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    South Dakota Medical Office Space for Sale

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    Sioux Falls, SD Aberdeen, SD Rapid City, SD
    10 results
    Rapid City Professional Office Building
    $995,000
    5,527 SF
    Rapid City Professional Office Building

    625 Flormann Street, Rapid City, SD 57701

    Professional office building near medical corridor in Rapid City, SD.
    • Prime location near Rapid City's established medical corridor, off Mount Rushmore Road.
    • Configured for medical, counseling, or service‑based use with reception, waiting area, and eight private offices.
    • Recent full interior remodel (2019) and basement renovation (2023).
    • Finished 1,494 SF basement provides flexible workspace and storage.
    • Security features include key card access, surveillance, and a secured vault.
    Updated: Apr 10
    View details
    Renovated Commercial Building in Spearfish
    $998,500
    2,400 SF
    Renovated Commercial Building in Spearfish

    747 Ames Avenue, Spearfish, SD 57783

    High-visibility commercial building with tenants in place.
    • High‑visibility and high‑traffic location in the heart of Spearfish.
    • Newer (built in 2007), completely renovated commercial building.
    • Currently has tenants in place (chiropractic office and spa) providing immediate investment income.
    • Luxurious spa and chiropractic office layout with 5 offices and 2 bathrooms.
    • Renovations include new windows, luxury vinyl flooring, maintenance‑free siding, and quality Malarkey Legacy shingles.
    Updated: Oct 20, 2025
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    Dakota Dunes Office Condo
    $450,000
    2,800 SF
    Dakota Dunes Office Condo

    2,800 SF office condo in Dakota Dunes, SD for sale.

    383 W Steamboat Dr, Ste 201, Dakota Dunes, SD 57049

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    Dakota Dunes Office Condo
    $450,000
    2,800 SF
    Dakota Dunes Office Condo

    2,800 SF office condo in Dakota Dunes, South Dakota.

    383 W Steamboat Dr, Ste 201, Dakota Dunes, SD 57049

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    Sioux Falls Adaptable Commercial Building
    $2,250,379
    49,424 SF
    Sioux Falls Adaptable Commercial Building

    49,424 SF vacant building suitable for daycare, medical, or office.

    4800 N 4th Ave, Sioux Falls, SD 57104

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    Sioux Falls Medical Office
    $1,400,000
    6,858 SF
    Sioux Falls Medical Office

    Medical office building with exam rooms and updated infrastructure.

    208 W 37th St, Sioux Falls, SD

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    Rapid City Medical Corridor Property
    $1,049,000
    5,527 SF
    Rapid City Medical Corridor Property

    Single tenant NNN investment property in Rapid City medical corridor.

    625 Flormann St, Rapid City, SD

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    Sioux Falls Office/Medical Building
    $1,980,000
    9,288 SF
    Sioux Falls Office/Medical Building

    Office/medical building with flexible space and ample parking.

    4904-4912 S Minnesota Ave, Sioux Falls, SD

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    Aberdeen Office/Medical Building For Sale
    $1,500,000
    19,600 SF
    Aberdeen Office/Medical Building For Sale

    Office/medical building on former Presentation College campus with ample parking.

    1500 N Main St, Aberdeen, SD 57401

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    Dakota Dunes Office Condo
    $395,000
    2,800 SF
    Dakota Dunes Office Condo

    2,800 SF office condo, currently a dental office.

    383 W Steamboat Dr, Dakota Dunes, SD 57049

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    Based on your search, we've compiled 72 Potential Opportunities for your consideration. Besides 10 Active listings in South Dakota, we suggest exploring several alternatives: similar 62 Off-Market properties to explore as potential leads

    Off-Market Properties in South Dakota

    Consider similar Off-Market properties in South Dakota. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    6301 41st St

    6301 41st St

    MEDICAL BUILDING • 3,108 SF
    Value Estimation
    $2,000,000
    6301 41st St, Sioux Falls, SD 57106-1217
    View details
    101 37th St

    101 37th St

    DENTAL BUILDING • 11,259 SF
    Value Estimation by Request
    101 37th St, Sioux Falls, SD 57105-5701
    View details
    2600 Western Ave

    2600 Western Ave

    DENTAL BUILDING • 2,948 SF
    Value Estimation by Request
    2600 Western Ave, Sioux Falls, SD 57105-4429
    View details
    2301 Lorraine Pl

    2301 Lorraine Pl

    DENTAL BUILDING • 1.66 Acres
    Value Estimation by Request
    2301 Lorraine Pl, Sioux Falls, SD 57106-3642
    View details
    809 Belfast St

    809 Belfast St

    MEDICAL BUILDING • 2,482 SF
    Value Estimation by Request
    809 Belfast St, Yankton, SD 57078-3324
    View details
    1700 Southeastern Ave

    1700 Southeastern Ave

    DENTAL BUILDING • 12,664 SF
    Value Estimation
    $610,000
    1700 Southeastern Ave, Sioux Falls, SD 57103-3227
    View details
    2001 Broadway Ave

    2001 Broadway Ave

    MEDICAL BUILDING • 2,000 SF
    Value Estimation by Request
    2001 Broadway Ave, Yankton, SD 57078-2032
    View details
    2300 Westlake Dr

    2300 Westlake Dr

    DENTAL BUILDING • 10,612 SF
    Value Estimation by Request
    2300 Westlake Dr, Sioux Falls, SD 57106-8527
    View details
    3805 Kiwanis Cir

    3805 Kiwanis Cir

    MEDICAL BUILDING • 4,686 SF
    Value Estimation
    $900,000
    3805 Kiwanis Cir, Sioux Falls, SD 57105-4266
    View details
    1710 Southeastern Ave

    1710 Southeastern Ave

    DENTAL BUILDING • 3,929 SF
    Value Estimation
    $800,000
    1710 Southeastern Ave, Sioux Falls, SD 57103-3381
    View details
    920 Broadway Ave

    920 Broadway Ave

    MEDICAL BUILDING • 25,256 SF
    Value Estimation
    $1,040,000
    920 Broadway Ave, Yankton, SD 57078-3532
    View details
    2521 Western Ave

    2521 Western Ave

    DENTAL BUILDING • 2,146 SF
    Value Estimation by Request
    2521 Western Ave, Sioux Falls, SD 57105-3430
    View details
    4001 Southeastern Ave

    4001 Southeastern Ave

    DENTAL BUILDING • 3,236 SF
    Value Estimation by Request
    4001 Southeastern Ave, Sioux Falls, SD 57103-5305
    View details
    Sioux Falls, SD 57106

    Sioux Falls, SD 57106

    DENTAL BUILDING • 8.27 Acres
    Value Estimation by Request
    Sioux Falls, SD 57106
    View details

    South Dakota Medical Office Space Investment Opportunities Market Analysis

    Explore 72 medical office space for sale in South Dakota, showcased through 10 active listings on our real estate platform. These investment opportunities span a total of 107,024 square feet of properties for sale, with an estimated market value of $11,522,879.

    Sale prices for medical spaces in South Dakota start at $450,000, averaging $1,152,287, and reaching up to $2,250,379 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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