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    Lancaster, SC Commercial Real Estate for Sale

    151 results
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    Map
    Two Professional Buildings Near MUSC
    $975,000
    0.82 Acres

    Two Professional Buildings Near MUSC

    1201 Colonial Cmns Ct, Lancaster, SC 29720

    Two professional office buildings near MUSC in Lancaster, South Carolina.

    • Prime location minutes from MUSC (Medical University of South Carolina).
    • Two professional office buildings on one property.
    • Zoned "PO" Professional Office by the City of Lancaster.
    • Building 1 features a medical office layout with 14 rooms and a wired X‑ray room.
    • New flooring and new roof installed in Building 1.
    Updated: Dec 1, 2025
    View details
    Lancaster Commercial Property - $149,900
    $149,900
    1,248 SF

    Lancaster Commercial Property - $149,900

    2836 Lynwood Dr, Lancaster, SC 29720

    Versatile Commercial Space, High-Traffic Area

    View details
    High-Visibility Lancaster Commercial Land
    $275,000
    2.39 Acres

    High-Visibility Lancaster Commercial Land

    Prime Lancaster location, high traffic, 2.39 acres.

    00 Highway 9 Byp, Lancaster, SC 29720
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    Highway 200 Commercial Land Opportunity
    $1,147,000
    6.30 Acres

    Highway 200 Commercial Land Opportunity

    6.3 Acres, Prime Lancaster Location

    0000 Hwy 200 Hwy, Lancaster, SC 29720
    View details
    Lancaster Commercial Property - 6 Acres
    $650,000
    6.10 Acres

    Lancaster Commercial Property - 6 Acres

    Versatile Commercial Space, Ample Parking

    1180 Garnette Rd, Lancaster, SC 29720
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    Lancaster Commercial Land Opportunity
    $599,000
    3.49 Acres

    Lancaster Commercial Land Opportunity

    High-Visibility 3.5-Acre Parcel, Prime Location

    00 Charlotte Hwy, Lancaster, SC 29720
    View details
    Lancaster Medical Office Complex
    $1,100,000
    0.82 Acres

    Lancaster Medical Office Complex

    Dual-Building Property, High-Income Potential

    1201 Colonial Cmns Ct, Lancaster, SC 29720
    View details
    Lancaster, SC Walgreens Investment
    $5,460,000
    14,820 SF

    Lancaster, SC Walgreens Investment

    High-yield NNN Walgreens, strong tenant.

    1101 Highway 9 Byp, Lancaster, SC 29720
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    Two Professional Buildings Near MUSC
    $1,100,000
    8,482 SF

    Two Professional Buildings Near MUSC

    Two professional buildings on one property near the Medical University.

    1201-1203 Colonial Commons Ct, Lancaster, SC 29720
    View details
    Lancaster Light Industrial Facility
    $325,000
    3,400 SF

    Lancaster Light Industrial Facility

    3,400 SF facility on 2 acres near Rock Hill.

    1537 Lynwood Dr, Lancaster, SC 29720
    View details
    Mixed-Use Investment Opportunity
    $1,150,000
    20,606 SF

    Mixed-Use Investment Opportunity

    Multi-tenant property with retail, office, industrial, and storage units.

    979-987 University Dr, Lancaster, SC 29720
    View details

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Commercial Land in Growing Area
    $649,900

    Commercial Land in Growing Area

    Commercial zoned land near E. & J. Gallo Winery site.

    5921 Lancaster Hwy, Fort Lawn, SC 29714
    View details
    Two Renovated Homes on 2 Acres
    $300,000
    2.19 Acres

    Two Renovated Homes on 2 Acres

    Two move-in ready homes, updated with new appliances and systems.

    2091 Catawba River Rd, Fort Lawn, SC 29714
    View details
    Cane Creek Waterfront Wilderness Sanctuary
    $495,000
    10.37 Acres

    Cane Creek Waterfront Wilderness Sanctuary

    10.37 acre Waxhaw refuge with 700 feet of creek.

    10 11, Waxhaw, NC 28173
    View details
    Waxhaw Land For Sale
    $425,000
    17.00 Acres

    Waxhaw Land For Sale

    17 acres of land near Waxhaw, North Carolina.

    01 Tirzah Church Rd, Waxhaw, NC 28173
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Commercial Land For Sale
    $3,000,000

    Commercial Land For Sale

    10+/- acres of commercial land available for development.

    10209 Walnut Crk Pkwy, Lancaster, SC
    View details
    Lancaster Commercial Land For Sale
    $1,147,000
    6.30 Acres

    Lancaster Commercial Land For Sale

    6.3 acre commercial land available in Lancaster, South Carolina.

    200 Hwy, Lancaster, SC 29720
    View details
    Lancaster Commercial Land For Sale
    $2,500,000
    18.00 Acres

    Lancaster Commercial Land For Sale

    Commercial land with development potential in Lancaster, South Carolina.

    Charlotte Hwy, Lancaster, SC 29720
    View details
    Lancaster Land For Sale
    $115,000
    11.66 Acres

    Lancaster Land For Sale

    11.66 acres of wooded property in downtown Lancaster, SC.

    Woodland Dr, Lancaster, SC 29720
    View details

    Explore Off-Market Properties in Lancaster, SC

    Consider similar Off-Market properties in Lancaster, SC. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    945-973 Highway 9 Byp

    945-973 Highway 9 Byp

    Restaurants • 12,800 SF
    Value Estimation by Request
    945-973 Highway 9 Byp, Lancaster, SC 29720
    View details
    Airport Rd And Barton Rd

    Airport Rd And Barton Rd

    Restaurants • 44,350 SF
    Value Estimation by Request
    0 Airport Rd And Barton Rd, Lancaster, SC 29720
    View details
    in Expanding Lancaster County! Restaurant For Sale With Real Est

    in Expanding Lancaster County! Restaurant For Sale With Real Est

    Restaurants • 2,814 SF
    Value Estimation by Request
    in Expanding Lancaster County! Restaurant For Sale With Real Est, Lancaster, SC 29720
    View details
    Hubbard Rd

    Hubbard Rd

    Commercial real estate • 5.13 Acres
    Value Estimation by Request
    Hubbard Rd, Lancaster, SC 29020
    View details
    000 Hubbard Rd

    000 Hubbard Rd

    Commercial real estate • 7.02 Acres
    Value Estimation by Request
    000 Hubbard Rd, Lancaster, SC 29720
    View details
    209 Main St

    209 Main St

    Restaurants • 96,454 SF
    Value Estimation by Request
    209 Main St, Lancaster, SC 29720
    View details
    00 Charlotte Hwy

    00 Charlotte Hwy

    Commercial real estate • 3.49 Acres
    Value Estimation by Request
    00 Charlotte Hwy, Lancaster, SC 29720
    View details
    000 Hubbard Rd

    000 Hubbard Rd

    Commercial real estate • 5.15 Acres
    Value Estimation by Request
    000 Hubbard Rd, Lancaster, SC 29020
    View details
    209 Main St

    209 Main St

    Restaurants
    Value Estimation by Request
    209 Main St, Lancaster, SC 29720
    View details
    00 Highway 9 Byp

    00 Highway 9 Byp

    Commercial real estate • 2.39 Acres
    Value Estimation by Request
    00 Highway 9 Byp, Lancaster, SC 29720
    View details
    1180 Garnette Rd

    1180 Garnette Rd

    Commercial real estate • 6.10 Acres
    Value Estimation by Request
    1180 Garnette Rd, Lancaster, SC 29720
    View details
    1201 Colonial Commons Ct

    1201 Colonial Commons Ct

    Medical offices • 8,482 SF
    Value Estimation by Request
    1201 Colonial Commons Ct, Lancaster, SC 29720
    View details
    905-933 Highway 9 Byp

    905-933 Highway 9 Byp

    Restaurants • 14,400 SF
    Value Estimation by Request
    905-933 Highway 9 Byp, Lancaster, SC 29720
    View details

    Lancaster, SC Commercial Real Estate Investment Opportunities Market Analysis

    Explore 1104 commercial real estate investment opportunities in Lancaster, SC with 151 listings featured on our commercial real estate marketplace. The current inventory includes 1,683,878,414 square feet of properties with an estimated value of $362,394,870.

    Estimated prices for commercial real estate in Lancaster, SC begin at $34,900, with an average of $542,507 and extend to $10,005,000.

    In Lancaster, SC, current investment values show:

    • Retail properties positioned at $447,363
    • Individual retail properties measuring $342,041
    • Other commercial real estate assessed at $447,902
    • Industrial properties calculated at $679,722
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    Browse Commercial real estate for Sale Near Lancaster, SC

    Popular Searches in Lancaster, SC

    Most Searched ZIP Codes in Lancaster, SC

    • 29720
    • 29707
    • 29020

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