Lancaster, SC Commercial Real Estate for Lease

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Main Street Commercial Space Available
Updated: Mar 6
Main Street Commercial Space Available

120 S Main St, Lancaster, SC 29720

$5,000/Mo
Prime location in downtown Lancaster
High visibility and foot traffic
Versatile layout for various commercial ventures
100% air conditioned showroom warehouse space
Excellent signage opportunities
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Industrial Land with Concrete Plant Approval
Updated: Jun 8
Industrial Land with Concrete Plant Approval

0000 Landsford Road #LOT B, Lancaster, SC 29720

Contact for pricing
12.1 acres of undeveloped land in Lancaster County
Partially cleared with a tree line and an existing driveway
County approved for use as a concrete plant
Lease terms: $12,000/month for a 5‑year term with all land included
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Retail, Office, Special Purpose
Retail, Office, Special Purpose

114 E Gay St, Lancaster, SC 29720

Contact for pricing
3,397 sqft

Retail space · 3,397 SF

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Retail Space in Lancaster, SC
Retail Space in Lancaster, SC

905-933 Hwy 9 Bypass W, Lancaster, SC 29720

Contact for pricing
27,200 sqft

Retail spaces available in Walmart-anchored community center.

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Lancaster Retail Space For Lease
Lancaster Retail Space For Lease

1256 Hwy 9 Bypass W, Lancaster, SC 29720

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181,542 sqft

Retail space available in a busy Lancaster shopping center.

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Retail Space Near Major Intersection
Retail Space Near Major Intersection

100 Monroe Hwy, Lancaster, SC 29720

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Retail property located near a highly trafficked intersection.

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Retail Space in Lancaster Center
Retail Space in Lancaster Center

945-973 Hwy 9 Bypass W, Lancaster, SC 29720

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27,200 sqft

Retail spaces available in Walmart-anchored community center.

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Based on your search, we've compiled 61 Potential Opportunities for your consideration. Besides 7 Active listings in Lancaster, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 50 Properties for Sales.

Commercial real estate for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Industrial Building with Yard Space
Industrial Building with Yard Space

4607 Helms Road, Waxhaw, NC 28173

Contact for pricing
2,300 sqft

Industrial building with yard space for rent in Waxhaw.

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Retail Center in Indian Land
Retail Center in Indian Land

Jim Wilson Road, Indian Land, SC 29707

Contact for pricing

Super-regional shopping center with high traffic and full occupancy.

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Large Farmland Tract for Lease
Large Farmland Tract for Lease

7171-7081 Sims Rd, Waxhaw, NC 28173

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Lease a substantial agricultural land tract in Waxhaw, suited for land-based operations and future development planning.

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Retail Space in Growing Corridor
Retail Space in Growing Corridor

Indian Land, SC 29707

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Retail space available 1/1/2026 in a high-growth area.

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Similar Spaces for Sale in Lancaster, SC

Consider Similar Space for Sale. We found 50 Spaces matching your search parameters.

Prime Development Land Lancaster, SC
Prime Development Land Lancaster, SC

2383 Charlotte Highway, Lancaster, SC 29720

$2,200,000
15.55 AC lot

Development opportunity on a growing corridor near residential communities.

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Retail Buildings For Sale
Retail Buildings For Sale

1317 Hwy 9 ByPass W, Lancaster, SC 29720

$550,000
2,175 sqft

Two commercial buildings for sale in a growing area.

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Thriving Child Development Center
Thriving Child Development Center

1699 N Rocky River Road, Lancaster, SC 29720

$3,200,000
9,398 sqft

Child development center with two buildings and outdoor playground.

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Eight-Home Rental Portfolio with Warehouse
Eight-Home Rental Portfolio with Warehouse

209 Rickenbacker Street, Lancaster, SC 29720

$985,000
0.88 AC lot

Adjacently located 2-bedroom, 1-bath rentals are 100% occupied, with an included 20-by-20 storage warehouse.

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Commercial Building with Fenced Parking
Commercial Building with Fenced Parking

305 E Arch Street #36, Lancaster, SC 29720

$250,000
1,653 sqft

Commercial building with open area, offices, and parking.

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Lancaster Commercial Building For Sale
Lancaster Commercial Building For Sale

401 E Gay Street, Lancaster, SC 29720

$139,999
0.12 AC lot

Commercial building in growing area with business or investment potential.

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Climate Controlled Warehouse with Docks
Climate Controlled Warehouse with Docks

1551 Hwy 9 Byp, Lancaster, SC 29720

Contact for pricing
349,000 sqft

100% climate controlled warehouse with multiple dock doors, in-place racking, and overhead production clearances.

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Historic Mixed-Use Retail/Office Buildings
Historic Mixed-Use Retail/Office Buildings

209-227 S. Main Street, Lancaster, SC 29720

Contact for pricing
29,151 sqft

Vacant 1930s buildings offer retail or office space and renovation opportunity in downtown Lancaster, South Carolina.

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Downtown Mixed-Use Building for Renovation
Downtown Mixed-Use Building for Renovation

229 S. Main Street, Lancaster, SC 29720

Contact for pricing
15,266 sqft

Vacant 1930s mixed-use property in downtown Lancaster, built for retail or office re-activation with renovation underway.

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Downtown Mixed-Use Redevelopment Property
Downtown Mixed-Use Redevelopment Property

210 S. White Street, Lancaster, SC 29720

Contact for pricing
22,251 sqft

Vacant 1930s retail/office buildings in downtown Lancaster offer a renovation-ready canvas for mixed-use redevelopment.

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1930s Retail/Office Building Portfolio
1930s Retail/Office Building Portfolio

116 Arch Street, Lancaster, SC 29720

Contact for pricing
29,444 sqft

Vacant, renovation-needed buildings offering flexible retail or office space in downtown Lancaster with convenient highway access.

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Lancaster Land with Highway Frontage
Lancaster Land with Highway Frontage

3080 Charlotte Highway, Lancaster, SC 29720

$1,600,000
25.00 AC lot

25 acres of land ideal for development or investment.

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Lancaster Commercial Land For Sale
Lancaster Commercial Land For Sale

Charlotte Hwy lot: 2, Lancaster, SC 29720

$2,500,000
18.00 AC lot

Commercial land with development potential in Lancaster, South Carolina.

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Waterfront Wedding Event Venue Property
Waterfront Wedding Event Venue Property

4223 Cedar Creek Rd, Lancaster, SC 29720

Contact for pricing
5,000 sqft

Boutique event venue on a bluff overlooking the Catawba River with purpose-built indoor space and outdoor gathering areas.

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Commercial-Resale Land with Home
Commercial-Resale Land with Home

1670 Lynwood Drive, Lancaster, SC 29720

$495,000
6.11 AC lot

Residential home on over six acres in Lancaster, SC with commercial/business zoning, sold as-is.

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General Business Development Land
General Business Development Land

2383 Charlotte Highway, Lancaster, SC 29720

$2,200,000
15.55 AC lot

Two-parcel tract with 463 feet of road frontage on Charlotte Highway, positioned beside Lancaster Medical Park in a growing residential corridor.

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Large Acreage with Road Frontage
Large Acreage with Road Frontage

1049 Culp Ferguson Road, Lancaster, SC 29720

$2,775,000
84.67 AC lot

84.67-acre property with frontage on Culp Ferguson Road and Porter Ranch Road, featuring cleared areas, fenced pastures, and a pond.

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Lancaster, SC Commercial real estate Market Trends and Statistics

Explore Commercial real estate leasing options in Lancaster, SC with 7 listings featured on our commercial real estate exchange. The current inventory includes 239,339 square feet of properties.
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