South Dakota Medical Office Space for Rent & Lease

$1.00 SF/Yr

5,600 SF

Class A Office Space Available

1220 Mt. Rushmore Rd, Rapid City, SD 57701

Move-in ready office space ideal for medical or professional services.

Prime location on Mt Rushmore Road with unparalleled visibility and access.
Move‑in ready Class A office space.
Well‑suited for medical practices or professional service providers, offering a functional and adaptable layout.
Includes 6 private offices, a conference room with kitchenette, and a 700 SF classroom.
Features built‑in workstations and a clerical room.

Updated: Mar 13, 2025

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$20 SF/Yr

2,958 SF

West Rapid City Office Space

1136 Jackson Blvd, Rapid City, SD 57702

Class A office suite in high-traffic West Rapid City location.

Class A traditional office space with 3,002 SqFt available in Lower Level Suite #2.
Immediate occupancy available.
High‑traffic location in West Rapid City with great curb appeal.
Comprehensive suite layout includes: reception area, meeting room, IT closet, break room, restrooms, and 4‑5 private offices.
Handicap accessible entryway and ample paved parking.

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5,694 SF

Retail/Medical Space Near Menards

Retail or medical space in a high-traffic Mitchell location.

819 E Spruce St, Mitchell, SD 57301

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3,840 SF

Medical Clinic Ready For Rent

Clinic space available for medical, therapy, or dental practices.

4914-4930 N Cliff Ave, Sioux Falls, SD 57104

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$10 SF/Yr

1,754 SF

Prime Sioux Falls Office Space

2,880 sq ft, Central Location, 55 Parking Spaces

3905 Western Ave, Sioux Falls, SD 57105

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$22 SF/Yr

21,040 SF

Prime Sioux Falls Retail Space

Class A Retail/Office, High Traffic Location

6205 Old Village Pl, Sioux Falls, SD 57108

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$10 SF/Yr

32,400 SF

Midland Shopping Center Office Suites

Rapid City, SD Office Space for Lease

909 Saint Patrick St, Rapid City, SD 57701

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$14 SF/Yr

9,160 SF

River Drive Office Spaces Available

High-visibility Union County office suites

1244-1248 River Dr, North Sioux City, SD 57049

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$146 SF/Yr

1,570 SF

Rapid City Office Suites for Lease

Downtown Rapid City Office Space - 1570 sq ft

701 Main St, Rapid City, SD 57701

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$13 SF/Yr

1,900 SF

West 41st Street Retail Space

Prime Sioux Falls retail/office opportunity.

5107 41St St, Sioux Falls, SD 57106

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$17 SF/Yr

2,665 SF

Fulton Plaza Office Suite, Rapid City

Prime Office Space, Rapid City, SD

1818 Fulton St, Rapid City, SD 57702

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$21 SF/Yr

660 SF

Rapid City Executive Office Suite

Downtown Rapid City office, 660 sq ft.

522 7Th St, Rapid City, SD 57701

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$12 SF/Yr

9,936 SF

Prime Office Condo/Lease Opportunity

Versatile Office Space, High-Traffic Location

4214 38Th St, Sioux Falls, SD 57106

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$24 SF/Yr

2,338 SF

West 57th St. Premier Space

High-traffic retail/office opportunity

4209 57Th St, Sioux Falls, SD 57108

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$8 SF/Yr

85,194 SF

Downtown Sioux Falls Office Space

Prime Office Space, Flexible Layouts, Downtown Sioux Falls

101 Phillips Ave, Sioux Falls, SD 57104

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$18 SF/Yr

15,814 SF

Rowe 57: Prime Sioux Falls Office Space

Modern Office Suites in Thriving Community

5025 Bahnson Ave, Sioux Falls, SD 57103

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$15 SF/Yr

3,768 SF

Meadows Square Office Suites

Prime Sioux Falls Office Space Available

3801 34Th St, Sioux Falls, SD 57106

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$16 SF/Yr

26,120 SF

Oakbrook II Office Space for Lease

Versatile Sioux Falls Office Building

5032 Bur Oak Pl, Sioux Falls, SD 57108

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Rock Island Building: Prime Office Space

$15 SF/Yr

13,413 SF

Rock Island Building: Prime Office Space

Downtown Sioux Falls office building, multiple suites available.

300 Phillips Ave, Sioux Falls, SD 57104

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$24 SF/Yr

8,673 SF

The Point on Main Street

Downtown Spearfish Office Space

344 Main St, Spearfish, SD 57783

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$12 SF/Yr

13,237 SF

Willow Creek Office Suites Available

Prime Sioux Falls office space, flexible layouts.

1704 Cleveland Ave, Sioux Falls, SD 57103

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$25 SF/Yr

5,000 SF

Prairie Towers: Class A Office Space

Modern Sioux Falls Offices, Multiple Sizes Available

200 85Th St, Sioux Falls, SD 57108

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Tan Tara Office: Prime Sioux Falls Space

Contact for pricing

9,488 SF

Tan Tara Office: Prime Sioux Falls Space

Class A Office, Multiple Tenancies Available

609 Tan Tara Cir, Sioux Falls, SD 57108

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$10 SF/Yr

20,278 SF

Harrisburg Crossing Office Space

Flexible Office Suites in Prime Location

220 Cliff Ave, Sioux Falls, SD 57103

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South Dakota Medical Office Space Leasing Opportunities Market Analysis

Explore Medical Office Space leasing options in South Dakota with 42 listings featured on our commercial real estate exchange. The current inventory includes 17,041,804,560 square feet of properties with an estimated lease value of $552 /Mo.

Estimated lease rates for Medical Office Space in South Dakota begin at $1.00 SF/Yr, with an average of $21 SF/Yr and extend to $146 SF/Yr.

South Dakota Medical Office Space for Lease

Class A Office Space Available

Move-in ready office space ideal for medical or professional services.

West Rapid City Office Space

Class A office suite in high-traffic West Rapid City location.

Retail/Medical Space Near Menards

Medical Clinic Ready For Rent

Prime Sioux Falls Office Space

Prime Sioux Falls Retail Space

Midland Shopping Center Office Suites

River Drive Office Spaces Available

Rapid City Office Suites for Lease

West 41st Street Retail Space

Fulton Plaza Office Suite, Rapid City

Rapid City Executive Office Suite

Prime Office Condo/Lease Opportunity

West 57th St. Premier Space

Downtown Sioux Falls Office Space

Rowe 57: Prime Sioux Falls Office Space

Meadows Square Office Suites

Oakbrook II Office Space for Lease

Rock Island Building: Prime Office Space

The Point on Main Street

Willow Creek Office Suites Available

Prairie Towers: Class A Office Space

Tan Tara Office: Prime Sioux Falls Space

Harrisburg Crossing Office Space

South Dakota Medical Office Space Leasing Opportunities Market Analysis

Medical Office Space by market

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South Dakota Medical Office Space for Lease

Class A Office Space Available

Move-in ready office space ideal for medical or professional services.

West Rapid City Office Space

Class A office suite in high-traffic West Rapid City location.

Retail/Medical Space Near Menards

Medical Clinic Ready For Rent

Prime Sioux Falls Office Space

Prime Sioux Falls Retail Space

Midland Shopping Center Office Suites

River Drive Office Spaces Available

Rapid City Office Suites for Lease

West 41st Street Retail Space

Fulton Plaza Office Suite, Rapid City

Rapid City Executive Office Suite

Prime Office Condo/Lease Opportunity

West 57th St. Premier Space

Downtown Sioux Falls Office Space

Rowe 57: Prime Sioux Falls Office Space

Meadows Square Office Suites

Oakbrook II Office Space for Lease

Rock Island Building: Prime Office Space

The Point on Main Street

Willow Creek Office Suites Available

Prairie Towers: Class A Office Space

Tan Tara Office: Prime Sioux Falls Space

Harrisburg Crossing Office Space

South Dakota Medical Office Space Leasing Opportunities Market Analysis

Medical Office Space by market

Popular cities

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