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    51 properties
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    Two-Story Historic Retail Building
    Updated: Feb 25
    Two-Story Historic Retail Building

    124 E Front Street, Sikeston, MO 63801

    $275,000
    14,642 sqft 0.22 AC lot
    Two leases on the ground floor
    Upstairs described as a blank canvas for future buildout
    Built in 1915 in a historic brick, two‑story structure
    Forced‑air heating and electric central air cooling
    Flat roof with public water and public sewer
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    Remodeled Professional Office Building
    Updated: Feb 27
    Remodeled Professional Office Building

    210 S Kingshighway Street, Sikeston, MO 63801

    $775,000
    1.67 AC lot
    Completely remodeled large commercial building (brick) built in 1964
    HVAC includes forced air heating and central air cooling
    Remodel scope included wiring, lights, electrical panels, bathrooms, and floors
    New fire alarm and sprinkler system
    Roof is about 75% new; parking lot resurfaced
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    Vacant Land Off Interstate Exit
    Vacant Land Off Interstate Exit

    2338 S Acres Drive, Sikeston, MO 63801

    $1,200,000
    22.84 AC lot

    Vacant ground totaling 22+ acres in Agricultural zoning, positioned just off an I-55 north exit for high-exposure development.

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    Modern Industrial Building with Office
    Modern Industrial Building with Office

    3046 Nash Rd, Scott City, MO 63780

    $1,480,000
    10,400 sqft 2.31 AC lot

    10,400 SF industrial building with office and warehouse space.

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    Commercial Land Parcel
    Commercial Land Parcel

    1168 Stallcup Drive, Sikeston, MO 63801

    $450,000
    2.93 AC lot

    Commercially zoned land parcel of 2.93 acres near major retailers and national hotel options.

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    Office Building on Corner Lot
    Office Building on Corner Lot

    202 S Kingshighway Street, Sikeston, MO 63801

    $279,000
    0.34 AC lot

    Office building with elevator and ramp access, 15 parking spaces, and central air on a corner lot.

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    Commercial Land Parcel
    Commercial Land Parcel

    109 Stallcup Drive, Sikeston, MO 63801

    $400,000
    2.63 AC lot

    Over 2.5-acre commercial lot near Wal-Mart and US 60/61.

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    Sikeston Commercial Building Investment Opportunity
    Sikeston Commercial Building Investment Opportunity

    808 E Wakefield Ave, Sikeston, MO 63801

    $979,500
    11,000 sqft

    High-visibility commercial building with income and upside potential.

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    Commercial Development Land Parcel
    Commercial Development Land Parcel

    224 S Interstate Drive, Sikeston, MO 63801

    $199,000
    2.00 AC lot

    A 2-acre commercial lot in Sikeston, MO, available for a build-to-suit development under commercial zoning.

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    Agricultural Land for Subdivision
    Agricultural Land for Subdivision

    615 David Lane, Miner, MO 63801

    $150,000
    20.16 AC lot

    Two agricultural-zoned lots totaling 20.16 acres in Miner, MO, suitable for residential or business development.

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    Industrial Flex Building with Drive-In Doors
    Industrial Flex Building with Drive-In Doors

    1705 Main St, Scott City, MO 63780

    $239,900
    4,780 sqft

    Flex industrial building with office area and four overhead drive-in doors, suited for retail or distribution use under C-1 zoning.

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    Commercial Development Land Site
    Commercial Development Land Site

    103 Grove Estates, Sikeston, MO 63801

    $144,000
    1.01 AC lot

    Commercially zoned tract with Highway 61 frontage for office, medical, and professional services near Sikeston residential areas.

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    Office Building with Flexible Suite Layout
    Office Building with Flexible Suite Layout

    713 Tanner, Sikeston, MO 63801

    $250,000

    Commercial zoned office building offering a flexible layout for a single suite or up to four office suites.

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    Flex-Industrial Headquarters Facility
    Flex-Industrial Headquarters Facility

    205 S New Madrid St, Sikeston, MO 63801

    $449,500
    19,498 sqft 1.00 AC lot

    Multi-parcel flex facility combining office infrastructure with a full-length drive-through warehouse for operations and distribution.

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    Historic Diner Restaurant Building
    Historic Diner Restaurant Building

    119 W Yoakum Avenue, Chaffee, MO 63740

    $150,000

    Old-school diner building currently set up as a restaurant in downtown Chaffee, Missouri.

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    Former Restaurant with Commercial Kitchen
    Former Restaurant with Commercial Kitchen

    1212 Linn, Sikeston, MO 63801

    $425,000

    Former restaurant includes a spacious dining area, commercial kitchen infrastructure, and ample parking for new concepts.

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    Retail and Office Building
    Retail and Office Building

    131 W Yoakum Ave, Chaffee, MO 63740

    $145,000
    4,437 sqft

    For sale on W. Yoakum Ave., the building offers professional office space and retail storefront opportunities.

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    Commercial Property with Storage and Duplex
    Commercial Property with Storage and Duplex

    101-103 Donald Fulton Dr, Sikeston, MO 63801

    $290,000
    4,244 sqft 1.22 AC lot

    Large commercial building and a separately fenced duplex with storage building and concrete parking.

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    Versatile Industrial Property Near I-55
    Versatile Industrial Property Near I-55

    4930 Nash Rd, Scott City, MO 63780

    $2,200,000
    21,600 sqft 3.17 AC lot

    21,600 SF industrial property with multiple buildings and convenient access.

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    Agricultural Land Tract
    Agricultural Land Tract

    County Road 351, Scott City, MO 63780

    $74,900
    12.50 AC lot

    Agricultural-zoned 12.5-acre tract near Scott City, offering options for hunting, timber, farming, or building.

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    Six-Door Auto Shop
    Six-Door Auto Shop

    410 Main Street, Scott City, MO 63780

    $290,000
    3,720 sqft

    Industrial facility with office support space, equipment, and off-street parking for automotive and service operations.

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    Move-In Ready Downtown Storefront
    Move-In Ready Downtown Storefront

    129 W Yoakum Ave, Chaffee, MO 63740

    $150,000
    2,279 sqft

    Charming downtown storefront offers 2,279 move-in-ready square feet with visibility and easy access on W. Yoakum Ave.

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    Prime Land I-55 Exit 69
    Prime Land I-55 Exit 69

    2338 South Acres Drive, Sikeston, MO 63801

    $1,200,000
    994,910 sqft 22.84 AC lot

    High-traffic vacant land suitable for retail or restaurant development.

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    Turnkey Restaurant Opportunity in Benton
    Turnkey Restaurant Opportunity in Benton

    25 W Tywappity St., Benton, MO 63736

    $499,000
    2,215 sqft

    Thriving restaurant business with building for sale in Benton, MO.

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    Scott County, MO Commercial Real Estate Market Trends and Statistics

    Explore 72 commercial real estate for sale in Scott County, MO, showcased through 51 active listings on our real estate platform. These investment opportunities span a total of 1,507,756 square feet of properties for sale, with an estimated market value of $23,768,225.

    Sale prices for business properties in Scott County, MO start at $74,900, averaging $625,479, and reaching up to $3,169,425 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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