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    Scott County, MO Office Spaces for Sale

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    Kansas City, MO Louis, MO Saint Louis, MO
    7 results
    Downtown Sikeston Commercial Office Building
    $279,000
    4,273 SF
    Downtown Sikeston Commercial Office Building

    202 S Kingshighway Street, Sikeston, MO 63801

    Commercial property with endless business opportunities in downtown Sikeston.
    • Large 7,638 sq ft building suitable for diverse business opportunities.
    • Prime downtown Sikeston location on a corner lot.
    • Includes 15 parking spaces with handicap accessibility (2 spaces and ramp).
    • Functional layout with reception area, open workspace, private offices, conference room, and break room.
    • Equipped with both stairs and an elevator for basement access.
    Updated: Dec 10, 2025
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    Remodeled Commercial Building in Sikeston
    $775,000
    1.67 Acres
    Remodeled Commercial Building in Sikeston

    210 S Kingshighway Street, Sikeston, MO 63801

    Remodeled commercial building suitable for single or multiple tenants.
    • Completely remodeled building ideal for single or multiple professional/service‑related tenants.
    • New fire alarm and sprinkler system for enhanced safety.
    • Parking on 3 sides of the building.
    • Large basement accessible by elevator or stairs, suitable for storage or additional offices.
    • Remodel includes new wiring, lights, electrical panels, bathrooms, and floors.
    Updated: Feb 26
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    Sikeston Commercial Building Investment Opportunity
    $979,500
    11,000 SF
    Sikeston Commercial Building Investment Opportunity

    High-visibility commercial building with income and upside potential.

    808 E Wakefield Ave, Sikeston, MO 63801

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    Modern Industrial Building with Office
    $1,480,000
    10,400 SF
    Modern Industrial Building with Office

    10,400 SF industrial building with office and warehouse space.

    3046 Nash Rd, Scott City, MO 63780

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    Historic Downtown Mixed-Use Opportunity
    $299,000
    14,642 SF
    Historic Downtown Mixed-Use Opportunity

    Two-story historic building in downtown Sikeston with modern potential.

    124 E Front Street, Sikeston, MO 63801

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    Chaffee, MO Diner Opportunity
    $150,000
    1,925 SF
    Chaffee, MO Diner Opportunity

    Historic downtown Chaffee diner with endless potential for various uses.

    119 W Yoakum Avenue, Chaffee, MO 63740

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    Commercial Building in High Traffic
    $400,000
    7,100 SF
    Commercial Building in High Traffic

    7100 sq ft commercial building in high traffic area.

    1218 Linn St, Sikeston, MO 63801

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    Based on your search, we've compiled 76 Potential Opportunities for your consideration. Besides 7 Active listings in Scott County, MO, we suggest exploring several alternatives: similar 65 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Commercial Land on Highway 61
    $144,000
    1.01 Acres
    Commercial Land on Highway 61

    Commercial land on high-traffic route near Sikeston Industrial Park.

    103 Grove Estates, Sikeston, MO 63801

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    Commercial Land Ready For Development
    $199,000
    2.00 Acres
    Commercial Land Ready For Development

    Two-acre commercial lot available for development in Sikeston, Missouri.

    224 S Interstate Drive, Sikeston, MO 63801

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    Commercial Land in Sikeston, MO
    $195,000
    0.72 Acres
    Commercial Land in Sikeston, MO

    Vacant, level commercial lot available in Sikeston, Missouri.

    116 Hospitality Drive, Sikeston, MO 63801

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    Cape Girardeau Commercial Land Opportunity
    $389,000
    10.20 Acres
    Cape Girardeau Commercial Land Opportunity

    7.5-acre commercial lot in prime Cape Girardeau location.

    0 Rear Commercial Street, Cape Girardeau, MO 63703

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    Off-Market Properties in Scott County, MO

    Consider similar Off-Market properties in Scott County, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    113 Main St
    OFFICE BUILDING
    2,150 SF Lot: 0.07 Acres
    Value Estimation by Request

    113 Main St, Chaffee, MO 63740-1031

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    2618 County Hwy 401
    OFFICE BUILDING
    5,700 SF Lot: 7.60 Acres
    Value Estimation by Request

    2618 County Hwy 401, Benton, MO 63736

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    816 Linn St
    OFFICE BUILDING
    2,135 SF Lot: 0.29 Acres
    Value Estimation by Request

    816 Linn St, Sikeston, MO 63801-2241

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    402 Yoakum Ave
    OFFICE BUILDING
    1,866 SF Lot: 0.26 Acres
    Value Estimation by Request

    402 Yoakum Ave, Chaffee, MO 63740-1824

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    1300 Main St
    OFFICE BUILDING
    540 SF Lot: 0.53 Acres
    Value Estimation by Request

    1300 Main St, Scott City, MO 63780

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    1705 Main St
    OFFICE BUILDING
    1,890 SF Lot: 0.38 Acres
    Value Estimation by Request

    1705 Main St, Scott City, MO 63780-1922

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    101 Plz Dr
    OFFICE BUILDING
    957 SF Lot: 0.26 Acres
    Value Estimation by Request

    101 Plz Dr, Sikeston, MO 63801-5136

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    613 Greer Ave
    MEDICAL BUILDING
    3,468 SF Lot: 0.30 Acres
    Value Estimation by Request

    613 Greer Ave, Sikeston, MO 63801

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    330 State Hwy H H
    OFFICE BUILDING
    10,400 SF Lot: 3.00 Acres
    Value Estimation by Request

    330 State Hwy H H, Sikeston, MO 63801-5349

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    228 Interstate Dr
    OFFICE BUILDING
    468 SF Lot: 0.60 Acres
    Value Estimation by Request

    228 Interstate Dr, Sikeston, MO 63801-8621

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    2830 Brewer Dr
    OFFICE BUILDING
    640 SF Lot: 1.60 Acres
    Value Estimation by Request

    2830 Brewer Dr, Sikeston, MO 63801

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    2232 Main St
    OFFICE BUILDING
    1,860 SF Lot: 0.30 Acres
    Value Estimation by Request

    2232 Main St, Scott City, MO 63780-1329

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    101 Kennedy Dr
    OFFICE BUILDING
    2,726 SF Lot: 0.56 Acres
    Value Estimation by Request

    101 Kennedy Dr, Sikeston, MO 63801-5126

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    215 Stoddard St
    OFFICE BUILDING
    3,212 SF Lot: 0.32 Acres
    Value Estimation by Request

    215 Stoddard St, Sikeston, MO 63801-4124

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    102 Smith Ave
    OFFICE BUILDING
    6,660 SF Lot: 0.48 Acres
    Value Estimation by Request

    102 Smith Ave, Sikeston, MO 63801-5240

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    Sikeston, MO 63801
    OFFICE BUILDING
    2,160 SF Lot: 2.72 Acres
    Value Estimation by Request

    Sikeston, MO 63801

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    103 Wright Ave
    OFFICE BUILDING
    693 SF Lot: 0.02 Acres
    Value Estimation by Request

    103 Wright Ave, Chaffee, MO 63740-1126

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    Scott County, MO Office Spaces Investment Opportunities Market Analysis

    Explore 72 office spaces for sale in Scott County, MO, showcased through 7 active listings on our real estate platform. These investment opportunities span a total of 49,340 square feet of properties for sale, with an estimated market value of $3,587,500.

    Sale prices for office spaces in Scott County, MO start at $150,000, averaging $597,916, and reaching up to $1,480,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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