Durham, NC Medical Office Space for Sale

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Raleigh, NC Morrisville, NC Chapel Hill, NC Cary, NC Hillsborough, NC Bahama, NC Creedmoor, NC Wake Forest, NC

Updated: Apr 30, 2025

Road-Front Office Live-Work Unit

3219 Guess Road Unit 3219, Durham, NC 27705

$750,000

1,600 sqft 0.50 AC lot

Office unit on a half‑acre lot with road frontage on busy Guess Road in Durham
Convenient access to Hwy 85, Duke, RTP, and major shopping centers
Central air conditioning
Heating: 3 (type not specified)
35x20 lot dimensions with asphalt and a clear lot

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This listing looks promising.

Here's a quick look at some key insights for

3219 Guess Road Unit 3219, Durham, NC 27705

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Est. Cap Rate

3.3%
NOI ÷ price
Est. NOI

$25K
Annual
Price @ 7% Cap

$353K
Suggested
Property Type

Single Family Residence
Built 1937

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Updated: Jun 19

Two-Story Office Building

3621 Lyckan Parkway, Durham, NC 27707

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12,000 sqft

12,000 SF, two‑story office building in Durham, North Carolina (Year built: 2004).
Offered in partial shell condition with key infrastructure already in place for interior build‑outs.
Interior can be customized for office or medical uses, including medical conversion suitability.
Supports a range of professional uses such as primary care, specialty medical, dental, and professional service firms.
Ample parking and layout intended for medical conversion.

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Medical Office & Wellness Center

3017 Pickett Rd, Durham, NC 27705

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25,317 sqft

Medical office and wellness center in high-traffic Durham location.

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Durham Office Near Highway 85

3219 Guess, Durham, NC 27705

$750,000

1,600 sqft

Office property close to Highway 85, Duke, and RTP.

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Turn a Listing Into an Investment Snapshot Cap Rate, Potential NOI, Demand score for every listing. Go To Analytics Center

Two-Story Standalone Office Condo

2741 Campus Walk Ave, Durham, NC 27705

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3,652 sqft

Brand-new cold dark shell office condo with ample natural light and space up to 1,826 SF per floor.

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Based on your search, we've compiled 21 Potential Opportunities for your consideration. Besides 5 Active listings in Durham, NC, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 8 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

Opportunities in Nearby Cities

Here are 4 Similar properties we found in Nearby Locations for your consideration.

Cary Lab Condo For Sale

100 Parkway Office Court, Cary, NC 27518

$1,900,000

4,800 sqft

4,800 SF lab condo in Parkway Professional Park.

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Medical Office Condo Suite

5623 Duraleigh Rd, Raleigh, NC 27612

Contact for pricing

1,200 sqft

Medical/office condo with lobby, reception, kitchenette, multiple exam/offices, storage, tech closet, and restroom.

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Medical Office Suite with New HVAC

5640 Six Forks Rd., Raleigh, NC 27609

Contact for pricing

1,200 sqft

Office suite with three offices, breakroom with kitchen, ADA bathroom, and a new HVAC system with a 10-year warranty.

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Class A Medical Office Development

115 Kildaire Park Dr., Cary, NC 27518

Contact for pricing

87,000 sqft

Medical office development near WakeMed Cary Hospital.

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Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Commercial Land Zoned Highway Business

1495 Concord Church Road, Creedmoor, NC 27522

$369,900

1.05 AC lot

1.0462-acre vacant lot with HB zoning, public utilities, and about 275 feet of road frontage on E. Lyon Station Road.

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High Growth Area Land Opportunity

1200 Granite Falls, Rolesville, NC 27587

$1,390,000

Land suitable for medical offices, daycare, senior living, multi-family.

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Office & Institutional Zoning Lot

College Street, Oxford, NC 27565

$150,000

0.65 AC lot

Cleared commercial lot with O&I zoning and 95 feet of road frontage on College St (Hwy 15).

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Corner Commercial Land

629 W Academy Street, Fuquay Varina NC 27526, Fuquay Varina, NC 27526

$950,000

1.44 AC lot

1.44-acre corner site zoned NC-CZD with all utilities on-site, positioned at Judd Parkway and NC Hwy 42.

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Off-Market Properties in Durham, NC

Consider similar Off-Market properties in Durham, NC. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

Medical Office Space

3026 Old Chapel Hill Rd, Durham, NC 27707

Value Estimation by Request

3,935 sqft

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Medical Office Space

5306-102 Hwy, Durham, NC 27713

Value Estimation by Request

2,028 sqft

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Medical Office Space

249 Nc Hwy 54- –, Durham, NC 27713

Value Estimation by Request

8,986 sqft

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Medical Office Space

249 Nc Highway 54, Durham, NC 27713

Value Estimation by Request

3,037 sqft

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Medical Office Space

4210 Roxboro St, Durham, NC 27704

Value Estimation by Request

2,408 sqft

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Medical Office Space

1804 Martin Luther King Jr Pkwy, Durham, NC 27707

Value Estimation by Request

9,992 sqft 2.53 AC lot

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Medical Office Space

4210 Roxboro St, Durham, NC 27704

Value Estimation by Request

2,408 sqft

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Medical Office Space

249 Nc Highway 54, Durham, NC 27713

Value Estimation by Request

3,037 sqft

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Durham, NC Medical Office Space Market Trends and Statistics

Explore 13 medical office space for sale in Durham, NC, showcased through 5 active listings on our real estate platform. These investment opportunities span a total of 44,169 square feet of properties for sale, with an estimated market value of $1,500,000.

Sale prices for medical spaces in Durham, NC average $750,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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Top Commercial Asset Segments

Commercial property segments ranked by active listings on the market

Demographics Overview

Population 314K

Population Growth (5Y) +7.7%

Median Household Income $79,426

College Educated 39.8%

High-Yield Neighborhoods for Investment

Identify Durham submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

Neighborhood	Average Price
27705	$750K
27707	$1.7M
27704	$2.5M

Taxes & Financing

Tax Rate (average for all types) 1.31%

Property Tax per SF $16.56 per SF

Tax Rate vs County Average 0.03 pp below county avg

Average Loan-to-Value 65.0%

Listings Trend

New vs delisted commercial listings in Durham County

New Delisted

Total CRE Inventory on Market (SF)

Property Size Breakdown

The majority of commercial real estate listings in Durham fall within the 50,000 to 100,000 square foot range.

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