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    Cape Girardeau, MO Commercial Real Estate for Sale

    95 results
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    Renovated Downtown Commercial Property
    $550,000
    4,548 SF

    Renovated Downtown Commercial Property

    224 N Frederick St, Cape Girardeau, MO 63701

    Versatile, renovated 11-bedroom property in downtown Cape Girardeau, Missouri.

    • Prime downtown location steps from dining, shopping, and campus.
    • Proven income‑producing property as a high‑demand sorority house.
    • Fully renovated in 2020 with 11 bedrooms and over 5,100 square feet.
    • Versatile property suitable for group housing, student rentals, or professional office space.
    • Generous lot with twenty‑five parking spaces.
    Updated: Jan 9
    View details
    Cape Girardeau Commercial Property For Sale
    $599,900
    8,280 SF

    Cape Girardeau Commercial Property For Sale

    1444 Independence St, Cape Girardeau, MO 63703

    Commercial property with parking, high traffic, and recent upgrades.

    • High daily traffic count and strategic location for maximum business visibility.
    • Over 25 parking spots available.
    • Large building with over 8000 sq ft of space suitable for a variety of businesses.
    • Recent upgrades including sewer lines and foam insulation.
    • Equipped with a commercial kitchen.
    Updated: Oct 17, 2025
    View details
    Broadway Commercial Space with Apartment
    $280,000
    5,100 SF

    Broadway Commercial Space with Apartment

    Versatile investment opportunity with remodeled apartment and commercial space.

    520 Broadway St, Cape Girardeau, MO 63701
    View details
    Leased Office Building For Sale
    $500,000
    7,140 SF

    Leased Office Building For Sale

    Two-story office building with 21 units and parking.

    2711 Thomas Dr, Cape Girardeau, MO 63701
    View details
    Ambulatory Surgery Center Investment Opportunity
    $8,050,000
    13,650 SF

    Ambulatory Surgery Center Investment Opportunity

    Single-tenant surgery center near St. Francis Medical Center for sale.

    3241 Percy Dr, Cape Girardeau, MO 63701
    View details
    Industrial Warehouse in Cape Girardeau
    $499,900
    3.90 Acres

    Industrial Warehouse in Cape Girardeau

    3.9 acres with 7,500 sq ft warehouse near I-55.

    840 S Kings Highway St, Cape Girardeau, MO 63703
    View details
    Cape Girardeau Commercial Property
    Pending
    $825,000
    7,000 SF

    Cape Girardeau Commercial Property

    Well-maintained commercial property with over 7,000 square feet.

    340 S Broadview St, Cape Girardeau, MO 63703
    View details
    Versatile Commercial Building in Cape
    $225,000
    0.57 Acres

    Versatile Commercial Building in Cape

    Adaptable 1800 sq ft commercial building in thriving Cape Girardeau.

    2357 Rust Ave, Cape Girardeau, MO 63703
    View details
    Versatile Commercial Property in Missouri
    $295,000
    2,920 SF

    Versatile Commercial Property in Missouri

    Adaptable commercial space with retail, office, and warehouse capabilities.

    225 Clark Ave, Cape Girardeau, MO 63701
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    Renovated Commercial Space in Cape Girardeau
    $239,900
    2,937 SF

    Renovated Commercial Space in Cape Girardeau

    Renovated commercial space with high potential in a prime location.

    230 N Sprigg St, Cape Girardeau, MO 63701
    View details
    Applebee's Net Lease Investment
    $1,875,000
    5,396 SF

    Applebee's Net Lease Investment

    Missouri Applebee's: 8% Cap Rate, NNN Lease

    202 Broadview St, Cape Girardeau, MO 63703
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    Prime Cape Girardeau Office Building
    $899,900
    13,694 SF

    Prime Cape Girardeau Office Building

    13,694 SF Executive Office Space

    18 Main St, Cape Girardeau, MO 63701
    View details
    Freestanding Restaurant in Cape Girardeau
    $1,950,000
    5,396 SF

    Freestanding Restaurant in Cape Girardeau

    Single-tenant restaurant with a new long-term lease.

    202 S Broadview St, Cape Girardeau, MO 63703
    View details

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Productive Farmland Tract For Sale
    $630,000
    84.00 Acres

    Productive Farmland Tract For Sale

    84+/- acre tillable farmland tract near Cape Girardeau, MO.

    146 Tract 1 Hwy, Mc Clure, IL 62957
    View details
    Productive Farmland Tract For Sale
    $1,155,000
    154.00 Acres

    Productive Farmland Tract For Sale

    154+/- acre tillable farmland tract with excellent access.

    146 Tract 2 Hwy, Mc Clure, IL 62957
    View details
    so you're a big time dreamer
    $499,900
    2,500 SF

    so you're a big time dreamer

    eh? ... nothing says the current use is carved in stone. Check out surrounding commercial properties offering a once-in-a-lifetime opportunity at a package deal to OWN just over 8 ACRES of commercial property on BOTH sides of this 4-Lane highway with 0ver 1

    592 State Hwy 146 Hwy, McClure, IL 62957
    View details
    McClure Commercial Building - Highway 146
    $360,000
    6,750 SF

    McClure Commercial Building - Highway 146

    High-traffic commercial property, flexible layout.

    589 State Hwy 146 Hwy, McClure, IL 62957
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Commercial Land in Cape Girardeau
    Pending
    Contact for pricing
    0.18 Acres

    Commercial Land in Cape Girardeau

    Commercial land available in Cape Girardeau, Missouri.

    803 Independence St, Cape Girardeau, MO 63703
    View details
    Commercial Land in Cape Girardeau
    $250,000
    6.02 Acres

    Commercial Land in Cape Girardeau

    6-acre commercial tract in the heart of Cape Girardeau.

    410 William St, Cape Girardeau, MO 63703
    View details

    Explore Off-Market Properties in Cape Girardeau, MO

    Consider similar Off-Market properties in Cape Girardeau, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    4300 Mo-74

    4300 Mo-74

    Flex space • 5,100 SF
    Value Estimation by Request
    4300 Mo-74, Cape Girardeau, MO 63701
    View details
    207-213 Kings Highway St

    207-213 Kings Highway St

    Retail properties • 30,000 SF
    Value Estimation by Request
    207-213 Kings Highway St, Cape Girardeau, MO 63703
    View details
    155 Siemers Dr

    155 Siemers Dr

    Retail properties • 46,692 SF
    Value Estimation by Request
    155 Siemers Dr, Cape Girardeau, MO 63701
    View details
    2070 Sprigg St

    2070 Sprigg St

    Multifamily properties • 248,038 SF
    Value Estimation by Request
    2070 Sprigg St, Cape Girardeau, MO 63701
    View details
    250 Silver Springs Rd

    250 Silver Springs Rd

    Retail properties • 23,464 SF
    Value Estimation by Request
    250 Silver Springs Rd, Cape Girardeau, MO 63703
    View details
    3049 William St

    3049 William St

    Medical offices • 79,122 SF
    Value Estimation by Request
    3049 William St, Cape Girardeau, MO 63703
    View details
    440 Mount Auburn Rd

    440 Mount Auburn Rd

    Office Properties & Spaces • 10,821 SF
    Value Estimation by Request
    440 Mount Auburn Rd, Cape Girardeau, MO 63703
    View details
    2905 Vly Crk Rd

    2905 Vly Crk Rd

    COMMERCIAL MISC • 1,776 SF
    Value Estimation
    $240,000
    2905 Vly Crk Rd, Cape Girardeau, MO 63701-8939
    View details
    5601 State Hwy 25

    5601 State Hwy 25

    COMMERCIAL MISC • 1,639 SF
    Value Estimation
    $220,000
    5601 State Hwy 25, Cape Girardeau, MO 63701-9267
    View details
    108 Main St

    108 Main St

    OFFICE/RESIDENTIAL (MIXED USE) • 6,674 SF
    Value Estimation
    $290,000
    108 Main St, Cape Girardeau, MO 63701-7309
    View details
    720 Themis St

    720 Themis St

    COMMERCIAL MISC • 1,185 SF
    Value Estimation
    $215,000
    720 Themis St, Cape Girardeau, MO 63701-5534
    View details

    Cape Girardeau, MO Commercial Real Estate Investment Opportunities Market Analysis

    Explore 196 commercial real estate investment opportunities in Cape Girardeau, MO with 95 listings featured on our commercial real estate marketplace. The current inventory includes 23,783,025 square feet of properties with an estimated value of $43,364,200.

    Estimated prices for commercial real estate in Cape Girardeau, MO begin at $34,900, with an average of $301,140 and extend to $8,050,000.

    In Cape Girardeau, MO, current investment values show:

    • Land positioned at $168,210
    • Residential land & home lots measuring $71,378
    • Other commercial real estate assessed at $289,750
    • Other specialty properties calculated at $231,341
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    Browse Commercial real estate for Sale Near Cape Girardeau, MO

    Popular Searches in Cape Girardeau, MO

    Most Searched ZIP Codes in Cape Girardeau, MO

    • 63701
    • 63703

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