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    San Diego County, CA Mixed-use Properties for Lease

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    18 properties
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    Freestanding Mixed-Use Building
    Updated: Nov 9
    Freestanding Mixed-Use Building

    1050 S Santa Fe, Vista, CA 92084

    $8,500/Mo
    2,700‑square‑foot building on nearly 1/2 an acre
    Equipped commercial kitchen with multiple office areas and open workspaces
    Loading access and gated parking
    Central air; built in 1950
    1050 S Santa Fe, Vista
    View details
    Mixed-Use Suite with Gated Patio
    Updated: Oct 6
    Mixed-Use Suite with Gated Patio

    7850 Golden Ave, Lemon Grove, CA 91945

    $4,150/Mo
    1,000 sqft
    1,000 SF of interior space
    Private gated patio
    Reception area, private rooms, and restroom with shower
    Zoning: 3‑VC3
    Across from Lemon Grove Academy Elementary, near Broadway
    View details
    Renovated Live-Work Space
    Renovated Live-Work Space

    4741 Point Loma, San Diego, CA 92106

    Sunset Cliffs
    $12,000/Mo
    750–3,376 sqft  Built 2016

    Ground-floor commercial space pairs with a private residence, dedicated parking, and flexible occupancy options.

    Furnished
    View details
    Live-Work Property with Separate Commercial Building
    Live-Work Property with Separate Commercial Building

    2971 Imperial Avenue, San Diego, CA 92102

    Logan Heights
    Contact for pricing
    700 sqft
    Road access

    A remodeled residence and a distinct storefront building share a gated driveway with alley access and on-site parking.

    6 parking spaces
    View details
    Mixed-Use Office and Retail Building
    Mixed-Use Office and Retail Building

    264 N Coast Hwy 101, Encinitas, CA 92024

    Contact for pricing
    1,730 sqft

    The property offers a flexible setting for office or retail occupancy.

    View details
    Mixed-Use Shopping Center
    Mixed-Use Shopping Center

    945 Carlsbad Village Dr, Carlsbad, CA 92008

    Barrio
    Contact for pricing
    8,000 sqft
    Corner location

    Retail availability is integrated with a 218-apartment development and includes a suite suited to a neighborhood market.

    178 parking spaces
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    Mixed-Use Property with Loading
    Mixed-Use Property with Loading

    8252-8280 Clairemont Mesa Boulevard, San Diego, CA 92111

    Kearny Mesa
    Contact for pricing
    Multi-tenant  2,932 sqft

    The San Diego park offers industrial and retail space, with building and monument signage available.

    Building and monument signage
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    Creative Office Sublease in Solana
    Creative Office Sublease in Solana

    312 South Cedros Avenue, Suite 312, Solana Beach, CA 92075

    Contact for pricing
    24–40 people  6,067 sqft

    Creative office sublease in Cedros Design District available for rent.

    View details
    San Diego Commercial Space Available
    San Diego Commercial Space Available

    9360-9420 Activity Rd., San Diego, CA 92126

    Mira Mesa
    Contact for pricing
    8,472 sqft  Built 2026

    Commercial space for lease in San Diego, California.

    View details
    Mixed-Use Property with Hotel Suites
    Mixed-Use Property with Hotel Suites

    2611 Adams Avenue, San Diego, CA 92116

    Mission Valley East
    Contact for pricing
    Built 2025 / renov 2025

    Furnished lodging suites operate alongside a separately leased restaurant component.

    View details
    Mixed-Use Retail and Office Building
    Mixed-Use Retail and Office Building

    264-266 N Coast Hwy 101, Encinitas, CA 92024

    Contact for pricing
    1,730 sqft building

    The property combines retail and office space in one building along North Coast Highway 101.

    View details
    RV Park with Restaurant
    RV Park with Restaurant

    9849 Sunrise Hwy, Mount Laguna, CA 91948

    Contact for pricing
    Built 1984

    The property combines permitted RV sites with a restaurant, apartment, manager’s quarters, and shared resident amenities.

    View details
    Mixed-Use Property with Retail Space
    Mixed-Use Property with Retail Space

    San Diego, CA 92116

    Adams North
    Contact for pricing

    Retail space is paired with five apartments, with alley access and on-site parking.

    View details
    Office and Retail Mixed-Use Property
    Office and Retail Mixed-Use Property

    5531-5535 Cancha De Golf, Rancho Santa Fe, CA 92091

    Contact for pricing
    21,868 sqft  2-story

    The offering pairs Class A office space with a separate, single-story retail building.

    View details
    San Diego Commercial Space For Lease
    San Diego Commercial Space For Lease

    17066 Goldentop Rd., San Diego, CA 92127

    Black Mountain Ranch
    Contact for pricing
    Built 2026

    Mixed-use, retail, office, and industrial spaces available for lease.

    View details
    Retail Space in Otay Ranch
    Retail Space in Otay Ranch

    1445 Town Center Dr, Chula Vista, CA

    Hilltop
    Contact for pricing
    736 sqft

    Streetfront retail space in a new mixed-use development.

    View details
    101 E Grand Ave
    101 E Grand Ave

    101 E Grand Ave, Escondido, CA 92025, Escondido, CA 92025

    $24 SF/Yr
    Built 1930

    6,500 SF of Retail Space Available in Escondido, CA 92025

    View details
    Gaslamp City Square Retail Space
    Gaslamp City Square Retail Space

    425-445 Island Ave, San Diego, CA

    Gaslamp
    Contact for pricing
    3,333 sqft

    Mixed-use property in the heart of San Diego's Gaslamp Quarter.

    View details
    18 active listings match your search: Mixed-Use for lease in San Diego County, CA. Based on your search, we've also compiled 83 Potential Opportunities for your consideration: 83 properties for sale.

    Similar Spaces for Sale in San Diego County, CA

    Consider Similar Space for Sale. We found 83 Spaces matching your search parameters.

    Mixed-Use Property with Residence
    Mixed-Use Property with Residence

    2971 Imperial Avenue, San Diego, CA 92102

    $1,080,000
    1,775 sqft 0.13 AC lot

    A detached home and separate street-facing commercial building share a gated site with alley access.

    View details
    Mixed-Use Building with Storefront
    Mixed-Use Building with Storefront

    4741 Point Loma, San Diego, CA 92107

    $2,295,000
    3,376 sqft

    Two commercial spaces occupy the lower level, with a four-bedroom residence above.

    View details
    Mixed-Use Property With Retail Units
    Mixed-Use Property With Retail Units

    2140 Alpine Blvd, Alpine, CA 91901

    $1,135,000
    4,972 sqft 0.44 AC lot

    The property combines three street-facing commercial suites with three residential units behind them.

    View details
    Four-Story Mixed-Use Building
    Four-Story Mixed-Use Building

    920 Kline Street, La Jolla, CA 92037

    $5,800,000
    20,000 sqft 1.50 AC lot

    Mixed retail and office occupancy is supported by an updated elevator and private baths in many suites.

    View details
    Mixed-Use Property with Alley Access
    Mixed-Use Property with Alley Access

    1434-44 Garnet Ave, San Diego, CA 92109

    $1,695,000
    1,622 sqft 0.14 AC lot

    Retail/office space includes a detached studio and rear open area.

    View details
    El Cajon Redevelopment Opportunity
    El Cajon Redevelopment Opportunity

    939 W Main, El Cajon, CA 92020

    $1,498,800
    3,800 sqft 0.48 AC lot

    Prime corner lot for mixed-use redevelopment in El Cajon.

    View details

    San Diego County, CA Mixed-use properties Market Trends and Statistics

    Explore Mixed-use properties leasing options in San Diego County, CA with 18 listings featured on our commercial real estate exchange. The current inventory includes 54,838 square feet of properties with an estimated lease value of $73.80.

    Estimated lease rates for Mixed-use properties in San Diego County, CA begin at $24 SF/Yr, with an average of $36.90 SF/Yr and extend to $49.80 SF/Yr.
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    Featured San Diego County Real Estate Agencies

    Realmo connects you with licensed San Diego County CRE brokers providing property specifications, local market pricing, and commercial transaction underwriting support.

    Century 21 Horizon
    4134 Adams Ave., #101 San Diego, CA 92116
    Phone: (619) 280-5888
    www.century21horizon.com
    The Roby Company
    13410 Pomerado Road Poway, CA 92064
    Phone: (858) 748-8002
    www.therobycompany.com
    Orchard Realty, Inc.
    2526 Washington St, PO Box 1869 Julian, CA 92036
    Phone: (760) 765-1000
    www.orchard-realty.com
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