Scott County, MO Office properties & Spaces for sale

Remodeled Commercial Building in Sikeston

$775,000

1.67 Acres

Remodeled Commercial Building in Sikeston

210 S Kingshighway Street, Sikeston, MO 63801

Remodeled commercial building suitable for single or multiple tenants.

Completely remodeled building ideal for single or multiple professional/service‑related tenants.
New fire alarm and sprinkler system for enhanced safety.
Parking on 3 sides of the building.
Large basement accessible by elevator or stairs, suitable for storage or additional offices.
Remodel includes new wiring, lights, electrical panels, bathrooms, and floors.

Updated: Feb 26

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Downtown Sikeston Commercial Office Building

$279,000

4,273 SF

Downtown Sikeston Commercial Office Building

202 S Kingshighway Street, Sikeston, MO 63801

Commercial property with endless business opportunities in downtown Sikeston.

Large 7,638 sq ft building suitable for diverse business opportunities.
Prime downtown Sikeston location on a corner lot.
Includes 15 parking spaces with handicap accessibility (2 spaces and ramp).
Functional layout with reception area, open workspace, private offices, conference room, and break room.
Equipped with both stairs and an elevator for basement access.

Updated: Dec 10, 2025

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Sikeston Commercial Building Investment Opportunity

$979,500

11,000 SF

Sikeston Commercial Building Investment Opportunity

High-visibility commercial building with income and upside potential.

808 E Wakefield Ave, Sikeston, MO 63801

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$1,480,000

10,400 SF

Modern Industrial Building with Office

10,400 SF industrial building with office and warehouse space.

3046 Nash Rd, Scott City, MO 63780

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$299,000

14,642 SF

Historic Downtown Mixed-Use Opportunity

Two-story historic building in downtown Sikeston with modern potential.

124 E Front Street, Sikeston, MO 63801

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$400,000

7,100 SF

Commercial Building in High Traffic

7100 sq ft commercial building in high traffic area.

1218 Linn St, Sikeston, MO 63801

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Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Renovated Commercial Building in Cape Girardeau

$239,900

2,937 SF

Renovated Commercial Building in Cape Girardeau

Renovated commercial building with high visibility in a prime location.

230 N Sprigg Street, Cape Girardeau, MO 63701

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$2,000,000

2.96 Acres

Commercial Land in Dexter, MO

Commercial property suitable for business, subdivision possible.

0 W Bus Hwy 60, Dexter, MO 63841

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$109,000

7,000 SF

Commercial Property on Highway 25

7000 sq ft commercial property on 1 acre lot.

2770 N Douglass, Malden, MO 63863

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$750,000

2.27 Acres

Paducah Commercial Land Opportunity

2.27+/- acre commercial lot in high-traffic area.

4735 Village Square Dr. - 1/2, Paducah, KY 42001

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Explore Off-Market Properties in Scott County, MO

Consider similar Off-Market properties in Scott County, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

113 Main St

OFFICE BUILDING • 2,150 SF

Value Estimation by Request

113 Main St, Chaffee, MO 63740-1031

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2618 County Hwy 401

OFFICE BUILDING • 5,700 SF

Value Estimation by Request

2618 County Hwy 401, Benton, MO 63736

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816 Linn St

OFFICE BUILDING • 2,135 SF

Value Estimation by Request

816 Linn St, Sikeston, MO 63801-2241

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402 Yoakum Ave

OFFICE BUILDING • 1,866 SF

Value Estimation by Request

402 Yoakum Ave, Chaffee, MO 63740-1824

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1300 Main St

OFFICE BUILDING • 540 SF

Value Estimation by Request

1300 Main St, Scott City, MO 63780

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1705 Main St

OFFICE BUILDING • 1,890 SF

Value Estimation by Request

1705 Main St, Scott City, MO 63780-1922

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101 Plz Dr

OFFICE BUILDING • 957 SF

Value Estimation by Request

101 Plz Dr, Sikeston, MO 63801-5136

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613 Greer Ave

MEDICAL BUILDING • 3,468 SF

Value Estimation by Request

613 Greer Ave, Sikeston, MO 63801

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330 State Hwy H H

OFFICE BUILDING • 10,400 SF

Value Estimation by Request

330 State Hwy H H, Sikeston, MO 63801-5349

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228 Interstate Dr

OFFICE BUILDING • 468 SF

Value Estimation by Request

228 Interstate Dr, Sikeston, MO 63801-8621

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2830 Brewer Dr

OFFICE BUILDING • 640 SF

Value Estimation by Request

2830 Brewer Dr, Sikeston, MO 63801

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2232 Main St

OFFICE BUILDING • 1,860 SF

Value Estimation by Request

2232 Main St, Scott City, MO 63780-1329

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101 Kennedy Dr

OFFICE BUILDING • 2,726 SF

Value Estimation by Request

101 Kennedy Dr, Sikeston, MO 63801-5126

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215 Stoddard St

OFFICE BUILDING • 3,212 SF

Value Estimation by Request

215 Stoddard St, Sikeston, MO 63801-4124

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102 Smith Ave

OFFICE BUILDING • 6,660 SF

Value Estimation by Request

102 Smith Ave, Sikeston, MO 63801-5240

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Sikeston, MO 63801

OFFICE BUILDING • 2,160 SF

Value Estimation by Request

Sikeston, MO 63801

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103 Wright Ave

OFFICE BUILDING • 693 SF

Value Estimation by Request

103 Wright Ave, Chaffee, MO 63740-1126

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301 Malone Ave

OFFICE BUILDING • 3,058 SF

Value Estimation by Request

301 Malone Ave, Sikeston, MO 63801-2827

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Scott County, MO Office Properties & Spaces Investment Opportunities Market Analysis

Explore 223 office properties & spaces for sale in Scott County, MO, showcased through 6 active listings on our real estate platform. These investment opportunities span a total of 9,741,283 square feet of properties for sale, with an estimated market value of $6,829,000.

Sale prices for office spaces in Scott County, MO start at $279,000, averaging $569,083, and reaching up to $775,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

Scott County, MO Office Properties & Spaces for Sale

Remodeled Commercial Building in Sikeston

Remodeled commercial building suitable for single or multiple tenants.

Downtown Sikeston Commercial Office Building

Commercial property with endless business opportunities in downtown Sikeston.