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    Leesburg, FL Medical Office Space for Lease

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    Fruitland Park, FL Wildwood, FL Groveland, FL
    Leesburg Office Space Available
    $3,000/Mo
    9,800 SF

    Leesburg Office Space Available

    401 E NORTH BOULEVARD, Leesburg, FL 34748

    Two office units available, suitable for various businesses.

    • Prime location near downtown Leesburg and the hospital, with easy access via 441 frontage.
    • Ample parking available for over 60 vehicles.
    • Two 2000 sq ft units available, connectable for a total of 4000 sq ft.
    • Existing layout includes reception areas, exam rooms, and waiting rooms, suitable for various businesses.
    • Monthly rent includes CAM and taxes.
    Updated: Feb 25
    View details
    Medical Office Near UF Health
    $26 SF/Yr
    8,642 SF

    Medical Office Near UF Health

    640 S LAKE STREET, Leesburg, FL 34748

    Medical office space for lease near UF Health Leesburg Hospital.

    • Directly across from UF Health Leesburg Hospital in a key medical hub.
    • 4,072 SQFT medical office space zoned C‑2.
    • Features eight exam rooms, multiple private offices, and a dedicated surgery room with private waiting room.
    • Abundant parking with 44+ spaces.
    • Recently replaced roof (3 years ago).
    Updated: Oct 6, 2025
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    Turn-Key Medical Office Building
    $135,198 SF/Yr
    7,511 SF

    Turn-Key Medical Office Building

    Medical office building near UF Health Hospital in Leesburg.

    1414 E MAIN STREET, Leesburg, FL 34748
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    Medical Office Space Available
    Contact for pricing
    5,396 SF

    Medical Office Space Available

    Move-in ready, renovated medical suites with ample parking.

    600 W North Blvd, Leesburg, FL
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    Retail/Medical Space on Highway 441
    Contact for pricing
    3,375 SF

    Retail/Medical Space on Highway 441

    Retail or medical spaces available on a high-traffic corridor.

    1450 E N Blvd, Leesburg, FL
    View details
    Based on your search, we've compiled 23 Potential Opportunities for your consideration. Besides 5 Active listings in Leesburg, FL, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 10 Properties for Sales.

    Medical Office Space for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Medical Office Space in Wildwood
    $103,320 SF/Yr
    2,952 SF

    Medical Office Space in Wildwood

    Turnkey medical office space in high-traffic retail and medical corridor.

    4064 E STATE ROAD 44, Wildwood, FL 34785
    View details
    Medical Office Space For Rent
    $76,000 SF/Yr
    2,000 SF

    Medical Office Space For Rent

    Class A medical office space in high-traffic location.

    102103-4669 E State Road 44, Wildwood, FL 34785
    View details
    Medical Office in The Villages
    $30 SF/Yr
    4,932 SF

    Medical Office in The Villages

    Turnkey medical office building on UF Health Spanish Plaines campus.

    1400 U.S. 441, Lady Lake, FL 32159
    View details
    Medical/Professional Office in The Villages
    $22 SF/Yr
    1,944 SF

    Medical/Professional Office in The Villages

    Upscale medical/professional office space for lease in Lady Lake.

    929 US-441, Lady Lake, FL 32159
    View details

    Similar Spaces for Sale in Leesburg, FL

    Consider Similar Space for Sale. We found 10 Spaces matching your search parameters.

    Leesburg Office Building on Highway 441
    $1,250,000
    9,800 SF
    Leesburg Office Building on Highway 441

    9,800 SF medical/professional office building with highway frontage.

    401 E NORTH BOULEVARD, Leesburg, FL 34748

    View details
    Leesburg Mixed-Use Commercial Property
    $1,600,000
    15,300 SF
    Leesburg Mixed-Use Commercial Property

    Turnkey investment opportunity with medical suites and self-storage units.

    711 N 3RD ST, Leesburg, FL 34748

    View details
    Medical/Professional Office Space on 441
    $1,250,000
    9,800 SF
    Medical/Professional Office Space on 441

    9,800 SF medical/professional office space with highway frontage.

    401 E NORTH Blvd, Leesburg, FL 34748

    View details
    Medical/Professional Office Building on 441
    $1,250,000
    9,800 SF
    Medical/Professional Office Building on 441

    9,800 sq ft medical/professional office building for sale.

    401 E NORTH BOULEVARD, Leesburg, FL 34748

    View details
    Freestanding Medical Office Building
    $330,000
    2,668 SF
    Freestanding Medical Office Building

    2,668 SF medical office in Leesburg's medical area.

    404 PERKINS STREET, Leesburg, FL 34748

    View details
    Land on US Hwy 441
    $165,000
    0.28 Acres
    Land on US Hwy 441

    Land suitable for medical office or multi-family development.

    E. NORTH BLVD (US HWY 441), Leesburg, FL 34748

    View details
    Medical Income Property Near UF
    $1,249,000
    4,028 SF
    Medical Income Property Near UF

    Single tenant medical building in UF Health Medical Plaza.

    700 DOCTORS COURT, Leesburg, FL 34748

    View details
    Medical Income Property Near UF
    $1,249,000
    4,028 SF
    Medical Income Property Near UF

    Single tenant medical building in UF Health Medical Plaza.

    700 Doctors Ct, Leesburg, FL 34748

    View details
    Medical Income Property Near UF
    $1,249,000
    4,028 SF
    Medical Income Property Near UF

    Single tenant medical building in UF Health Medical Plaza.

    700 Doctors Court, Leesburg, FL 34748

    View details
    Leesburg Development Site For Sale
    $299,000
    Leesburg Development Site For Sale

    Four-lot development site suitable for professional offices and medical facilities.

    1024, 1034, 1036, 1038 W. Dixie Avenue, Leesburg, FL 34748

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    WINTER PARK Land Lease Opportunity
    $8,500/Mo
    23,056 SF

    WINTER PARK Land Lease Opportunity

    Commercial land lease opportunity in Winter Park, Florida.

    5589 LAKE HOWELL ROAD, Winter Park, FL 32792
    View details
    Valdosta Commercial Land For Lease
    Contact for pricing
    43,560 SF

    Valdosta Commercial Land For Lease

    Prime commercial land in high-growth Valdosta corridor, suitable for various uses.

    Inner Perimeter Rd & Park Ave., Valdosta, GA 31602
    View details
    Prime Commercial Lot For Rent
    $7,500/Mo

    Prime Commercial Lot For Rent

    0.66 acre commercial lot with high visibility.

    Tift Avenue N, Tifton, GA 31794
    View details
    Prime Development Opportunity in Greenville
    Contact for pricing

    Prime Development Opportunity in Greenville

    1.27 acre interstate-visible land for ground lease or build-to-suit.

    39 Airpark Ct, Greenville, SC 29607
    View details

    Leesburg, FL Medical Office Space Leasing Opportunities Market Analysis

    Explore Medical Office Space leasing options in Leesburg, FL with 5 listings featured on our commercial real estate exchange. The current inventory includes 25,953 square feet of properties with an estimated lease value of $135,227.

    Estimated lease rates for Medical Office Space in Leesburg, FL begin at $3 SF/Yr, with an average of $45,075 and extend to $135,198.
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