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    Portsmouth, NH Office Space for Lease

    50 results
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    Retail/Office Space in Portsmouth
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    Retail/Office Space in Portsmouth

    33 Deer St, Portsmouth, NH 03801

    Updated retail/office space with patio in revitalized North End.

    • Prime location on desirable Deer Street in Portsmouth's revitalized North End.
    • Newly updated interior with fresh paint and new flooring.
    • Generous patio/outdoor space adjacent to the Sheraton Hotel and Conference Center.
    • One included underground parking space.
    • Rent includes water, sewer, and trash.
    Updated: Jan 16
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    Portsmouth Office Space For Lease
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    48,787 SF

    Portsmouth Office Space For Lease

    500 Maplewood Ave, Portsmouth, NH 03801

    Versatile office space in Portsmouth, accessible from city or bypass.

    • Convenient location off Route 1 Bypass, accessible from the city.
    • Versatile first‑floor layout with open showroom/bullpen, 8 private offices, and 2 conference/team rooms.
    • Includes a kitchen and 2 restrooms.
    • Additional storage rooms on the first floor.
    • Large, unfinished 3,921sf second‑floor space suitable for storage or future office build‑out.
    Updated: Dec 30, 2025
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    Prime Portsmouth Commercial Space Available
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    174,240 SF

    Prime Portsmouth Commercial Space Available

    High-traffic location suitable for retail, medical, restaurant, or office use.

    750 Lafayette Rd, Portsmouth, NH 03801
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    Downtown Portsmouth Modern Office Space
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    Downtown Portsmouth Modern Office Space

    Modern office space in downtown Portsmouth with parking and amenities.

    299 Hanover St, Portsmouth, NH 03801
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    Portsmouth Office Space For Lease
    $10 SF/Yr
    8,202 SF

    Portsmouth Office Space For Lease

    Versatile office space available for lease in Portsmouth, New Hampshire.

    500 Maplewood Ave, Portsmouth, NH 03801
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    Versatile Commercial Space on Lafayette Road
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    174,240 SF

    Versatile Commercial Space on Lafayette Road

    Adaptable space suitable for medical, retail, restaurant, or office use.

    750 Lafayette Rd, Portsmouth, NH 03801
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    Prime Portsmouth Commercial Space Available
    Contact for pricing
    4,792 SF

    Prime Portsmouth Commercial Space Available

    1,470 SF office/retail space in high-traffic Portsmouth location.

    1290 Woodbury Ave, Portsmouth, NH 03801
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    Downtown Portsmouth Office Suites Available
    Contact for pricing

    Downtown Portsmouth Office Suites Available

    Move-in-ready office suites in a vibrant downtown location.

    10 Vaughan St, Portsmouth, NH 03801
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    Downtown Portsmouth Office Space Available
    Contact for pricing

    Downtown Portsmouth Office Space Available

    Move-in-ready office suites in a vibrant, walkable downtown location.

    10 Vaughan St, Portsmouth, NH 03801
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    Professional Office Space For Lease
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    1,500 SF

    Professional Office Space For Lease

    Individual offices for healthcare practitioners and therapists in Portsmouth, NH.

    4 Greenleaf Woods Dr, Portsmouth, NH 03801
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    Downtown Portsmouth Office Space Available
    Contact for pricing

    Downtown Portsmouth Office Space Available

    Move-in-ready office suites in a vibrant downtown location.

    10 Vaughan St, Portsmouth, NH 03801
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    Portsmouth Office Space For Lease
    $10 SF/Yr
    8,202 SF

    Portsmouth Office Space For Lease

    8,202 SF Office, Prime Location

    500 Maplewood Ave, Portsmouth, NH 03801
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    Class A Office Space for Lease
    $12 SF/Yr
    62,322 SF

    Class A Office Space for Lease

    Modern, 11,412 SF Executive Office Suite

    300 Constitution Ave, Portsmouth, NH 03801
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    Office Space Near Downtown Portsmouth
    $19 SF/Yr
    10,244 SF

    Office Space Near Downtown Portsmouth

    Office spaces with natural light and convenient location near I-95.

    135 Commerce Way, Portsmouth, NH 03801
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    Class A Office Park Space
    $18 SF/Yr
    2,000 SF

    Class A Office Park Space

    Amenity-rich, ENERGY STAR certified office space for rent.

    1 New Hampshire Ave, Portsmouth, NH
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    Class A Office/Retail Space
    $32 SF/Yr
    2,325 SF

    Class A Office/Retail Space

    First-floor office/retail space in a Gold LEED certified building.

    12-12 Portwalk Pl, Portsmouth, NH
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    Class A Office Space Available
    $18 SF/Yr
    16,027 SF

    Class A Office Space Available

    Flexible office suites with modern amenities and ample parking.

    273 Corporate Dr, Portsmouth, NH 03801
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    Downtown Portsmouth Office Space Available
    $18 SF/Yr

    Downtown Portsmouth Office Space Available

    Second-floor office space in Vaughan Mall, downtown Portsmouth.

    10 Vaughan Mall St, Portsmouth, NH 03801
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    Versatile Studio Space For Lease
    $1,500 / Mo

    Versatile Studio Space For Lease

    Studio/flex space near Pease International Tradeport, Portsmouth, NH.

    282 Corporate Dr, Portsmouth, NH 03801
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    Renovated Office Space For Lease
    $450 / Mo
    165 SF

    Renovated Office Space For Lease

    Newly renovated office condominium in medical park, convenient location.

    230 Lafayette Rd, Portsmouth, NH 03801
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    Economical Office and Warehouse Space
    $12 SF/Yr
    2,539 SF

    Economical Office and Warehouse Space

    Flexible office and warehouse space near major routes.

    200 International Dr, Portsmouth, NH 03801
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    Turnkey Penthouse Executive Office Suite
    $35 SF/Yr
    3,921 SF

    Turnkey Penthouse Executive Office Suite

    Exclusive penthouse office suite with private elevator access and six offices.

    30 Penhallow St, Portsmouth, NH 03801
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    Downtown Rollinsford Office/Retail Space
    $2,500 / Mo

    Downtown Rollinsford Office/Retail Space

    Office/retail space in historic downtown Rollinsford, near Dover and Somersworth.

    82 Front St, Portsmouth, NH 03869
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    Turn-Key Office Space Available
    $1,100 / Mo

    Turn-Key Office Space Available

    Office space for rent in Portsmouth, NH includes utilities.

    2 Greenleaf Woods Dr, Portsmouth, NH 03801
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    Portsmouth, NH Office space Leasing Opportunities Market Analysis

    Explore Office space leasing options in Portsmouth, NH with 62 listings featured on our commercial real estate exchange. The current inventory includes 8,143,106,400 square feet of properties with an estimated lease value of $591 /Mo.

    Estimated lease rates for Office space in Portsmouth, NH begin at $10 SF/Yr, with an average of $21 SF/Yr and extend to $85 SF/Yr.
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    Browse Office space for Lease Near Portsmouth, NH

    Popular Searches in Portsmouth, NH

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    Most Searched ZIP Codes in Portsmouth, NH

    • 03801
    • 03869

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