Saint Helena, SC Office Properties & Spaces for sale

Versatile Commercial Property on Highway 21

$595,000

3,520 SF

Versatile Commercial Property on Highway 21

2123 Sea Island Pkwy, Saint Helena Island, SC 29920

Mixed-use property with high visibility and flexible layout.

Prime Hwy‑21 frontage on Harbor Island with high visibility.
Versatile 3,520 SF three‑story building suitable for office, live‑work, residential, or short‑term rental use.
Gorgeous Lowcountry water and marsh views.
Proximity to Fripp Island, Harbor Island, and Dataw Island.
Includes a 1,000 SF utility shed and paved parking lot.

Updated: Feb 16

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Explore Opportunities in Nearby Cities

Here are 4 Similar properties we found in Nearby Locations for your consideration.

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8,944 SF

Lady's Island Office Space

Conveniently located 1,250 SF office space on major thoroughfare.

189 Sea Island Pkwy, Beaufort, SC 29907

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Waterfront Mixed-Use Landmark Property

Unique mixed-use property with panoramic waterfront views in downtown Beaufort.

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Office Warehouse Units For Sale

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Hilton Head Commercial Space Available

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Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

$429,000

3.90 Acres

Highway Frontage Land Parcel

Land with flexible zoning and high visibility on Sea Island.

785 Sea Island Pkwy, Saint Helena Island, SC 29920

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Explore Off-Market Properties in Saint Helena, SC

Consider similar Off-Market properties in Saint Helena, SC. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

1000 Sea Is Pkwy

OFFICE BUILDING • 2,100 SF

Value Estimation by Request

1000 Sea Is Pkwy, Saint Helena Island, SC 29920-4313

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1 Tarpon Blvd

OFFICE (GENERAL) • 6,735 SF

Value Estimation by Request

1 Tarpon Blvd, Fripp Island, SC 29920-7160

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572 Sea Is Pkwy

OFFICE BUILDING • 1,232 SF

Value Estimation by Request

572 Sea Is Pkwy, Saint Helena Island, SC 29920-4205

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211 Cotton Dike Rd

OFFICE BUILDING • 2,800 SF

Value Estimation by Request

211 Cotton Dike Rd, Saint Helena Island, SC 29920-3804

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25 Langford Rd

OFFICE BUILDING • 864 SF

Value Estimation by Request

25 Langford Rd, Saint Helena Island, SC 29920

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2 Hbr Dr

OFFICE BUILDING • 1,400 SF

Value Estimation by Request

2 Hbr Dr, Saint Helena Island, SC 29920-7164

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34 Susie Ln

OFFICE BUILDING • 1,072 SF

Value Estimation by Request

34 Susie Ln, Saint Helena Island, SC 29920

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2123 Sea Is Pkwy

OFFICE BUILDING • 3,520 SF

Value Estimation by Request

2123 Sea Is Pkwy, St Helena Is, SC 29920-5020

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2119 Sea Is Pkwy

OFFICE BUILDING • 1,440 SF

Value Estimation by Request

2119 Sea Is Pkwy, Saint Helena Island, SC 29920-5001

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213 Tarpon Blvd

OFFICE BUILDING • 861 SF

Value Estimation by Request

213 Tarpon Blvd, Fripp Island, SC 29920

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2143 Sea Is Pkwy

OFFICE BUILDING • 1,112 SF

Value Estimation by Request

2143 Sea Is Pkwy, Saint Helena Island, SC 29920-5001

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173 Peaches Hl Cir

OFFICE BUILDING • 2,080 SF

Value Estimation by Request

173 Peaches Hl Cir, St Helena Is, SC 29920-5920

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1551 Sea Is Pkwy

OFFICE BUILDING • 5,348 SF

Value Estimation

$725,000

1551 Sea Is Pkwy, Saint Helena Island, SC 29920-4001

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159 Ephraim Rd

OFFICE BUILDING • 2,624 SF

Value Estimation

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159 Ephraim Rd, Saint Helena Island, SC 29920-6111

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Frances Butler Ln

MEDICAL BUILDING • 9,412 SF

Value Estimation by Request

Frances Butler Ln, Saint Helena Island, SC 29920

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Saint Helena Island, SC 29920

OFFICE BUILDING • 1,411 SF

Value Estimation by Request

Saint Helena Island, SC 29920

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Saint Helena, SC Office Properties & Spaces Investment Opportunities Market Analysis

Explore 17 office properties & spaces for sale in Saint Helena, SC on our real estate platform. These investment opportunities span a total of 1,711,472 square feet of properties for sale, with an estimated market value of $43,060,000.

Sale prices for office spaces in Saint Helena, SC start at $60,000, averaging $4,784,444, and reaching up to $26,255,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

Saint Helena, SC Office Properties & Spaces for Sale

Versatile Commercial Property on Highway 21

Mixed-use property with high visibility and flexible layout.