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    Durham, NC Medical Office Space for Sale

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    Raleigh, NC Chapel Hill, NC Morrisville, NC
    Colonial Square Office/Medical Building
    $3,499,000
    21,532 SF
    Colonial Square Office/Medical Building

    4400 Ben Franklin Boulevard, Durham, NC 27704

    Multi-functional commercial building in Durham's Independence Park.
    • Significant income generation from leased area: $227,739 in 2024.
    • Large, multi‑functional commercial building with 21,532 total square feet.
    • Located in a sought‑after office/medical park in northern Durham County.
    • Flexible space suitable for various professional uses (medical, office, education, law).
    • Features include an elevator, ample storage, and a loading dock.
    Updated: Aug 7, 2025
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    Medical Office & Wellness Center
    Contact for pricing
    25,317 SF
    Medical Office & Wellness Center

    3017 Pickett Rd, Durham, NC 27705

    Medical office and wellness center in high-traffic Durham location.
    • Rare medical office building with attached fitness/medspa.
    • Prime re‑positioning opportunity for sale or lease.
    • Located in a high‑traffic area (approx. 4,200 vehicles daily).
    • Recently vacated, ready for immediate occupancy/renovation.
    • Versatile spaces suitable for a variety of medical and wellness services.
    Updated: Mar 13
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    Durham Office Near Highway 85
    $750,000
    1,600 SF
    Durham Office Near Highway 85

    Office property close to Highway 85, Duke, and RTP.

    3219 Guess, Durham, NC 27705

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    Renovated Medical Office Condos
    Contact for pricing
    41,588 SF
    Renovated Medical Office Condos

    Newly renovated medical office condos for sale in Durham, NC.

    4020 N Roxboro St, Durham, NC 27704

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    Based on your search, we've compiled 20 Potential Opportunities for your consideration. Besides 4 Active listings in Durham, NC, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 8 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Second-Generation Medical Space Available
    Contact for pricing
    185,637 SF
    Second-Generation Medical Space Available

    Hard-to-find medical space with significant economic advantages in a dynamic community.

    8300 Health Park, Raleigh, NC 27615

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    Chapel Hill Freestanding Building
    $3,200,000
    9,800 SF
    Chapel Hill Freestanding Building

    Two-story building on 0.66 acres in established commercial corridor.

    110 S Estes Dr, Chapel Hill, NC 27514

    View details
    Eastowne Office Condo For Sale
    $325,000
    1,453 SF
    Eastowne Office Condo For Sale

    Office condo in Eastowne, currently occupied by a medical practice.

    150 Providence Rd, Suite 102, Chapel Hill, NC 27514

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    Medical Office Space Available
    Contact for pricing
    25,000 SF
    Medical Office Space Available

    Move-in-ready medical office space in Brier Creek area.

    8851 Ellstree Lane, Raleigh, NC 27617

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    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Cary Parkway Land For Sale
    $1,375,000
    2.29 Acres
    Cary Parkway Land For Sale

    Land available along SW Cary Parkway suitable for various commercial uses.

    1016 Kilarney Ridge Loop, Cary, NC 27511

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    Jones Dairy Road Land Parcel
    Contact for pricing
    Jones Dairy Road Land Parcel

    Land approved for 49,000 SF medical development.

    416 Jones Dairy Road, Wake Forest, NC 27587

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    High Growth Area Land Opportunity
    $1,390,000
    High Growth Area Land Opportunity

    Land suitable for medical offices, daycare, senior living, multi-family.

    1200 Granite Falls, Rolesville, NC 27587

    View details
    Cleared Commercial Lots in Oxford
    $100,000
    0.51 Acres
    Cleared Commercial Lots in Oxford

    Two commercial lots in downtown Oxford, suitable for various businesses.

    209 Broad Street, Oxford, NC 27565

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    Off-Market Properties in Durham, NC

    Consider similar Off-Market properties in Durham, NC. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    3026 Old Chapel Hill Rd

    3026 Old Chapel Hill Rd

    Medical Office Space • 3,935 SF
    Value Estimation by Request
    3026 Old Chapel Hill Rd, Durham, NC 27707
    View details
    5306-102 Hwy

    5306-102 Hwy

    Medical Office Space • 2,028 SF
    Value Estimation by Request
    5306-102 Hwy, Durham, NC 27713
    View details
    249 Nc Hwy 54- –

    249 Nc Hwy 54- –

    Medical Office Space • 8,986 SF
    Value Estimation by Request
    249 Nc Hwy 54- –, Durham, NC 27713
    View details
    249 Nc Highway 54

    249 Nc Highway 54

    Medical Office Space • 3,037 SF
    Value Estimation by Request
    249 Nc Highway 54, Durham, NC 27713
    View details
    4210 Roxboro St

    4210 Roxboro St

    Medical Office Space • 2,408 SF
    Value Estimation by Request
    4210 Roxboro St, Durham, NC 27704
    View details
    1804 Martin Luther King Jr Pkwy

    1804 Martin Luther King Jr Pkwy

    Medical Office Space • 9,992 SF
    Value Estimation by Request
    1804 Martin Luther King Jr Pkwy, Durham, NC 27707
    View details
    4210 Roxboro St

    4210 Roxboro St

    Medical Office Space • 2,408 SF
    Value Estimation by Request
    4210 Roxboro St, Durham, NC 27704
    View details
    249 Nc Highway 54

    249 Nc Highway 54

    Medical Office Space • 3,037 SF
    Value Estimation by Request
    249 Nc Highway 54, Durham, NC 27713
    View details

    Durham, NC Medical Office Space Investment Opportunities Market Analysis

    Explore 12 medical office space for sale in Durham, NC, showcased through 4 active listings on our real estate platform. These investment opportunities span a total of 23,132 square feet of properties for sale, with an estimated market value of $4,249,000.

    Sale prices for medical spaces in Durham, NC start at $750,000, averaging $2,124,500, and reaching up to $3,499,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Top Commercial Asset Segments

    Office Units 57
    Office buildings 32
    Medical Office Space 15
    Coworking space 7
    Creative space 2

    Property Size Breakdown

    The majority of commercial real estate listings in Durham fall within the 50,000 to 100,000 square foot range.

    Demographics Overview

    Population 314K
    Population Growth (5Y) +7.7%
    Median Household Income $79,426
    College Educated 39.8%

    High-Yield Neighborhoods for Strategic Investment

    Identify Durham submarkets with the highest inventory density on the market and evaluate the median listing prices of real estate assets

    Neighborhood Average Price
    27705 $544.5K
    27704 $3.5M

    Taxes & Financing

    Tax Rate (average for all types) 1.31%
    Property Tax per SF $16.56 per sq ft
    Tax Rate vs County Average 0.03 pp below county avg
    Average Loan-to-Value 65.0%

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