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    South Portland, ME Office Units for Lease

    18 results
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    South Portland Retail/Office Opportunity
    Contact for pricing
    11,890 SF

    South Portland Retail/Office Opportunity

    264 Gorham Rd, South Portland, ME 04106

    Modern, adaptable space in high-traffic Maine Mall area.

    • Prime location in the Maine Mall retail trade area with high visibility.
    • Easy access from I‑95 and I‑295.
    • Newer construction (built in 2019).
    • Adaptable space suitable for retail or traditional office uses.
    • Large pylon sign on Gorham Road.
    Updated: Sep 23, 2025
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    Office Space in John Roberts
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    10,000 SF

    Office Space in John Roberts

    9 Donald B Dean Dr, South Portland, ME 04106

    Class A office space available for rent in South Portland.

    • Class A office space.
    • 10,000± SF available or subdividable.
    • In close proximity to the Maine Mall & I‑295.
    • Prominent building with great visibility.
    • Located in John Roberts Office Park.
    Updated: Nov 10, 2025
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    South Portland Office Space Available
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    6,321 SF

    South Portland Office Space Available

    Office space for lease near Maine Mall and Portland Jetport.

    311 Darling Ave, South Portland, ME 04106
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    Class-A Office Suite For Lease
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    5,121 SF

    Class-A Office Suite For Lease

    Full-floor office suite in South Portland's Maine Mall area.

    30 Long Creek Dr, South Portland, ME 04106
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    Class A Office Sublease Available
    Contact for pricing
    7,599 SF

    Class A Office Sublease Available

    7,599±SF Class A office space for sublease in South Portland.

    500 Southborough Dr, South Portland, ME 04106
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    South Portland Office Space Available
    Contact for pricing
    2,525 SF

    South Portland Office Space Available

    Office space for lease in landmark South Portland building.

    100 Brickhill Ave, South Portland, ME 04108
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    South Portland Flex/Retail Space
    $15 SF/Yr
    5,500 SF

    South Portland Flex/Retail Space

    5,500± SF office/retail with warehouse, near I-295.

    2325 Broadway, South Portland, ME 04106
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    Corner Office Suite For Rent
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    4,040 SF

    Corner Office Suite For Rent

    4,040± SF office suite with ample free parking.

    202 Gannett Dr, South Portland, ME 04106
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    South Portland Warehouse and Office
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    2,725 SF

    South Portland Warehouse and Office

    Warehouse and office space for lease in South Portland.

    1 Madison St, South Portland, ME 04101
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    Sable Oaks Office Space Available
    $21 SF/Yr
    66,000 SF

    Sable Oaks Office Space Available

    Class A office suites, South Portland, ME.

    707 Sable Oaks Dr, South Portland, ME 04106
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    South Portland Office Space Available
    Contact for pricing
    2,500 SF

    South Portland Office Space Available

    2,500± SF office space for lease in South Portland.

    141 Main St, South Portland, ME 04106
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    Class A Office Space Available
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    36,703 SF

    Class A Office Space Available

    Class A office space for lease near major transportation routes.

    179 John Roberts Rd, South Portland, ME 04106
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    South Portland Office Space Available
    Contact for pricing
    11,162 SF

    South Portland Office Space Available

    Office space for lease in South Portland with ample parking.

    600 Sable Oaks Dr, South Portland, ME 04106
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    South Portland Class A Office
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    8,114 SF

    South Portland Class A Office

    Class A office and flex space in South Portland for lease.

    75 John Roberts Rd, South Portland, ME 04106
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    South Portland Office Space Available
    Contact for pricing
    2,601 SF

    South Portland Office Space Available

    Class A office space for lease near I-95 and I-295.

    324 Cummings Rd, South Portland, ME 04106
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    Class A Office Space Available
    Contact for pricing
    4,759 SF

    Class A Office Space Available

    Class A office space for lease in South Portland, Maine.

    600 Southborough Dr, South Portland, ME 04106
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    Class A Office in Park
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    4,334 SF

    Class A Office in Park

    Class A office space available for rent in South Portland.

    707 Sable Oaks Dr, South Portland, ME 04106
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    Class A Office Suite Available
    Contact for pricing
    3,765 SF

    Class A Office Suite Available

    3,765 SF office suite for lease in South Portland.

    82 Running Hill Rd, South Portland, ME 04106
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    Based on your search, we've compiled 22 Potential Opportunities for your consideration. Besides 18 Active listings in South Portland, ME, we suggest exploring alternatives. Similar 4 Properties for Sales.

    Explore Similar Spaces for Sale in South Portland, ME

    Consider Similar Space for Sale. We found 4 Spaces in Nearby Locations matching your search parameters.

    Mixed-Use Property in South Portland
    $560,000
    4,370 SF

    Mixed-Use Property in South Portland

    Mixed-use property with office spaces and apartment in South Portland.

    854 Broadway, South Portland, ME 04106
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    Mixed-Use Property in South Portland
    $560,000
    0.23 Acres

    Mixed-Use Property in South Portland

    Mixed-use property with office spaces and apartment in South Portland.

    854 Broadway, South Portland, ME 04106
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    South Portland Office Suites for Lease
    $925,000
    4,530 SF

    South Portland Office Suites for Lease

    Office suites for lease near Maine Mall and major highways.

    25 Long Creek Dr, South Portland, ME 04106
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    Office Space Near Maine Mall
    $3,800,000
    19,188 SF

    Office Space Near Maine Mall

    2,495 SF mixed-use/office space near Maine Mall.

    244 Western Ave, South Portland, ME 04106
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    South Portland, ME Office Units Leasing Opportunities Market Analysis

    Explore Office Units leasing options in South Portland, ME with 22 listings featured on our commercial real estate exchange. The current inventory includes 3,175,524,000 square feet of properties with an estimated lease value of $51 SF/Yr.

    Estimated lease rates for Office Units in South Portland, ME begin at $15 SF/Yr, with an average of $17 SF/Yr and extend to $21 SF/Yr.
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    Popular Searches in South Portland, ME

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    Most Searched ZIP Codes in South Portland, ME

    • 04106
    • 04101
    • 04108

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