Scott County, MO Office Spaces for Sale

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11 properties

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Updated: Feb 27

Remodeled Professional Office Building

210 S Kingshighway Street, Sikeston, MO 63801

$775,000

1.67 AC lot

Completely remodeled large commercial building (brick) built in 1964
HVAC includes forced air heating and central air cooling
Remodel scope included wiring, lights, electrical panels, bathrooms, and floors
New fire alarm and sprinkler system
Roof is about 75% new; parking lot resurfaced

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Updated: Oct 16, 2025

Automotive Shop and Office Buildings

1018 Linn Street, Sikeston, MO 63801

$550,000

4.20 AC lot

Two Morton buildings on site: office building ~24x48 with a 15x48 covered porch, plus shop building ~48x75
Shop building features 2 sets of drive‑through doors and 2 walk‑through doors and 11‑foot walls
Property includes irrigation and is served by public water; cable is available
Utilities/amenities listed: natural gas heating and wall unit cooling
Construction and building finishes include metal siding and concrete flooring

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Downtown Office Building with Parking

202 S Kingshighway Street, Sikeston, MO 63801

$279,000

0.34 AC lot

Corner lot office building includes a receptionist area, multiple offices, and basement level with elevator access.

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Modern Industrial Building with Office

3046 Nash Rd, Scott City, MO 63780

$1,480,000

10,400 sqft 2.31 AC lot

10,400 SF industrial building with office and warehouse space.

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Flexible Office Building

713 Tanner, Sikeston, MO 63801

$250,000

Well-maintained office building configured as one suite or up to four suites with multiple private entrances and parking.

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Sikeston Commercial Building Investment Opportunity

808 E Wakefield Ave, Sikeston, MO 63801

$979,500

11,000 sqft

High-visibility commercial building with income and upside potential.

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Flex-Industrial Headquarters Facility

205 S New Madrid St, Sikeston, MO 63801

$449,500

19,498 sqft 1.00 AC lot

Multi-parcel flex facility combining office infrastructure with a full-length drive-through warehouse for operations and distribution.

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Showroom, Office and Shop Building

229 Airport Rd, Scott City, MO 63780

Contact for pricing

8,516 sqft 5.00 AC lot

Multi-use showroom, office, and shop building with multiple drive-through doors and fenced paving/gravel exterior areas.

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Retail and Office Building

131 W Yoakum Ave, Chaffee, MO 63740

$145,000

4,437 sqft

For sale on W. Yoakum Ave., the building offers professional office space and retail storefront opportunities.

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Commercial Building in High Traffic

1218 Linn St, Sikeston, MO 63801

$400,000

7,100 sqft 0.74 AC lot

7100 sq ft commercial building in high traffic area.

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Gated Flex and Workshop Property

299 County Highway 539, Miner, MO 63801

Contact for pricing

7,800 sqft 2.72 AC lot

Gated property with a 2.72-acre yard, 2,160-square-foot office, and 7,800-square-foot workshop plus barn/open storage.

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Based on your search, we've compiled 76 Potential Opportunities for your consideration. Besides 11 Active listings in Scott County, MO, we suggest exploring several alternatives: similar 61 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Commercial Development Land Site

103 Grove Estates, Sikeston, MO 63801

$144,000

1.01 AC lot

Commercially zoned tract with Highway 61 frontage for office, medical, and professional services near Sikeston residential areas.

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Commercial Development Land Parcel

224 S Interstate Drive, Sikeston, MO 63801

$199,000

2.00 AC lot

A 2-acre commercial lot in Sikeston, MO, available for a build-to-suit development under commercial zoning.

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Vacant Commercial Land Lot

116 Hospitality Drive, Sikeston, MO 63801

$195,000

0.72 AC lot

Vacant, level commercial-zoned lot outside the flood plain, suitable for a future development footprint.

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Renovated Downtown Office and Retail Building

230 N Sprigg Street, Cape Girardeau, MO 63701

$239,900

2,937 sqft 0.25 AC lot

Renovated commercial building on a high-traffic downtown corridor, offering flexible space for offices or storefront services.

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Off-Market Properties in Scott County, MO

Consider similar Off-Market properties in Scott County, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

OFFICE BUILDING

113 Main St, Chaffee, MO 63740-1031

Value Estimation by Request

2,150 sqft 0.07 AC lot

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OFFICE BUILDING

2618 County Hwy 401, Benton, MO 63736

Value Estimation by Request

5,700 sqft 7.60 AC lot

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OFFICE BUILDING

816 Linn St, Sikeston, MO 63801-2241

Value Estimation by Request

2,135 sqft 0.29 AC lot

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OFFICE BUILDING

402 Yoakum Ave, Chaffee, MO 63740-1824

Value Estimation by Request

1,866 sqft 0.26 AC lot

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OFFICE BUILDING

1300 Main St, Scott City, MO 63780

Value Estimation by Request

540 sqft 0.53 AC lot

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OFFICE BUILDING

1705 Main St, Scott City, MO 63780-1922

Value Estimation by Request

1,890 sqft 0.38 AC lot

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OFFICE BUILDING

101 Plz Dr, Sikeston, MO 63801-5136

Value Estimation by Request

957 sqft 0.26 AC lot

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MEDICAL BUILDING

613 Greer Ave, Sikeston, MO 63801

Value Estimation by Request

3,468 sqft 0.30 AC lot

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OFFICE BUILDING

330 State Hwy H H, Sikeston, MO 63801-5349

Value Estimation by Request

10,400 sqft 3.00 AC lot

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OFFICE BUILDING

228 Interstate Dr, Sikeston, MO 63801-8621

Value Estimation by Request

468 sqft 0.60 AC lot

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OFFICE BUILDING

2830 Brewer Dr, Sikeston, MO 63801

Value Estimation by Request

640 sqft 1.60 AC lot

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OFFICE BUILDING

2232 Main St, Scott City, MO 63780-1329

Value Estimation by Request

1,860 sqft 0.30 AC lot

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OFFICE BUILDING

101 Kennedy Dr, Sikeston, MO 63801-5126

Value Estimation by Request

2,726 sqft 0.56 AC lot

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Scott County, MO Office Spaces Market Trends and Statistics

Explore 72 office spaces for sale in Scott County, MO, showcased through 11 active listings on our real estate platform. These investment opportunities span a total of 52,435 square feet of properties for sale, with an estimated market value of $3,454,000.

Sale prices for office spaces in Scott County, MO start at $145,000, averaging $690,800, and reaching up to $1,480,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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