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    Leesburg, FL Medical Office Space for Lease

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    Fruitland Park, FL Wildwood, FL Groveland, FL Lady Lake, FL The Villages, FL Tavares, FL Eustis, FL Mount Dora, FL
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    Leesburg Office Space Available
    Updated: Feb 25
    Leesburg Office Space Available

    401 E NORTH BOULEVARD, Leesburg, FL 34748

    $3,000/Mo
    9,800 sqft $3.67 SF/Yr
    Prime location near downtown Leesburg and the hospital, with easy access via 441 frontage.
    Ample parking available for over 60 vehicles.
    Two 2000 sq ft units available, connectable for a total of 4000 sq ft.
    Existing layout includes reception areas, exam rooms, and waiting rooms, suitable for various businesses.
    Monthly rent includes CAM and taxes.
    View details
    Medical Office Building with Surgery Room
    Updated: Oct 6, 2025
    Medical Office Building with Surgery Room

    640 S LAKE STREET, Leesburg, FL 34748

    $26/Mo
    8,642 sqft $0.04 SF/Yr
    4,072 SF medical office for lease directly across from UF Health Leesburg Hospital
    9 exam rooms plus multiple private offices, ample storage, and a dedicated surgery room
    Separate private waiting room for the surgery room and a spacious waiting and reception area
    Zoned C‑2; block construction and central air
    Roof replaced about 3 years ago
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    Medical Office Near UF Health
    Medical Office Near UF Health

    640 S LAKE St, Leesburg, FL 34748

    $105,872 SF/Yr
    4,072 sqft $35,925,898/Mo

    4,072 SF medical office space for lease.

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    Medical Office Building with Monument Signage
    Medical Office Building with Monument Signage

    600 W North Blvd, Leesburg, FL 34788

    Contact for pricing
    11,234 sqft

    Recently renovated ground-floor medical suites with covered drop-off and signage for easy patient access.

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    Turn-Key Medical Office Building
    Turn-Key Medical Office Building

    1414 E MAIN STREET, Leesburg, FL 34748

    $135,198 SF/Yr
    7,511 sqft $84,622,681/Mo

    Medical office building near UF Health Hospital in Leesburg.

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    Leesburg Medical Park Office Space
    Leesburg Medical Park Office Space

    704 DOCTORS COURT, Leesburg, FL 34748

    $14,112/Mo
    1,008 sqft $168 SF/Yr

    Medical office space for lease near UF Health Leesburg.

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    Medical Office Space Available
    Medical Office Space Available

    33041 PROFESSIONAL DRIVE, Leesburg, FL 34788

    $36,720 SF/Yr
    2,040 sqft $6,242,400/Mo

    Nicely finished medical office space, convenient location, available for lease.

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    Retail/Medical Space on Highway 441
    Retail/Medical Space on Highway 441

    1450 E N Blvd, Leesburg, FL

    Contact for pricing
    3,375 sqft

    Retail or medical spaces available on a high-traffic corridor.

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    Based on your search, we've compiled 28 Potential Opportunities for your consideration. Besides 8 Active listings in Leesburg, FL, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 12 Properties for Sales.

    Medical Office Space for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Single-Story Outpatient Medical Facility
    Single-Story Outpatient Medical Facility

    305 County Road 466A, Fruitland Park, FL 34731

    Contact for pricing
    2,189 sqft

    Purpose-built outpatient healthcare space with 14-foot clear height and signage facing Miller Blvd.

    View details
    New Medical/Professional Shell Spaces
    New Medical/Professional Shell Spaces

    871 Highway 466, Lady Lake, FL 32159

    $48,000 SF/Yr
    4,000 sqft $16,000,000/Mo

    New construction medical/professional spaces with build-out options available.

    View details
    Prime Commercial Office Space Available
    Prime Commercial Office Space Available

    3360 US HIGHWAY 441/27, Fruitland Park, FL 34731

    $30,000 SF/Yr

    Highly visible office space for lease with flexible options.

    View details
    Medical Office in The Villages
    Medical Office in The Villages

    1400 U.S. 441, Lady Lake, FL 32159

    $30 SF/Yr
    4,932 sqft $12,330/Mo

    Turnkey medical office building on UF Health Spanish Plaines campus.

    View details

    Similar Spaces for Sale in Leesburg, FL

    Consider Similar Space for Sale. We found 12 Spaces matching your search parameters.

    Leesburg Office Building on Highway 441
    Leesburg Office Building on Highway 441

    401 E NORTH BOULEVARD, Leesburg, FL 34748

    $1,250,000
    9,800 sqft 1.13 AC lot

    9,800 SF medical/professional office building with highway frontage.

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    Leesburg Mixed-Use Commercial Property
    Leesburg Mixed-Use Commercial Property

    711 N 3RD ST, Leesburg, FL 34748

    $1,600,000
    15,300 sqft 0.87 AC lot

    Turnkey investment opportunity with medical suites and self-storage units.

    View details
    Medical/Professional Office Space on 441
    Medical/Professional Office Space on 441

    401 E NORTH Blvd, Leesburg, FL 34748

    $1,250,000
    9,800 sqft

    9,800 SF medical/professional office space with highway frontage.

    View details
    Medical Income Property Near UF
    Medical Income Property Near UF

    700 DOCTORS Ct, Leesburg, FL 34748

    $1,249,000
    4,028 sqft 0.54 AC lot

    Single tenant medical building in UF Health Medical Plaza.

    View details
    Leesburg Self Storage Investment Opportunity
    Leesburg Self Storage Investment Opportunity

    711 N 3RD ST, Leesburg, FL 34748

    $1,600,000
    15,300 sqft 0.87 AC lot

    Turnkey, income-producing mixed-use property in a high-growth Central Florida market.

    View details
    C-3 Zoned Commercial Development Land
    C-3 Zoned Commercial Development Land

    E. NORTH BLVD (US HWY 441), Leesburg, FL 34748

    $165,000
    0.28 AC lot

    Build a medical office or related services on this C-3 zoned parcel near active office uses.

    View details
    Freestanding Medical Office Building
    Freestanding Medical Office Building

    404 PERKINS STREET, Leesburg, FL 34748

    $330,000
    2,668 sqft 0.75 AC lot

    2,668 SF medical office in Leesburg's medical area.

    View details
    Professional Office Building For Sale
    Professional Office Building For Sale

    1904 Thomas Ave, Leesburg, FL 34748

    $2,900,000
    19,278 sqft 2.74 AC lot

    First-class professional office building with established income and value-add opportunity.

    View details
    Medical Income Property Near UF
    Medical Income Property Near UF

    700 Doctors Ct, Leesburg, FL 34748

    $1,249,000
    4,028 sqft 0.54 AC lot

    Single tenant medical building in UF Health Medical Plaza.

    View details
    Medical Income Property Near UF
    Medical Income Property Near UF

    700 Doctors Ct, Leesburg, FL 34748

    $1,249,000
    4,028 sqft 0.53 AC lot

    Single tenant medical building in UF Health Medical Plaza.

    View details
    Medical Income Property Near UF
    Medical Income Property Near UF

    700 DOCTORS COURT, Leesburg, FL 34748

    $1,249,000
    4,028 sqft 0.54 AC lot

    Single tenant medical building in UF Health Medical Plaza.

    View details
    Leesburg Medical/Office Building For Sale
    Leesburg Medical/Office Building For Sale

    170 North Blvd E, Leesburg, FL 34748

    $999,000
    5,415 sqft

    5,415 SF medical/office building on a signalized corner.

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    WINTER PARK Land Lease Opportunity
    WINTER PARK Land Lease Opportunity

    5589 LAKE HOWELL ROAD, Winter Park, FL 32792

    $8,500/Mo
    23,056 sqft $4.42 SF/Yr

    Commercial land lease opportunity in Winter Park, Florida.

    View details
    Prime Commercial Lot For Rent
    Prime Commercial Lot For Rent

    Tift Avenue N, Tifton, GA 31794

    $7,500/Mo

    0.66 acre commercial lot with high visibility.

    View details
    Prime Development Opportunity in Greenville
    Prime Development Opportunity in Greenville

    39 Airpark Ct, Greenville, SC 29607

    Contact for pricing

    1.27 acre interstate-visible land for ground lease or build-to-suit.

    View details
    Corner Lot on Highway 72
    Corner Lot on Highway 72

    30472 Highway 72, Madison, AL 35756

    $5,000/Mo
    1,875 sqft $32 SF/Yr

    1.7 acre corner lot zoned for commercial, medical, residential.

    View details

    Leesburg, FL Medical Office Space Market Trends and Statistics

    Explore Medical Office Space leasing options in Leesburg, FL with 8 listings featured on our commercial real estate exchange. The current inventory includes 33,073 square feet of properties with an estimated lease value of $277,987.

    Estimated lease rates for Medical Office Space in Leesburg, FL begin at $3.67 SF/Yr, with an average of $46,331 and extend to $135,198.
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