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    Scott County, MO Commercial Real Estate for Sale

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    Kansas City, MO Saint Louis, MO Louis, MO
    43 listings
    Sikeston Commercial Property For Sale
    $699,900
    2,196 SF
    Sikeston Commercial Property For Sale

    1207 W Malone Avenue, Sikeston, MO 63801

    Commercial property in Sikeston, Missouri, suitable for retail or automotive.
    • Durable construction featuring aluminum siding, brick, and concrete.
    • Cooling system equipped with ceiling fan(s) and electric cooling.
    • Secure exterior with security lights.
    • Features tile and ceramic tile flooring.
    • Comes with a freezer.
    Updated: May 4
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    Historic Downtown Sikeston Retail Opportunity
    $275,000
    14,642 SF
    Historic Downtown Sikeston Retail Opportunity

    124 E Front Street, Sikeston, MO 63801

    Two-story retail space in high-traffic downtown Sikeston.
    • Prime downtown location with high visibility and foot traffic.
    • Value‑add opportunity with a blank canvas upstairs for customization.
    • Existing leases on the ground floor provide immediate income.
    • Historic building (built in 1915) with unique character.
    • Close proximity to retail, professional services, and restaurants.
    Updated: Feb 25
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    Sikeston Car Wash with Expansion Potential
    $1,000,000
    40,511 SF
    Sikeston Car Wash with Expansion Potential

    Turnkey car wash with expansion potential in high-demand market.

    531 N Main Street, Sikeston, MO 63780

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    Sikeston Carwash with High Visibility
    $1,250,000
    40,946 SF
    Sikeston Carwash with High Visibility

    Turnkey carwash with high traffic, visibility, and recurring revenue.

    900 S Main Street, Sikeston, MO 63801

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    Downtown Sikeston Commercial Office Building
    $279,000
    4,273 SF
    Downtown Sikeston Commercial Office Building

    Commercial property with endless business opportunities in downtown Sikeston.

    202 S Kingshighway Street, Sikeston, MO 63801

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    Remodeled Commercial Building in Sikeston
    $775,000
    1.67 Acres
    Remodeled Commercial Building in Sikeston

    Remodeled commercial building suitable for single or multiple tenants.

    210 S Kingshighway Street, Sikeston, MO 63801

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    Multi-Tenant Storage and Commercial Space
    $549,000
    1.30 Acres
    Multi-Tenant Storage and Commercial Space

    For sale investment property with leased commercial spaces and 35 storage units on a 1.3-acre lot.

    2008 & 2010 N Main Street, Sikeston, MO 63801

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    Sikeston Warehouse with Highway Access
    $1,100,000
    24,700 SF
    Sikeston Warehouse with Highway Access

    Large warehouse with easy access to I-55 and I-57.

    300 Matthews Lane, Sikeston, MO 63801

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    Sikeston Commercial Property For Sale
    $650,000
    1.28 Acres
    Sikeston Commercial Property For Sale

    Prime commercial location with high visibility and established business history.

    1105 S Main Street, Sikeston, MO 63801

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    Sikeston Retail Property For Sale
    $550,000
    1,150 SF
    Sikeston Retail Property For Sale

    Established family-owned business with high visibility for over 30 years.

    1018 Linn Street, Sikeston, MO 63801

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    Historical Building in Downtown Sikeston
    $269,000
    6,321 SF
    Historical Building in Downtown Sikeston

    Two-story historic building in downtown Sikeston, ideal for investors.

    112 Front Street, Sikeston, MO 63801

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    Configurable Office Building with Parking
    $250,000
    Configurable Office Building with Parking

    Versatile office building offers flexible suite configuration, multiple private entrances, and on-site parking for staff and visitors.

    713 Tanner, Sikeston, MO 63801

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    Commercial Land Parcel
    $450,000
    2.93 Acres
    Commercial Land Parcel

    Commercially zoned land suited for development near major retail, dining, and hotels on the south end of Sikeston.

    1168 Stallcup Drive, Sikeston, MO 63801

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    Prime Land Off I-55
    $1,200,000
    22.84 Acres
    Prime Land Off I-55

    22+ acre vacant land with high visibility and traffic.

    2338 S Acres Drive, Sikeston, MO 63801

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    Sikeston Industrial Warehouse on 8+ Acres
    $350,000
    10,000 SF
    Sikeston Industrial Warehouse on 8+ Acres

    Industrial warehouse with I-55 frontage, ideal for logistics or distribution.

    608b State Highway H, Sikeston, MO 63801

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    Modern Industrial Building with Office
    $1,480,000
    10,400 SF
    Modern Industrial Building with Office

    10,400 SF industrial building with office and warehouse space.

    3046 Nash Rd, Scott City, MO 63780

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    Flex-Industrial Headquarters Facility
    $449,500
    19,498 SF
    Flex-Industrial Headquarters Facility

    Multi-parcel flex facility combining office infrastructure with a full-length drive-through warehouse for operations and distribution.

    205 S New Madrid St, Sikeston, MO 63801

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    Former Restaurant with Commercial Kitchen
    $425,000
    Former Restaurant with Commercial Kitchen

    Existing dining space and commercial kitchen infrastructure support a range of food service or retail concepts with ample parking.

    1212 Linn, Sikeston, MO 63801

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    Versatile Industrial Property Near I-55
    $2,200,000
    21,600 SF
    Versatile Industrial Property Near I-55

    21,600 SF industrial property with multiple buildings and convenient access.

    4930 Nash Rd, Scott City, MO 63780

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    Sikeston Commercial Building Investment Opportunity
    $979,500
    11,000 SF
    Sikeston Commercial Building Investment Opportunity

    High-visibility commercial building with income and upside potential.

    808 E Wakefield Ave, Sikeston, MO 63801

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    Commercial Land on Highway 61
    $144,000
    1.01 Acres
    Commercial Land on Highway 61

    Commercial land on high-traffic route near Sikeston Industrial Park.

    103 Grove Estates, Sikeston, MO 63801

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    Historic Downtown Mixed-Use Opportunity
    $299,000
    14,642 SF
    Historic Downtown Mixed-Use Opportunity

    Two-story historic building in downtown Sikeston with modern potential.

    124 E Front Street, Sikeston, MO 63801

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    Chaffee, MO Diner Opportunity
    $150,000
    1,925 SF
    Chaffee, MO Diner Opportunity

    Historic downtown Chaffee diner with endless potential for various uses.

    119 W Yoakum Avenue, Chaffee, MO 63740

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    Commercial Land in Sikeston, MO
    $400,000
    2.63 Acres
    Commercial Land in Sikeston, MO

    2.63 acres in booming retail and hospitality area.

    109 Stallcup Drive, Sikeston, MO 63801

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    Scott County, MO Commercial Real Estate Market Trends and Statistics

    Explore 72 commercial real estate for sale in Scott County, MO, showcased through 43 active listings on our real estate platform. These investment opportunities span a total of 1,273,219 square feet of properties for sale, with an estimated market value of $14,969,900.

    Sale prices for business properties in Scott County, MO start at $150,000, averaging $748,495, and reaching up to $2,200,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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