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    Missouri Medical Office Space for Lease

    227 results
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    Joplin Office Space Available
    $12 SF/Yr
    5,000 SF

    Joplin Office Space Available

    2613 S Main St, Joplin, MO 64804

    Second floor office space with elevator and ample parking.

    • Centrally located with easy access to retail, restaurants, and major roads.
    • Great natural light throughout with several large windows.
    • Large on‑site parking lot.
    • Elevator access.
    • Strong visibility along South Main Street.
    Updated: Feb 26
    View details
    Updated Medical/Professional Office Space
    $12 SF/Yr
    46,609 SF

    Updated Medical/Professional Office Space

    5540-5552 N Farmer Branch Rd, Ozark, MO 65721

    Move-in ready medical/professional office space in Ozark, Missouri.

    • Move‑in ready, updated medical/professional office space (9,649 SF).
    • Excellent visibility and access at the intersection of N. Farmer Branch Road and State Highway NN, near US Highway 65.
    • Ideal layout for medical use with 32+ private rooms, 5 restrooms, reception area, kitchen, and multiple waiting areas.
    • Located in a high‑traffic commercial corridor near established businesses.
    • Flexible space suitable for medical, wellness, professional office, or retail use.
    Updated: Mar 3
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    St Charles Medical/Dental Office
    $20 SF/Yr
    69,260 SF

    St Charles Medical/Dental Office

    2880 SF medical/dental office space in high-traffic area.

    2043 S Old Highway 94, Saint Charles, MO 63303
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    Versatile Commercial Property Near I-44
    $600,000
    7,318 SF

    Versatile Commercial Property Near I-44

    Adaptable commercial space near the Joplin medical corridor and I-44.

    5734 S Main St, Joplin, MO 64801
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    Troy Office Building For Lease
    $3,000 / Mo

    Troy Office Building For Lease

    Office building for lease with multiple exam rooms and entrances.

    104 Sarah Ann Blvd, Troy, MO 63379
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    6,500 SF Commercial Space
    $6,000 / Mo
    31,363 SF

    6,500 SF Commercial Space

    6,500 SF commercial space for lease in Poplar Bluff, MO.

    3999 Highway Pp, Poplar Bluff, MO 63901
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    Joplin Commercial Space For Rent
    $700 / Mo
    700 SF

    Joplin Commercial Space For Rent

    Medical/financial office space for lease in Joplin's Southern district.

    1531 W 32Nd St, Joplin, MO 64804
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    St. Joseph Avenue Commercial Space
    $12 SF/Yr
    46,174 SF

    St. Joseph Avenue Commercial Space

    8500 SF commercial space suitable for various businesses.

    1515 St Joseph Ave, St Joseph, MO 64505
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    East Sunshine Office and Dental Suites
    $14 SF/Yr
    40,000 SF

    East Sunshine Office and Dental Suites

    Office and dental suites for lease in Sunshine Business Center.

    3259 E Sunshine St, Springfield, MO 65804
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    Retail and Office Spaces Available
    $8 SF/Yr
    37,193 SF

    Retail and Office Spaces Available

    Retail and office spaces for lease in Medical Mile.

    3010-3050 S National Ave, Springfield, MO 65804
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    Medical Office Space Available
    $1,900 / Mo
    1,200 SF

    Medical Office Space Available

    2700 SF medical office with multiple exam/office rooms.

    3800 S Elizabeth St, Independence, MO 64057
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    New Medical Office Space
    $22 SF/Yr
    5,295 SF

    New Medical Office Space

    Shell space in new medical office building for lease.

    1950 Diamond Pkwy, Kansas City, MO
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    Medical Office Space For Rent
    $23 SF/Yr
    1,082 SF

    Medical Office Space For Rent

    Class A medical office space adjacent to Lee’s Summit Medical Center.

    2100 SE Shenandoah Dr, Lees Summit, MO 64063
    View details
    Medical/Office Space Available For Lease
    $20 SF/Yr
    4,213 SF

    Medical/Office Space Available For Lease

    4,213 SF medical/office space available in January 2025.

    7421 S Outer 364, Dardenne Prairie, MO 63368
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    Medical Office Space on Campus
    $28 SF/Yr
    2,241 SF

    Medical Office Space on Campus

    Medical office connected to SSM DePaul Hospital with amenities.

    12277 De Paul Dr, Bridgeton, MO 63044
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    Class A Office Building
    $21 SF/Yr
    3,300 SF

    Class A Office Building

    Class A office building with high visibility and ample parking.

    5301 Veterans Memorial Pkwy, St Peters, MO 63376
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    Medical Mile Office Space
    $500 / Mo
    7,953 SF

    Medical Mile Office Space

    Individual offices available for lease in medical mile.

    3800 S Fremont Ave, Springfield, MO 65804
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    Sikeston Medical/Office Space Available
    Contact for pricing

    Sikeston Medical/Office Space Available

    Multi-tenant commercial building near Missouri Delta Medical Center.

    808 E Wakefield Ave, Sikeston, MO 63801
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    Professional Office Space Near Medical Mile
    $17 SF/Yr

    Professional Office Space Near Medical Mile

    Move-in ready office space near Springfield's Medical Mile.

    1354 E Kingsley St, Springfield, MO 65804
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    Class A Mixed-Use Building
    $23 SF/Yr

    Class A Mixed-Use Building

    Medical/Office space for lease in Wildwood Town Center.

    16721-16759 Main St, Grover, MO 63040
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    Office/Medical Building Near Hospitals
    $1,850,000
    6,127 SF

    Office/Medical Building Near Hospitals

    9,658 SF three-tenant building near SSM St. Clare Hospital.

    830-850 Horan Dr, Fenton, MO 63026
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    Well-Maintained Office Building For Rent
    $19 SF/Yr
    2,104 SF

    Well-Maintained Office Building For Rent

    Office building with highway visibility and convenient access.

    755 S New Ballas Rd St, Louis, MO
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    Move-in Ready Medical Office Space
    $20 SF/Yr
    2,390 SF

    Move-in Ready Medical Office Space

    2,390 SF medical office space in South County.

    4412-4428 Telegraph Rd St, Louis, MO
    View details
    Versatile Office Space Available
    $15 SF/Yr
    1,300 SF

    Versatile Office Space Available

    Office space for creative, professional, or medical use.

    4173-4193 Cres Dr St, Louis, MO
    View details

    Missouri Medical Office Space Leasing Opportunities Market Analysis

    Explore Medical Office Space leasing options in Missouri with 337 listings featured on our commercial real estate exchange. The current inventory includes 150,875,565,916 square feet of properties with an estimated lease value of $2,568 /Mo.

    Estimated lease rates for Medical Office Space in Missouri begin at $0.75 SF/Yr, with an average of $24 SF/Yr and extend to $276 SF/Yr.
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