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    Sioux Falls, SD Medical Office Space for Sale

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    Tea, SD Harrisburg, SD Renner, SD
    Sioux Falls Adaptable Commercial Building
    $2,250,379
    49,424 SF
    Sioux Falls Adaptable Commercial Building

    4800 N 4th Ave, Sioux Falls, SD 57104

    49,424 SF vacant building suitable for daycare, medical, or office.
    • Large Vacant Space: 49,424 SF
    • Suitable for Daycare, Medical, or Office Use
    • Ample Parking: 104 Spaces
    • Sprinkler System: Wet
    • Dock Door: 1
    Updated: Jan 27
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    Sioux Falls Medical Office
    $1,400,000
    6,858 SF
    Sioux Falls Medical Office

    208 W 37th St, Sioux Falls, SD

    Medical office building with exam rooms and updated infrastructure.
    • Large main level (4,743 SF) with 11 exam rooms suitable for medical practice.
    • New parking lot (2023).
    • Lower level (1,349 SF) with locker room, restroom with shower, meeting room, laundry and storage.
    • X‑ray room.
    • Two private offices.
    Updated: Mar 21, 2025
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    Sioux Falls Office/Medical Building
    $1,980,000
    9,288 SF
    Sioux Falls Office/Medical Building

    Office/medical building with flexible space and ample parking.

    4904-4912 S Minnesota Ave, Sioux Falls, SD

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    Based on your search, we've compiled 80 Potential Opportunities for your consideration. Besides 3 Active listings in Sioux Falls, SD, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 69 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Dakota Dunes Office Condo
    $450,000
    2,800 SF
    Dakota Dunes Office Condo

    2,800 SF office condo in Dakota Dunes, South Dakota.

    383 W Steamboat Dr, Ste 201, Dakota Dunes, SD 57049

    View details
    Professional Building with Exam Rooms
    Contact for pricing
    1,994 SF
    Professional Building with Exam Rooms

    Professional building featuring multiple exam rooms and office spaces.

    2912 Hamilton Blvd 103, Sioux City, IA 51104

    View details
    Downtown Office Space Available
    Contact for pricing
    13,723 SF
    Downtown Office Space Available

    Centrally located office space with parking and modern amenities.

    700 4th Street, Sioux City, IA, Sioux City, IA 51101

    View details
    Dakota Dunes Office Condo
    $395,000
    2,800 SF
    Dakota Dunes Office Condo

    2,800 SF office condo, currently a dental office.

    383 W Steamboat Dr, Dakota Dunes, SD 57049

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Commercial Lot in Growing Tea
    $220,000
    0.68 Acres
    Commercial Lot in Growing Tea

    High-visibility commercial lot in a high-growth Sioux Falls metro area.

    500 N Heritage Pkwy, Tea, SD 57064

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    Mankato Commercial Land For Sale
    $165,000
    1.08 Acres
    Mankato Commercial Land For Sale

    Accessible 1.08-acre lot suitable for various business types.

    1763 Bassett Drive, Mankato, MN 56001

    View details
    Commercial Lot in Medical Area
    $277,000
    1.06 Acres
    Commercial Lot in Medical Area

    Prime commercial lot in St. Cloud's medical arts area.

    2030 Stearns Way, Saint Cloud, MN 56303

    View details
    Commercial Land in Nebraska City
    $295,000
    80,046 SF
    Commercial Land in Nebraska City

    1.84 acre commercial land suitable for various development projects.

    17-8-14 LOT C-2 ARBOR VILLAGE ADDITION, Nebraska City, NE 68410

    View details

    Off-Market Properties in Sioux Falls, SD

    Consider similar Off-Market properties in Sioux Falls, SD. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    6301 41st St

    6301 41st St

    MEDICAL BUILDING • 3,108 SF
    Value Estimation
    $2,000,000
    6301 41st St, Sioux Falls, SD 57106-1217
    View details
    101 37th St

    101 37th St

    DENTAL BUILDING • 11,259 SF
    Value Estimation by Request
    101 37th St, Sioux Falls, SD 57105-5701
    View details
    2600 Western Ave

    2600 Western Ave

    DENTAL BUILDING • 2,948 SF
    Value Estimation by Request
    2600 Western Ave, Sioux Falls, SD 57105-4429
    View details
    2301 Lorraine Pl

    2301 Lorraine Pl

    DENTAL BUILDING • 1.66 Acres
    Value Estimation by Request
    2301 Lorraine Pl, Sioux Falls, SD 57106-3642
    View details
    1700 Southeastern Ave

    1700 Southeastern Ave

    DENTAL BUILDING • 12,664 SF
    Value Estimation
    $610,000
    1700 Southeastern Ave, Sioux Falls, SD 57103-3227
    View details
    2300 Westlake Dr

    2300 Westlake Dr

    DENTAL BUILDING • 10,612 SF
    Value Estimation by Request
    2300 Westlake Dr, Sioux Falls, SD 57106-8527
    View details
    3805 Kiwanis Cir

    3805 Kiwanis Cir

    MEDICAL BUILDING • 4,686 SF
    Value Estimation
    $900,000
    3805 Kiwanis Cir, Sioux Falls, SD 57105-4266
    View details
    1710 Southeastern Ave

    1710 Southeastern Ave

    DENTAL BUILDING • 3,929 SF
    Value Estimation
    $800,000
    1710 Southeastern Ave, Sioux Falls, SD 57103-3381
    View details
    2521 Western Ave

    2521 Western Ave

    DENTAL BUILDING • 2,146 SF
    Value Estimation by Request
    2521 Western Ave, Sioux Falls, SD 57105-3430
    View details
    4001 Southeastern Ave

    4001 Southeastern Ave

    DENTAL BUILDING • 3,236 SF
    Value Estimation by Request
    4001 Southeastern Ave, Sioux Falls, SD 57103-5305
    View details
    Sioux Falls, SD 57106

    Sioux Falls, SD 57106

    DENTAL BUILDING • 8.27 Acres
    Value Estimation by Request
    Sioux Falls, SD 57106
    View details
    4601 Homefield Dr

    4601 Homefield Dr

    DENTAL BUILDING • 13,064 SF
    Value Estimation
    $640,000
    4601 Homefield Dr, Sioux Falls, SD 57106-3506
    View details
    3401 Kelley Ave

    3401 Kelley Ave

    MEDICAL BUILDING • 4,376 SF
    Value Estimation by Request
    3401 Kelley Ave, Sioux Falls, SD 57106-6300
    View details
    518 Sycamore Ave

    518 Sycamore Ave

    DENTAL BUILDING • 2,500 SF
    Value Estimation by Request
    518 Sycamore Ave, Sioux Falls, SD 57110-5737
    View details
    2100 Marion Rd

    2100 Marion Rd

    MEDICAL BUILDING • 86,566 SF
    Value Estimation
    $8,590,000
    2100 Marion Rd, Sioux Falls, SD 57106-3646
    View details
    3400 26th St

    3400 26th St

    DENTAL BUILDING • 3,135 SF
    Value Estimation by Request
    3400 26th St, Sioux Falls, SD 57103-4183
    View details
    229 39th St Ste, Unit 100

    229 39th St Ste, Unit 100

    MEDICAL BUILDING • 3,420 SF
    Value Estimation by Request
    229 39th St Ste, Sioux Falls, SD 57105-5700
    View details
    1711 10th St

    1711 10th St

    DENTAL BUILDING • 4,320 SF
    Value Estimation by Request
    1711 10th St, Sioux Falls, SD 57103-1805
    View details
    202 37th St

    202 37th St

    MEDICAL BUILDING • 3,600 SF
    Value Estimation by Request
    202 37th St, Sioux Falls, SD 57105
    View details
    911 20th St

    911 20th St

    MEDICAL BUILDING • 81,404 SF
    Value Estimation
    $2,905,000
    911 20th St, Sioux Falls, SD 57105-1042
    View details
    716 19th St

    716 19th St

    MEDICAL BUILDING • 11,390 SF
    Value Estimation
    $665,000
    716 19th St, Sioux Falls, SD 57105-0904
    View details

    Sioux Falls, SD Medical Office Space Investment Opportunities Market Analysis

    Explore 72 medical office space for sale in Sioux Falls, SD, showcased through 3 active listings on our real estate platform. These investment opportunities span a total of 65,570 square feet of properties for sale, with an estimated market value of $5,630,379.

    Sale prices for medical spaces in Sioux Falls, SD start at $1,400,000, averaging $1,876,793, and reaching up to $2,250,379 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Top Commercial Asset Segments

    Office Units 125
    Office buildings 29
    Medical Office Space 5
    Serviced offices 2
    Coworking space 1

    Property Size Breakdown

    The majority of commercial real estate listings in Sioux Falls fall within the 50,000 to 100,000 square foot range.

    Demographics Overview

    Population 204K
    Population Growth (5Y) +15.2%
    Median Household Income $77,935
    College Educated 16.5%

    High-Yield Neighborhoods for Strategic Investment

    Identify Sioux Falls submarkets with the highest inventory density on the market and evaluate the median listing prices of real estate assets

    Neighborhood Average Price
    57104 $2.3M

    Taxes & Financing

    Tax Rate (average for all types) 1.71%
    Property Tax per SF $30.71 per sq ft
    Tax Rate vs County Average 0.01 pp above county avg
    Average Loan-to-Value 65.0%

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