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    Portsmouth, NH Office Space for Lease

    49 results
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    Retail/Office Space in Portsmouth
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    Retail/Office Space in Portsmouth

    33 Deer St, Portsmouth, NH 03801

    Updated retail/office space with patio in Portsmouth's North End.

    • Prime location on desirable Deer Street in Portsmouth's revitalized North End.
    • Newly updated interior with fresh paint and new flooring.
    • Generous patio/outdoor space adjacent to the Sheraton Hotel and Conference Center.
    • One underground parking space included with rent.
    • Rent includes water, sewer, and trash.
    Updated: Mar 3
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    Prime Portsmouth Commercial Space Available
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    4,792 SF

    Prime Portsmouth Commercial Space Available

    1290 Woodbury Ave, Portsmouth, NH 03801

    1,470 SF office/retail space in high-traffic Portsmouth location.

    • High‑visibility location on Woodbury Avenue in a high‑traffic commercial area.
    • Easy access to Interstate 95 and proximity to shopping plazas (Market Basket, Whole Foods).
    • Flexible 1,470 SF interior layout easily reconfigured for various professional, medical, or retail uses.
    • Ample on‑site parking for clients and employees.
    • Abundant natural light and 10' ceilings creating a bright, welcoming atmosphere.
    Updated: Feb 24
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    Downtown Portsmouth Office For Lease
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    Downtown Portsmouth Office For Lease

    Office space for lease in downtown Portsmouth, available immediately.

    159 Middle St, Portsmouth, NH 03801
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    Portsmouth Office Space For Lease
    Contact for pricing
    48,787 SF

    Portsmouth Office Space For Lease

    Versatile office space in Portsmouth, accessible from city or bypass.

    500 Maplewood Ave, Portsmouth, NH 03801
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    Downtown Portsmouth Modern Office Space
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    Downtown Portsmouth Modern Office Space

    Modern office space in downtown Portsmouth with parking and amenities.

    299 Hanover St, Portsmouth, NH 03801
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    Portsmouth Office Space For Lease
    $10 SF/Yr
    8,202 SF

    Portsmouth Office Space For Lease

    Versatile office space available for lease in Portsmouth, New Hampshire.

    500 Maplewood Ave, Portsmouth, NH 03801
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    Downtown Portsmouth Office Space Available
    Contact for pricing

    Downtown Portsmouth Office Space Available

    Move-in-ready office suites in a vibrant downtown location.

    10 Vaughan St, Portsmouth, NH 03801
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    Downtown Portsmouth Office Space Available
    Contact for pricing

    Downtown Portsmouth Office Space Available

    Move-in-ready office suites in a vibrant, walkable downtown location.

    10 Vaughan St, Portsmouth, NH 03801
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    Downtown Portsmouth Office Suites Available
    Contact for pricing

    Downtown Portsmouth Office Suites Available

    Move-in-ready office suites in a vibrant downtown location.

    10 Vaughan St, Portsmouth, NH 03801
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    Prime Portsmouth Commercial Space Available
    Contact for pricing
    174,240 SF

    Prime Portsmouth Commercial Space Available

    High-traffic location suitable for retail, medical, restaurant, or office use.

    750 Lafayette Rd, Portsmouth, NH 03801
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    Versatile Commercial Space on Lafayette Road
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    174,240 SF

    Versatile Commercial Space on Lafayette Road

    Adaptable space suitable for medical, retail, restaurant, or office use.

    750 Lafayette Rd, Portsmouth, NH 03801
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    Professional Office Space For Lease
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    1,500 SF

    Professional Office Space For Lease

    Individual offices for healthcare practitioners and therapists in Portsmouth, NH.

    4 Greenleaf Woods Dr, Portsmouth, NH 03801
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    Downtown Rollinsford Office/Retail Space
    $2,500 / Mo

    Downtown Rollinsford Office/Retail Space

    Office/retail space in historic downtown Rollinsford, near Dover and Somersworth.

    82 Front St, Portsmouth, NH 03869
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    Versatile Studio Space For Lease
    $1,500 / Mo

    Versatile Studio Space For Lease

    Studio/flex space near Pease International Tradeport, Portsmouth, NH.

    282 Corporate Dr, Portsmouth, NH 03801
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    Retail/Office Space For Lease
    $16 SF/Yr
    4,100 SF

    Retail/Office Space For Lease

    Retail/office space with ample parking and convenient highway access.

    72 Mirona Rd, Portsmouth, NH 03801
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    Modern Office Space Available
    $24 SF/Yr
    3,679 SF

    Modern Office Space Available

    Contemporary office space in premier business corridor, available April 2026.

    75 Portsmouth Blvd, Portsmouth, NH 03801
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    Class A Office Space Available
    $18 SF/Yr
    3,172 SF

    Class A Office Space Available

    Class A office space for rent in Portsmouth, NH.

    210 Commerce Way, Portsmouth, NH 03801
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    Downtown Portsmouth Office Space Available
    $2,000 / Mo

    Downtown Portsmouth Office Space Available

    Professional office space in downtown Portsmouth with parking.

    507 State St, Portsmouth, NH 03801
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    Turn-Key Office Space Available
    $1,100 / Mo

    Turn-Key Office Space Available

    Office space for rent in Portsmouth, NH includes utilities.

    2 Greenleaf Woods Dr, Portsmouth, NH 03801
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    Pease Tradeport Office/Industrial Space
    $8,250,000
    5,320 SF

    Pease Tradeport Office/Industrial Space

    Office and industrial space for lease at Pease Tradeport.

    125 Aviation Ave, Portsmouth, NH 03801
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    Portsmouth Office Space For Rent
    $25 SF/Yr
    5,100 SF

    Portsmouth Office Space For Rent

    Professional office space available in a premier Portsmouth building.

    1000 Market St, Portsmouth, NH 03801
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    Class A Office Space Sublease
    $22 SF/Yr

    Class A Office Space Sublease

    Class A office space for sublease in Portsmouth, NH.

    90 Aboretum Dr, Portsmouth, NH 03801
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    Downtown Portsmouth Office Space Available
    $29 SF/Yr

    Downtown Portsmouth Office Space Available

    Second-floor office space in Vaughan Mall, downtown Portsmouth.

    10 Vaughan Mall St, Portsmouth, NH 03801
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    Downtown Portsmouth Office Space Available
    $18 SF/Yr

    Downtown Portsmouth Office Space Available

    Second-floor office space in downtown Portsmouth's Vaughan Mall.

    10 Vaughan Mall St, Portsmouth, NH 03801
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    Portsmouth, NH Office space Leasing Opportunities Market Analysis

    Explore Office space leasing options in Portsmouth, NH with 61 listings featured on our commercial real estate exchange. The current inventory includes 4,701,300,120 square feet of properties with an estimated lease value of $129 SF/Yr.

    Estimated lease rates for Office space in Portsmouth, NH begin at $1.17 SF/Yr, with an average of $14 SF/Yr and extend to $25 SF/Yr.
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    Browse Office space for Lease Near Portsmouth, NH

    Popular Searches in Portsmouth, NH

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    Most Searched ZIP Codes in Portsmouth, NH

    • 03801
    • 03869

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