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    South Dakota
    Medical Premises

    South Dakota Medical Office Space for Sale

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    Sioux Falls, SD Rapid City, SD Aberdeen, SD Huron, SD Lead, SD Watertown, SD Spearfish, SD Tea, SD
    8 properties
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    Sioux Falls Adaptable Commercial Building
    Updated: Jan 27
    Sioux Falls Adaptable Commercial Building

    4800 N 4th Ave, Sioux Falls, SD 57104

    $2,250,379
    49,424 sqft
    Large Vacant Space: 49,424 SF
    Suitable for Daycare, Medical, or Office Use
    Ample Parking: 104 Spaces
    Sprinkler System: Wet
    Dock Door: 1
    View details
    Turnkey Veterinary Facility
    Updated: Sep 4, 2025
    Turnkey Veterinary Facility

    1603 Broadway Ave, Yankton, SD 57078

    $999,900
    3,480 sqft
    Turnkey veterinary operation with grooming and boarding setup
    Established business on Yankton’s Broadway Avenue since 1989
    Fully equipped for a pet grooming and boarding division
    Up to 13 off‑street parking spaces for customers
    6+ on‑street (employee) parking spaces
    View details
    Single-Tenant Medical Office Building
    Single-Tenant Medical Office Building

    350 W Anchor Drive, Dakota Dunes, SD 57049

    Contact for pricing
    10,800 sqft

    Recently remodeled office building built in 1991, leased long term to Dunes Surgical Hospital.

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    Turn a Listing Into an Investment Snapshot Cap Rate, Potential NOI, Demand score for every listing. Go To Analytics Center
    High-End Dakota Dunes Office Space
    High-End Dakota Dunes Office Space

    211 Sioux Point Rd, Dakota Dunes, SD 57049

    Contact for pricing
    1.73 AC lot

    Professionally managed office space in a prime business district.

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    Office and Dental Building
    Office and Dental Building

    2200 S Minnesota Ave, Sioux Falls, SD 57105

    Contact for pricing

    Office and dental building along Minnesota Avenue with leased upper-level dental space and main level space available.

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    Medical Office Condo Suite
    Medical Office Condo Suite

    6709 S Minnesota Ave, Sioux Falls, SD 57108

    Contact for pricing

    Office condo features a lobby and waiting area, private offices, exam rooms, and in-suite restrooms.

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    Aberdeen Office/Medical Building For Sale
    Aberdeen Office/Medical Building For Sale

    1500 N Main St, Aberdeen, SD 57401

    Contact for pricing
    19,600 sqft 1.95 AC lot

    Office/medical building on former Presentation College campus with ample parking.

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    Dakota Dunes Office Condo
    Dakota Dunes Office Condo

    383 W Steamboat Dr, Dakota Dunes, SD 57049

    Contact for pricing
    2,800 sqft

    2,800 SF office condo, currently a dental office.

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    Based on your search, we've compiled 72 Potential Opportunities for your consideration. Besides 8 Active listings in South Dakota, we suggest exploring several alternatives: similar 64 Off-Market properties to explore as potential leads

    Off-Market Properties in South Dakota

    Consider similar Off-Market properties in South Dakota. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    6301 41st St
    MEDICAL BUILDING

    6301 41st St, Sioux Falls, SD 57106-1217

    $2,000,000
    Estimated value
    3,108 sqft 0.35 AC lot
    View details
    101 37th St
    DENTAL BUILDING

    101 37th St, Sioux Falls, SD 57105-5701

    $440,000
    Estimated value
    11,259 sqft 1.60 AC lot
    View details
    2600 Western Ave
    DENTAL BUILDING

    2600 Western Ave, Sioux Falls, SD 57105-4429

    $490,000
    Estimated value
    2,948 sqft 0.23 AC lot
    View details
    2301 Lorraine Pl
    DENTAL BUILDING

    2301 Lorraine Pl, Sioux Falls, SD 57106-3642

    $320,000
    Estimated value
    1.66 AC lot
    View details
    809 Belfast St
    MEDICAL BUILDING

    809 Belfast St, Yankton, SD 57078-3324

    $335,000
    Estimated value
    2,482 sqft 0.30 AC lot
    View details
    1700 Southeastern Ave
    DENTAL BUILDING

    1700 Southeastern Ave, Sioux Falls, SD 57103-3227

    $610,000
    Estimated value
    12,664 sqft 1.65 AC lot
    View details
    2001 Broadway Ave
    MEDICAL BUILDING

    2001 Broadway Ave, Yankton, SD 57078-2032

    $310,000
    Estimated value
    2,000 sqft 0.23 AC lot
    View details
    2300 Westlake Dr
    DENTAL BUILDING

    2300 Westlake Dr, Sioux Falls, SD 57106-8527

    $455,000
    Estimated value
    10,612 sqft 1.05 AC lot
    View details
    3805 Kiwanis Cir
    MEDICAL BUILDING

    3805 Kiwanis Cir, Sioux Falls, SD 57105-4266

    $995,000
    Estimated value
    4,686 sqft 0.69 AC lot
    View details
    1710 Southeastern Ave
    DENTAL BUILDING

    1710 Southeastern Ave, Sioux Falls, SD 57103-3381

    $885,000
    Estimated value
    3,929 sqft 0.45 AC lot
    View details
    920 Broadway Ave
    MEDICAL BUILDING

    920 Broadway Ave, Yankton, SD 57078-3532

    $1,125,000
    Estimated value
    25,256 sqft 1.09 AC lot
    View details
    2521 Western Ave
    DENTAL BUILDING

    2521 Western Ave, Sioux Falls, SD 57105-3430

    $290,000
    Estimated value
    2,146 sqft 0.14 AC lot
    View details
    4001 Southeastern Ave
    DENTAL BUILDING

    4001 Southeastern Ave, Sioux Falls, SD 57103-5305

    $280,000
    Estimated value
    3,236 sqft 0.54 AC lot
    View details
    Sioux Falls, SD 57106
    DENTAL BUILDING

    Sioux Falls, SD 57106

    $205,000
    Estimated value
    8.27 AC lot
    View details
    2701 Fox Run Pkwy
    DENTAL BUILDING

    2701 Fox Run Pkwy, Yankton, SD 57078-5350

    $355,000
    Estimated value
    3,016 sqft 0.50 AC lot
    View details
    811 Belfast St
    DENTAL BUILDING

    811 Belfast St, Yankton, SD 57078-3324

    $290,000
    Estimated value
    1,868 sqft 0.30 AC lot
    View details

    South Dakota Medical Office Space Market Trends and Statistics

    Explore 72 medical office space for sale in South Dakota, showcased through 8 active listings on our real estate platform. These investment opportunities span a total of 66,504 square feet of properties for sale, with an estimated market value of $3,250,279.

    Sale prices for medical spaces in South Dakota start at $999,900, averaging $1,625,139, and reaching up to $2,250,379 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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