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    Cape Girardeau, MO Commercial Real Estate for Sale

    121 results
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    Versatile Riverfront Commercial Property
    Pending
    $400,000
    4,400 SF

    Versatile Riverfront Commercial Property

    450 N Main St, Cape Girardeau, MO 63701

    Prime riverfront property suitable for office, restaurant, warehouse, or mixed-use.

    • Prime riverfront location directly on the Mississippi River.
    • High visibility and ideal location for downtown development and parking.
    • Versatile property suitable for office, restaurant, warehouse, or mixed‑use concepts.
    • Existing warehouse on the property.
    • Metal siding construction.
    Updated: Feb 18
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    Versatile Commercial Space in Missouri
    $900,000
    7,396 SF

    Versatile Commercial Space in Missouri

    20 N Spanish St, Cape Girardeau, MO 63701

    7,396 SF commercial building with banquet, dining, and bar areas.

    • Prime location in the heart of historic downtown Cape Girardeau.
    • Large 7,396 sq ft commercial space with versatile layout.
    • Configured with a 60‑seat banquet space, 135‑seat dining area, and dedicated bar.
    • Potential to be easily divided into two separate units.
    • Efficient, centrally located kitchen with direct access to dining and banquet areas.
    Updated: Jan 30
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    Downtown Cape Girardeau Commercial Lot
    Pending
    $450,000
    1.04 Acres

    Downtown Cape Girardeau Commercial Lot

    Prime commercial lot near casino, ideal for development.

    N Main St, Cape Girardeau, MO 63701
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    Versatile Commercial Property For Sale
    $295,000
    2,920 SF

    Versatile Commercial Property For Sale

    High-visibility commercial property with flexible layout and spacious attached warehouse.

    225 Clark Ave, Cape Girardeau, MO 63701
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    Cape Girardeau Commercial Property
    Pending
    $825,000
    7,000 SF

    Cape Girardeau Commercial Property

    Well-maintained commercial property with over 7,000 square feet.

    340 S Broadview St, Cape Girardeau, MO 63703
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    Versatile Commercial Building in Cape
    $225,000
    0.57 Acres

    Versatile Commercial Building in Cape

    Adaptable 1800 sq ft commercial building in thriving Cape Girardeau.

    2357 Rust Ave, Cape Girardeau, MO 63703
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    Cape Girardeau Mixed-Use Investment
    $489,900
    7,282 SF

    Cape Girardeau Mixed-Use Investment

    Leased commercial spaces with residential unit for income growth.

    1606 Independence St, Cape Girardeau, MO 63703
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    Renovated Downtown Commercial Property
    $500,000
    4,548 SF

    Renovated Downtown Commercial Property

    Versatile 11-bedroom property in downtown Cape Girardeau.

    224 N Frederick St, Cape Girardeau, MO 63701
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    Leased Office Building For Sale
    $500,000
    7,140 SF

    Leased Office Building For Sale

    Two-story office building with 21 units and parking.

    2711 Thomas Dr, Cape Girardeau, MO 63701
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    Renovated Commercial Space in Cape Girardeau
    $239,900
    2,937 SF

    Renovated Commercial Space in Cape Girardeau

    Renovated commercial space with high potential in a prime location.

    230 N Sprigg St, Cape Girardeau, MO 63701
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    Commercial Land in Cape Girardeau
    $250,000
    6.02 Acres

    Commercial Land in Cape Girardeau

    6-acre commercial tract in the heart of Cape Girardeau.

    410 William St, Cape Girardeau, MO 63703
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    Commercial Condominiums in Historic Building
    $129,900
    4,300 SF

    Commercial Condominiums in Historic Building

    Four commercial condominiums in downtown Cape Girardeau.

    937 Broadway St, Cape Girardeau, MO 63701
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    Industrial Warehouse in Cape Girardeau
    $499,900
    3.90 Acres

    Industrial Warehouse in Cape Girardeau

    3.9 acres with 7,500 sq ft warehouse near I-55.

    840 S Kings Highway St, Cape Girardeau, MO 63703
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    Ambulatory Surgery Center Investment Opportunity
    $8,050,000
    13,650 SF

    Ambulatory Surgery Center Investment Opportunity

    Single-tenant surgery center near St. Francis Medical Center for sale.

    3241 Percy Dr, Cape Girardeau, MO 63701
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    Broadway Commercial Space with Apartment
    $280,000
    5,100 SF

    Broadway Commercial Space with Apartment

    Versatile investment opportunity with remodeled apartment and commercial space.

    520 Broadway St, Cape Girardeau, MO 63701
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    Commercial Land in Cape Girardeau
    Pending
    Contact for pricing
    0.18 Acres

    Commercial Land in Cape Girardeau

    Commercial land available in Cape Girardeau, Missouri.

    803 Independence St, Cape Girardeau, MO 63703
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    Two-Level Office Building For Sale
    $815,000

    Two-Level Office Building For Sale

    9,857 SF office building with multiple offices and restrooms.

    10 Doctors Park, Cape Girardeau, MO 63703
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    Downtown Office Building For Sale
    $899,900

    Downtown Office Building For Sale

    13,694 SF office building in historic downtown Cape Girardeau.

    18 N Main St, Cape Girardeau, MO 63701
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    Cape Girardeau Medical Office Building
    $270,000

    Cape Girardeau Medical Office Building

    2,546 SF medical office building in a thriving complex.

    62 Doctors Park, Cape Girardeau, MO 63703
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    Downtown Cape Girardeau Office/Flex Space
    Contact for pricing

    Downtown Cape Girardeau Office/Flex Space

    5,225 SF office/flex space in downtown Cape Girardeau.

    122 S Spanish St, Cape Girardeau, MO 63701
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    Cape Girardeau Industrial Building For Sale
    Contact for pricing

    Cape Girardeau Industrial Building For Sale

    10,000 SF industrial building with office and warehouse space.

    2109 Rust Ave, Cape Girardeau, MO 63703
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    Prime Retail Space in Cape
    Contact for pricing

    Prime Retail Space in Cape

    4,500 SF retail space in historic downtown Cape Girardeau.

    731 Broadway St, Cape Girardeau, MO 63701
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    Prime Location Office Suites
    Contact for pricing

    Prime Location Office Suites

    Excellent visibility office suites near I-55 and Highway 74.

    440 S Mount Auburn Rd, Cape Girardeau, MO 63703
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    Cape Girardeau Retail Opportunity
    Contact for pricing

    Cape Girardeau Retail Opportunity

    46,000 SF retail space in West Cape Centre.

    201 S Broadview St, Cape Girardeau, MO 63703
    View details

    Cape Girardeau, MO Commercial Real Estate Investment Opportunities Market Analysis

    Explore 57 commercial real estate for sale in Cape Girardeau, MO, showcased through 121 active listings on our real estate platform. These investment opportunities span a total of 8,011,364 square feet of properties for sale, with an estimated market value of $19,029,600.

    Sale prices for business properties in Cape Girardeau, MO start at $75,000, averaging $1,001,557, and reaching up to $8,050,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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