Durham, NC Medical Office Space for Sale

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Raleigh, NC Chapel Hill, NC Morrisville, NC

6 properties

Updated: Aug 7, 2025

Colonial Square Office/Medical Building

4400 Ben Franklin Boulevard, Durham, NC 27704

$3,499,000

21,532 sqft · 2.10 AC lot

Significant income generation from leased area: $227,739 in 2024.
Large, multi‑functional commercial building with 21,532 total square feet.
Located in a sought‑after office/medical park in northern Durham County.
Flexible space suitable for various professional uses (medical, office, education, law).
Features include an elevator, ample storage, and a loading dock.

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Updated: Jun 25

Renovated Mixed-Use Restaurant and Offices

2022 Chapel Hill Rd., Durham, NC 27707

$1,700,000

Historic Davis Baking Company building, completely renovated in 2017 into a mixed‑use property
Full‑service restaurant space with a huge kitchen, plus additional cafe space
Rooftop dining patio connected to the dining room via stairs
Second‑floor office space included, with an additional ±1,000 SF unit used as a salon and chiropractic office
Layout could be divided into two separate restaurant concepts with shared large kitchen

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Two-Story Office and Medical Building

4400 Ben Franklin Boulevard, Durham, NC 27704

$3,499,000

21,532 sqft

Flexible office and medical facility with elevator, ample storage, and a loading dock, including existing leased area.

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Two-Story Office Building

3621 Lyckan Parkway, Durham, NC 27707

Contact for pricing

12,000 sqft

Two-story, partial-shell office building with infrastructure in place for customized office or medical build-outs.

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Durham Office Near Highway 85

3219 Guess, Durham, NC 27705

$750,000

1,600 sqft

Office property close to Highway 85, Duke, and RTP.

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Medical Office & Wellness Center

3017 Pickett Rd, Durham, NC 27705

Contact for pricing

25,317 sqft

Medical office and wellness center in high-traffic Durham location.

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Based on your search, we've compiled 22 Potential Opportunities for your consideration. Besides 6 Active listings in Durham, NC, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 8 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

Opportunities in Nearby Cities

Here are 4 Similar properties we found in Nearby Locations for your consideration.

Chapel Hill Freestanding Building

110 S Estes Dr, Chapel Hill, NC 27514

$3,200,000

9,800 sqft

Two-story building on 0.66 acres in established commercial corridor.

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Second-Generation Medical Space Available

8300 Health Park, Raleigh, NC 27615

Contact for pricing

185,637 sqft

Hard-to-find medical space with significant economic advantages in a dynamic community.

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Eastowne Office Condo For Sale

150 Providence Rd, Suite 102, Chapel Hill, NC 27514

$325,000

1,453 sqft

Office condo in Eastowne, currently occupied by a medical practice.

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Medical Office Space Available

8851 Ellstree Lane, Raleigh, NC 27617

Contact for pricing

25,000 sqft

Move-in-ready medical office space in Brier Creek area.

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Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Creedmoor Land Near I-85

1495 Concord Church Road, Creedmoor, NC 27522

$369,900

1.05 AC lot

1.0462 acre commercial lot near I-85 in Creedmoor, NC.

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Jones Dairy Road Land Parcel

416 Jones Dairy Road, Wake Forest, NC 27587

Contact for pricing

Land approved for 49,000 SF medical development.

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High Growth Area Land Opportunity

1200 Granite Falls, Rolesville, NC 27587

$1,390,000

Land suitable for medical offices, daycare, senior living, multi-family.

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Commercial Lot in Oxford, NC

College Street, Oxford, NC 27565

$150,000

0.65 AC lot

Commercial lot near Granville Medical Center, ready to build.

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Off-Market Properties in Durham, NC

Consider similar Off-Market properties in Durham, NC. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

Medical Office Space

3026 Old Chapel Hill Rd, Durham, NC 27707

Value Estimation by Request

3,935 sqft

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Medical Office Space

5306-102 Hwy, Durham, NC 27713

Value Estimation by Request

2,028 sqft

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Medical Office Space

249 Nc Hwy 54- –, Durham, NC 27713

Value Estimation by Request

8,986 sqft

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Medical Office Space

249 Nc Highway 54, Durham, NC 27713

Value Estimation by Request

3,037 sqft

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Medical Office Space

4210 Roxboro St, Durham, NC 27704

Value Estimation by Request

2,408 sqft

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Medical Office Space

1804 Martin Luther King Jr Pkwy, Durham, NC 27707

Value Estimation by Request

9,992 sqft · 2.53 AC lot

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Medical Office Space

4210 Roxboro St, Durham, NC 27704

Value Estimation by Request

2,408 sqft

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Medical Office Space

249 Nc Highway 54, Durham, NC 27713

Value Estimation by Request

3,037 sqft

View details

Durham, NC Medical Office Space Market Trends and Statistics

Explore 14 medical office space for sale in Durham, NC, showcased through 6 active listings on our real estate platform. These investment opportunities span a total of 44,664 square feet of properties for sale, with an estimated market value of $7,748,000.

Sale prices for medical spaces in Durham, NC start at $750,000, averaging $2,582,666, and reaching up to $3,499,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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Top Commercial Asset Segments

Commercial property segments ranked by active listings on the market

Demographics Overview

Population 314K

Population Growth (5Y) +7.7%

Median Household Income $79,426

College Educated 39.8%

High-Yield Neighborhoods for Investment

Identify Durham submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

Neighborhood	Average Price
27705	$750K
27707	$1.7M
27704	$3.5M

Taxes & Financing

Tax Rate (average for all types) 1.31%

Property Tax per SF $16.56 per SF

Tax Rate vs County Average 0.03 pp below county avg

Average Loan-to-Value 65.0%

Listings Trend

New vs delisted commercial listings in Durham County

New Delisted

Total CRE Inventory on Market (SF)

Property Size Breakdown

The majority of commercial real estate listings in Durham fall within the 50,000 to 100,000 square foot range.

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