use Potential

Three adjoining properties in Kittery with redevelopment potential.

143 State Rd, Kittery, ME 03904
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Prime Kittery Commercial Site
$2,500,000
2.17 Acres

Prime Kittery Commercial Site

High-visibility Route 1 location, excellent zoning.

275 Us Route 1, Kittery, ME 03904
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Route One Flex Space For Sale
$370,000
3,125 SF

Route One Flex Space For Sale

York, ME commercial condo: 3,125 sq ft, high traffic location.

433 Us-1, York, ME 03909
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Route One York Commercial Condo
$385,000
3,125 SF

Route One York Commercial Condo

Prime Location, Versatile Space, High Traffic

433 Rte, York, ME 03909
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Explore Off-Market Properties in Portsmouth, NH

Consider similar Off-Market properties in Portsmouth, NH. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

112 Penhallow St

112 Penhallow St

OFFICE/RESIDENTIAL (MIXED USE) • 2,732 SF
Value Estimation by Request
112 Penhallow St, Portsmouth, NH 03801-3833
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515-517 Middle St

515-517 Middle St

OFFICE/RESIDENTIAL (MIXED USE) • 6,689 SF
Value Estimation
$925,000
515-517 Middle St, Portsmouth, NH 03801
View details
105 Daniel St

105 Daniel St

OFFICE/RESIDENTIAL (MIXED USE) • 3,195 SF
Value Estimation by Request
105 Daniel St, Portsmouth, NH 03801-3810
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29 Congress St

29 Congress St

OFFICE/RESIDENTIAL (MIXED USE) • 3,006 SF
Value Estimation by Request
29 Congress St, Portsmouth, NH 03801-4004
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54 Daniel St

54 Daniel St

OFFICE/RESIDENTIAL (MIXED USE) • 4,167 SF
Value Estimation by Request
54 Daniel St, Portsmouth, NH 03801-3829
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913 Sagamore Ave

913 Sagamore Ave

OFFICE/RESIDENTIAL (MIXED USE) • 720 SF
Value Estimation by Request
913 Sagamore Ave, Portsmouth, NH 03801-5594
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142 State St

142 State St

OFFICE/RESIDENTIAL (MIXED USE) • 12,884 SF
Value Estimation
$1,760,000
142 State St, Portsmouth, NH 03801-3826
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181 Hl St

181 Hl St

OFFICE/RESIDENTIAL (MIXED USE) • 0.37 Acres
Value Estimation by Request
181 Hl St, Portsmouth, NH 03801-3923
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169 Islington St

169 Islington St

OFFICE/RESIDENTIAL (MIXED USE) • 3,009 SF
Value Estimation by Request
169 Islington St, Portsmouth, NH 03801
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123 Market St

123 Market St

OFFICE/RESIDENTIAL (MIXED USE) • 8,428 SF
Value Estimation
$1,730,000
123 Market St, Portsmouth, NH 03801-3742
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105 Market St

105 Market St

OFFICE/RESIDENTIAL (MIXED USE) • 6,460 SF
Value Estimation
$2,680,000
105 Market St, Portsmouth, NH 03801-3703
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180 Islington St

180 Islington St

OFFICE/RESIDENTIAL (MIXED USE) • 3,354 SF
Value Estimation by Request
180 Islington St, Portsmouth, NH 03801-4204
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359 Marcy St

359 Marcy St

OFFICE/RESIDENTIAL (MIXED USE) • 1,481 SF
Value Estimation by Request
359 Marcy St, Portsmouth, NH 03801-5208
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591 Middle St

591 Middle St

OFFICE/RESIDENTIAL (MIXED USE) • 1,828 SF
Value Estimation by Request
591 Middle St, Portsmouth, NH 03801-5012
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442 Middle St

442 Middle St

OFFICE/RESIDENTIAL (MIXED USE) • 2,778 SF
Value Estimation by Request
442 Middle St, Portsmouth, NH 03801-5017
View details
426 Middle St

426 Middle St

OFFICE/RESIDENTIAL (MIXED USE) • 2,306 SF
Value Estimation by Request
426 Middle St, Portsmouth, NH 03801-5017
View details
205 Bartlett St

205 Bartlett St

OFFICE/RESIDENTIAL (MIXED USE) • 1,107 SF
Value Estimation by Request
205 Bartlett St, Portsmouth, NH 03801-3601
View details
201 Cate St

201 Cate St

OFFICE/RESIDENTIAL (MIXED USE) • 2,697 SF
Value Estimation by Request
201 Cate St, Portsmouth, NH 03801-4173
View details

Portsmouth, NH Mixed-Use Properties Investment Opportunities Market Analysis

Explore 125 mixed-use properties for sale in Portsmouth, NH, showcased through 6 active listings on our real estate platform. These investment opportunities span a total of 368,081 square feet of properties for sale, with an estimated market value of $36,480,000.

Sale prices for multi use buildings in Portsmouth, NH start at $225,000, averaging $1,072,941, and reaching up to $5,400,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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