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    South Dakota Medical Office Space for Lease

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    Sioux Falls, SD Aberdeen, SD Rapid City, SD Tea, SD Spearfish, SD Brandon, SD Dakota Dunes, SD Harrisburg, SD
    Medical Office Suite with Exam Rooms
    Updated: Aug 13
    Medical Office Suite with Exam Rooms

    2333 W 57th St, Sioux Falls, SD 57108

    Contact for pricing
    5,054 sqft
    5,054‑square‑foot medical office space with reception, exam rooms, offices, open workspace, breakroom, and storage
    21,600 VPD (2025) along 57th Street
    Convenient access to I‑229 and I‑29
    In‑suite restrooms included
    Co‑tenants include Pharmacy Specialties and Clinic, Denton Combs Center, and Dr. Meierhenry Women’s Health
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    Remodeled Medical Clinic Suite
    Updated: Mar 17
    Remodeled Medical Clinic Suite

    711 N Sioux Point Rd, Dakota Dunes, SD 57049

    Contact for pricing
    4,042 sqft
    Medical clinic with 7 exam rooms, 4 restrooms, a shower, 2 private offices, and full kitchens on each floor
    6 exam rooms and 1 private office have windows
    Remodeled in 2019
    Employee parking in rear; lease rate includes property taxes, insurance, and common area maintenance
    Tenant pays data and utilities; FF&E is negotiable
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    Sunlit Office Unit
    Sunlit Office Unit

    789 Deadwood Ave, Rapid City, SD 57702

    Contact for pricing
    1,904 sqft

    Flexible front-facing space supports office, medical, or retail operations with nearby off-street parking.

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    Medical Office Suite
    Medical Office Suite

    909 E Saint Patrick St, Rapid City, SD 57701

    Contact for pricing
    4,985 sqft

    Medical office suite in Midland Shopping Center with three exam rooms, perimeter offices, and large shared waiting and restroom area.

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    Medical Clinic Ready For Rent
    Medical Clinic Ready For Rent

    4914-4930 N Cliff Ave, Sioux Falls, SD

    Contact for pricing
    3,840 sqft 1.51 AC lot

    Clinic space available for medical, therapy, or dental practices.

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    Based on your search, we've compiled 15 Potential Opportunities for your consideration. Besides 5 Active listings in South Dakota, we suggest exploring alternatives. Similar 10 Properties for Sales.

    Similar Spaces for Sale in South Dakota

    Consider Similar Space for Sale. We found 10 Spaces matching your search parameters.

    Office Building with Walkout Lower Level
    Office Building with Walkout Lower Level

    1737 S Cleveland Ave, Sioux Falls, SD 57103

    $1,150,000
    6,284 sqft 0.53 AC lot

    Two levels offer private offices, open work areas, support facilities and independent exterior access to the lower floor.

    View details
    Medical Office Building
    Medical Office Building

    108 W 4th St, Dell Rapids, SD 57022

    $925,000
    5,670 sqft 0.41 AC lot

    Two-level building with separately accessed office space and an existing year-to-year lease.

    View details
    Renovated Medical Office Space
    Renovated Medical Office Space

    747 Ames Ave, Spearfish, SD 57783

    $998,500
    2,400 sqft

    The facility accommodates a chiropractic practice and spa with multiple offices and two bathrooms.

    View details
    Medical Office with Attached Garage
    Medical Office with Attached Garage

    1116 S County Rd, Freeman, SD 57029

    $250,000
    2,204 sqft 1.50 AC lot

    A separate residential-style area includes a kitchen, full bath, laundry, and a bedroom currently used as an office.

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    Office Building with Monument Signage
    Office Building with Monument Signage

    3800 S Kiwanis Ave, Sioux Falls, SD 57105

    Contact for pricing
    10,572 sqft

    Corner office property with access from both streets, monument signage, lawn irrigation, and an enclosed dumpster area.

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    Medical Office Building
    Medical Office Building

    108 W FOURTH ST, Dell Rapids, SD 57022

    Contact for pricing
    5,670 sqft

    B-2 General Business zoning supports professional office use with a separately configured leased office level.

    View details
    Medical Office Building with Flexible Layout
    Medical Office Building with Flexible Layout

    725 N Lacrosse Street, Rapid City, SD 57701

    $2,499,000
    24,344 sqft

    Two entrances and separate service areas support medical, administrative, and multi-tenant office configurations.

    View details
    Medical and Daycare Office Building
    Medical and Daycare Office Building

    4800 N 4th Ave, Sioux Falls, SD 57104

    Contact for pricing
    49,424 sqft

    Freestanding building currently laid out for daycare with wet sprinkler system, heat pumps, and parking for 104 vehicles.

    View details
    High-End Dakota Dunes Office Space
    High-End Dakota Dunes Office Space

    211 Sioux Point Rd, Dakota Dunes, SD 57049

    Contact for pricing
    1.73 AC lot

    Professionally managed office space in a prime business district.

    View details
    Dakota Dunes Office Condo
    Dakota Dunes Office Condo

    383 W Steamboat Dr, Dakota Dunes, SD 57049

    Contact for pricing
    2,800 sqft

    2,800 SF office condo, currently a dental office.

    View details

    South Dakota Medical Office Space Market Trends and Statistics

    Explore Medical Office Space leasing options in South Dakota with 5 listings featured on our commercial real estate exchange. The current inventory includes 19,825 square feet of properties.
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