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    Sikeston, MO Retail Properties & Spaces for Sale

    12 results
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    Historic Downtown Sikeston Retail Opportunity
    $275,000
    14,642 SF

    Historic Downtown Sikeston Retail Opportunity

    124 E Front St, Sikeston, MO 63801

    Two-story retail space in high-traffic downtown Sikeston.

    • Prime downtown location with high visibility and foot traffic.
    • Value‑add opportunity with a blank canvas upstairs for customization.
    • Existing leases on the ground floor provide immediate income.
    • Historic building (built in 1915) with unique character.
    • Close proximity to retail, professional services, and restaurants.
    Updated: Feb 25
    View details
    Sikeston Commercial Property For Sale
    $650,000
    1.28 Acres

    Sikeston Commercial Property For Sale

    1105 S Main St, Sikeston, MO 63801

    Prime commercial location with high visibility and established business history.

    • Prime commercial location with high‑visibility at a 4‑way stoplight intersection.
    • Zoned C3 Highway Commercial, ideal for QSR or redevelopment.
    • Outstanding traffic count and accessibility.
    • Proven location with a 20+ year history.
    • Substantial 471’ highway frontage and 1.2‑acre lot size.
    Updated: Mar 3
    View details
    Sikeston Car Wash with Expansion Potential
    $1,000,000
    40,511 SF

    Sikeston Car Wash with Expansion Potential

    Turnkey car wash with expansion potential in high-demand market.

    531 N Main St, Sikeston, MO 63780
    View details
    Historical Building in Downtown Sikeston
    $269,000
    6,321 SF

    Historical Building in Downtown Sikeston

    Two-story historic building in downtown Sikeston, ideal for investors.

    112 Front St, Sikeston, MO 63801
    View details
    Sikeston Commercial Property For Sale
    $600,000
    1.30 Acres

    Sikeston Commercial Property For Sale

    Income-producing property with commercial spaces and storage units.

    2008 N Main St, Sikeston, MO 63801
    View details
    Sikeston Carwash with High Visibility
    $1,250,000
    40,946 SF

    Sikeston Carwash with High Visibility

    Turnkey carwash with high traffic, visibility, and recurring revenue.

    900 S Main St, Sikeston, MO 63801
    View details
    Sikeston Retail Property For Sale
    $550,000
    1,150 SF

    Sikeston Retail Property For Sale

    Established family-owned business with high visibility for over 30 years.

    1018 Linn St, Sikeston, MO 63801
    View details
    Sikeston Commercial Property with Income
    $290,000
    4,244 SF

    Sikeston Commercial Property with Income

    Commercial building, duplex, and storage on 1.22 acres.

    101-103 Donald Fulton Dr, Sikeston, MO 63801
    View details
    Historic Downtown Mixed-Use Opportunity
    $299,000
    14,642 SF

    Historic Downtown Mixed-Use Opportunity

    Two-story historic building in downtown Sikeston with modern potential.

    124 E Front St, Sikeston, MO 63801
    View details
    Sikeston Commercial Building Investment Opportunity
    $979,500

    Sikeston Commercial Building Investment Opportunity

    High-visibility commercial building with income and upside potential.

    808 E Wakefield Ave, Sikeston, MO 63801
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    Neighborhood Center with Established Businesses
    Contact for pricing

    Neighborhood Center with Established Businesses

    Neighborhood center with high traffic, visibility, and established businesses.

    1100 S Main St, Sikeston, MO 63801
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    Turnkey Carwash in Sikeston, MO
    Contact for pricing
    40,946 SF

    Turnkey Carwash in Sikeston, MO

    Established carwash with high traffic, visibility, and membership program.

    900 S Main St, Sikeston, MO 63801
    View details
    Based on your search, we've compiled 20 Potential Opportunities for your consideration. Besides 12 Active listings in Sikeston, MO, we suggest exploring several alternatives: 4 properties in Nearby Cities, plus 4 Land Listings that present a potential for development.

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Retail Building on Highway 105
    $84,000
    1,452 SF

    Retail Building on Highway 105

    Retail building with great visibility and expansion potential.

    2380 S Main St, Charleston, MO 63834
    View details
    Remodeled Commercial Property in Charleston
    $350,000
    4,173 SF

    Remodeled Commercial Property in Charleston

    Turnkey commercial property with residential zoning in prime location.

    506 S Main St, Charleston, MO 63834
    View details
    Prime Dexter Retail Opportunity
    $999,500

    Prime Dexter Retail Opportunity

    High-visibility retail space with drive-thru and highway access.

    1007 W Business Us Highway 60, Dexter, MO 63841
    View details
    Remodeled Commercial Building in Downtown
    $259,900
    4,000 SF

    Remodeled Commercial Building in Downtown

    Turn-key restaurant or flexible commercial space in downtown Dexter.

    117 S Locust St, Dexter, MO 63841
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Commercial Land on Highway 61
    $144,000
    1.01 Acres

    Commercial Land on Highway 61

    Commercial land on high-traffic route near Sikeston Industrial Park.

    103 Grove St, Sikeston, MO 63801
    View details
    Commercial Land in Retail Area
    $500,000
    1.05 Acres

    Commercial Land in Retail Area

    1.05 acres of commercial land for development in Sikeston.

    1209 Lawrence St, Sikeston, MO 63801
    View details
    Commercial Land in Sikeston, MO
    $195,000
    0.72 Acres

    Commercial Land in Sikeston, MO

    Vacant, level commercial lot available in Sikeston, Missouri.

    116 Hospitality Dr, Sikeston, MO 63801
    View details
    Prime Land for Commercial Development
    $3,960,000
    88.00 Acres

    Prime Land for Commercial Development

    88 acres at I-55 and I-57, Sikeston, MO.

    Ables Rd, Sikeston, MO 63801
    View details

    Explore Off-Market Properties in Sikeston, MO

    Consider similar Off-Market properties in Sikeston, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    138 Frnt St

    138 Frnt St

    RETAIL STORES (PERSONAL SERVICES) • 4,800 SF
    Value Estimation by Request
    138 Frnt St, Sikeston, MO 63801-2860
    View details
    209 Center St Sta, Unit A

    209 Center St Sta, Unit A

    RETAIL STORES (PERSONAL SERVICES) • 6,480 SF
    Value Estimation by Request
    209 Center St Sta, Sikeston, MO 63801-4228
    View details
    Sikeston, MO 63801

    Sikeston, MO 63801

    RETAIL STORES (PERSONAL SERVICES) • 2,376 SF
    Value Estimation by Request
    Sikeston, MO 63801
    View details
    105 St

    105 St

    RETAIL STORES (PERSONAL SERVICES) • 600 SF
    Value Estimation by Request
    105 St, Sikeston, MO 63801
    View details
    105 Campanella Dr

    105 Campanella Dr

    AUTO REPAIR, GARAGE • 7,500 SF
    Value Estimation by Request
    105 Campanella Dr, Sikeston, MO 63801-5220
    View details
    127 Ctr St

    127 Ctr St

    RETAIL STORES (PERSONAL SERVICES) • 9,616 SF
    Value Estimation by Request
    127 Ctr St, Sikeston, MO 63801-4109
    View details
    143 Ctr St

    143 Ctr St

    RETAIL STORES (PERSONAL SERVICES) • 1,296 SF
    Value Estimation by Request
    143 Ctr St, Sikeston, MO 63801-4107
    View details
    124 County Hwy 539

    124 County Hwy 539

    RETAIL STORES (PERSONAL SERVICES) • 6,960 SF
    Value Estimation by Request
    124 County Hwy 539, Sikeston, MO 63801
    View details
    83 County Hwy 539

    83 County Hwy 539

    AUTO REPAIR, GARAGE • 6,000 SF
    Value Estimation by Request
    83 County Hwy 539, Sikeston, MO 63801
    View details
    705 Davis Blvd

    705 Davis Blvd

    RETAIL STORES (PERSONAL SERVICES) • 8,740 SF
    Value Estimation by Request
    705 Davis Blvd, Sikeston, MO 63801-1960
    View details
    801 Delmar Str

    801 Delmar Str

    AUTO REPAIR, GARAGE • 2,400 SF
    Value Estimation by Request
    801 Delmar Str, Sikeston, MO 63801-4512
    View details
    707 Frisco St

    707 Frisco St

    AUTO REPAIR, GARAGE • 1,450 SF
    Value Estimation by Request
    707 Frisco St, Sikeston, MO 63801-2608
    View details

    Sikeston, MO Retail Properties & Spaces Investment Opportunities Market Analysis

    Explore 279 retail properties & spaces for sale in Sikeston, MO, showcased through 12 active listings on our real estate platform. These investment opportunities span a total of 1,538,642 square feet of properties for sale, with an estimated market value of $12,704,000.

    Sale prices for stores in Sikeston, MO start at $269,000, averaging $552,347, and reaching up to $1,250,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Most Searched ZIP Codes in Sikeston, MO

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