Scott County, MO Office Spaces for sale

Downtown Sikeston Commercial Office Building

$279,000

4,273 SF

Downtown Sikeston Commercial Office Building

202 S Kingshighway Street, Sikeston, MO 63801

Commercial property with endless business opportunities in downtown Sikeston.

Large 7,638 sq ft building suitable for diverse business opportunities.
Prime downtown Sikeston location on a corner lot.
Includes 15 parking spaces with handicap accessibility (2 spaces and ramp).
Functional layout with reception area, open workspace, private offices, conference room, and break room.
Equipped with both stairs and an elevator for basement access.

Updated: Dec 10, 2025

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Remodeled Commercial Building in Sikeston

$775,000

1.67 Acres

Remodeled Commercial Building in Sikeston

210 S Kingshighway Street, Sikeston, MO 63801

Remodeled commercial building suitable for single or multiple tenants.

Completely remodeled building ideal for single or multiple professional/service‑related tenants.
New fire alarm and sprinkler system for enhanced safety.
Parking on 3 sides of the building.
Large basement accessible by elevator or stairs, suitable for storage or additional offices.
Remodel includes new wiring, lights, electrical panels, bathrooms, and floors.

Updated: Feb 26

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Sikeston Commercial Building Investment Opportunity

$979,500

11,000 SF

Sikeston Commercial Building Investment Opportunity

High-visibility commercial building with income and upside potential.

808 E Wakefield Ave, Sikeston, MO 63801

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$1,480,000

10,400 SF

Modern Industrial Building with Office

10,400 SF industrial building with office and warehouse space.

3046 Nash Rd, Scott City, MO 63780

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$299,000

14,642 SF

Historic Downtown Mixed-Use Opportunity

Two-story historic building in downtown Sikeston with modern potential.

124 E Front Street, Sikeston, MO 63801

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$150,000

1,925 SF

Chaffee, MO Diner Opportunity

Historic downtown Chaffee diner with endless potential for various uses.

119 W Yoakum Avenue, Chaffee, MO 63740

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$400,000

7,100 SF

Commercial Building in High Traffic

7100 sq ft commercial building in high traffic area.

1218 Linn St, Sikeston, MO 63801

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Based on your search, we've compiled 76 Potential Opportunities for your consideration. Besides 7 Active listings in Scott County, MO, we suggest exploring several alternatives: similar 65 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

$144,000

1.01 Acres

Commercial Land on Highway 61

Commercial land on high-traffic route near Sikeston Industrial Park.

103 Grove Estates, Sikeston, MO 63801

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$199,000

2.00 Acres

Commercial Land Ready For Development

Two-acre commercial lot available for development in Sikeston, Missouri.

224 S Interstate Drive, Sikeston, MO 63801

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$195,000

0.72 Acres

Commercial Land in Sikeston, MO

Vacant, level commercial lot available in Sikeston, Missouri.

116 Hospitality Drive, Sikeston, MO 63801

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Cape Girardeau Commercial Land Opportunity

$389,000

10.20 Acres

Cape Girardeau Commercial Land Opportunity

7.5-acre commercial lot in prime Cape Girardeau location.

0 Rear Commercial Street, Cape Girardeau, MO 63703

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Off-Market Properties in Scott County, MO

Consider similar Off-Market properties in Scott County, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

OFFICE BUILDING

2,150 SF Lot: 0.07 Acres

Value Estimation by Request

113 Main St, Chaffee, MO 63740-1031

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OFFICE BUILDING

5,700 SF Lot: 7.60 Acres

Value Estimation by Request

2618 County Hwy 401, Benton, MO 63736

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OFFICE BUILDING

2,135 SF Lot: 0.29 Acres

Value Estimation by Request

816 Linn St, Sikeston, MO 63801-2241

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OFFICE BUILDING

1,866 SF Lot: 0.26 Acres

Value Estimation by Request

402 Yoakum Ave, Chaffee, MO 63740-1824

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OFFICE BUILDING

540 SF Lot: 0.53 Acres

Value Estimation by Request

1300 Main St, Scott City, MO 63780

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OFFICE BUILDING

1,890 SF Lot: 0.38 Acres

Value Estimation by Request

1705 Main St, Scott City, MO 63780-1922

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OFFICE BUILDING

957 SF Lot: 0.26 Acres

Value Estimation by Request

101 Plz Dr, Sikeston, MO 63801-5136

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MEDICAL BUILDING

3,468 SF Lot: 0.30 Acres

Value Estimation by Request

613 Greer Ave, Sikeston, MO 63801

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OFFICE BUILDING

10,400 SF Lot: 3.00 Acres

Value Estimation by Request

330 State Hwy H H, Sikeston, MO 63801-5349

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OFFICE BUILDING

468 SF Lot: 0.60 Acres

Value Estimation by Request

228 Interstate Dr, Sikeston, MO 63801-8621

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OFFICE BUILDING

640 SF Lot: 1.60 Acres

Value Estimation by Request

2830 Brewer Dr, Sikeston, MO 63801

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OFFICE BUILDING

1,860 SF Lot: 0.30 Acres

Value Estimation by Request

2232 Main St, Scott City, MO 63780-1329

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OFFICE BUILDING

2,726 SF Lot: 0.56 Acres

Value Estimation by Request

101 Kennedy Dr, Sikeston, MO 63801-5126

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OFFICE BUILDING

3,212 SF Lot: 0.32 Acres

Value Estimation by Request

215 Stoddard St, Sikeston, MO 63801-4124

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OFFICE BUILDING

6,660 SF Lot: 0.48 Acres

Value Estimation by Request

102 Smith Ave, Sikeston, MO 63801-5240

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OFFICE BUILDING

2,160 SF Lot: 2.72 Acres

Value Estimation by Request

Sikeston, MO 63801

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OFFICE BUILDING

693 SF Lot: 0.02 Acres

Value Estimation by Request

103 Wright Ave, Chaffee, MO 63740-1126

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Scott County, MO Office Spaces Investment Opportunities Market Analysis

Explore 72 office spaces for sale in Scott County, MO, showcased through 7 active listings on our real estate platform. These investment opportunities span a total of 49,340 square feet of properties for sale, with an estimated market value of $3,587,500.

Sale prices for office spaces in Scott County, MO start at $150,000, averaging $597,916, and reaching up to $1,480,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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