Add Listing
    Durham, NC
    For Lease
    • For Sale
    • For Lease
    • Recently Sold
    • Property Lookup
    • Brokers
    Space Uses
    • Retail
    • Restaurant
    • Office
    • Coworking
    • Medical Space
    • Automotive
    • Industrial
    • Warehouse
    • Flex
    • Hospitality
    • Sports & Entertainment
    • Specialty
    Rent
    Rent
    $
    $
    Size
    Property Size / SF

    Durham, NC Office Units for Lease

    Notify Me
    List
    Map
    Chapel Hill, NC Raleigh, NC Cary, NC
    35 results
    Flexible Office Suite on Highway 54
    $45,045 SF/Yr
    2,145 SF
    Flexible Office Suite on Highway 54

    1906 Carolina 54, Durham, NC 27713

    First-floor office suite with eight private offices, updated interiors, and ample parking on a high-traffic corridor.
    • First‑floor office space fronting Hwy 54 with eight private offices, conference/work areas, and a kitchenette
    • New interior updates include paint, flooring, ceiling tiles, and LED lighting, plus updated lavatories
    • Can be easily divided into two smaller spaces (call for details)
    • Ample off‑street parking with a freshly paved and striped parking lot
    • Central heating and central air; shingle roof
    Updated: Nov 10, 2025
    View details
    Professional Office Condos For Lease
    $2,400/Mo
    5,120 SF
    Professional Office Condos For Lease

    2741 Campus Walk Ave, Building 400, Durham, NC 27705

    Office condos for lease near Duke University Medical Center.
    • Prime location minutes from Duke University Medical Center, VA Hospital, and downtown Durham.
    • Easy access to Durham Freeway, 15‑501, Interstate‑85, and Erwin Road.
    • Professional office buildouts suitable for medical, dental, legal, accounting, financial, and consulting uses.
    • Two office condos available: Unit 100 (±1,226 SF) and Unit 300 (±1,279 SF).
    • Two‑story building with elevator access.
    Updated: Jan 27
    View details
    Prime Medical Office Space Available
    $18 SF/Yr
    2,312 SF
    Prime Medical Office Space Available

    Versatile medical/office space in Durham's thriving North Duke corridor.

    2609 N Duke Street, Durham, NC 27704

    View details
    Plug and Play Lab Space
    $30 SF/Yr
    94,603 SF
    Plug and Play Lab Space

    Move-in ready lab and office space in Durham, NC.

    4025 Stirrup Creek Drive, Durham, NC 27703

    View details
    Roxboro Road Professional Office Space
    $20 SF/Yr
    2,408 SF
    Roxboro Road Professional Office Space

    Office space ideal for professional services and medical offices.

    4210 N. Roxboro Street, Suite 140, Durham, NC 27704

    View details
    First Floor Office Unit For Lease
    $45,045 SF/Yr
    2,145 SF
    First Floor Office Unit For Lease

    Flexible office unit with ample parking and high traffic count.

    100-a-1906 E Nc Highway 54, Durham, NC 27713

    View details
    Luxury Mixed-Use Development Near Duke
    $25 SF/Yr
    118,000 SF
    Luxury Mixed-Use Development Near Duke

    Class A mixed-use development near Duke University and hospitals.

    2812 & 2816 Erwin Rd |, Durham, NC 27705

    View details
    Downtown Durham Office Space Available
    Contact for pricing
    16,692 SF
    Downtown Durham Office Space Available

    Office spaces for lease in the heart of downtown Durham.

    433 W. Main Street, Durham, NC 27701

    View details
    Downtown Durham Office Space
    $38 SF/Yr
    20,126 SF
    Downtown Durham Office Space

    Office space in the heart of Downtown Durham's West Village.

    614 West Main Street, Durham, NC 27701

    View details
    Office Space in Durham
    $30 SF/Yr
    7,943 SF
    Office Space in Durham

    7943 SF office space available for lease.

    700 West Main Street, Durham, NC 27701

    View details
    Office Space Near American Tobacco
    $36 SF/Yr
    15,998 SF
    Office Space Near American Tobacco

    Office space for rent adjacent to Durham's historic district.

    302 East Pettigrew Street, Durham, NC 27701

    View details
    Downtown Durham Office Space
    Contact for pricing
    41,000 SF
    Downtown Durham Office Space

    Full floor office space in downtown Durham's iconic tower.

    212 West Main Street, Durham, NC 27701

    View details
    Durham Lab Space for Lease
    Contact for pricing
    1,476 SF
    Durham Lab Space for Lease

    Lab space available for lease in Durham, North Carolina.

    4505 Emperor Blvd, Durham, NC 27703

    View details
    Durham Commercial Space on Hillsborough
    Contact for pricing
    2,978 SF
    Durham Commercial Space on Hillsborough

    2,978 SF commercial space in Durham's Downtown submarket.

    2810 Hillsborough Road, Durham, NC 27705

    View details
    Downtown Durham Office Space
    Contact for pricing
    47,477 SF
    Downtown Durham Office Space

    Centrally located office space in historic Durham tower.

    411 West Chapel Hill Street, Durham, NC 27701

    View details
    Office Space Near University Hill
    Contact for pricing
    12,500 SF
    Office Space Near University Hill

    Office space with high visibility, convenience, and walkability.

    3917 University Dr, Durham, NC 27707

    View details
    R&D Lab Suites Available
    Contact for pricing
    203,239 SF
    R&D Lab Suites Available

    R&D lab suites ranging from 4,345 RSF to 7,381 RSF.

    380 East Pettigrew Street, Durham, NC 27701

    View details
    Durham Office Space For Rent
    Contact for pricing
    24,855 SF
    Durham Office Space For Rent

    Office space in Durham, convenient location near I-40 and Highway 55.

    2520 Meridian Parkway, Durham, NC 27713

    View details
    Durham Office Space For Rent
    Contact for pricing
    11,054 SF
    Durham Office Space For Rent

    Office space in prime Durham location with easy access.

    2505 Meridian Parkway, Durham, NC 27713

    View details
    Durham Office Space For Rent
    Contact for pricing
    25,952 SF
    Durham Office Space For Rent

    Office space for rent with prime location in Durham.

    2700 Meridian Parkway, Durham, NC 27713

    View details
    Durham Office Space For Rent
    Contact for pricing
    19,277 SF
    Durham Office Space For Rent

    Office space available in Durham, close to major transport routes.

    2800 Meridian Parkway, Durham, NC 27713

    View details
    Modern Office Space Available
    $25 SF/Yr
    7,306 SF
    Modern Office Space Available

    7,306 SF office space, currently leased until 2026.

    101-103 W Main St, Durham, NC

    View details
    Office Condo Near I-85
    Contact for pricing
    3,000 SF
    Office Condo Near I-85

    Office condo for rent near I-85 in Durham.

    1816 Front St, Durham, NC 27705

    View details
    Durham Flex Space For Rent
    $4,500/Mo
    1,233 SF
    Durham Flex Space For Rent

    Flex space with accessibility to the Greater Triangle Area.

    2528 S Alston Avenue, Durham, NC 27713

    View details

    Durham, NC Office Units Leasing Opportunities Market Analysis

    Explore Office Units leasing options in Durham, NC with 35 listings featured on our commercial real estate exchange. The current inventory includes 292,565 square feet of properties with an estimated lease value of $90,434.

    Estimated lease rates for Office Units in Durham, NC begin at $5 SF/Yr, with an average of $6,028 /Mo and extend to $45,045.
    List
    Map

    Popular Searches in Durham, NC

    Popular Categories

    Most Searched ZIP Codes in Durham, NC

    • 27701
    • 27713
    • 27705
    • 27703
    • 27704
    • 27707

    Select Neighborhood

    Google sign-in failed. Please try again or use another login method.
    Sign Up Successful!
    You now have access to more from Realmo!