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    49 properties
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    Historic Two-Story Storefront
    Updated: Feb 25
    Historic Two-Story Storefront

    124 E Front Street, Sikeston, MO 63801

    $275,000
    14,642 sqft 0.22 AC lot
    14,642‑square‑foot commercial building on a 0.22‑acre parcel
    Two‑story brick building constructed in 1915
    Two existing leases occupy the ground floor
    Open upper level available for future buildout or occupancy
    High ceilings and a flat roof
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    Flex Building with Storage Units
    Updated: Aug 26
    Flex Building with Storage Units

    330 State Highway H, Sikeston, MO 63801

    $799,000
    2.99 AC lot
    17,000‑square‑foot metal building on approximately 2.99 acres
    Approximately 12,000 square feet of insulated warehouse space
    Approximately 5,000 square feet of office area with 7 offices, a kitchen, and 4 bathrooms
    3‑phase electrical service, floor drains, newer HVAC, and newer water heater
    Four 14‑foot bay doors support warehouse access and deliveries
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    Church and Community Campus
    Church and Community Campus

    951 S Kingshighway, Sikeston, MO 63801

    $1,600,000
    5.10 AC lot

    Two substantial buildings provide auditorium, classrooms, offices, meeting areas, kitchens, gymnasium, storage, and multipurpose space.

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    Two-Building Religious Facility Campus
    Two-Building Religious Facility Campus

    951 S Kingshighway, Sikeston, MO 63801

    $1,600,000
    19,813 sqft 5.10 AC lot

    Two substantial buildings provide auditorium, classrooms, offices, multipurpose space, kitchens, storage, and community-oriented gathering areas.

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    Corner-Lot Office Building
    Corner-Lot Office Building

    202 S Kingshighway Street, Sikeston, MO 63801

    $185,000
    0.34 AC lot

    Two-level layout includes reception, offices, open work areas, conference space, restrooms, kitchen break room, storage, and elevator access.

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    Historic Two-Story Storefront
    Historic Two-Story Storefront

    112 Front Street, Sikeston, MO 63801

    $190,000
    0.11 AC lot

    Brick construction, public water, and central air serve this downtown commercial property.

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    35-Unit Self Storage Facility
    35-Unit Self Storage Facility

    2008 & 2010 N Main Street, Sikeston, MO 63801

    $549,000
    1.30 AC lot

    Self-storage property with leased commercial space and durable concrete construction.

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    Historic Two-Story Storefront
    Historic Two-Story Storefront

    124 E Front St, Sikeston, MO 63801

    $275,000
    14,642 sqft

    Downtown commercial building with leased ground-floor space and an unfinished upper level.

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    Commercial Land Near Interstate Access
    Commercial Land Near Interstate Access

    2338 S Acres Drive, Sikeston, MO 63801

    $1,100,000
    22.84 AC lot

    Vacant commercial land with agricultural zoning and direct proximity to Interstate 55 access.

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    Remodeled Office Building
    Remodeled Office Building

    210 S Kingshighway Street, Sikeston, MO 63801

    $775,000
    1.67 AC lot

    Remodeled brick office property with multiple entrances, updated building systems, and basement space.

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    Sikeston Commercial Building Investment Opportunity
    Sikeston Commercial Building Investment Opportunity

    808 E Wakefield Ave, Sikeston, MO 63801

    $979,500
    11,000 sqft

    High-visibility commercial building with income and upside potential.

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    Commercial Land Parcel
    Commercial Land Parcel

    1168 Stallcup Drive, Sikeston, MO 63801

    $450,000
    2.93 AC lot

    Commercial-zoned land positioned near major retailers, restaurants, and nearby hotels.

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    Warehouse with Dual-Unit Flexibility
    Warehouse with Dual-Unit Flexibility

    300 Matthews Lane, Sikeston, MO 63801

    $1,100,000
    1.20 AC lot

    Metal-sided warehouse offering loading access, office space, and a separate shop area.

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    Flex-Industrial Headquarters Facility
    Flex-Industrial Headquarters Facility

    205 S New Madrid St, Sikeston, MO 63801

    $449,500
    19,498 sqft 1.00 AC lot

    Multi-parcel flex facility combining office infrastructure with a full-length drive-through warehouse for operations and distribution.

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    Metal-Sided Gas Station Property
    Metal-Sided Gas Station Property

    133 W Malone Avenue, Sikeston, MO 63801

    $299,000
    0.22 AC lot

    Metal-sided commercial property with documented gas station operations through 2022.

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    Commercial Land Parcel
    Commercial Land Parcel

    109 Stallcup Drive, Sikeston, MO 63801

    $400,000
    2.63 AC lot

    Commercial-zoned land positioned near retail, hotels, restaurants, and shopping services.

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    Industrial Flex Building with Drive-In Doors
    Industrial Flex Building with Drive-In Doors

    1705 Main St, Scott City, MO 63780

    $239,900
    4,780 sqft

    Flex industrial building with office area and four overhead drive-in doors, suited for retail or distribution use under C-1 zoning.

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    Agricultural Land for Subdivision
    Agricultural Land for Subdivision

    615 David Lane, Miner, MO 63801

    $150,000
    20.16 AC lot

    Two agricultural-zoned lots totaling 20.16 acres in Miner, MO, suitable for residential or business development.

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    Modern Industrial Building with Office
    Modern Industrial Building with Office

    3046 Nash Rd, Scott City, MO 63780

    $1,480,000
    10,400 sqft 2.31 AC lot

    10,400 SF industrial building with office and warehouse space.

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    Brick Downtown Diner
    Brick Downtown Diner

    119 W Yoakum Avenue, Chaffee, MO 63740

    $135,000

    Existing restaurant layout with commercial appliances and public water service in downtown Chaffee.

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    Six-Door Auto Shop
    Six-Door Auto Shop

    410 Main St, Scott City, MO 63780

    $290,000
    3,720 sqft

    Industrial facility with office support space, equipment, and off-street parking for automotive and service operations.

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    Commercial Land with Highway Frontage
    Commercial Land with Highway Frontage

    103 Grove Estates, Sikeston, MO 63801

    $144,000
    1.01 AC lot

    C-1 zoning and public utilities support neighborhood-serving retail, office, medical, and professional uses.

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    Retail and Office Building
    Retail and Office Building

    131 W Yoakum Ave, Chaffee, MO 63740

    $145,000
    4,437 sqft

    For sale on W. Yoakum Ave., the building offers professional office space and retail storefront opportunities.

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    Drive-Through Restaurant Property
    Drive-Through Restaurant Property

    1105 S Main Street, Sikeston, MO 63801

    $650,000
    1.28 AC lot

    Existing restaurant building with highway frontage, signalized intersection access, and C3 Highway Commercial zoning.

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    Scott County, MO Commercial Real Estate Market Trends and Statistics

    Explore 72 commercial real estate for sale in Scott County, MO, showcased through 49 active listings on our real estate platform. These investment opportunities span a total of 590,580 square feet of properties for sale, with an estimated market value of $24,428,150.

    Sale prices for business properties in Scott County, MO start at $90,000, averaging $610,703, and reaching up to $2,200,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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