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    Saint Helena, SC Commercial Real Estate for Lease

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    Commercial Space on Sea Island Parkway
    $2,750 / Mo
    2,178 SF

    Commercial Space on Sea Island Parkway

    2123 Sea Island Pkwy, Saint Helena Island, SC 29920

    Commercial space with high visibility near Fripp and Hunting Islands.

    • Prime commercial location on Sea Island Parkway offering high visibility.
    • Close proximity to Fripp Island (5 miles) and Hunting Island (under 1 mile).
    • Ample parking for clients and employees.
    • Basement currently occupied by a vacation rental business (can vacate if needed).
    • Separate entrance/exit for basement tenant.
    Updated: Jan 15
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    Harbor Island Commercial Office Space
    $450 / Mo
    436 SF

    Harbor Island Commercial Office Space

    2123 Sea Island Pkwy, Saint Helena Island, SC 29920

    Office space available on Harbor Island, excellent visibility and access.

    • High visibility location directly off Sea Island Parkway.
    • Ample on‑site parking and easy access.
    • Proximity to Fripp Island (5 miles) and Hunting Island (under 1 mile).
    • Basement currently occupied by a vacation rental business (tenant can vacate).
    • Opportunity to lease additional office spaces, full building, or individual floors.
    Updated: Jan 15
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    St. Helena Island Convenience Store
    $960 / Mo
    21,780 SF

    St. Helena Island Convenience Store

    Convenience store on a half-acre lot in St. Helena.

    1210 Seaside Rd, Saint Helena Island, SC 29920
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    Commercial Space on Harbor Island
    $1,200 / Mo
    436 SF

    Commercial Space on Harbor Island

    Commercial property with high visibility near Fripp and Hunting Islands.

    2123 Sea Is Pkwy Unit, Saint Helena Island, SC 29920
    View details
    Based on your search, we've compiled 24 Potential Opportunities for your consideration. Besides 4 Active listings in Saint Helena, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 16 Properties for Sales.

    Explore Commercial real estate for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Island Shops: Prime Retail Space
    Contact for pricing
    149,824 SF

    Island Shops: Prime Retail Space

    Walmart-anchored shopping center; space available.

    265 Sea Island Pkwy, Beaufort, SC 29907
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    Retail Center Shadow-Anchored by Walmart
    Contact for pricing

    Retail Center Shadow-Anchored by Walmart

    Retail spaces available in high-traffic, Walmart shadow-anchored shopping center.

    277 Sea Island Pkwy, Beaufort, SC 29907
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    Renovated Office Space For Rent
    $1,600 / Mo

    Renovated Office Space For Rent

    Newly renovated 650 SF office space with utilities included.

    1 Merchants Ln, Ladys Island, SC 29907
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    New Custom-Built Office Suites
    $1,500 / Mo
    3,049 SF

    New Custom-Built Office Suites

    Pre-leasing custom office suites with private entrances, available Q2 2026.

    101 Ladys Island Cmns, Ladys Island, SC 29907
    View details

    Explore Similar Spaces for Sale in Saint Helena, SC

    Consider Similar Space for Sale. We found 16 Spaces in Nearby Locations matching your search parameters.

    Harbor Island Commercial Opportunity
    $1,950,000
    0.93 Acres

    Harbor Island Commercial Opportunity

    Restaurant and roadside marketplace near Fripp and Hunting Islands.

    2111 Sea Island Pkwy, Saint Helena Island, SC 29920
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    St. Helena Island Commercial Property
    $1,450,000
    6.98 Acres

    St. Helena Island Commercial Property

    Commercial property in the heart of St. Helena Island.

    1760 Sea Island Pkwy, Saint Helena Island, SC 29920
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    Versatile Commercial Property on Highway 21
    $595,000
    3,520 SF

    Versatile Commercial Property on Highway 21

    Mixed-use property with high visibility and flexible layout.

    2123 Sea Island Pkwy, Saint Helena Island, SC 29920
    View details
    St. Helena Island Mixed-Use Land
    $429,000
    3.90 Acres

    St. Helena Island Mixed-Use Land

    3.9 acre mixed-use land with development potential.

    785 Sea Island Pkwy, Saint Helena Island, SC 29920
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    Highway Frontage Land Parcel
    $429,000
    3.90 Acres

    Highway Frontage Land Parcel

    Land with flexible zoning and high visibility on Sea Island.

    785 Sea Island Pkwy, Saint Helena Island, SC 29920
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    St. Helena Island Commercial Land
    $299,000
    1.70 Acres

    St. Helena Island Commercial Land

    1.7 acres of commercial land with highway frontage.

    1860 Sea Island Pkwy, Saint Helena Island, SC 29920
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    St. Helena Island Wooded Land
    $180,000
    5.00 Acres

    St. Helena Island Wooded Land

    Five-acre wooded parcels available on Seaside Road, St. Helena Island.

    1751 Seaside Rd, Saint Helena Island, SC 29920
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    St. Helena Island Land Opportunity
    $175,000
    7.17 Acres

    St. Helena Island Land Opportunity

    7.17 acres on St. Helena Island, South Carolina.

    161 Carolina Cswy, Saint Helena Island, SC 29920
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    St. Helena Island Agricultural Land
    $225,000
    6.90 Acres

    St. Helena Island Agricultural Land

    6.9-acre agricultural land near Beaufort and Hunting Island State Park.

    1344 Sea Island Pkwy, Saint Helena Island, SC 29920
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    Waterfront Equestrian Estate Opportunity
    $2,299,900

    Waterfront Equestrian Estate Opportunity

    30-acre waterfront property with equestrian facilities on St. Helena Island.

    71 Tropicana Rd, Saint Helena Island, SC 29920
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    30-Acre Waterfront Estate
    $2,299,900
    30.00 Acres

    30-Acre Waterfront Estate

    30-acre waterfront estate on St. Helena Island, currently an equestrian center.

    71 Tropicana Rd, Saint Helena Island, SC 29920
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    St. Helena Island Land Parcel
    $575,000
    10.76 Acres

    St. Helena Island Land Parcel

    10.76 acre property near beaches and boat landings.

    272 Dulamo Rd, Saint Helena Island, SC 29920
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    9 Acres on St. Helena Island
    $400,000
    9.00 Acres

    9 Acres on St. Helena Island

    Scenic Lowcountry property with wooded areas on St. Helena Island.

    278 Dulamo Rd, Saint Helena Island, SC 29920
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    St. Helena Island Land Tract
    $149,000
    8.92 Acres

    St. Helena Island Land Tract

    Large land tract with high and dry sections on St. Helena.

    1236 Seaside Rd, Saint Helena Island, SC 29920
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    7 Acres Tidal Creek Land
    $375,000
    7.00 Acres

    7 Acres Tidal Creek Land

    Pristine 7-acre land with tidal creek access, no HOA.

    J. Stephens Path, Saint Helena Island, SC 29920
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    Saint Helena Island Waterfront Land
    Contact for pricing

    Saint Helena Island Waterfront Land

    Scenic property with timber and frontage on Village Creek.

    1323 Sea Island Pkwy, Saint Helena Island, SC 29920
    View details

    Saint Helena, SC Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Saint Helena, SC with 20 listings featured on our commercial real estate exchange. The current inventory includes 1,081,559,953 square feet of properties with an estimated lease value of $61 SF/Yr.

    Estimated lease rates for Commercial real estate in Saint Helena, SC begin at $0.53 SF/Yr, with an average of $15 SF/Yr and extend to $33 SF/Yr.
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