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    Saint Helena, SC Commercial Real Estate for Sale

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    Columbia, SC Aiken, SC Greenville, SC
    11 results
    Harbor Island Commercial Opportunity
    $1,950,000
    0.93 Acres

    Harbor Island Commercial Opportunity

    Saint Helena Island, SC 29920

    Restaurant and roadside marketplace near Fripp and Hunting Islands.

    • Prime location on Sea Island Parkway, easy access to Fripp and Hunting Island
    • Established restaurant with commercial kitchen, bar, expansive indoor/outdoor seating
    • Roadside marketplace ideal for selling fresh seafood, fishing gear, and tackle
    • Large acreage (approx. one acre with three separate lots) offering flexibility for future development
    • Oyster wash‑down station, licensed and connected to water
    Updated: Feb 16
    View details
    St. Helena Island Commercial Land
    $390,000
    3.90 Acres

    St. Helena Island Commercial Land

    Saint Helena Island, SC 29920

    Prime development opportunity with flexible zoning and high-traffic frontage.

    • Prime development opportunity on Sea Island Parkway (Highway 21) with excellent visibility.
    • Flexible zoning across multiple parcels: T2RC (mixed‑use) and T2R (rural).
    • Seller offering up to $10,000 toward demolition or renovation costs at closing.
    • Combination of high‑traffic frontage and quiet rear acreage.
    • T2RC zoning allows for retail, office, residential, and limited light industrial development.
    Updated: Nov 10, 2025
    View details
    St. Helena Island Mixed-Use Land
    $390,000
    3.90 Acres

    St. Helena Island Mixed-Use Land

    3.9 acre mixed-use land with development potential.

    Saint Helena Island, SC 29920
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    Waterfront Equestrian Estate Opportunity
    $2,299,900

    Waterfront Equestrian Estate Opportunity

    30-acre waterfront property with equestrian facilities on St. Helena Island.

    71 Tropicana Road, Saint Helena Island, SC 29920
    View details
    St. Helena Island Land Tract
    $149,000
    8.92 Acres

    St. Helena Island Land Tract

    Large land tract with high and dry sections on St. Helena.

    Saint Helena Island, SC 29920
    View details
    St. Helena Island Commercial Property
    $1,450,000
    6.98 Acres

    St. Helena Island Commercial Property

    Commercial property in the heart of St. Helena Island.

    Saint Helena Island, SC 29920
    View details
    30-Acre Waterfront Estate
    $2,299,900
    30.00 Acres

    30-Acre Waterfront Estate

    30-acre waterfront estate on St. Helena Island, currently an equestrian center.

    Saint Helena Island, SC 29920
    View details
    St. Helena Island Land Opportunity
    $175,000
    7.17 Acres

    St. Helena Island Land Opportunity

    7.17 acres on St. Helena Island, South Carolina.

    Saint Helena Island, SC 29920
    View details
    St. Helena Island Commercial Land
    $299,000
    1.70 Acres

    St. Helena Island Commercial Land

    1.7 acres of commercial land with highway frontage.

    Saint Helena Island, SC 29920
    View details
    Saint Helena Island Waterfront Land
    $550,000

    Saint Helena Island Waterfront Land

    Scenic property with timber and frontage on Village Creek.

    1323 Sea Island Parkway, Saint Helena Island, SC 29920
    View details
    St. Helena Island Commercial Land
    $200,000
    2.00 Acres

    St. Helena Island Commercial Land

    Two acre residential/commercial land for sale in St. Helena Island.

    Saint Helena Island, SC 29920
    View details
    Based on your search, we've compiled 196 Potential Opportunities for your consideration. Besides 11 Active listings in Saint Helena, SC, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 181 Off-Market properties to explore as potential leads

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Highway 21 Commercial Development Opportunity
    $1,250,000

    Highway 21 Commercial Development Opportunity

    Prime commercial land with high visibility and traffic count.

    205 Sea Island Parkway, Beaufort, SC 29907
    View details
    Highway Frontage Commercial Development Opportunity
    $1,250,000
    2.50 Acres

    Highway Frontage Commercial Development Opportunity

    Prime commercial land with high visibility and development potential.

    205 Sea Island Parkway, Beaufort, SC 29907
    View details
    Beaufort County Land For Sale
    $1,100,000
    287,932 SF

    Beaufort County Land For Sale

    Land with great potential near Beaufort and Walmart complex.

    291 Sea Island Parkway, Beaufort, SC 29907
    View details
    Beaufort Land Parcel For Sale
    $199,000
    3.40 Acres

    Beaufort Land Parcel For Sale

    3.4 acre building lot near town and airport.

    Airport Cir.& 56 Thomas Atkins Road, Beaufort, SC 29907
    View details

    Explore Off-Market Properties in Saint Helena, SC

    Consider similar Off-Market properties in Saint Helena, SC. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    791 Sea Is Pkwy

    791 Sea Is Pkwy

    RETAIL STORES (PERSONAL SERVICES) • 8,000 SF
    Value Estimation
    $1,115,000
    791 Sea Is Pkwy, Saint Helena Island, SC 29920
    View details
    13 Olde Church Rd

    13 Olde Church Rd

    COMMERCIAL (GENERAL) • 3.39 Acres
    Value Estimation by Request
    13 Olde Church Rd, Saint Helena Island, SC 29920-4006
    View details
    467 Porpoise Cir

    467 Porpoise Cir

    HIGH-RISE APARTMENTS • 1,440 SF
    Value Estimation by Request
    467 Porpoise Cir, Saint Helena Island, SC 29920-7211
    View details
    1551 Sea Is Pkwy

    1551 Sea Is Pkwy

    OFFICE BUILDING • 5,348 SF
    Value Estimation
    $725,000
    1551 Sea Is Pkwy, Saint Helena Island, SC 29920-4001
    View details
    336 Fripp Pt Rd

    336 Fripp Pt Rd

    RECREATIONAL, ENTERTAINMENT
    Value Estimation by Request
    336 Fripp Pt Rd, Saint Helena Island, SC 29920
    View details
    15 Blazing Star Ln

    15 Blazing Star Ln

    COMMERCIAL (GENERAL) • 1.34 Acres
    Value Estimation by Request
    15 Blazing Star Ln, St Helena Is, SC 29920-6314
    View details
    1782 Sea Is Pkwy

    1782 Sea Is Pkwy

    COMMERCIAL (GENERAL) • 0.50 Acres
    Value Estimation by Request
    1782 Sea Is Pkwy, Saint Helena Island, SC 29920-4818
    View details
    1788 Sea Is Pkwy

    1788 Sea Is Pkwy

    RETAIL STORES (PERSONAL SERVICES) • 3,200 SF
    Value Estimation by Request
    1788 Sea Is Pkwy, St Helena Is, SC 29920-4818
    View details
    Saint Helena Island, SC 29920

    Saint Helena Island, SC 29920

    COMMERCIAL (GENERAL) • 0.66 Acres
    Value Estimation by Request
    Saint Helena Island, SC 29920
    View details
    1205 Sea Is Pkwy

    1205 Sea Is Pkwy

    COMMERCIAL (GENERAL) • 4.82 Acres
    Value Estimation by Request
    1205 Sea Is Pkwy, St Helena Is, SC 29920-4307
    View details
    Saint Helena Island, SC 29920

    Saint Helena Island, SC 29920

    LABOR CAMPS (INDUSTRIAL) • 21.98 Acres
    Value Estimation by Request
    Saint Helena Island, SC 29920
    View details
    Saint Helena Island, SC 29920

    Saint Helena Island, SC 29920

    HIGH-RISE APARTMENTS • 2,732 SF
    Value Estimation by Request
    Saint Helena Island, SC 29920
    View details
    Saint Helena Island, SC 29920

    Saint Helena Island, SC 29920

    HIGH-RISE APARTMENTS • 5,228 SF
    Value Estimation by Request
    Saint Helena Island, SC 29920
    View details

    Saint Helena, SC Commercial Real Estate Investment Opportunities Market Analysis

    Explore 192 commercial real estate for sale in Saint Helena, SC, showcased through 11 active listings on our real estate platform. These investment opportunities span a total of 2,853,180 square feet of properties for sale, with an estimated market value of $7,302,900.

    Sale prices for business properties in Saint Helena, SC start at $149,000, averaging $811,433, and reaching up to $2,299,900 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Most Searched ZIP Codes in Saint Helena, SC

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