Neffsville, PA Office Spaces for Sale

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27 properties

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Updated: Nov 25, 2025

Downtown Lancaster Assemblage For Sale

37-45 North Duke Street, Lancaster, PA 17603

$2,295,000

30,008 sqft

Single tenant net lease with 100% occupancy through 2027.
Prime downtown Lancaster location across from the courthouse and near Penn Square.
Three‑parcel assemblage totaling approximately 30,000 SF.
Includes 27 on‑site parking spaces.
Potential redevelopment opportunity for multi‑family or mixed‑use.

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This listing looks promising.

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37-45 North Duke Street, Lancaster, PA 17603

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Est. Cap Rate

7.3%
Above avg (5.9%)
Est. NOI

$167K
Annual
Price @ 7% Cap

$2.39M
Above asking

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Updated: Aug 24

Turnkey Medical Office Facility

60 W WALNUT Street, Lancaster, PA 17603

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0.72 AC lot

Multiple clinical suites with dental equipment, fixtures, and furnishings in place
Flexible configuration for one multispecialty practice or multiple dental and medical users
On‑site parking at 60 W Walnut Street, Lancaster, PA 17603
0.72‑acre parcel
Central Air cooling

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Mixed-Use Property with Separate Entrances

112 W CHESTNUT STREET, Lancaster, PA 17603

$594,900

1,864 sqft

First-floor retail and office space pairs with a two-bedroom apartment above.

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Clear-Span Open Office Suite

313 W LIBERTY STREET #335, Lancaster, PA 17603

$156,135

10,409 sqft

Office suite with reception, mailroom, private restroom, server room, and large windows in a wheelchair-accessible office building.

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Leased Office Condominium Units

1525 Oregon Pike, Lancaster, PA 17601

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5,000 sqft

Five office condominium units within Oregon Commons, totaling approximately 5,000 square feet, are fully leased to two tenants.

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Professional Condo in Downtown Lancaster

128 East Grant Street, Lancaster, PA 17602

$115,000

1,242 sqft

Upscale condo with offices and conference room in downtown Lancaster.

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Industrial Building with Office

216 Wohlsen Way, Lancaster, PA 17603

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29,011 sqft

Industrial building includes well-appointed office space, two dock doors, three drive-in doors, and 36 on-site parking spaces.

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Corner Office Unit with Parking

222 E ORANGE STREET #100, Lancaster, PA 17602

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1,320 sqft

Historic suite offers a glass entry, private restroom, built-in storage, and dedicated signage.

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Mixed-Use Storefront and Residence

305 N QUEEN ST, Lancaster, PA 17603

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3,316 sqft

First-floor storefront with flexible space plus an upscale 2nd- and 3rd-floor residence, suited for live-work operations.

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Office Unit With Elevator Access

415 N PRINCE STREET, Lancaster, PA 17603

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1,810 sqft

Condominium-style professional space in a restored building with parking garage access and a central Lancaster City business address.

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Office Suite with Open Floor Plan

425 N PRINCE STREET #001, Lancaster, PA 17603

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3,252 sqft

A mostly open 3,252 SF office suite with original wood beams, exposed stone walls, and natural light.

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Second-Floor Office Suite

3002 HEMPLAND ROAD #2, Lancaster, PA 17601

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882 sqft

Professional office layout with private rooms, reception space, and a conference room in a business park setting.

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Historic Building Retail/Office Suite

325 N QUEEN STREET #101, Lancaster, PA 17603

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1,420 sqft

Bright suite with large street-facing windows, private restroom, and a treatment/storage room in the Keppel Building.

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Bi-Level Office Suite with Staircase

325 N QUEEN STREET #G-03, Lancaster, PA 17603

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1,065 sqft

Bi-level suite in the historic Keppel Building with two open work areas connected by a spiral staircase.

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Three-Story Brick Building For Sale

100 North Queen Street, Lancaster, PA 17603

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77,294 sqft

Three-story brick building with finished lower level and outside space.

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Mixed-Use Warehouse and Retail Building

548-550 New Holland Ave, Lancaster, PA 17602

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10,938 sqft 0.68 AC lot

Free-standing C-2 building combines retail, office, warehouse space with dock and grade-level doors, plus a second-floor apartment.

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Five-Unit Mixed-Use Property

205 E King St, Lancaster, PA 17602

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3,322 sqft

First-floor commercial space supports a combination of residential and business uses in downtown Lancaster.

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Private Outdoor Viewing Deck Office Building

311 HARRISBURG AVENUE, Lancaster, PA 17603

$4,250,000

Office building converted from a tobacco warehouse with a private outdoor viewing deck into Penn Medicine Stadium.

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Medical Building Near Residential Community

3045 Marietta Ave, Lancaster, PA

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15,710 sqft 1.69 AC lot

Three-story medical building with grade-level entrances and elevator access.

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Office Space with Apartment

1515 Oregon Pike, Lancaster, PA 17601

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2,280 sqft

Office suite includes private offices, open area, front office, and bath, plus an upstairs apartment and parking.

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Commercial Office/Retail Building

2205 Oregon Pike, Lancaster, PA 17601

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4,435 sqft

Well-maintained office building currently totaling 4,435 SF and zoned for Commercial Office/retail use.

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Office Suite for Sale

22E East Roseville Road, Neffsville, PA 17601

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For sale office suite offering 1,726 SF of enclosed workspace.

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Lancaster Commercial Property with Drive-Through

1950 Old Philadelphia Pike, Lancaster, PA 17602

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2,935 sqft

High-visibility commercial property with drive-through and flexible zoning.

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Corporate Headquarters Office Building

1770 Hempstead Road, Lancaster, PA 17601

$443,993

14,095 sqft

Recently constructed office space in a corporate headquarters building available for sale.

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Neffsville, PA Office Spaces Market Trends and Statistics

Explore 27 office spaces for sale in Neffsville, PA, showcased through 27 active listings on our real estate platform. These investment opportunities span a total of 263,292 square feet of properties for sale, with an estimated market value of $7,855,028.

Sale prices for office spaces in Neffsville, PA start at $115,000, averaging $1,309,171, and reaching up to $4,250,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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Top Commercial Asset Segments

Commercial property segments ranked by active listings on the market

Demographics Overview

Population 56K

Population Growth (5Y) +7.7%

Median Household Income $96,433

College Educated 66.4%

Listings Trend

New vs delisted commercial listings in Lancaster County

New Delisted

Total CRE Inventory on Market (SF)

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