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    Saint Helena, SC Office Properties & Spaces for Sale

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    New
    Highway 21 Mixed-Use Opportunity
    $650,000
    0.47 Acres

    Highway 21 Mixed-Use Opportunity

    2123 Sea Island Pkwy, Saint Helena Island, SC 29920

    Versatile property with Hwy-21 frontage, suitable for various uses.

    • Prime Hwy‑21 frontage on Harbor Island with high visibility.
    • Versatile 3,520 SF three‑story building suitable for office, live‑work, residential, or short‑term rental use.
    • Gorgeous Lowcountry water and marsh views.
    • Proximity to Fripp Island, Harbor Island, and Dataw Island.
    • Includes a 1,000 SF utility shed and paved parking lot.
    Last Update: Dec 9
    View details
    Based on your search, we've compiled 22 Potential Opportunities for your consideration. Besides 1 Active listings in Saint Helena, SC, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 16 Off-Market properties to explore as potential leads, plus 1 Land Listings that present a potential for development.

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Office/Medical Suite Near Port Royal
    Contact for pricing
    3,224 SF

    Office/Medical Suite Near Port Royal

    Office/medical suite for lease near Port Royal in Beaufort, SC.
    1264 Ribaut Rd, Beaufort, SC 29902
    View details
    Beaufort Medical Office Building
    $575,000
    5,480 SF

    Beaufort Medical Office Building

    Prime Beaufort location, 5,480 SF, $575,000
    2749 Boundary St, Beaufort, SC 29906
    View details
    Office Warehouse Units For Sale
    Contact for pricing
    10,000 SF

    Office Warehouse Units For Sale

    Two warehouse units with office space, available October 1, 2025.
    12 Cardinal Rd, Hilton Head Island, SC 29926
    View details
    Medical Office Suite Near Hospital
    Contact for pricing
    1,500 SF

    Medical Office Suite Near Hospital

    Ground floor medical office suite available near Hilton Head Hospital.
    23 Main St, Hilton Head Island, SC 29926
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    New
    Highway Frontage Land Parcel
    $429,000
    3.90 Acres

    Highway Frontage Land Parcel

    Land with flexible zoning and high visibility on Sea Island.
    785 Sea Island Pkwy, Saint Helena Island, SC 29920
    View details

    Explore Off-Market Properties in Saint Helena, SC

    Consider similar Off-Market properties in Saint Helena, SC. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    1000 Sea Is Pkwy

    1000 Sea Is Pkwy

    OFFICE BUILDING • 2,100 SF
    Value Estimation by Request
    1000 Sea Is Pkwy, Saint Helena Island, SC 29920-4313
    View details
    1 Tarpon Blvd

    1 Tarpon Blvd

    OFFICE (GENERAL) • 6,735 SF
    Value Estimation
    $6,755,000
    1 Tarpon Blvd, Fripp Island, SC 29920-7160
    View details
    572 Sea Is Pkwy

    572 Sea Is Pkwy

    OFFICE BUILDING • 1,232 SF
    Value Estimation by Request
    572 Sea Is Pkwy, Saint Helena Island, SC 29920-4205
    View details
    211 Cotton Dike Rd

    211 Cotton Dike Rd

    OFFICE BUILDING • 2,800 SF
    Value Estimation by Request
    211 Cotton Dike Rd, Saint Helena Island, SC 29920-3804
    View details
    25 Langford Rd

    25 Langford Rd

    OFFICE BUILDING • 864 SF
    Value Estimation by Request
    25 Langford Rd, Saint Helena Island, SC 29920
    View details
    2 Hbr Dr

    2 Hbr Dr

    OFFICE BUILDING • 1,400 SF
    Value Estimation by Request
    2 Hbr Dr, Saint Helena Island, SC 29920-7164
    View details
    34 Susie Ln

    34 Susie Ln

    OFFICE BUILDING • 1,072 SF
    Value Estimation by Request
    34 Susie Ln, Saint Helena Island, SC 29920
    View details
    2123 Sea Is Pkwy

    2123 Sea Is Pkwy

    OFFICE BUILDING • 3,520 SF
    Value Estimation by Request
    2123 Sea Is Pkwy, St Helena Is, SC 29920-5020
    View details
    2119 Sea Is Pkwy

    2119 Sea Is Pkwy

    OFFICE BUILDING • 1,440 SF
    Value Estimation
    $24,555,000
    2119 Sea Is Pkwy, Saint Helena Island, SC 29920-5001
    View details
    213 Tarpon Blvd

    213 Tarpon Blvd

    OFFICE BUILDING • 861 SF
    Value Estimation
    $7,430,000
    213 Tarpon Blvd, Fripp Island, SC 29920
    View details
    2143 Sea Is Pkwy

    2143 Sea Is Pkwy

    OFFICE BUILDING • 1,112 SF
    Value Estimation by Request
    2143 Sea Is Pkwy, Saint Helena Island, SC 29920-5001
    View details
    173 Peaches Hl Cir

    173 Peaches Hl Cir

    OFFICE BUILDING • 2,080 SF
    Value Estimation
    $180,000
    173 Peaches Hl Cir, St Helena Is, SC 29920-5920
    View details
    1551 Sea Is Pkwy

    1551 Sea Is Pkwy

    OFFICE BUILDING • 5,348 SF
    Value Estimation by Request
    1551 Sea Is Pkwy, Saint Helena Island, SC 29920-4001
    View details
    159 Ephraim Rd

    159 Ephraim Rd

    OFFICE BUILDING • 2,624 SF
    Value Estimation by Request
    159 Ephraim Rd, Saint Helena Island, SC 29920-6111
    View details
    Frances Butler Ln

    Frances Butler Ln

    MEDICAL BUILDING • 9,412 SF
    Value Estimation by Request
    Frances Butler Ln, Saint Helena Island, SC 29920
    View details
    Saint Helena Island, SC 29920

    Saint Helena Island, SC 29920

    OFFICE BUILDING • 1,411 SF
    Value Estimation by Request
    Saint Helena Island, SC 29920
    View details

    Saint Helena, SC Office Properties & Spaces Investment Opportunities Market Analysis

    Explore 17 office properties & spaces for sale in Saint Helena, SC on our real estate platform. These investment opportunities span a total of 1,711,472 square feet of properties for sale, with an estimated market value of $43,115,000.

    Prices for office spaces in Saint Helena, SC start at $60,000, averaging $4,790,555, and reaching up to $26,255,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you have the most current data.

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    Browse Office Properties & Spaces for Sale Near Saint Helena, SC

    Popular Searches in Saint Helena, SC

    Most Searched ZIP Codes in Saint Helena, SC

    • 29920

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