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    Columbia, SC
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    Columbia, SC Medical Office Space for Sale

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    12 properties
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    Renovated Office Building
    Updated: Dec 3, 2025
    Renovated Office Building

    8311 Two Notch Road, Columbia, SC 29223

    $850,000
    5,969 sqft
    5,969 SF fully renovated office building
    Multiple private entrances support multi‑tenant use or separated business functions
    Conference room with updated interior finishes
    Kitchen and break area included
    Substantial storage space for business operations
    View details
    Renovated Mixed-Use Property
    Updated: Apr 23
    Renovated Mixed-Use Property

    3201 Broad River Road, Columbia, SC 29210

    $250,000
    1,138 sqft 0.50 AC lot
    1,138‑square‑foot mixed‑use property renovated in 2014
    Two suites with medical spa, retail, reception, storage, and conference areas
    0.5‑acre site with approximately 75 feet of road frontage
    15 on‑site parking spaces and a roundabout driveway
    GC zoning with central air conditioning
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    Retail Space with Monument Signage
    Retail Space with Monument Signage

    9704 Two Notch Rd, Columbia, SC 29223

    $2,950,000
    1.78 AC lot

    The property combines restaurant space with a leased dental suite.

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    See hot listings in Columbia

    Scored against comparables nationwide. These are worth a look.

    Scored against comparables nationwide. These are worth a look.

    Cap Rate available after sign in
    Est. NOI available after sign in
    Local Demand available after sign in
    Medical Office Space with On-Site Parking
    Medical Office Space with On-Site Parking

    1701 Saint Julian Pl, Columbia, SC 29204

    Contact for pricing
    14,442 sqft

    Multiple suite configurations accommodate smaller private practices, with plumbing throughout for medical use.

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    Vacant Medical Office Space
    Vacant Medical Office Space

    100 Jimmy Love Ln, Columbia, SC 29212

    Contact for pricing
    9,668 sqft

    Existing clinical layout supports outpatient, administrative, and patient-facing operations.

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    Office Building with Courtyard
    Office Building with Courtyard

    2712 Middleburg Dr, Columbia, SC 29204

    Contact for pricing
    48,184 sqft 3.32 AC lot

    Partially occupied office property with vacant suites available for immediate upfit and occupancy.

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    Realmo Analytics Monitor Off-market properties and contact owners who are ready to sell. Many signals applied to make quality leads for you. Get Leads
    Renovated Two-Suite Office Units
    Renovated Two-Suite Office Units

    3201 Broad River Road, Columbia, SC 29210

    $250,000

    Flexible commercial layout with reception, private storage, two bathrooms, and ample on-site parking.

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    Four-Story Medical Office Building
    Four-Story Medical Office Building

    8 Medical Park Road, Columbia, SC 29203

    Contact for pricing

    Connected to Prisma Health Heart Hospital, the property is master-leased to Prisma Health-Midlands under a net lease.

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    Turnkey Dental Office For Sale
    Turnkey Dental Office For Sale

    741 Greenlawn Dr, Columbia, SC 29209

    Contact for pricing
    4,325 sqft

    Dental office for sale in Southeast Columbia near Garners Ferry.

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    Second-Floor Medical Office Suite, Suite 200
    Second-Floor Medical Office Suite, Suite 200

    2113 Adams Grove, Columbia, SC 29203

    Contact for pricing
    11,131 sqft

    Second-floor medical office suite with a large central waiting room and 8 exam rooms plus 2 procedure rooms.

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    Medical Office with Imaging Rooms
    Medical Office with Imaging Rooms

    74 Polo Rd, Columbia, SC 29223

    Contact for pricing
    9,975 sqft

    Specialized clinical layout includes diagnostic rooms, laboratory space, offices, and on-site parking.

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    Medical Office Condo For Sale
    Medical Office Condo For Sale

    2113 Adams Grove, Columbia, SC 29203

    Contact for pricing
    22,263 sqft

    Class A medical office condo available for sale or lease.

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    Based on your search, we've compiled 63 Potential Opportunities for your consideration. Besides 12 Active listings in Columbia, SC, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 45 Off-Market properties to explore as potential leads, plus 2 Land Listings that present a potential for development.

    Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    West Columbia Medical Office Opportunity
    West Columbia Medical Office Opportunity

    110 Medical Cir, West Columbia, SC 29169

    $4,000,000
    10,840 sqft

    Medical office building for sale in West Columbia, SC.

    View details
    Medical NNN Investment Opportunity
    Medical NNN Investment Opportunity

    125 Park Pl Ct, Lexington, SC 29072

    Contact for pricing
    4,715 sqft

    Single tenant medical property for sale in Lexington, SC.

    View details
    Two-Story Medical Office Building
    Two-Story Medical Office Building

    160 Medical Circle, West Columbia, SC 29169

    $1,400,000

    Multi-tenant office property with elevator service, ADA access, updated roof and HVAC systems, and separate tenant access points.

    View details
    GC-Zoned Commercial Land
    GC-Zoned Commercial Land

    101 Swartz Rd, Lexington, SC 29072

    Contact for pricing
    0.92 AC lot

    The site is identified for office, law firm, dental, or medical office uses.

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Office/Institutional Development Land
    Office/Institutional Development Land

    401 Arrowwood Road, Columbia, SC 29210

    $169,000
    1.61 AC lot

    OI-zoned site supports medical, professional office, educational, and community facility development with access to regional roadways.

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    Commercial Land with Utility Access
    Commercial Land with Utility Access

    2551 Augusta Highway lot: 0, Lexington, SC 29072

    $3,400,000
    9.06 AC lot

    ID-zoned tract with public water and multiple utilities serving the site.

    View details

    Off-Market Properties in Columbia, SC

    Consider similar Off-Market properties in Columbia, SC. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    200 Outlet Pointe Blvd
    MEDICAL BUILDING

    200 Outlet Pointe Blvd, Columbia, SC 29210-5667

    Estimated value:
    $385,000
    2,601 sqft 0.62 AC lot
    View details
    214 Outlet Pointe Blvd
    MEDICAL BUILDING

    214 Outlet Pointe Blvd, Columbia, SC 29210-5667

    Estimated value:
    $310,000
    2,614 sqft 0.30 AC lot
    View details
    23 Surrey Ct
    MEDICAL BUILDING

    23 Surrey Ct, Columbia, SC 29212-3139

    Estimated value:
    $415,000
    2,808 sqft 0.32 AC lot
    View details
    7037 Saint Andrews Rd
    MEDICAL BUILDING

    7037 Saint Andrews Rd, Columbia, SC 29212-1177

    Estimated value:
    $2,465,000
    8,197 sqft 0.42 AC lot
    View details
    2302 Bush Riv Rd
    MEDICAL BUILDING

    2302 Bush Riv Rd, Columbia, SC 29210-5649

    Estimated value:
    $365,000
    4,230 sqft 0.61 AC lot
    View details
    2617 Ashland Rd
    MEDICAL BUILDING

    2617 Ashland Rd, Columbia, SC 29210-5005

    Estimated value:
    $710,000
    3,268 sqft 1.44 AC lot
    View details
    7039 Saint Andrews Rd
    MEDICAL BUILDING

    7039 Saint Andrews Rd, Columbia, SC 29212-1177

    Estimated value:
    $795,000
    2,112 sqft 0.12 AC lot
    View details
    1526 Lk Murray Blvd
    MEDICAL CLINIC

    1526 Lk Murray Blvd, Columbia, SC 29212-8622

    Estimated value:
    $2,020,000
    12,584 sqft 1.50 AC lot
    View details
    100 Jimmy Love Ln
    MEDICAL BUILDING

    100 Jimmy Love Ln, Columbia, SC 29212-3159

    Estimated value:
    $3,260,000
    7,692 sqft 1.05 AC lot
    View details
    7035 Saint Andrews Rd
    MEDICAL CLINIC

    7035 Saint Andrews Rd, Columbia, SC 29212-1177

    Estimated value:
    $190,000
    1.12 AC lot
    View details
    7041 Saint Andrews Rd
    MEDICAL CLINIC

    7041 Saint Andrews Rd, Columbia, SC 29212-1177

    Estimated value:
    $100,000
    5.74 AC lot
    View details
    7037 Saint Andrews Rd
    MEDICAL CLINIC

    7037 Saint Andrews Rd, Columbia, SC 29212-1177

    Estimated value:
    $205,000
    0.55 AC lot
    View details

    Columbia, SC Medical Office Space Market Trends and Statistics

    Explore 57 medical office space for sale in Columbia, SC, showcased through 12 active listings on our real estate platform. These investment opportunities span a total of 127,095 square feet of properties for sale, with an estimated market value of $4,300,000.

    Sale prices for medical spaces in Columbia, SC start at $250,000, averaging $1,075,000, and reaching up to $2,950,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Top Commercial Asset Segments

    Commercial property segments ranked by active listings on the market

    Office Units 140
    Office buildings 112
    Medical Office Space 52
    Coworking space 4
    Creative space 2

    Demographics Overview

    Population 346K
    Population Growth (5Y) +1.3%
    Median Household Income $58,909
    College Educated 20.7%

    High-Yield Neighborhoods for Investment

    Identify Columbia submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

    Neighborhood Average Price
    29210 $250K
    29223 $1.9M

    Taxes & Financing

    Average Loan-to-Value 65.0%

    Listings Trend

    New vs delisted commercial listings in Richland County

    New Delisted

    Property Size Breakdown

    The majority of commercial real estate listings in Columbia fall within the 100,000+ square foot range.

    How Realmo verifies these figures

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    Most Searched ZIP Codes in Columbia, SC

    • 29203
    • 29223
    • 29204
    • 29210
    • 29209
    • 29212
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