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    Columbia County, FL Medical Office Space for Sale

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    Main Boulevard Office Building
    $395,000
    1,823 SF

    Main Boulevard Office Building

    229 SW Main Blvd, Lake City, FL 32025

    Class B office building on a corner lot for sale.

    • High‑visibility location on Main Boulevard with 13,000\u00b1 daily traffic count.
    • Includes a second building suitable for commercial use, lease, or residential conversion.
    • Ample parking and two access points on a corner lot.
    • Features a radio tower, offering potential additional income or utility.
    • Secure basement for file storage and utilities.
    Updated: Jan 27
    View details
    Lake City Professional Office
    $295,000
    1,208 SF

    Lake City Professional Office

    1166 SW Main Blvd, Lake City, FL 32025

    Commercial office building with reception, exam rooms, and bathroom.

    • Great location on Main Blvd.
    • Previously used as a dental office, suitable for similar practices.
    • Includes 4 exam rooms/offices.
    • Reception/lobby area with front desk and window.
    • Brick construction.
    Updated: Dec 22, 2025
    View details
    Based on your search, we've compiled 77 Potential Opportunities for your consideration. Besides 2 Active listings in Columbia County, FL, we suggest exploring several alternatives: similar 75 Off-Market properties to explore as potential leads

    Explore Off-Market Properties in Columbia County, FL

    Consider similar Off-Market properties in Columbia County, FL. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    782 Sisters Welcome Rd

    782 Sisters Welcome Rd

    MEDICAL BUILDING • 4,294 SF
    Value Estimation by Request
    782 Sisters Welcome Rd, Lake City, FL 32025-0442
    View details
    879 Main Blvd

    879 Main Blvd

    Individual retail properties
    Value Estimation by Request
    879 Main Blvd, Lake City, FL 32025
    View details
    4601 Us Hwy 90

    4601 Us Hwy 90

    MEDICAL BUILDING • 5,680 SF
    Value Estimation by Request
    4601 Us Hwy 90, Lake City, FL 32055-4880
    View details
    215 Prosperity Pl

    215 Prosperity Pl

    MEDICAL BUILDING • 4,620 SF
    Value Estimation by Request
    215 Prosperity Pl, Lake City, FL 32024-0699
    View details
    155 Enterprise Way

    155 Enterprise Way

    MEDICAL BUILDING • 4,780 SF
    Value Estimation by Request
    155 Enterprise Way, Lake City, FL 32055-8837
    View details
    256 Professional Gln

    256 Professional Gln

    MEDICAL BUILDING • 8,895 SF
    Value Estimation
    $2,230,000
    256 Professional Gln, Lake City, FL 32025-1104
    View details
    2970 Us Hwy 90

    2970 Us Hwy 90

    MEDICAL BUILDING • 7,381 SF
    Value Estimation
    $570,000
    2970 Us Hwy 90, Lake City, FL 32055-4700
    View details
    1615 Main Blvd

    1615 Main Blvd

    MEDICAL BUILDING • 10,939 SF
    Value Estimation
    $670,000
    1615 Main Blvd, Lake City, FL 32025-1108
    View details
    215 Prosperity Pl

    215 Prosperity Pl

    MEDICAL BUILDING • 2,760 SF
    Value Estimation by Request
    215 Prosperity Pl, Lake City, FL 32024-0699
    View details
    4241 American Ln

    4241 American Ln

    MEDICAL BUILDING • 5,566 SF
    Value Estimation
    $545,000
    4241 American Ln, Lake City, FL 32055-4881
    View details
    1840 Barnett Way

    1840 Barnett Way

    MEDICAL BUILDING • 5,051 SF
    Value Estimation by Request
    1840 Barnett Way, Lake City, FL 32025
    View details
    272 Bentley Pl

    272 Bentley Pl

    MEDICAL BUILDING • 6,960 SF
    Value Estimation
    $810,000
    272 Bentley Pl, Lake City, FL 32025-6972
    View details
    777 Duval St

    777 Duval St

    MEDICAL BUILDING • 2,760 SF
    Value Estimation by Request
    777 Duval St, Lake City, FL 32055-5806
    View details
    263 Professional Gln

    263 Professional Gln

    MEDICAL BUILDING • 2,420 SF
    Value Estimation by Request
    263 Professional Gln, Lake City, FL 32025-1105
    View details
    733 State Rd 47

    733 State Rd 47

    MEDICAL BUILDING • 5,836 SF
    Value Estimation by Request
    733 State Rd 47, Lake City, FL 32025-0453
    View details
    351 Franklin St

    351 Franklin St

    MEDICAL BUILDING • 9,324 SF
    Value Estimation by Request
    351 Franklin St, Lake City, FL 32055-3000
    View details
    1166 Main Blvd

    1166 Main Blvd

    MEDICAL BUILDING • 1,350 SF
    Value Estimation by Request
    1166 Main Blvd, Lake City, FL 32025-5780
    View details
    2941 Us Highway 90

    2941 Us Highway 90

    Medical Office Space
    Value Estimation by Request
    2941 Us Highway 90, Lake City, FL 32025
    View details
    208 Prosperity Pl

    208 Prosperity Pl

    MEDICAL BUILDING • 7,445 SF
    Value Estimation
    $590,000
    208 Prosperity Pl, Lake City, FL 32024-0684
    View details
    763 Main Blvd

    763 Main Blvd

    MEDICAL BUILDING • 8,612 SF
    Value Estimation
    $875,000
    763 Main Blvd, Lake City, FL 32025-5791
    View details
    1740 Us Hwy 90

    1740 Us Hwy 90

    MEDICAL BUILDING • 2,835 SF
    Value Estimation by Request
    1740 Us Hwy 90, Lake City, FL 32055-4718
    View details
    165 Vision Gln

    165 Vision Gln

    MEDICAL BUILDING • 7,188 SF
    Value Estimation by Request
    165 Vision Gln, Lake City, FL 32025-1111
    View details

    Columbia County, FL Medical Office Space Investment Opportunities Market Analysis

    Explore 77 medical office space for sale in Columbia County, FL on our real estate platform. These investment opportunities span a total of 2,382,588 square feet of properties for sale, with an estimated market value of $37,085,000.

    Sale prices for medical spaces in Columbia County, FL start at $50,000, averaging $607,950, and reaching up to $9,290,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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