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    South Dakota Medical Office Space for Lease

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    Sioux Falls, SD Aberdeen, SD Rapid City, SD Tea, SD Brandon, SD Dakota Dunes, SD Watertown, SD Yankton, SD
    7 properties
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    Remodeled Medical Clinic Suite
    Updated: Mar 17
    Remodeled Medical Clinic Suite

    711 N Sioux Point Rd, Dakota Dunes, SD 57049

    Contact for pricing
    4,042 sqft
    Medical clinic with 7 exam rooms, 4 restrooms, a shower, 2 private offices, and full kitchens on each floor
    6 exam rooms and 1 private office have windows
    Remodeled in 2019
    Employee parking in rear; lease rate includes property taxes, insurance, and common area maintenance
    Tenant pays data and utilities; FF&E is negotiable
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    Second-Level Class A Medical Office Suite
    Updated: Nov 25, 2025
    Second-Level Class A Medical Office Suite

    6709 S Minnesota Ave, Sioux Falls, SD 57108

    Contact for pricing
    3,552 sqft
    Sublease through 4/30/2027 for a second‑level Class A medical office suite
    3,552 SF floor plan with nine offices plus reception/waiting and break room
    Four offices include bathrooms and showers
    Recently renovated common areas with restrooms and a conference room
    Elevator and stairway access directly to the suite
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    Medical Office Building
    Medical Office Building

    3400 S Holbrook Ave, Sioux Falls, SD 57106

    Contact for pricing
    3,185 sqft

    Recently painted medical office building at a controlled intersection with established veterinary clinic improvements.

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    Medical Office Suite
    Medical Office Suite

    909 E Saint Patrick St, Rapid City, SD 57701

    Contact for pricing
    4,985 sqft

    Medical office suite in Midland Shopping Center with three exam rooms, perimeter offices, and large shared waiting and restroom area.

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    Medical Office Suite with Operatories
    Medical Office Suite with Operatories

    1704 S Cleveland Ave, Sioux Falls, SD 57103

    Contact for pricing
    1,351 sqft

    Three operatories feature hands-free sinks, storage, and access to common area restrooms.

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    Medical Clinic Ready For Rent
    Medical Clinic Ready For Rent

    4914-4930 N Cliff Ave, Sioux Falls, SD

    Contact for pricing
    3,840 sqft 1.51 AC lot

    Clinic space available for medical, therapy, or dental practices.

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    Office
    Office

    6709 S Minnesota Ave, Sioux Falls, SD 57108

    Contact for pricing

    Medical Office Space

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    Based on your search, we've compiled 14 Potential Opportunities for your consideration. Besides 7 Active listings in South Dakota, we suggest exploring alternatives. Similar 7 Properties for Sales.

    Similar Spaces for Sale in South Dakota

    Consider Similar Space for Sale. We found 7 Spaces matching your search parameters.

    Sioux Falls Adaptable Commercial Building
    Sioux Falls Adaptable Commercial Building

    4800 N 4th Ave, Sioux Falls, SD 57104

    $2,250,379
    49,424 sqft

    49,424 SF vacant building suitable for daycare, medical, or office.

    View details
    Turnkey Veterinary Facility
    Turnkey Veterinary Facility

    1603 Broadway Ave, Yankton, SD 57078

    $999,900
    3,480 sqft

    Turnkey veterinary operation with grooming and boarding setup, plus parking for customers and employees.

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    Single-Tenant Medical Office Building
    Single-Tenant Medical Office Building

    350 W Anchor Drive, Dakota Dunes, SD 57049

    Contact for pricing
    10,800 sqft

    Recently remodeled office building built in 1991, leased long term to Dunes Surgical Hospital.

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    High-End Dakota Dunes Office Space
    High-End Dakota Dunes Office Space

    211 Sioux Point Rd, Dakota Dunes, SD 57049

    Contact for pricing
    1.73 AC lot

    Professionally managed office space in a prime business district.

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    Office and Dental Building
    Office and Dental Building

    2200 S Minnesota Ave, Sioux Falls, SD 57105

    Contact for pricing

    Office and dental building along Minnesota Avenue with leased upper-level dental space and main level space available.

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    Medical Office Condo Suite
    Medical Office Condo Suite

    6709 S Minnesota Ave, Sioux Falls, SD 57108

    Contact for pricing

    Office condo features a lobby and waiting area, private offices, exam rooms, and in-suite restrooms.

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    Dakota Dunes Office Condo
    Dakota Dunes Office Condo

    383 W Steamboat Dr, Dakota Dunes, SD 57049

    Contact for pricing
    2,800 sqft

    2,800 SF office condo, currently a dental office.

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    South Dakota Medical Office Space Market Trends and Statistics

    Explore Medical Office Space leasing options in South Dakota with 7 listings featured on our commercial real estate exchange. The current inventory includes 20,955 square feet of properties.
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